Tan0004663 (gene) Snake gourd v1

Overview
NameTan0004663
Typegene
OrganismTrichosanthes anguina (Snake gourd v1)
Descriptionmitochondrial import receptor subunit TOM7-1-like
LocationLG09: 69355374 .. 69356342 (+)
RNA-Seq ExpressionTan0004663
SyntenyTan0004663
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: five_prime_UTRexonCDSpolypeptidethree_prime_UTR
Hold the cursor over a type above to highlight its positions in the sequence below.
GTTTAAAGGTAGTACAACAGTCGCGCAATAAAACACGAAGGTACCCGCGTTCAGCAGAGATCGAATTCTCGTAACAATGGCGTCGAAGGTTTCTCTTAAAAGCAAGGGCAAGAGCACCAAGGGTTCTTCGAAGTCATCTGAGGAGAAATCCAAAACCCAAGCCTTCAAGGAATGGACCACTTGGGCTGTGAAGAAAGCCAAGGTCATCACCCACTATGGCTTTATTCCTCTGGTCATCATCATCGGCATGAACTCTGAACCTAAGCCTCAGCTCTCCCAACTTCTCAGCCCCGTCTAATCTTATTGCTTTCCATACCTTTATCTCCAAGATTTACCGCTTTTTAATGATGGATCAGTTCCTTCTCGTCGATTCACGACTTGGGTTTCTCTTTTATGCGGATCTTTTTTTGGGGGGTTAGTTGGCGTATAAAATTTAGTTAGGTTTGGGTATAATATTGCGTTTCTCGTTCTTGGCATGCTTGAACTACAGAAGACATGTAATAATTTGAGCGAAATTTTTTAACTATTTTGCACTTCTGATGAAGTATTTGATTATGTTATCGCCTTGTCGGTTTGAATTTTGGTGCAGTTCTCTTTTCCAAATTTTGTCTTTTTATTCAGATTATTGAATGGGTTAGGGTTTAATTGCTCTATCTGATCGAAATTGAGTGACAGTATCATCAATGAAGCGCACGCGAGGGATAGGCTGTTGGTGTATTATCAAAAAGCCCATTTTATGGTGGCCATTTTTCCTACCTTCTTCCTCATGGTAACTGATCAAGGTTTTGTGATCACCATTGTATGACTTGATGATTCTATTATCTTTCATTATGTTCTAGCATGTAGAATGTTTCCTTTAAATTATTGTGATCATGAGTAAACTTTAACTCCAATGTCTAAACTCTCCTTGACATGAGCTTGGGGATTCTGTTAATGTTCATGTTCTTAACATTATGTGTTATCTGCCCC

mRNA sequence

GTTTAAAGGTAGTACAACAGTCGCGCAATAAAACACGAAGGTACCCGCGTTCAGCAGAGATCGAATTCTCGTAACAATGGCGTCGAAGGTTTCTCTTAAAAGCAAGGGCAAGAGCACCAAGGGTTCTTCGAAGTCATCTGAGGAGAAATCCAAAACCCAAGCCTTCAAGGAATGGACCACTTGGGCTGTGAAGAAAGCCAAGGTCATCACCCACTATGGCTTTATTCCTCTGGTCATCATCATCGGCATGAACTCTGAACCTAAGCCTCAGCTCTCCCAACTTCTCAGCCCCGTCTAATCTTATTGCTTTCCATACCTTTATCTCCAAGATTTACCGCTTTTTAATGATGGATCAGTTCCTTCTCGTCGATTCACGACTTGGGTTTCTCTTTTATGCGGATCTTTTTTTGGGGGGTTAGTTGGCGTATAAAATTTAGTTAGGTTTGGGTATAATATTGCGTTTCTCGTTCTTGGCATGCTTGAACTACAGAAGACATGTAATAATTTGAGCGAAATTTTTTAACTATTTTGCACTTCTGATGAAGTATTTGATTATGTTATCGCCTTGTCGGTTTGAATTTTGGTGCAGTTCTCTTTTCCAAATTTTGTCTTTTTATTCAGATTATTGAATGGGTTAGGGTTTAATTGCTCTATCTGATCGAAATTGAGTGACAGTATCATCAATGAAGCGCACGCGAGGGATAGGCTGTTGGTGTATTATCAAAAAGCCCATTTTATGGTGGCCATTTTTCCTACCTTCTTCCTCATGGTAACTGATCAAGGTTTTGTGATCACCATTGTATGACTTGATGATTCTATTATCTTTCATTATGTTCTAGCATGTAGAATGTTTCCTTTAAATTATTGTGATCATGAGTAAACTTTAACTCCAATGTCTAAACTCTCCTTGACATGAGCTTGGGGATTCTGTTAATGTTCATGTTCTTAACATTATGTGTTATCTGCCCC

Coding sequence (CDS)

ATGGCGTCGAAGGTTTCTCTTAAAAGCAAGGGCAAGAGCACCAAGGGTTCTTCGAAGTCATCTGAGGAGAAATCCAAAACCCAAGCCTTCAAGGAATGGACCACTTGGGCTGTGAAGAAAGCCAAGGTCATCACCCACTATGGCTTTATTCCTCTGGTCATCATCATCGGCATGAACTCTGAACCTAAGCCTCAGCTCTCCCAACTTCTCAGCCCCGTCTAA

Protein sequence

MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNSEPKPQLSQLLSPV
Homology
BLAST of Tan0004663 vs. ExPASy Swiss-Prot
Match: Q9ASY8 (Mitochondrial import receptor subunit TOM7-1 OS=Arabidopsis thaliana OX=3702 GN=TOM7-1 PE=1 SV=1)

HSP 1 Score: 91.3 bits (225), Expect = 5.0e-18
Identity = 50/76 (65.79%), Postives = 60/76 (78.95%), Query Frame = 0

Query: 1  MASKVSL---KSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIG 60
          M S +SL   K KGK +KG+S SS++KSK    KEWT W++KKAKV+THYGFIPLVI +G
Sbjct: 1  MESTISLKVNKGKGKGSKGAS-SSDDKSKFDVVKEWTNWSLKKAKVVTHYGFIPLVIFVG 60

Query: 61 MNSEPKPQLSQLLSPV 74
          MNS+PKP L QLLSPV
Sbjct: 61 MNSDPKPHLFQLLSPV 75

BLAST of Tan0004663 vs. ExPASy Swiss-Prot
Match: Q3ECI7 (Mitochondrial import receptor subunit TOM7-2 OS=Arabidopsis thaliana OX=3702 GN=TOM7-2 PE=2 SV=1)

HSP 1 Score: 86.3 bits (212), Expect = 1.6e-16
Identity = 49/77 (63.64%), Postives = 60/77 (77.92%), Query Frame = 0

Query: 1  MASKVSLKSKGKS--TKGSSKSSEE--KSKTQAFKEWTTWAVKKAKVITHYGFIPLVIII 60
          MA+K +LK KGK+  +KGSS SS     SK + FK+WT W+++KAKV THYGFIPL+III
Sbjct: 1  MAAKSTLKIKGKAKPSKGSSSSSSSSASSKYKVFKDWTNWSLQKAKVATHYGFIPLIIII 60

Query: 61 GMNSEPKPQLSQLLSPV 74
          GMNS+PKP L  LLSPV
Sbjct: 61 GMNSDPKPHLFHLLSPV 77

BLAST of Tan0004663 vs. ExPASy Swiss-Prot
Match: O82067 (Mitochondrial import receptor subunit TOM7-1 OS=Solanum tuberosum OX=4113 GN=TOM7-1 PE=3 SV=3)

HSP 1 Score: 84.7 bits (208), Expect = 4.6e-16
Identity = 47/71 (66.20%), Postives = 53/71 (74.65%), Query Frame = 0

Query: 7  LKSKGKSTKGSSKSSEEKSKT----QAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNSEP 66
          LK KGK+TK ++ + E+        +  KEW TW  KKAKVITHYGFIPLVIIIGMNSEP
Sbjct: 2  LKPKGKNTKKAAAADEDDGAVAVVGKFVKEWGTWTAKKAKVITHYGFIPLVIIIGMNSEP 61

Query: 67 KPQLSQLLSPV 74
          KP LSQLLSPV
Sbjct: 62 KPSLSQLLSPV 72

BLAST of Tan0004663 vs. NCBI nr
Match: XP_022921829.1 (mitochondrial import receptor subunit TOM7-1-like [Cucurbita moschata] >XP_022988536.1 mitochondrial import receptor subunit TOM7-1-like [Cucurbita maxima] >XP_023516449.1 mitochondrial import receptor subunit TOM7-1-like [Cucurbita pepo subsp. pepo] >KAG6589655.1 Mitochondrial import receptor subunit TOM7-1, partial [Cucurbita argyrosperma subsp. sororia] >KAG7023343.1 Mitochondrial import receptor subunit TOM7-1, partial [Cucurbita argyrosperma subsp. argyrosperma])

HSP 1 Score: 129.8 bits (325), Expect = 9.6e-27
Identity = 69/73 (94.52%), Postives = 72/73 (98.63%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MASKVSL+SKGKS+KGSSKSSE+KS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASKVSLRSKGKSSKGSSKSSEDKSTTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. NCBI nr
Match: XP_038879584.1 (mitochondrial import receptor subunit TOM7-1-like [Benincasa hispida])

HSP 1 Score: 129.8 bits (325), Expect = 9.6e-27
Identity = 69/73 (94.52%), Postives = 72/73 (98.63%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MASKVSL+SKGKS+KGSSKSSEEKS TQ+FKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASKVSLRSKGKSSKGSSKSSEEKSATQSFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. NCBI nr
Match: XP_022930857.1 (mitochondrial import receptor subunit TOM7-1-like [Cucurbita moschata] >XP_023529840.1 mitochondrial import receptor subunit TOM7-1-like [Cucurbita pepo subsp. pepo] >KAG7021670.1 Mitochondrial import receptor subunit TOM7-1, partial [Cucurbita argyrosperma subsp. argyrosperma])

HSP 1 Score: 129.0 bits (323), Expect = 1.6e-26
Identity = 70/73 (95.89%), Postives = 70/73 (95.89%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MAS VSLKSKGKSTKGSSKSSE KS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASNVSLKSKGKSTKGSSKSSEGKSATQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. NCBI nr
Match: KAG6587702.1 (Mitochondrial import receptor subunit TOM7-1, partial [Cucurbita argyrosperma subsp. sororia])

HSP 1 Score: 129.0 bits (323), Expect = 1.6e-26
Identity = 70/73 (95.89%), Postives = 70/73 (95.89%), Query Frame = 0

Query: 1   MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
           MAS VSLKSKGKSTKGSSKSSE KS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 57  MASNVSLKSKGKSTKGSSKSSEGKSATQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 116

Query: 61  EPKPQLSQLLSPV 74
           EPKPQLSQLLSPV
Sbjct: 117 EPKPQLSQLLSPV 129

BLAST of Tan0004663 vs. NCBI nr
Match: XP_008455820.1 (PREDICTED: mitochondrial import receptor subunit TOM7-1-like [Cucumis melo] >TYJ98347.1 mitochondrial import receptor subunit TOM7-1-like [Cucumis melo var. makuwa])

HSP 1 Score: 128.6 bits (322), Expect = 2.1e-26
Identity = 69/73 (94.52%), Postives = 71/73 (97.26%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MASKVSL+SKGKS+K SSKSSEEKS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASKVSLRSKGKSSKSSSKSSEEKSATQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. ExPASy TrEMBL
Match: A0A6J1JHG5 (mitochondrial import receptor subunit TOM7-1-like OS=Cucurbita maxima OX=3661 GN=LOC111485747 PE=3 SV=1)

HSP 1 Score: 129.8 bits (325), Expect = 4.6e-27
Identity = 69/73 (94.52%), Postives = 72/73 (98.63%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MASKVSL+SKGKS+KGSSKSSE+KS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASKVSLRSKGKSSKGSSKSSEDKSTTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. ExPASy TrEMBL
Match: A0A6J1E1M9 (mitochondrial import receptor subunit TOM7-1-like OS=Cucurbita moschata OX=3662 GN=LOC111429970 PE=3 SV=1)

HSP 1 Score: 129.8 bits (325), Expect = 4.6e-27
Identity = 69/73 (94.52%), Postives = 72/73 (98.63%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MASKVSL+SKGKS+KGSSKSSE+KS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASKVSLRSKGKSSKGSSKSSEDKSTTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. ExPASy TrEMBL
Match: A0A6J1ERT8 (mitochondrial import receptor subunit TOM7-1-like OS=Cucurbita moschata OX=3662 GN=LOC111437215 PE=3 SV=1)

HSP 1 Score: 129.0 bits (323), Expect = 7.9e-27
Identity = 70/73 (95.89%), Postives = 70/73 (95.89%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MAS VSLKSKGKSTKGSSKSSE KS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASNVSLKSKGKSTKGSSKSSEGKSATQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. ExPASy TrEMBL
Match: A0A5D3BGU9 (Mitochondrial import receptor subunit TOM7-1-like OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold232G00780 PE=3 SV=1)

HSP 1 Score: 128.6 bits (322), Expect = 1.0e-26
Identity = 69/73 (94.52%), Postives = 71/73 (97.26%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MASKVSL+SKGKS+K SSKSSEEKS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASKVSLRSKGKSSKSSSKSSEEKSATQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. ExPASy TrEMBL
Match: A0A1S3C1D2 (mitochondrial import receptor subunit TOM7-1-like OS=Cucumis melo OX=3656 GN=LOC103495918 PE=3 SV=1)

HSP 1 Score: 128.6 bits (322), Expect = 1.0e-26
Identity = 69/73 (94.52%), Postives = 71/73 (97.26%), Query Frame = 0

Query: 1  MASKVSLKSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60
          MASKVSL+SKGKS+K SSKSSEEKS TQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS
Sbjct: 1  MASKVSLRSKGKSSKSSSKSSEEKSATQAFKEWTTWAVKKAKVITHYGFIPLVIIIGMNS 60

Query: 61 EPKPQLSQLLSPV 74
          EPKPQLSQLLSPV
Sbjct: 61 EPKPQLSQLLSPV 73

BLAST of Tan0004663 vs. TAIR 10
Match: AT5G41685.1 (Mitochondrial outer membrane translocase complex, subunit Tom7 )

HSP 1 Score: 91.3 bits (225), Expect = 3.5e-19
Identity = 50/76 (65.79%), Postives = 60/76 (78.95%), Query Frame = 0

Query: 1  MASKVSL---KSKGKSTKGSSKSSEEKSKTQAFKEWTTWAVKKAKVITHYGFIPLVIIIG 60
          M S +SL   K KGK +KG+S SS++KSK    KEWT W++KKAKV+THYGFIPLVI +G
Sbjct: 1  MESTISLKVNKGKGKGSKGAS-SSDDKSKFDVVKEWTNWSLKKAKVVTHYGFIPLVIFVG 60

Query: 61 MNSEPKPQLSQLLSPV 74
          MNS+PKP L QLLSPV
Sbjct: 61 MNSDPKPHLFQLLSPV 75

BLAST of Tan0004663 vs. TAIR 10
Match: AT1G64220.1 (translocase of outer membrane 7 kDa subunit 2 )

HSP 1 Score: 86.3 bits (212), Expect = 1.1e-17
Identity = 49/77 (63.64%), Postives = 60/77 (77.92%), Query Frame = 0

Query: 1  MASKVSLKSKGKS--TKGSSKSSEE--KSKTQAFKEWTTWAVKKAKVITHYGFIPLVIII 60
          MA+K +LK KGK+  +KGSS SS     SK + FK+WT W+++KAKV THYGFIPL+III
Sbjct: 1  MAAKSTLKIKGKAKPSKGSSSSSSSSASSKYKVFKDWTNWSLQKAKVATHYGFIPLIIII 60

Query: 61 GMNSEPKPQLSQLLSPV 74
          GMNS+PKP L  LLSPV
Sbjct: 61 GMNSDPKPHLFHLLSPV 77

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
Q9ASY85.0e-1865.79Mitochondrial import receptor subunit TOM7-1 OS=Arabidopsis thaliana OX=3702 GN=... [more]
Q3ECI71.6e-1663.64Mitochondrial import receptor subunit TOM7-2 OS=Arabidopsis thaliana OX=3702 GN=... [more]
O820674.6e-1666.20Mitochondrial import receptor subunit TOM7-1 OS=Solanum tuberosum OX=4113 GN=TOM... [more]
Match NameE-valueIdentityDescription
XP_022921829.19.6e-2794.52mitochondrial import receptor subunit TOM7-1-like [Cucurbita moschata] >XP_02298... [more]
XP_038879584.19.6e-2794.52mitochondrial import receptor subunit TOM7-1-like [Benincasa hispida][more]
XP_022930857.11.6e-2695.89mitochondrial import receptor subunit TOM7-1-like [Cucurbita moschata] >XP_02352... [more]
KAG6587702.11.6e-2695.89Mitochondrial import receptor subunit TOM7-1, partial [Cucurbita argyrosperma su... [more]
XP_008455820.12.1e-2694.52PREDICTED: mitochondrial import receptor subunit TOM7-1-like [Cucumis melo] >TYJ... [more]
Match NameE-valueIdentityDescription
A0A6J1JHG54.6e-2794.52mitochondrial import receptor subunit TOM7-1-like OS=Cucurbita maxima OX=3661 GN... [more]
A0A6J1E1M94.6e-2794.52mitochondrial import receptor subunit TOM7-1-like OS=Cucurbita moschata OX=3662 ... [more]
A0A6J1ERT87.9e-2795.89mitochondrial import receptor subunit TOM7-1-like OS=Cucurbita moschata OX=3662 ... [more]
A0A5D3BGU91.0e-2694.52Mitochondrial import receptor subunit TOM7-1-like OS=Cucumis melo var. makuwa OX... [more]
A0A1S3C1D21.0e-2694.52mitochondrial import receptor subunit TOM7-1-like OS=Cucumis melo OX=3656 GN=LOC... [more]
Match NameE-valueIdentityDescription
AT5G41685.13.5e-1965.79Mitochondrial outer membrane translocase complex, subunit Tom7 [more]
AT1G64220.11.1e-1763.64translocase of outer membrane 7 kDa subunit 2 [more]
InterPro
Analysis Name: InterPro Annotations of Snake gourd (anguina) v1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR012621Mitochondrial import receptor subunit TOM7PFAMPF08038Tom7coord: 31..70
e-value: 2.2E-17
score: 62.4
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..28
NoneNo IPR availablePANTHERPTHR34944:SF2MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7coord: 1..73
NoneNo IPR availablePANTHERPTHR34944MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7coord: 1..73

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Tan0004663.1Tan0004663.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0030150 protein import into mitochondrial matrix
cellular_component GO:0016021 integral component of membrane
cellular_component GO:0005742 mitochondrial outer membrane translocase complex
molecular_function GO:0016788 hydrolase activity, acting on ester bonds
molecular_function GO:0003676 nucleic acid binding