MELO3C018593.2 (gene) Melon (DHL92) v3.6.1

Overview
NameMELO3C018593.2
Typegene
OrganismCucumis melo (Melon (DHL92) v3.6.1)
DescriptionCysteine proteinase inhibitor
Locationchr01 : 1344317 .. 1344988 (-)
Genome Viewer
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: five_prime_UTRexonCDSthree_prime_UTR
Hold the cursor over a type above to highlight its positions in the sequence below.
ATCATCACAAACTAAACCTTTTGTCCATAATACACACACCAATAACTAAATCAAGTTAGATATCACAATGATTTCTACCGTGCTTGCCAACATCGGTCAACATGATCCCATCCTCCATGTGACGTCAAAGGATACGAAGGGTGATCATCAATCCGAATGGATATCGATTCGCGCTATCGAAGACCCTTACGTGCAAGAAGTCGCGAAATTCGCCGTGAGAGAGTTCGAGAAGGAAAAAATGGCAAGATCTCAATACAAACGGTTGCTAAGTTGTTGGATTAAAGAGGAGATGGGAGGTATAAAATATCGTCTTATCCTCGAGGTAATTAAAGAAGAAAAAATTGAGGGTAAATATGAGGCTATTGTATGGGAGGCTTCTGGCCGTTTGATTATAAGGAAGCTTAAGCTTATATCTTTCATGCCTTGTATGCATGGGGTTGCATGACATTTCCATCCCCTCTTTGTATAATTCAATCTACAAAGCTTATGGTGTGAAATGCCATTGGTAAAATAAACAAAAAAAGGAAAAAGAAGTATATATATACTTTCTATGTAAAATTCTCTTCTCTATGTTATTCAAAAACTATGGATCTTTGTGTTCAATCAAACAATTAATCATCCAATCAACTTAGTTTTTAGATTTATATTTTGAATTTATTCATAATGTGAAAA

mRNA sequence

ATCATCACAAACTAAACCTTTTGTCCATAATACACACACCAATAACTAAATCAAGTTAGATATCACAATGATTTCTACCGTGCTTGCCAACATCGGTCAACATGATCCCATCCTCCATGTGACGTCAAAGGATACGAAGGGTGATCATCAATCCGAATGGATATCGATTCGCGCTATCGAAGACCCTTACGTGCAAGAAGTCGCGAAATTCGCCGTGAGAGAGTTCGAGAAGGAAAAAATGGCAAGATCTCAATACAAACGGTTGCTAAGTTGTTGGATTAAAGAGGAGATGGGAGGTATAAAATATCGTCTTATCCTCGAGGTAATTAAaGAAGAAAAAATTGAGGGTAAATATGAGGCTATTGTATGGGAGGCTTCTGGCCGTTTGATTATAAGGAAGCTTAAGCTTATATCTTTCATGCCTTGTATGCATGGGGTTGCATGACATTTCCATCCCCTCTTTGTATAATTCAATCTACAAAGCTTATGGTGTGAAATGCCATTGGTAAAATAAACAAAAAAAGGAAAAAGAAGTATATATATACTTTCTATGTAAAATTCTCTTCTCTATGTTATTCAAAAACTATGGATCTTTGTGTTCAATCAAACAATTAATCATCCAATCAACTTAGTTTTTAGATTTATATTTTGAATTTATTCATAATGTGAAAA

Coding sequence (CDS)

ATGATTTCTACCGTGCTTGCCAACATCGGTCAACATGATCCCATCCTCCATGTGACGTCAAAGGATACGAAGGGTGATCATCAATCCGAATGGATATCGATTCGCGCTATCGAAGACCCTTACGTGCAAGAAGTCGCGAAATTCGCCGTGAGAGAGTTCGAGAAGGAAAAAATGGCAAGATCTCAATACAAACGGTTGCTAAGTTGTTGGATTAAAGAGGAGATGGGAGGTATAAAATATCGTCTTATCCTCGAGGTAATTAAAGAAGAAAAAATTGAGGGTAAATATGAGGCTATTGTATGGGAGGCTTCTGGCCGTTTGATTATAAGGAAGCTTAAGCTTATATCTTTCATGCCTTGTATGCATGGGGTTGCATGA

Protein sequence

MISTVLANIGQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEEKIEGKYEAIVWEASGRLIIRKLKLISFMPCMHGVA
Homology
[Close]
BLAST of MELO3C018593.2 vs. NCBI nr
Match: KGN43767.1 (Cystatin domain containing protein [Cucumis sativus])

HSP 1 Score: 239.6 bits (610), Expect = 5.8e-60
Identity = 116/125 (92.80%), Postives = 122/125 (97.60%), Query Frame = 0 

Query: 1   MISTVLANIGQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFAVREFEKEKMAR 60
           MIST+LAN+GQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFA+REFEKEKMAR
Sbjct: 1   MISTLLANVGQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFAMREFEKEKMAR 60

Query: 61  SQYKRLLSCWIKEEMGGIKYRLILEVIKEEKIEGKYEAIVWEASGRLIIRKLKLISFMPC 120
            QYKRLLSCWIKEEMGGIKYRL+LEVIKEEK+EGKYEA+VWEASGRLIIRKLKLISFMP 
Sbjct: 61  FQYKRLLSCWIKEEMGGIKYRLVLEVIKEEKLEGKYEAVVWEASGRLIIRKLKLISFMPS 120

Query: 121 MHGVA 126
           MHG A
Sbjct: 121 MHGAA 125

[Close]
BLAST of MELO3C018593.2 vs. NCBI nr
Match: XP_022973098.1 (cysteine proteinase inhibitor 5-like [Cucurbita maxima])

HSP 1 Score: 60.8 bits (146), Expect = 3.7e-06
Identity = 32/89 (35.96%), Postives = 55/89 (61.80%), Query Frame = 0 

Query: 31  WISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEE 90
           W  I+ ++DP++QE+ KFAV E+ K+     ++K ++     + + G+ YRL++E  K E
Sbjct: 31  WEKIKDVKDPHIQEIGKFAVSEYNKQSKGALEFKDVVK-GESQVVSGMNYRLVIEAKKGE 90

Query: 91  KIEGKYEAIVWEASGRLIIRKLKLISFMP 120
            I GKY+A+VWE + +     ++L SF P
Sbjct: 91  SI-GKYQALVWEKAWQ---HFMELTSFKP 114

[Close]
BLAST of MELO3C018593.2 vs. NCBI nr
Match: XP_022927193.1 (cysteine proteinase inhibitor 5-like [Cucurbita moschata])

HSP 1 Score: 60.5 bits (145), Expect = 4.8e-06
Identity = 31/89 (34.83%), Postives = 55/89 (61.80%), Query Frame = 0 

Query: 31  WISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEE 90
           W  I+ ++DP++QE+ KFAV E+ K+     ++K ++     + + G+ YRL++E  K E
Sbjct: 31  WEKIKDVKDPHIQEIGKFAVSEYNKQSKGALEFKDVVK-GESQVVSGMNYRLVIEAKKGE 90

Query: 91  KIEGKYEAIVWEASGRLIIRKLKLISFMP 120
            I GKY+A++WE + +     ++L SF P
Sbjct: 91  SI-GKYQALIWEKAWQ---HFMELTSFKP 114

[Close]
BLAST of MELO3C018593.2 vs. NCBI nr
Match: XP_023520814.1 (cysteine proteinase inhibitor 5-like [Cucurbita pepo subsp. pepo])

HSP 1 Score: 60.1 bits (144), Expect = 6.3e-06
Identity = 32/89 (35.96%), Postives = 54/89 (60.67%), Query Frame = 0 

Query: 31  WISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEE 90
           W  I+ ++DP++QE+ KFAV E+ K+     ++K ++     + + G  YRL++E  K E
Sbjct: 31  WEKIKDVKDPHIQEIGKFAVSEYNKQSKGALEFKDVVK-GESQVVSGTNYRLVIEAKKGE 90

Query: 91  KIEGKYEAIVWEASGRLIIRKLKLISFMP 120
            I GKY+A+VWE + +     ++L SF P
Sbjct: 91  SI-GKYQALVWEKAWQ---HFMELTSFKP 114

[Close]
BLAST of MELO3C018593.2 vs. NCBI nr
Match: XP_022975708.1 (cysteine proteinase inhibitor A-like [Cucurbita maxima])

HSP 1 Score: 57.4 bits (137), Expect = 4.1e-05
Identity = 41/112 (36.61%), Postives = 56/112 (50.00%), Query Frame = 0 

Query: 1   MISTVLANIGQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFAVREFEKEKMAR 60
           M S V A  GQ++ +     +D KG    +W  I  I DPYVQE+ +FAV E  K     
Sbjct: 1   MSSYVEAAPGQNEAVF----QDQKGIECGQWEPIVNIMDPYVQELGRFAVMENNKNTRGH 60

Query: 61  SQYKRLLSCWIKEEMGGIKYRLILEVIKEEKIEGKYEAIV----WEASGRLI 109
            ++  ++  W  + + G  YRLI+E   E    G YEAIV    WE +  LI
Sbjct: 61  LKFICVIKGW-TQVVAGKNYRLIIEACNELGFPGTYEAIVYVKPWEKTWELI 107

[Close]
BLAST of MELO3C018593.2 vs. Swiss-Prot
Match: sp|Q10Q47|CYT7_ORYSJ (Putative cysteine proteinase inhibitor 7 OS=Oryza sativa subsp. japonica OX=39947 GN=Os03g0210100 PE=3 SV=1)

HSP 1 Score: 48.1 bits (113), Expect = 8.1e-05
Identity = 30/83 (36.14%), Postives = 46/83 (55.42%), Query Frame = 0 

Query: 37  IEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEEKIEGKY 96
           I DP+VQE+ ++AV E ++   A       ++   K+ + G+ YRL LE       +G+Y
Sbjct: 35  INDPHVQELGRWAVAEEDRGVAAGGLTFERVTDGEKQVVAGVNYRLTLEASSSGAKDGRY 94

Query: 97  EAIVWEASGRLIIRKLKLISFMP 120
           EA+V+E   R   R  KL+SF P
Sbjct: 95  EAVVYEQDPRSNAR--KLVSFEP 115

[Close]
BLAST of MELO3C018593.2 vs. TrEMBL
Match: tr|A0A0A0K644|A0A0A0K644_CUCSA (Cysteine proteinase inhibitor OS=Cucumis sativus OX=3659 GN=Csa_7G066240 PE=3 SV=1)

HSP 1 Score: 239.6 bits (610), Expect = 3.8e-60
Identity = 116/125 (92.80%), Postives = 122/125 (97.60%), Query Frame = 0 

Query: 1   MISTVLANIGQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFAVREFEKEKMAR 60
           MIST+LAN+GQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFA+REFEKEKMAR
Sbjct: 1   MISTLLANVGQHDPILHVTSKDTKGDHQSEWISIRAIEDPYVQEVAKFAMREFEKEKMAR 60

Query: 61  SQYKRLLSCWIKEEMGGIKYRLILEVIKEEKIEGKYEAIVWEASGRLIIRKLKLISFMPC 120
            QYKRLLSCWIKEEMGGIKYRL+LEVIKEEK+EGKYEA+VWEASGRLIIRKLKLISFMP 
Sbjct: 61  FQYKRLLSCWIKEEMGGIKYRLVLEVIKEEKLEGKYEAVVWEASGRLIIRKLKLISFMPS 120

Query: 121 MHGVA 126
           MHG A
Sbjct: 121 MHGAA 125

[Close]
BLAST of MELO3C018593.2 vs. TrEMBL
Match: tr|A0A2P2NS36|A0A2P2NS36_RHIMU (Cysteine proteinase inhibitor OS=Rhizophora mucronata OX=61149 PE=3 SV=1)

HSP 1 Score: 62.0 bits (149), Expect = 1.1e-06
Identity = 37/89 (41.57%), Postives = 53/89 (59.55%), Query Frame = 0 

Query: 31  WISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEE 90
           W  I  + DP+VQE+A +AVRE+     A  + +RL+    K+ + GIKYRL+L  +KE 
Sbjct: 32  WTPITNLSDPHVQEIASYAVREYNHRSNANLKLQRLVK-GEKQVVSGIKYRLVL-AVKEG 91

Query: 91  KIEGKYEAIVWEASGRLIIRKLKLISFMP 120
             + KY+A+VWE +        KLISF P
Sbjct: 92  GSDKKYQAVVWEKAWE---HFRKLISFKP 115

[Close]
BLAST of MELO3C018593.2 vs. TrEMBL
Match: tr|A0A2I0ARN8|A0A2I0ARN8_9ASPA (Cysteine proteinase inhibitor OS=Apostasia shenzhenica OX=1088818 GN=CYS5 PE=3 SV=1)

HSP 1 Score: 56.2 bits (134), Expect = 6.0e-05
Identity = 32/87 (36.78%), Postives = 52/87 (59.77%), Query Frame = 0 

Query: 31  WISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEE 90
           W  I+ + DP+VQE+A+FAV E  K+     Q  R++S    + + G+KYRL+L+     
Sbjct: 68  WQPIKNLSDPHVQEIARFAVAEHNKKGSGLLQLSRVVS-GETQVVSGVKYRLVLQATGGS 127

Query: 91  KIEGKYEAIVWEASGRLIIRKLKLISF 118
              G+YEA+VWE   +  ++  +L+SF
Sbjct: 128 GAYGEYEAVVWE---KAWVKFRQLLSF 150

[Close]
BLAST of MELO3C018593.2 vs. TrEMBL
Match: tr|A0A1U8PY17|A0A1U8PY17_GOSHI (Cysteine proteinase inhibitor OS=Gossypium hirsutum OX=3635 GN=LOC107963097 PE=3 SV=1)

HSP 1 Score: 54.7 bits (130), Expect = 1.7e-04
Identity = 30/82 (36.59%), Postives = 51/82 (62.20%), Query Frame = 0 

Query: 31  WISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEE 90
           W  I+ I+DP+V E+A+FA+ E+ K+     + + ++     + + GI Y L+L+V K+E
Sbjct: 20  WTPIKNIKDPHVTEIAEFAIDEYNKQSKGNLKLEEVVK-GKTQVVSGINYTLVLQV-KDE 79

Query: 91  KIEGKYEAIVWEASGRLIIRKL 113
            ++  YEA+VWE +  L  RKL
Sbjct: 80  TVDNSYEAVVWEKAW-LKFRKL 98

[Close]
BLAST of MELO3C018593.2 vs. TrEMBL
Match: tr|A0A2P5X992|A0A2P5X992_GOSBA (Cysteine proteinase inhibitor OS=Gossypium barbadense OX=3634 GN=GOBAR_AA20764 PE=3 SV=1)

HSP 1 Score: 54.7 bits (130), Expect = 1.7e-04
Identity = 30/82 (36.59%), Postives = 51/82 (62.20%), Query Frame = 0 

Query: 31  WISIRAIEDPYVQEVAKFAVREFEKEKMARSQYKRLLSCWIKEEMGGIKYRLILEVIKEE 90
           W  I+ I+DP+V E+A+FA+ E+ K+     + + ++     + + GI Y L+L+V K+E
Sbjct: 33  WTPIKNIKDPHVTEIAEFAIDEYNKQSKGNLKLEEVVK-GKTQVVSGINYTLVLQV-KDE 92

Query: 91  KIEGKYEAIVWEASGRLIIRKL 113
            ++  YEA+VWE +  L  RKL
Sbjct: 93  TVDNSYEAVVWEKAW-LKFRKL 111

The following BLAST results are available for this feature:
BLAST of MELO3C018593.2 vs. NCBI nr
Match NameE-valueIdentityDescription
KGN43767.15.8e-6092.80Cystatin domain containing protein [Cucumis sativus][more]
XP_022973098.13.7e-0635.96cysteine proteinase inhibitor 5-like [Cucurbita maxima][more]
XP_022927193.14.8e-0634.83cysteine proteinase inhibitor 5-like [Cucurbita moschata][more]
XP_023520814.16.3e-0635.96cysteine proteinase inhibitor 5-like [Cucurbita pepo subsp. pepo][more]
XP_022975708.14.1e-0536.61cysteine proteinase inhibitor A-like [Cucurbita maxima][more]
BLAST of MELO3C018593.2 vs. TAIR10
Match NameE-valueIdentityDescription
BLAST of MELO3C018593.2 vs. Swiss-Prot
Match NameE-valueIdentityDescription
sp|Q10Q47|CYT7_ORYSJ8.1e-0536.14Putative cysteine proteinase inhibitor 7 OS=Oryza sativa subsp. japonica OX=3994... [more]
BLAST of MELO3C018593.2 vs. TrEMBL
Match NameE-valueIdentityDescription
tr|A0A0A0K644|A0A0A0K644_CUCSA3.8e-6092.80Cysteine proteinase inhibitor OS=Cucumis sativus OX=3659 GN=Csa_7G066240 PE=3 SV... [more]
tr|A0A2P2NS36|A0A2P2NS36_RHIMU1.1e-0641.57Cysteine proteinase inhibitor OS=Rhizophora mucronata OX=61149 PE=3 SV=1[more]
tr|A0A2I0ARN8|A0A2I0ARN8_9ASPA6.0e-0536.78Cysteine proteinase inhibitor OS=Apostasia shenzhenica OX=1088818 GN=CYS5 PE=3 S... [more]
tr|A0A1U8PY17|A0A1U8PY17_GOSHI1.7e-0436.59Cysteine proteinase inhibitor OS=Gossypium hirsutum OX=3635 GN=LOC107963097 PE=3... [more]
tr|A0A2P5X992|A0A2P5X992_GOSBA1.7e-0436.59Cysteine proteinase inhibitor OS=Gossypium barbadense OX=3634 GN=GOBAR_AA20764 P... [more]
Annotated Terms
The following terms have been associated with this gene:
Vocabulary: Molecular Function
TermDefinition
GO:0004869cysteine-type endopeptidase inhibitor activity
Vocabulary: INTERPRO
TermDefinition
IPR027214Cystatin
IPR000010Cystatin_dom
GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0010951 negative regulation of endopeptidase activity
biological_process GO:0010466 negative regulation of peptidase activity
biological_process GO:0008150 biological_process
cellular_component GO:0005575 cellular_component
molecular_function GO:0004869 cysteine-type endopeptidase inhibitor activity
molecular_function GO:0030414 peptidase inhibitor activity
molecular_function GO:0003674 molecular_function
Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
MELO3C018593.2.1MELO3C018593.2.1mRNA


InterPro
Analysis Name: InterPro Annotations of melon v3.6.1
Date Performed: 2018-09-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000010Cystatin domainPFAMPF16845SQAPIcoord: 34..105
e-value: 6.4E-12
score: 45.6
NoneNo IPR availableGENE3DG3DSA:3.10.450.10coord: 30..123
e-value: 1.5E-14
score: 55.8
NoneNo IPR availablePANTHERPTHR11413:SF65CYSTEINE PROTEINASE INHIBITOR 5coord: 17..118
NoneNo IPR availableSUPERFAMILYSSF54403Cystatin/monellincoord: 31..120
IPR027214CystatinPANTHERPTHR11413CYSTATIN FAMILY MEMBERcoord: 17..118

Synteny
The following gene(s) are orthologous to this gene:
GeneOrthologueOrganismBlock
MELO3C018593.2Csa7G066240Cucumber (Chinese Long) v2cumedB509
MELO3C018593.2CSPI07G06040Wild cucumber (PI 183967)cpimedB523
MELO3C018593.2Cucsa.218360Cucumber (Gy14) v1cgymedB377
MELO3C018593.2CmaCh19G004710Cucurbita maxima (Rimu)cmamedB530
MELO3C018593.2CmoCh11G014750Cucurbita moschata (Rifu)cmomedB100
MELO3C018593.2Lsi03G007240Bottle gourd (USVL1VR-Ls)lsimedB263
MELO3C018593.2Cp4.1LG15g03650Cucurbita pepo (Zucchini)cpemedB259
MELO3C018593.2CsGy7G005700Cucumber (Gy14) v2cgybmedB465
MELO3C018593.2Cla012895Watermelon (97103) v1medwmB185
MELO3C018593.2ClCG09G015860Watermelon (Charleston Gray)medwcgB159
MELO3C018593.2Bhi05G000747Wax gourdmedwgoB219
MELO3C018593.2Carg22817Silver-seed gourdcarmedB0301
MELO3C018593.2CsaV3_7G007000Cucumber (Chinese Long) v3cucmedB536
The following gene(s) are paralogous to this gene:

None

The following block(s) are covering this gene:
GeneOrganismBlock
MELO3C018593.2Silver-seed gourdcarmedB0300
MELO3C018593.2Silver-seed gourdcarmedB0737
MELO3C018593.2Watermelon (97103) v2medwmbB198
MELO3C018593.2Watermelon (97103) v2medwmbB209
MELO3C018593.2Wax gourdmedwgoB220
MELO3C018593.2Cucurbita maxima (Rimu)cmamedB104
MELO3C018593.2Cucurbita maxima (Rimu)cmamedB106
MELO3C018593.2Cucurbita maxima (Rimu)cmamedB535
MELO3C018593.2Cucurbita moschata (Rifu)cmomedB091
MELO3C018593.2Cucurbita moschata (Rifu)cmomedB518
MELO3C018593.2Cucurbita moschata (Rifu)cmomedB523
MELO3C018593.2Cucurbita pepo (Zucchini)cpemedB715
MELO3C018593.2Cucurbita pepo (Zucchini)cpemedB725
MELO3C018593.2Wild cucumber (PI 183967)cpimedB267
MELO3C018593.2Melon (DHL92) v3.6.1medmedB094
MELO3C018593.2Bottle gourd (USVL1VR-Ls)lsimedB260
MELO3C018593.2Watermelon (Charleston Gray)medwcgB171
MELO3C018593.2Watermelon (97103) v1medwmB203