HG10011918 (gene) Bottle gourd (Hangzhou Gourd) v1

Overview
NameHG10011918
Typegene
OrganismLagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
DescriptionGlutathione peroxidase
LocationChr01: 15428236 .. 15429230 (-)
RNA-Seq ExpressionHG10011918
SyntenyHG10011918
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: polypeptideCDS
Hold the cursor over a type above to highlight its positions in the sequence below.
ATGCATTTCATTATCTCCTTCATCCTCCTCATTCATGCCTCTCGGACAACCAGTGCAGGAAGTTTGTTTAAAATTCAATCTAATTTGTTGAAGACAACCCTCTATTTCTTCTACATGGTCTTTTCACTCCCCATTGGTGCTCTATTTCATAACATCTCAATCTCCGTATGTTGTCGGCACTCATAATAAGATAATGCTATTATAGAAATGAAAAGCATAAATCTCCTATAAAAATGAATAACGAGAGAGCTGAAATATTTGGAAAAGAGCGCTTATATTCTAGCTCTTAAACTTTTTGTCAGATGTATGATTGAAAAAAACTATCTTTACGACTGAAACCGTACAAAAAAATTGATACTCTTGCTTAGTTAATTTATTTTTGAAATTAATTGATGTCTTGTGATTTAGAGATATCCCATTTTAGGGGGGGAAAAAAAGAGCCACACATTATTCCACGCCCTACATAGTCTCGTATTATTGATAGTCTCATGAGTAGTCAGATTTATTTTCTTAAGCTCTACCAATATGTATATTGAATAATTATATACGGATTGAAGAAACTCAGCCTGCACCTGTTCCTGCCACTTCTATTTATCAATGACAGCTTGATGTTTCATTAAGAAAACCCAGCCTGTGCTTTTTGCTGCAATGAGATGAACTGTGTGTAGTATACCACGCTGCACTTTAAACTTATCAGTACATGGAGAGTATCGTTTGGTCACTTTCATTTAAATGAGAATTATTAAATCTGTACTTTACTCTTTGAACTATTAATTCTGGTTTTAAAACAGCCCATTTTTTGTTTTCAGGTAAGTGTGAACGGCCCTGATACGGCACCCGTCTATAAGTTCCTCAAAGCTAGTAAAACTGGATTTTTGGGGTCTAGAATAAAGTGGAATTTTACCAAGTTCTTAGTTGACAAAGAAGGTCGTGCCATCAAACGTTATGGCACGACCACTACTCCCCTGGCAATTGAGGTAATTCTCAATAGCTAG

mRNA sequence

ATGCATTTCATTATCTCCTTCATCCTCCTCATTCATGCCTCTCGGACAACCAGTGCAGGAAGTTTGTTTAAAATTCAATCTAATTTGTTGAAGACAACCCTCTATTTCTTCTACATGGTCTTTTCACTCCCCATTGGTGCTCTATTTCATAACATCTCAATCTCCGTAAGTGTGAACGGCCCTGATACGGCACCCGTCTATAAGTTCCTCAAAGCTAGTAAAACTGGATTTTTGGGGTCTAGAATAAAGTGGAATTTTACCAAGTTCTTAGTTGACAAAGAAGGTCGTGCCATCAAACGTTATGGCACGACCACTACTCCCCTGGCAATTGAGGTAATTCTCAATAGCTAG

Coding sequence (CDS)

ATGCATTTCATTATCTCCTTCATCCTCCTCATTCATGCCTCTCGGACAACCAGTGCAGGAAGTTTGTTTAAAATTCAATCTAATTTGTTGAAGACAACCCTCTATTTCTTCTACATGGTCTTTTCACTCCCCATTGGTGCTCTATTTCATAACATCTCAATCTCCGTAAGTGTGAACGGCCCTGATACGGCACCCGTCTATAAGTTCCTCAAAGCTAGTAAAACTGGATTTTTGGGGTCTAGAATAAAGTGGAATTTTACCAAGTTCTTAGTTGACAAAGAAGGTCGTGCCATCAAACGTTATGGCACGACCACTACTCCCCTGGCAATTGAGGTAATTCTCAATAGCTAG

Protein sequence

MHFIISFILLIHASRTTSAGSLFKIQSNLLKTTLYFFYMVFSLPIGALFHNISISVSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIEVILNS
Homology
BLAST of HG10011918 vs. NCBI nr
Match: XP_022155674.1 (probable glutathione peroxidase 5 [Momordica charantia])

HSP 1 Score: 117.5 bits (293), Expect = 7.8e-23
Identity = 56/56 (100.00%), Postives = 56/56 (100.00%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE
Sbjct: 105 VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 160

BLAST of HG10011918 vs. NCBI nr
Match: XP_023533991.1 (probable glutathione peroxidase 5 [Cucurbita pepo subsp. pepo])

HSP 1 Score: 116.3 bits (290), Expect = 1.7e-22
Identity = 55/56 (98.21%), Postives = 56/56 (100.00%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPL+IE
Sbjct: 105 VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLSIE 160

BLAST of HG10011918 vs. NCBI nr
Match: XP_022995871.1 (probable glutathione peroxidase 5 [Cucurbita maxima])

HSP 1 Score: 116.3 bits (290), Expect = 1.7e-22
Identity = 55/56 (98.21%), Postives = 56/56 (100.00%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPL+IE
Sbjct: 105 VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLSIE 160

BLAST of HG10011918 vs. NCBI nr
Match: XP_022931092.1 (probable glutathione peroxidase 5 [Cucurbita moschata] >KAG6606430.1 putative glutathione peroxidase 4, partial [Cucurbita argyrosperma subsp. sororia] >KAG7036371.1 putative glutathione peroxidase 4 [Cucurbita argyrosperma subsp. argyrosperma])

HSP 1 Score: 116.3 bits (290), Expect = 1.7e-22
Identity = 55/56 (98.21%), Postives = 56/56 (100.00%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPL+IE
Sbjct: 105 VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLSIE 160

BLAST of HG10011918 vs. NCBI nr
Match: XP_008449386.1 (PREDICTED: probable glutathione peroxidase 5 [Cucumis melo] >KAA0057378.1 putative glutathione peroxidase 5 [Cucumis melo var. makuwa] >TYK30067.1 putative glutathione peroxidase 5 [Cucumis melo var. makuwa])

HSP 1 Score: 113.2 bits (282), Expect = 1.5e-21
Identity = 53/56 (94.64%), Postives = 55/56 (98.21%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V+VNGPDTAPVYKFLKASKTGFLG+RIKWNFTKFLVDKEG AIKRYGTTTTPLAIE
Sbjct: 105 VNVNGPDTAPVYKFLKASKTGFLGTRIKWNFTKFLVDKEGHAIKRYGTTTTPLAIE 160

BLAST of HG10011918 vs. ExPASy Swiss-Prot
Match: Q8L910 (Probable glutathione peroxidase 4 OS=Arabidopsis thaliana OX=3702 GN=GPX4 PE=2 SV=1)

HSP 1 Score: 87.0 bits (214), Expect = 1.5e-16
Identity = 41/56 (73.21%), Postives = 45/56 (80.36%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNG + AP+YKFLKASK  FLGSRIKWNFTKFLV K+G  I RYGT  TPL+IE
Sbjct: 105 VRVNGQNAAPIYKFLKASKPTFLGSRIKWNFTKFLVGKDGLVIDRYGTMVTPLSIE 160

BLAST of HG10011918 vs. ExPASy Swiss-Prot
Match: Q9LYB4 (Probable glutathione peroxidase 5 OS=Arabidopsis thaliana OX=3702 GN=GPX5 PE=1 SV=1)

HSP 1 Score: 86.3 bits (212), Expect = 2.5e-16
Identity = 39/56 (69.64%), Postives = 46/56 (82.14%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNG + APVYKFLK+ K  FLGSRIKWNFTKFLV K+G+ I RYGTT +PL+I+
Sbjct: 107 VRVNGQNAAPVYKFLKSKKPSFLGSRIKWNFTKFLVGKDGQVIDRYGTTVSPLSIQ 162

BLAST of HG10011918 vs. ExPASy Swiss-Prot
Match: O23968 (Probable phospholipid hydroperoxide glutathione peroxidase OS=Helianthus annuus OX=4232 GN=GPXHA-2 PE=2 SV=1)

HSP 1 Score: 84.7 bits (208), Expect = 7.4e-16
Identity = 37/56 (66.07%), Postives = 46/56 (82.14%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V+VNG +  P+YKFLK+SK GFLG  IKWNFTKFLVD+EG+ + RY  TT+PL+IE
Sbjct: 115 VNVNGKEADPLYKFLKSSKGGFLGDSIKWNFTKFLVDREGKVVDRYAPTTSPLSIE 170

BLAST of HG10011918 vs. ExPASy Swiss-Prot
Match: Q9SZ54 (Putative glutathione peroxidase 7, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=GPX7 PE=3 SV=2)

HSP 1 Score: 82.4 bits (202), Expect = 3.7e-15
Identity = 36/56 (64.29%), Postives = 44/56 (78.57%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNGP TAP+YKFLK++  GFLG  IKWNF KFLVDK+G+ ++RY  TT+P  IE
Sbjct: 169 VDVNGPSTAPIYKFLKSNAGGFLGDIIKWNFEKFLVDKKGKVVERYPPTTSPFQIE 224

BLAST of HG10011918 vs. ExPASy Swiss-Prot
Match: O49069 (Probable phospholipid hydroperoxide glutathione peroxidase OS=Gossypium hirsutum OX=3635 PE=2 SV=1)

HSP 1 Score: 82.0 bits (201), Expect = 4.8e-15
Identity = 36/56 (64.29%), Postives = 43/56 (76.79%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNG + AP+YKFLK+SK GF G  IKWNF+KFLVDKEG  + RY  TTTP ++E
Sbjct: 105 VDVNGDNAAPLYKFLKSSKGGFFGDSIKWNFSKFLVDKEGNVVDRYSPTTTPASME 160

BLAST of HG10011918 vs. ExPASy TrEMBL
Match: A0A6J1DQY9 (Glutathione peroxidase OS=Momordica charantia OX=3673 GN=LOC111022751 PE=3 SV=1)

HSP 1 Score: 117.5 bits (293), Expect = 3.8e-23
Identity = 56/56 (100.00%), Postives = 56/56 (100.00%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE
Sbjct: 105 VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 160

BLAST of HG10011918 vs. ExPASy TrEMBL
Match: A0A6J1K339 (Glutathione peroxidase OS=Cucurbita maxima OX=3661 GN=LOC111491269 PE=3 SV=1)

HSP 1 Score: 116.3 bits (290), Expect = 8.4e-23
Identity = 55/56 (98.21%), Postives = 56/56 (100.00%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPL+IE
Sbjct: 105 VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLSIE 160

BLAST of HG10011918 vs. ExPASy TrEMBL
Match: A0A6J1ESJ2 (Glutathione peroxidase OS=Cucurbita moschata OX=3662 GN=LOC111437382 PE=3 SV=1)

HSP 1 Score: 116.3 bits (290), Expect = 8.4e-23
Identity = 55/56 (98.21%), Postives = 56/56 (100.00%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPL+IE
Sbjct: 105 VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLSIE 160

BLAST of HG10011918 vs. ExPASy TrEMBL
Match: A0A5A7UQH6 (Glutathione peroxidase OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold216G00400 PE=3 SV=1)

HSP 1 Score: 113.2 bits (282), Expect = 7.1e-22
Identity = 53/56 (94.64%), Postives = 55/56 (98.21%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V+VNGPDTAPVYKFLKASKTGFLG+RIKWNFTKFLVDKEG AIKRYGTTTTPLAIE
Sbjct: 105 VNVNGPDTAPVYKFLKASKTGFLGTRIKWNFTKFLVDKEGHAIKRYGTTTTPLAIE 160

BLAST of HG10011918 vs. ExPASy TrEMBL
Match: A0A1S3BLX5 (Glutathione peroxidase OS=Cucumis melo OX=3656 GN=LOC103491282 PE=3 SV=1)

HSP 1 Score: 113.2 bits (282), Expect = 7.1e-22
Identity = 53/56 (94.64%), Postives = 55/56 (98.21%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V+VNGPDTAPVYKFLKASKTGFLG+RIKWNFTKFLVDKEG AIKRYGTTTTPLAIE
Sbjct: 105 VNVNGPDTAPVYKFLKASKTGFLGTRIKWNFTKFLVDKEGHAIKRYGTTTTPLAIE 160

BLAST of HG10011918 vs. TAIR 10
Match: AT2G48150.1 (glutathione peroxidase 4 )

HSP 1 Score: 87.0 bits (214), Expect = 1.1e-17
Identity = 41/56 (73.21%), Postives = 45/56 (80.36%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNG + AP+YKFLKASK  FLGSRIKWNFTKFLV K+G  I RYGT  TPL+IE
Sbjct: 105 VRVNGQNAAPIYKFLKASKPTFLGSRIKWNFTKFLVGKDGLVIDRYGTMVTPLSIE 160

BLAST of HG10011918 vs. TAIR 10
Match: AT3G63080.1 (glutathione peroxidase 5 )

HSP 1 Score: 86.3 bits (212), Expect = 1.8e-17
Identity = 39/56 (69.64%), Postives = 46/56 (82.14%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNG + APVYKFLK+ K  FLGSRIKWNFTKFLV K+G+ I RYGTT +PL+I+
Sbjct: 107 VRVNGQNAAPVYKFLKSKKPSFLGSRIKWNFTKFLVGKDGQVIDRYGTTVSPLSIQ 162

BLAST of HG10011918 vs. TAIR 10
Match: AT4G31870.1 (glutathione peroxidase 7 )

HSP 1 Score: 82.4 bits (202), Expect = 2.6e-16
Identity = 36/56 (64.29%), Postives = 44/56 (78.57%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNGP TAP+YKFLK++  GFLG  IKWNF KFLVDK+G+ ++RY  TT+P  IE
Sbjct: 169 VDVNGPSTAPIYKFLKSNAGGFLGDIIKWNFEKFLVDKKGKVVERYPPTTSPFQIE 224

BLAST of HG10011918 vs. TAIR 10
Match: AT2G25080.1 (glutathione peroxidase 1 )

HSP 1 Score: 80.9 bits (198), Expect = 7.6e-16
Identity = 34/56 (60.71%), Postives = 44/56 (78.57%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNGP TAP+Y+FLK++  GFLG  IKWNF KFL+DK+G+ ++RY  TT+P  IE
Sbjct: 172 VDVNGPSTAPIYEFLKSNAGGFLGGLIKWNFEKFLIDKKGKVVERYPPTTSPFQIE 227

BLAST of HG10011918 vs. TAIR 10
Match: AT4G11600.1 (glutathione peroxidase 6 )

HSP 1 Score: 78.2 bits (191), Expect = 4.9e-15
Identity = 35/56 (62.50%), Postives = 41/56 (73.21%), Query Frame = 0

Query: 56  VSVNGPDTAPVYKFLKASKTGFLGSRIKWNFTKFLVDKEGRAIKRYGTTTTPLAIE 112
           V VNG   APVYKFLK+SK G  G  IKWNF KFLVDK+G  + R+  TT+PL+IE
Sbjct: 166 VDVNGDKAAPVYKFLKSSKGGLFGDGIKWNFAKFLVDKDGNVVDRFAPTTSPLSIE 221

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
XP_022155674.17.8e-23100.00probable glutathione peroxidase 5 [Momordica charantia][more]
XP_023533991.11.7e-2298.21probable glutathione peroxidase 5 [Cucurbita pepo subsp. pepo][more]
XP_022995871.11.7e-2298.21probable glutathione peroxidase 5 [Cucurbita maxima][more]
XP_022931092.11.7e-2298.21probable glutathione peroxidase 5 [Cucurbita moschata] >KAG6606430.1 putative gl... [more]
XP_008449386.11.5e-2194.64PREDICTED: probable glutathione peroxidase 5 [Cucumis melo] >KAA0057378.1 putati... [more]
Match NameE-valueIdentityDescription
Q8L9101.5e-1673.21Probable glutathione peroxidase 4 OS=Arabidopsis thaliana OX=3702 GN=GPX4 PE=2 S... [more]
Q9LYB42.5e-1669.64Probable glutathione peroxidase 5 OS=Arabidopsis thaliana OX=3702 GN=GPX5 PE=1 S... [more]
O239687.4e-1666.07Probable phospholipid hydroperoxide glutathione peroxidase OS=Helianthus annuus ... [more]
Q9SZ543.7e-1564.29Putative glutathione peroxidase 7, chloroplastic OS=Arabidopsis thaliana OX=3702... [more]
O490694.8e-1564.29Probable phospholipid hydroperoxide glutathione peroxidase OS=Gossypium hirsutum... [more]
Match NameE-valueIdentityDescription
A0A6J1DQY93.8e-23100.00Glutathione peroxidase OS=Momordica charantia OX=3673 GN=LOC111022751 PE=3 SV=1[more]
A0A6J1K3398.4e-2398.21Glutathione peroxidase OS=Cucurbita maxima OX=3661 GN=LOC111491269 PE=3 SV=1[more]
A0A6J1ESJ28.4e-2398.21Glutathione peroxidase OS=Cucurbita moschata OX=3662 GN=LOC111437382 PE=3 SV=1[more]
A0A5A7UQH67.1e-2294.64Glutathione peroxidase OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold2... [more]
A0A1S3BLX57.1e-2294.64Glutathione peroxidase OS=Cucumis melo OX=3656 GN=LOC103491282 PE=3 SV=1[more]
Match NameE-valueIdentityDescription
AT2G48150.11.1e-1773.21glutathione peroxidase 4 [more]
AT3G63080.11.8e-1769.64glutathione peroxidase 5 [more]
AT4G31870.12.6e-1664.29glutathione peroxidase 7 [more]
AT2G25080.17.6e-1660.71glutathione peroxidase 1 [more]
AT4G11600.14.9e-1562.50glutathione peroxidase 6 [more]
InterPro
Analysis Name: InterPro Annotations of Bottle gourd (Hangzhou Gourd) v1
Date Performed: 2022-08-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3D3.40.30.10Glutaredoxincoord: 18..115
e-value: 3.9E-21
score: 77.1
NoneNo IPR availablePANTHERPTHR11592:SF106GLUTATHIONE PEROXIDASEcoord: 53..112
IPR000889Glutathione peroxidasePANTHERPTHR11592GLUTATHIONE PEROXIDASEcoord: 53..112
IPR000889Glutathione peroxidasePROSITEPS51355GLUTATHIONE_PEROXID_3coord: 56..116
score: 22.784517
IPR036249Thioredoxin-like superfamilySUPERFAMILY52833Thioredoxin-likecoord: 56..113

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
HG10011918.1HG10011918.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0098869 cellular oxidant detoxification
biological_process GO:0006979 response to oxidative stress
cellular_component GO:0005829 cytosol
molecular_function GO:0004602 glutathione peroxidase activity