Tan0004448 (gene) Snake gourd v1

Overview


Name	Tan0004448
Type	gene
Organism	Trichosanthes anguina (Snake gourd v1)
Description	DNA topoisomerase
Location	LG08: 56527731 .. 56635665 (-)
RNA-Seq Expression	Tan0004448
Synteny	Tan0004448

Sequences

The following sequences are available for this feature:

Gene sequence (with intron)

Legend: polypeptideexonCDS

Hold the cursor over a type above to highlight its positions in the sequence below.

ATGTCCGGCGGCCGTCCGATCACCGTTCTCAATGTAGCAGAGAAGCCATCGGTGGCGAAATCTGTGGCCACCATACTCTCCAGGAACCAGGGCCTTCGAGTTCGCGACGGTCGTTCTCGCTACAACAAGATTTTCGAGTTCAACTACGCCATTCGAGGCCAGTCTTGCAATATGCTCGTCACCTCCGTCACAGGTCATTTGATGGAGCTCGAGTTCGAAGAACGGTACCGCAAATGGCATTCCTGTGACCCAGCCGAGCTTTTCCATGCTCCCGTCCGCAAATTTGTCCCCGAGGTCTGTCTCCTTTTCTTCTTACGTTCATTATCCTTTGCTTTGCTTCCTAGACACCGTGTCGCGTCTGATGTTCCATGATAGAGACAAATAGATGCATTAATTTGTAGCATTCAGTGCAATGTCAGTTTAGCTCGTAGCAGATTCTGAAAGGAGGCCTATAAAAAATTGGGGCTTCCATCATTCTCTTGCAACTTGTACTCCCTCTATGAAATCTAATTTCTCTCCTAGAGCTCCTGCCATTTGTAAAACTCCGTTGACCTATAAAAACGTGGCTTGGCTTAGCAATTTGTGTCTTTTCTCAATCACTATCCTTCCACATCCAAGCACTCTCTAACAAGTATCTCAAACCTCATCAAGGAACTTTCACCCACAAGTCTCATAATTGCCACATGGGCATGCCTTTAAAATTCACCCCATGACACAAAGCTATATAAGGTCTGCTTGGTAGTCCAGGCAGTTTACAAATTTTGAGCTGGATTTTTCATTGAAGTTAAAACTGCTGTTAGGACAAGATGGATATAAAGAGGACATTGGAACAAGAAGCTAGAAGGTGTCAATGGCTCGTCCTCTGGCTTGATTGTGATAGAGAAGGAGAAAATATTGCCTTTGAAGTCGTGGAAGTTTGCACAGCAGTGAATTGTCATCTTAACATTAAGAGGGCCCACTTCTCTGCTTTGATCGAAAGGTTCCATATCCTAAATCTCTTTTTTATTTTGCCATGTAGTTGTCCAAAGTTCATAACTTCTACATAGTATATGGTAATCTTGAATTCAGGGATATTCACGAAGCTGTGCAAAATCTTGTCCAACCAAATAAATGGTTTGCTGATGCGGTTGATGCTAGACAAGTAAGTGCACTTCTTATAGAACTTCCATTTTGTTGTAATTGAGAAGCAAGATATTGTAGGATCTGGCTTTGTGGAAGTGGGTTCTGTTTACTACTATAACTACGGTTACTTTTGAAATCCATTGAGGAGATGCTGCAGGCAGAATCAAACCAAATAACTACGGTTACTTTTATACTTGCAGGAAATTGATCTAAGAATTGGTGCTTCTTTTACTAGGTTCCAAACTATGCTGTTGAAAGATGCATTTAATATTGATTCTGTCACAGATGACAAAAATGTTATTTTGAGTTATGGGCCTTGTCAGGTATGTTAAGGACCTAAGGTGCTTGCTTTACATTATTTTCTTACTTTTATTTCACAACCGGTGATGCTTACTTGCATGCCTTCTTACTTTCTTCTTTCCTAGTTTCCTACTCTTGGTTTTGTTGTTGAGCGGTACTGGGAGATTCAATCCCATGAGCCAGAAGAATTTTGGACGATCAACTGTTCGCACAATTCTGATGATGGAATTTCTACATTTAATTGGACGTAAGTTGCTAATGGCTTGATTTATTTGATAATTTCAAACTTTTTACAACCAAACTGTAACTGTTTTTTTTTTTGACAAGGCAACAAAAACCGAAATTTCATTGAAATAATGAAACGAGACTAATGCTCAAAATACAATAACACAACAAAGATAAGAATGTGCCAAACACCAATAAAAAAACCAAATAAACGCTCCTAACCAAAAACAAAGTGTGGCTAAATCTTACAAAACTAAATTAATGAGAGTAAATATAAGCATGCCAATTTAAATTAATGATAGAAATAGAAAAACTCTCGAAGGCTTTGGATAGAGCACACCAGGAAAAGGCCTTTAGAAGAATATCTACGTAACGAGCTTCCCAAGACAAAGCAATCCCTTCAAAATTCTCTGATTCCTTTCGAACCAAACAACCGCCAAGATGGCTTTAACCGCAATACCCCACAAAATCGAGGCCCTCTTGTGGAGGAGAGGACCAATCAAAAGTTGAAGAACACACTCTTTAAGAGTTCCGGCGAAAACCCAACTAACATCAAACAATTGAAACAACTTAATCCTCCCCTATACATCAAGGCCCCTTACGGCATGCAACTAAAGCATTCCACTCCTCCCAAAGCCGCTTTCTTTCTCTATATTTGTTGGGACCATAAAGAACAAACCCCCAGACTTACCCGTCGCATCAATGTGATCCCAACTTACCTCTCGGGAACTCCCTAAAGATTTGATGAAATTCCCATCGATAGTCACCGGAGCCAAACTGTAACTGTTAGTAATTATTAGGTATATTCATTTTGCAGGAGAGGGAATCTATTTGATTATACTTGTGCTGTTTTGCTCTATGAAATGTGTGTACAAGAATCGACTGCTACGGTGAGTATGTTGAAATTTAACCACGTATAATAATCCATATGCATGCTGCTCCTGCATTTATAATCTTCCAATTCTATTTAGGTTGTAAATGTTAGACGACAAGAGACGTTAAAGTATCCTCCTCATCCATTGAATACAATTGAACTTGAAAAACGAGCTTCACGGTACTTCCGAATGAGTTCTGAACACACTATGAAGGTTAGCAACCAAGAGTTATCTTTGCTTCATCACTAATAATTTTGCATTCATCAACTTATTTCATTTCCTTGTGCCTTTTGAGTTTCTCATGCAACATTGTTTTATGGAAATAGGTATATTACGTAATGATCCTCTTGTTTGTGTCACCCCTATTTAATTTAGTATTGAACCTTTTTCATATTAGTAACAAAAAAGTTTTAACTTGTTTTGATTGTTTTAAGGTGGCCGAAGATCTGTACCAAGCAGGTTTCATTAGTTATCCTCGTACAGAGACTGATTGCTTTTCTCAAAGGACCGATCTTCATGTAGGTATATGTTTTGGTGATGGTCTCCATAACCAATCTCACTGGCAACTTTTGCTTACTGGAGCTAACAATTTTGAATTTGAACTATTTGTCTGCTTTTAACTCCTAGTTTTCCGTGGGCAAAAATTTAGTAAATTTTTAATTGGAGCAAACTTAAACAACTGTCATTGAAATAATGTATTTATTATTATTATTTAGAATACTTTTGTGTTTTTCCATCTTTAGGATGAAGGTGTAGCTTTTCTAACGTTGAATTTGAACAAAGGCTCCTTAGTTTTTGATGAGCATAGCATGACCAACCATAAGTGCTTCTCATTATAGGCTACCTATAAAGGGAAGCACTCATGGCTGAGCTCTTGAAAGTTTGATTCTTTCATTTTTTCTCAATGGAAGTTTAGTTCTTCGTAAAACAAAGTTTTGTTTCAACAAAGGCTTGCTAATTTACTTGAAAGTATGACTCTAAAGCTATTAATTATGCGTAACTTTCATCTTACAATTCCCTGCAATCCTTGCCTTTTCTAGTGAAAAATGGGAAACATGTCTAATGGGCTCAATTTTGTCCTTGTTAGCTTGTTGATTTAATGGGTGCTTTAAGAATTTCAATAATACAGGCGATTGTGCAAGAACAACAAGAACACCAAATATGGGGAGCCTATGCACAAAGGTTGCTGGATCCTGGATCAGGACTTTGGAGGAATCCTAGTGGTGGTGGCCATGATGACAAAGCCCATCCACCTATTCACCCAACGAAGTTCTCTGCTGGGGAACGCAGATGGAGCCAAGATCATCATGTAAAAGTTTTTCTTTACTTGTCTGTTAAATTGCATATTTGTGTTGAAGTTTTTTTTCCCTCTTTTTACTTTGGTCTTTGTAAATTGTCTTCTTATTAGTTCTCAGTCATCAATAACTGTGAGATTTTCTTTTTCCAGAGAGTGTATGAGCTAGTCGTTCGCCATTTTCTGGCATGTGTCTCACAGCCAGCTGTAGGTGCTGTGACCACTGTTGAAATTGATATTGCTGGTGAATTGTTTTCTACATCTGGGAGAATGATACTAGCAGTAAGTTCTCTATATAAATTTCCTGAATCTTTTATTTTTAAAATGTTTAATCCTATTTTGAGATAATGCCTTGGTGATTGCCAAGCTGGGATGAACCGCATGTACTTAACAGCCCCCATGTTGAATGCCTCTACTCCTGTCTTACAGAAAAAGCACAATTGTTAGGTTTCCTAGTACATTTGACTATAACATATTCTTTCCATTCATCATTTTTTTGTAAGTTAAAAGAGGCCTTTTTTGAAAGTTAAAGAAGCCGTGATCAAAGTAATCTATTAAATAGAAATGTATTGTTTTTGTTTCGTATTAAAAATATTTATGCTTAATCGTGTTCTTTTACGTGCTTTTGACTAAAATACTTGTTATTGTGAGATCAAATATGAGAGTCTTCTATTCATTCTATGCAATAGAGTCAAATATATATAGGAATACATGAAAGTCCTAAACTAATAAATGTAAAATGACAATAAAGGACAAAAGGTTAATAAGCTTCTAAATATACATATATACTATAACACTCCTCCTCAAGTTGGAGCATGTATGTTAATCATGCCTAACTTATTACAAAGATAATCTATTTGAACTTCATTTAAAGCTTTCGTGAAAATATTTCCTAATTGTTCTCCAACTTTCACATACCCAGTAGACACCAAACCTTGTTATATTTTCTCACGAACAAAATGACAATCAAGTTCAATATGTTTAGTTCGCTCATGAAAAACCGGGTTGGATGCAATATGAAGAGCAACTTAGTTGTCACACCACAACTTGGTCGGAACTGTAATATTGAAGCCTAATTCAATCAACAGTTGATGTACCCACATTATTTCACATACTGATTGTGCCATAGCTCTGTATTCTGATTCAACACTTGATCGAGAAACTACATTTTGTTTATTACTTGTTGGTGTTGATATAATTAAATTTGCCATAACCTATCAGCTTAAGCTTTTGGATTAATTGGTGATTTACATGGTATCAGAGCCTAGGGTTTTCTAGGGCAATTAGGGTTCTTTGTTTTTGTTGTCCTTAGGGATTTGGAACTAATTAGGGTTTGAGATTTGAAGGTTTAAGTCCTTTGTGTGTGAGGTTTGCTTGTTGCCACTACTATCGAAACTCTCTTCACCGCCAAAATCCATTCTTTGTTGTCGCATGGAAGCTACTTGCCGCCACCAGAAATCTCATTTTTTTTTTTTTTTTTTGGCTTCGCTCGGTTTGCATACTCTTTCTAGTGGTGTGCTTGTTGGGGTCATATCCCTCTCGGTTTAGGGTCGGTTTGAGACACCCCTCTTTGGCAATCTAGGGTTTTTGGTACAATTGTTTTGGGCCTTTCAATCTGCTTTTTGTGGTCCTTTTTCTTTTCTTTAGTTATGGTGACAAGAAAGGTATGGTGATGACGGAGATGATCCCTATGGTGTCAAAGATTACGTAACATAAGCTTAATGGGTCTAATTTTTATGCATGGCGGACAAACATTCGTCACTACATTCGAGTCTCGATATGGATGATCATGTCACCGAAATTCACCACCGATGATGATACTAGAAAAAATTGGTTCTGCGATGATTCTAGGCTTATTCTACAAATAAAGAACTCTATTGAGAGCAACATCGTAGGGTTGGTTAATCATTGTGAATCTGTTCACGAGCTCTTGGAATATTTGGAATTCCTTTACTCGAAAAGGGAATATTAGTAGAGTGTTTGATGTATGCAAAACTCTCTTTCAACTTTGATCAAGGTGAGAAATCTCGACTAGTTACTTTATGGAGTGCAAAACATCATATGCAGAGTTTAATGCCTTGTTGCCTATTAGTAATGATGTGAAAGTTCAAACTGCACAACGTGAACAACTGTTCATCATGAGTTTTTTAGTTGGTCTCGCTTCTAAATATGATATGGCAAAAGATCAAGTTCTATCTAGCTCTGACATCTCCTCATTGGAAGATGCTTATACTCGCATACTTAAATGCGAGAAGTCGCAGTAACCTTGCCACACCGAGTCAAACAGGTGCCTTGGTTGGACAGAGACAGTGAGTACAAAGGAAACAGAGGGGTTGGACCCAACGCATATAAAGGTAATTCGAACACTCGGAGAGCAAACTCGAGCGATATTGTTTGTCACTACTGCCATAAGTCTGGTCATATGAAGCGTGATTGCAGACGATTGTTGAATAGAGGCCAGAGGTTTCCATCTGCGCATGTTGCCTCTACACCTGATAATCCCGATAAATCTATCTCGATTTCTGCAGAGGAGTTTGCTCAGTTCCGCCAGTATCAAGAGTCGCTAAAGGCGTCATCCTCCACTCTCTATTATTCTTGTCATTCTTGACACGGGTAATACATCTACGTGTCTTCTTTCCTCCTCTTCCAAATGGGTCATGAGACTCTGCGCCTCGATCATATGACGGTAATCCAAATTTATTCTCTCATATCTCAATAGTATAAATCTTCACCTAATGTTACTATAGTGATGGGACCACCTCTCTCTGCTTTCTGGTTGCACCTTTGTCAATCTTACCAAGTCAATTTCCTTGTTTTCTGTTTTAAGTTTACCGCAGTTCTCCTTTAACTTGATTTCAGTTAGTAAGCTCACTCGAGATCTAAATTGTTGTGTCTTATTCTTTCCTGGTTATTGTTTATTTCGGGATCTTTTGTGAAAGAAGACTATTGGTAAAGGCAACGAATCGGGAGGTCTCTATATTTTTGAACCACACATATCCACGATCGTTCCATGCTCTACAGTTGACCTCTCCTTTTGAAGAACATTGTCGTTTGGGTCATCCATCTTTTCTGTCTTGAAGAGTCTTCGTCCTCAATTTAATCACTTGTCTTCGTTAGATTGCGAGTCATGTCAGTTTGCTAAATTTCATCGTCTAAGTATGTATCCTAGAGTCAATAAACGAGCTAATGCTCCATTTGAGTTAGTTCATTCGATGTTTGGGGTCCTTGTCTGTTGAGTCTAAGCGAGGGTTTCGGTACTTTGTTACATTTGTCGATGATTTTTCTCGTGTCACGTGGTTATATTTAATGAAGAATCGTTCTGAGTTACTTTCTCATTTTCGCAATTTTCATGCTGAAATTCGTACTCAATATCATGGTTCTCTTAAAGTTCGCAAAGTGATAATGCTAAGGAATACTTTTCTCATGCTCTTAGTTCTTATCTAAGTGAACATGGCATTCTACATCAATCCTCATGTGTTGATACTCCGTCTCAAAATGGAGTTGTGCCGAACGAAAGAATCGCCATCTCCTTGAAACAACAAGAGCCTTAATGTTTCAGATGAATGTCCCCAAACAATTTTGGGCTGATGCTATATTGACGGCTTGTTTCTTAATCAATCGTATGCCCTCGTCGGTTCTTAAAGGTGAGATACCTTATCGTATTTTGTGCCCCAGCCTCCCTGCGTTCCCTCTCCCACCGAAAATCTTTGGTTGTACTTGCTTTGTTCGAGATGTTCGCCTCTTCTCACCAAACTCGATCCAAAATCTTTAAAATGTGTCTTCCTTGGTTATTCTCGTGTCCAAAAGGGTATCGGTGCTATTCTCCTAGTCTTGATCGTTACTTTGTCTCTCCTGATGTCACGTTCTTTGAAGATTCTTCTTTCTTTACTTCATCTTCGAATACGTGTCAGGGGGAGCATCGAGAGGACGAGGATGATTTTCTTGTTTATACAATTTTCTCCTCTTGTGAGTCTTCGGGTGCTTCTTCTCCATCTCCATCCGTTTGTATTAACCCACCTATCACTCAGGTTTATTCTCGACGACGACCTCCTTCAGATGCATGCCCTGTGCAGGAGGCTTCTTTGTCATTGGATTCAGGAACAAACGATGATCTTCCTATTGCACTTCGTAAAGGTAAACGTCAATGCACATATCCTATTTCCTCTTTTGTTTCATATAACCATTTGTCATCTTCTACTTGTTCATTCATTGCATCCTCCAATCTATATATCTGTTCTAAGATCATTTCTGAAGCTTTGTCTCATCCTCGGTTGGCGTCTTTGCAATGGTGGAGAGATGATGACCGCTTAGATGACAATTGTACTTGGGATTTAGTGTCTCTTCCCGCAGGAAAGAAATCTATTGGTTGTAAGTGGGTCTTTGCGGTTAAAGTCAATCCAGATGGATCTGTTGCTCGATTGAAAGCTCGCTTGTTGCTAAAGGCTACGCACAAACTTATGGGATTGACTATTACGATACATTTTCTCCTGTTGCTAAAATGACTTCACCAGGTTATTCATTTCATTAGCATCGATTCATCACTGGCCATTGCATCAACTTGATATTAAAAATGCCTTTCTTCATGATGATCTTGGGGAAGAGGTGTATATGGAGCAACCTCCAGGGTTTGTTGCTCAGGGGGAGAAGGGAAAGGTATGTCGCCTTCGTAAATCCTTGTATGGATTAAAGCGAGTCCACGAGCATGGTTTGGGAAATTCACTCGGTGATTGAAAGCTTTGGAATGAGAAAGAGCAAATCGAGATCATTCATGTTTTACAAGCGATGCGAGAGTGGTGTCATCCTGTTGGTTGTGTATGTTAACGATATTGTGATTACAGGAGATGATACATTGGGCATCCAATCTCTCAAGACCTTTCTCCATAGTCAATTCCACACGAAAGATTTGGGAATGTTGAAATACTTTCTAGGAATTGAGGTAATGAGAAGCAAGAAGGGAATCATGCTATCACAGAGAAAGTATGTTATTGACTTGTTGGTCAAACAGGGGAAGTTAGGGGGCTAAGCCATGTAGTACCCGATGATGCCTAATGTACAACTCACAAATGATGGAGAATTATTGAAAGATCCCGAAGCGATATAGGAGGTTGGTGGGAAAACTCAATTATCTTACAAGATAACTTTCGACCCGGACATAGCTTATTCGATGAGTATTGTGAGCGATTACATGTCTTCTCCTACAATTGATCATTGGGTGCAGTGGTGGAACAGTTTTTGTGTTATTTGAAAGCGGCTCTGGCGTGGTTTATTATATAAGAGCTATGGGCATATGAACATTGAATGTTTCTCGATGATCTTGATTGGGGGATCTAAGGAAGATAGAAGGTCAACGTCGAGGATATTGTGTATTCGTTGGTGGTAATTCGGTTTCTTGGAAGAGTAAGAAACAAAATGTGGTTTCACGATCAAGTCTTTGAGTCGAATATAGAGCAATGGCACAATCTGGTGCATGTGAATTAGTTTGGATCGTCAACTTCTTATTGAATTGGGATTTGATATCACAACACCGACCAAATTGTGGTGTGATAATCAAGCGACTCTACATATAGCATCTAATCCATTATTCATGAGAGAACTAAACACATTGAAGTTGATTGTCATTTTGTACGTGAGAAGATACAACAAGGTTTGATATCGACGGGGATATGTGAAGACTGAGAGCAATTAGGAGATATCTTCACCAAAGCATTGAACAGAGACACGAATTGATTACCTCTCTCAACAAGTTGTGCATGATGGATATATATGCTCCAACTTGAGGGGAGTGTTAGAGTCCTTATATTAGTATAATTGTATTTTGTTAATATAACTCTAAGGGTGTCCTTTATTGTCTTTTTACGCTCTTCTATTTAGGTTAACCTCAGATACTTGTATATATATATATCTTGAGTGAATGGAATAGAAACATACCGATTCTCTCATACTTTAGCATTAACATGGTATCGGAGCGGGAGAACACGTGTTCGAACCACAGTGAAGTCGTTTTCTCCCAATTAATATTGATTTGTACTTGTTGGCGCCTTTGTTCAATTTCCATTTCCAAGCCTGAAGTTAGGGAGAGTGTTTGATTTCCACTTGTTGGGTCTTTGTTTAAATTTGTAAACCCACAAGTGAGGGGGAGTGTTGGTGTTGATATAATTAAATTTGCCATAACCTATCAGCTTAAGCTTTTGGATTAATTGGTGATTTACAATTAATTGCTTCCAATTGTACTTTTCCATGAGACCCAATTGCTTCCAACAAAAACACAATAACCAGTAGTCTATCTTCTATCTTTTCTTGATCCTGCCCAATCAACGTCTGAAAAACACTCAATCTTCATATGTCCATGATCTTTATATAAGATCCCACGTCCAGGTGCAACTTTCAGATAGCATAGAATTTGTTGTACGACGACTCAATGATATGATCCAGTGTTAGAGATGTCCATTAGTTCCACTCTCTGGTTCGCTTGTGGTGGAGCCTGGTCTCTCGGATTGAGCACAAACGTTGTTAACTTGTTACTCTTGTCGCTTGTTGCAGTTCGCCGTGGGTTTCAGAAGGGCACGCAGTGTCACGGTCATGCTTGTCCAGGGCGTGTTGCCCATGGCCGCATGGCCGTCCCCATCCTTTTTCATTATGTTATCATGTTATCTATTTCATTCAGTTTTGTTATTTCATTTCCTTGTAGTTTTGCGAGCGTATGACTCCTCGCCAAAATGATGTCCAAGGGTGTCATAGCCAAACATTCTAGAATGTACTATAGGGGGATGCGACTATTCATCAATTCTCCCTACCAAGAGTTATATGCTAGTTAAGCGTGACTTTCATTATTTGCTTATCAGCTGTATAACTAACTTTCTAAATGCTTCCAAACGTTTTCCAAATGTTTTCACAAACTTTCTCTAACCCCGTTTTCTAAAATCGTTTTTTCGAGAACAGGGGTGGAGGTTGCGAGATAGGCCCCCTGGGCCACCGACGATCCGAATTTGAGTTGGTGACTTACTCGTGGCGAGAGTAAGTGCCGCCGCGGCCGCGACGAGACCCTTTGAGAAGGGCGACGTGACAGATTGGTATCGAGCCTAGTTGGCTCTCTGAAAAGCGCGGACATAGTAACCATGCTGCGAAAATGATTGAATAAATCGATAGAGAGCGATTGATCGAGATCGAAGAGCAAACTCTTTCTTAGCGAGGTCCTCGACGATGTTCGGTTCTTGGAATCTCGTTTGGAAGAGATTGCAACCAAGACCGACGTGATAGATGCGGTAGCTGGCCGCCTTGATGCAAAGCCCATCAAAGAGTTGATGGAGCGGGTCGAGACCCTTGAACAAAGAGTAAACCGTAATGAAATTTTTGAGTGTGGTGATAGCTCATCGGGCTCTGTTGCCCAAATAGAGGAACGTGTCGATGGTCTGGACAGTTCCCAAAAGATATTGGATCAGATGTTTGCTGACCTTTCGCACGATGTGAGAGCTGCCCTGGGAGTCTGTAGGGCTGAGATGAGAGAGATGGCTGCTAAGCTAAATCTCACCATGGTAGCGATGGGAAGGCAGACCCCACCTGGGGGCGAGACTAGACCTGGTAAGAAGAGGATTCCCGAACCGAGACCCTTCTGTGGGGTTCGAGATGCCAAACTGCTAGAGAACTTTATCTTTGATATGGAACAGTACTTTCGAGCAATGGGCACCGTGATCGAAGAAGAAAAAGTTACCTTGGCAACGATGTACCTAGAAGAAGATGCCAAGTTGTGGTGGAGGACGCGCTATATGGACATCCAAGAGGGGAGATGTATCATTGACACCTGGGAGACACTGAAGGAAGATTTACGTTCACAGTTTTTCCCTGGAACGTAGAAATTCTTGCAAGGCGTAAACTGCGAGAGCTGAAACAGAAAGGGACCATTCGAGAGTACGTCAAGCAGTTTGCAGGATTGATGTTGGACATTCGAGACATGTCCGAGAAAGACAAGGTCTTCTGCTTTGTTGAGGGCTTGCAGTCGTGGGCTAGGTCCAAATTGTACGAGCAGCGATTGCAAAGCCTAACTGAAGCTTATGCAGCAACAGAACGACTATTCGATTTGAATAGTGAATTGGGTGATGAACGGTCTCAAGAAGCGAGACAAAACAAAACCTCCCCACGGGGGGACAACAGATTTCATCGTCCTAACTCTCCTAAGAGTGGGGGAGAGGACGAGTCGAGAAGTGAAAGGGGAGACAATCGGAAGTCCCCTCAGAGGAGTGGAAATTCGTGGCAGAGACCACAAAACAAGAGTAACTACTACCAGAAGTGTATTCTATGCGACGGGCCTCACCGAGTGAGTGACTGCTAGAGTAAAGTGGCCCTCAAGGCTTTTCAAGCGACCTTAGAGGCAGAAAAGGGAAAAGAAGTTGACGATACGGAAGTCGAGTCCGTACGGGAAGAGGATTGTGAGAATCCACGCATGGGCGCCTTAAAGTACTTGTCGGCTCTCCAGAAGAATGTGGGGGAGACAAAAGACCTATCAAGCAAAGACCTCATGTACGTGGACGCATGAGTTAATAACAGATCAACCAGGAGCACTATGGTTGATTCGGGAGCCACCCACAATTTCGTTTCAGAGACAGAAGCGAGACGGTTGAACTTGGCTTGGAACCGAGATCCAGGAAGGATGAAAGCTGTTAATTCGGCAGCCCTACCAATTTCAGGAATCGCGAAGGGAGTGATCGTCCGAATGGGGGACTGGAATGACCGAGTCGACCTTGTTGTTGTTAAGATGGATGACTTTGATGTCGTATTAGGAATGAAGTTCCTTCTTCAACATAAAGTCATACCAGTTCCACTTGCAAAATGCCTGGTAATAACGGGAAGTAACCGTACCGTAGTGCATGCAAAGCTGAAGCAACCTAGCGGTGCTAGAGTAATATCGGCCCTACAGTTGAGGATGGGCCCAATTGATCATTGGGGCAATATGCCCCGAGTATGTAACCACCGTAATGAGAGAAGTGGTGGTCGAGTGTATACACACCCTAGAGAGTTAAAGGGAAAAGCAGCTCTAGTGCAAGAGTGCACGCGAGAAGCGCCGAGGCGCGGGAATGAGGGAGTCGGTCAGAGACATACCCCTCATGGAGTAGAAGTGACGGTGAGACCTGCAGTGTCGAGGCCAGACCAACCTAGAGCTTGGAAAAAGCAAGGACAGGGTAACACTAGGAAGAGTGGAGTGTCAAACTCGTCGATCCAATTGAAGAATTCCTTTGAGGTCCTAGCTGAAGGGACTGAATCAGATGCTGACCCACATGAGAAGGTGCAGCAGTTATTGCAGAAGTGGAAGGAAGCCTTGGGCACAGAAGTCCGTTGGGATCGAGCTGGAGACGTGAAGACTGTTGACCCAGGGCCATCGTGTTCGAAGAGTGTCGGTTGACGAGGACGTCAACCATTTAAGTGAGGGAGAATGTCACGGTCATGCTTGTCCAGGGCGTGTTGCCCATGGCCGCATGGCCGTCCCCATCATTTTTCATTATGTTATCATGTTATGTATTTCATTCAGCTTTGTTATTTCATATCCTTGTAGTTTTGCGGGCGTATGACTTCTTGACAAAATGACGTGCAAGGGTGTCATAGCCAAATATTCAGAATGTACTATAGGGAGATGCGACTATTCATCAATTCTCCCTACCAAGAGTTATATGCTAGTTAAACGTGACTTTCATTATTTGCTTATCAGCTGTATAACTAACTTTCTAAATGCTTCCAAACGTTTTCCAAATGTTTTCACAAACTTTCTCTAACCCTGTTTCTAAAATCGTTTTCTCGAGAACGGGGGTGAAGGTTGCGAGATAGGCCTCGTGGGCCACCGGCGATCCGAATTTGAGTTGGCTGACTTACTCGCGAGCGAGAGTAAGTGCCGCATGGCCGCATCGAGACCTTTTGAGAAGGGCGACCGTGACACGCAGGACTGAAGGCCAGTCGCCGAGGGTACCCTTGTTGGTTTGGTGCCGATTCCTTCCATCGCGTGGGTGTGTTCCCCATGGAGACATTCACCTGCTGCATCGGTAATCAAACTTTTGTATCTGGGCGGATGGGGTAGAAGCGTTTCTCTTGGATGAAGGATCCTCCTCAACGATTTGACTCACAGTGGACCACGTCGTCTGGTTCTGAGATTCTTTTGCTAAAATCTCCAACGATGTTTCGGCTTACTTCTCCAAAAGAAAGTATAAGGATGATCAAGCTACTCTGGGATTTTTTAAGATCAGGAATAAGATTGGCTAGGCTGTTGAAGGTGCCGTTTGGCCTCCCTCTGGTGGAAGACGATTGTTTGTGGTCCCTCTGGGAAGTAATAGCCTCAGGTGGGCGGTGTTTTGGGACTGCCTAACAGACTTCCTTTTCTCTCTTGGTAGCCCCCACTTGTGGCTGAATTTGGATGGGTTGGAGGGGATTACTAACAGCTCTTCGGCATCAGGACGATTGAATCTGGATGGATTGGGGGTGATTACTAACAATTCTTCGACGTTTATGACCCCTAATGTGCAGCGTTCTGTTCGACCCCCTCTTTTGCTTCCGAAGGGTTATTGGGTTAGGAAGGCGGATGAGGTTCTAACAGTGGACATCGAGAAGGTCTGGGTGGCCACGAGACTGTTTGCACACACTCATTGGGCAAAGGATGTGCTTCATTCATTATTCGGCTGCAACCTACAGATTAATCCTTTTGCAAATGATAAAGCAATCATTCTATTTAAAGGTGTGTTGACTACGGATTTGGAAGGGAATCTGTCATGCAACGATGGAAGGTGACGAGTGATTGGAGATCTTCATCGATTACTTGAGCGATGGGATGACCGAGTGCACGGGTTGCCTTCAATGGTGGTTGGATACGGAGGTTGGGTTGCCATCAAGAATTTTCCGTTAAGATTGTGGAGGAAAGATGTTTCTGAAGCAATTGGTCAGCATTTTGGGGGATTGTTGGAAGTCTCCTTAGATACTCTTAACCTCACTGATATTTCAGTGACAAAGATCAAGGTGGCTCCTAATATTTGTGGTTTTTGTCTGTCTTTCATTCCAATAAAAGACCCAATACTTGGGAATTTTTGGCTTCTTTATGAATTCATGGGAACACTGAAGGTCCCTGATAGGTTGAAGGAAGCCTTGACTTTGAAAGATGTTGAAAATCCGATTGATTTGGAAAGAATCTATCAGGTTTGGGTAGATGAATCATCTCTGGATTTGATGCAGGGGACAGATGAAATTGAGTATTCTAATTTGTGTTTTGGGTCGTTTGAGAAAGACTTGTCCACAGGAGAGGTTCCTCTTCAAGTGAATGAATCTATTAATGAACATATTAATAACGCCTCTCTGATGAATCAATTGAATGGTTTAGATTCCTTGAAATCTAACTCTGGTTTAAATGTGCCTCTTAATGACAGCAGTTTGAAGAAGTCGAGGGGGCATATGAATGGTAATGGGGAAGCATCGGGTACTCAAAACTTATTGTTGGGATTGGAAGAGGGTGTTGATGATTCAGGTTATGGAAGTGTTGAAGGTATATGAATGGGGCATATGAATGGTAATGGGGAAGCAAAATTGCAGGTTATGGAAGTGTTGAAGGGTGGATACTCCATTTCGATTAAGGCAAATTCTCTTAGTGGGAATTCCTTTTGGGTGTCCAATTTCTATGGACCTAATCATTACTATGAAAGAAAATTTTTGTGGGAGGAGTGGCGTGCCCTTTCTGGTTATTGCTGCGGGCCTTGGTGTTTGGGTGGAGACTTTAATATTACTAGATGGGCTCATGAACGAATGCCCCAACGTAGGGTAACAAAGGGGATGAAGAAATTTAATTAGCTCATAAATGAGACAGGGGTGCTGGAGGTCCTTCTCTCTAATGGTGCCTTCACCTGGTCAAAACCAAGATGTGAAAGTTCCAGGTTCCTCATTGATAGATTTTTTATTAATGCTGAGTGGGATGCTTTGTTTGAGAGCACGGGGGCTAGCAGGCAAGCTAGGATTTTCTCTGATCACTTTCCCTTGCTCCTGGAAGCTGGAACTTTTCAGTGGGGGCCCTCTCCCTTTCGTTTTTACAATTCGTGGCTTGACTTGGGAGATTGTGTTAAGCTAGTGGAAGAGACACTTAGAGGGGATACATCTCACGGCTGGGTTGGCTTTGTGATTACCACTAAGCTTTGAACTGTTAAAAATGTGTTGAAACAGTGGTACGGGGAATTTGAAAAATTGAAGAGGCAGAAGGAGGCTGATTTACTAGAAGAAATAAAGTGGTTGGATAGCAAAGCAAACTCTTCCTCTCTTTCAGCATTGAATTTCGGCTAAAAACGCAACTTTGGGGGAATTAGCTGACTTGTATCTCAGAGAGGAACATGATTTGATGCAAAAGTGCAAGCTTACGTGGCTAAAGGAAGGGGATGAAAATACCTCGTTCTTTCATACATTTTTGGCAGCAAAGAAGAGAAAGAGGCTTATTGTGGAAATTACAAGTTTGAGTGGTCATAGCCTAATACTGGCAAGAGACATTGAAGAGAAGATTATTGATTTCTTTGCATCTTTGTATTCACGTAGTGGGGGGAGTAGGTTTATGCCAGTATTCATCTCTTGGGAGATGATCTCTGCAACTCAGAATACCTCTTTGATTAAGCCATTCTCTCAGGAGGAAATCTTAGCAGCTTTAAAAGGGTTGGGAAGAAACAAAGCGCCGGGGCCTGATGGTTTCACCACTGAGTTTTATCTTAGGTTTTGGAAGCTTCTTAAGGATGATGTGTTGAGATTTTTTGAAGAATTTTATGTTAATGGGCACCTAAATATGGCTCAATAGGAAACTCTTATATGCTTAATTCAGAAGAAGGAGGCTGCCAAATCGATCAAAGACTTTCGTCCTATCAGCCTAGTTACCTCCTCGTATAAATTGCCAGCCAAGGTGTTGGCGGAAAGGCTTAAAGAGGTTATGCCATCAATTATTTCTGATACTCAGAGTGCATTCATTCATGGGAGACAGATCTTGGATCCAATTCTAATTGCTAATGAGGTGGTGGAGGAGTATTGTGCTAAGAGAAAAAAGGGGTGGCTGTTAAAGATTGATCTCGAGAAGGCCTTTGATTGTGTGGATTGGGATTTTCTAGAAGAGGTAATGGTGCTTAAGGGTTTCCATGCCAAATGGATTCAGTTGATTTTGGGGTGCATTAAGAGCCCTACGTTCTCCGTTTTTAATAATGGAAGCCCGAAAGGTAGAATCAGGGCAACTAAGGGGTTAAGGCAGGGGGATCCTCTCTCCCCTTTCCTTTTCTTGCTGGCATCTGAGGCCTTATGCTTCTTTGTAAAGCGAATGGTTGAGCAAGGGTCGGTGGAGGGCTTTGTGATGGGCAGGGATAGGGTGCAGATCTCTATTTTGCAGTTTGCTGATGACACTTTGTTGTTTTGTAAATTTGATGACAAAATGTTGAATGTGCTGGTTGACACCATTGGTCTGTTTGAATCTTGTTCAGGTCTGAGGATGAACTGGATGAAGTCAACAATCTCTGGGGTCAATATTGACGAGGATTTAGGGCTGGAAATGGCTGAGAAATTGGGATGCAAGGTGGGTCCCTTTCCTATCTCTTATTTGGGGTTGCCCCTTGGAGGATATTCGAGGAAATCAACCTTTTGGCAACCAGTTATGGATAGTTTTGAAAGAAAGGTGGATAGATGGCGTAAATTCAATCTATCCAGAGGTGGACGTCTTATGCTCTTCCGTTCTTGCAAGTCTACCTCTGCACTATTTCTCAATTTTTGAACTCCCCGTGGCTGTAAGTCTTCAACTGGAAAAGAAAATCAGAAATTTCTTCTAGGAGGGTAGATCCATTTCGAAAATTAATCACCTAGTTCGTTGGGACAACGTGAGGAAGGATAGAACGATAGGGGGCCTGGGTTTAGGTGATTTGCAAAGAAGGAATAAACCCTTTTTAGCTAAATGAGGTTGGAGGTTTGGTAATGAACCCTTGACTTTATGGAGACGGGTGGTGGCAAGCATACATGGTGAAGCAAAGAATGGGTGGTCCTCGTTGTTAGCCAGGGGGAAGAGCTTCAGAAGTCCTTGGCTGAATATAGCTAAGCAATGGGAGGAAGTAAGCTGCCTGACTCGACTTCATTTTGAGAATGGTAGTCGAATTCAATTTTGGAATGATAATTGGGTGGGGGGGATACCTTTGAAGATCAAGTTCCCCTTGTTATTTCGTATTTCGAATAACCCTGAGGGGTGTGTTGTTGATTTTTGGGATAGTGTAGCCTCGACTTGGAGCATATCCTTCAGAAGAAACTTGAAGGATGACGAGTCAGTGAAATTTATTCTTTCACTAGGATTATTGAACGATCTAAGGCCATCAGTCAATGAACATTGGAGGGAGTGGAGTATAGAGTCTTCAGGGGTTTTTCTATTAGCTCTTTGGTGTCTTTTTTTGGGAAAGGGCTGGTTGTGGATAAGAGATTGTATCAGTCTCTTTGGTTTTCCTTTTGCCCTATAAGGGTAAATGTTCTGTTATGGATCTTGATTCATGGAAGAGTTAATACAGCAGAAGTCCTTCAGAAAAAGTAGCCTTCCTTGTTGCTGCGACCTTCGATTTGTGGGTTCTGTTTGCAAGCTGAGGAAACCTCTATGCACATTTTCTTTCAGCGTGTATATGCGAGATGTTGTTGGGAAAAGTAGCTGGGCATTTTTGGTGTCTCTTGGGTCTTTGATAATTCAGTTTCTGGAAATATTTGTCAGTTGCTGGTGGGTCCTGTTTTGAGTTCTAAAGCTAGAGTGTTATGGATGGGGTCAAAGCTATTGTTTCTGAGTTATGGTTTGAAAGAAATCAAAGGCTGTTTGAAGATAAAGGGCTGGAATGGTCTAGAAGATTTGATTCCATCATCCTGAAAGCCTCATTTTGGAGCCCCCTCTCTAAGGACTTGGCTGGATATTCCCTCTCAGATTTGTGTTTTTCTTGACAGCCTTTTTTGTCTTCCAGCTAGTGTTGCTTTATATTGCTTTGTTTGAATTTTCTTCCTGGTTTTTATGCTTTTCTTCTTTGTATTGTCTTTATTGTTTGTTATTTTATACTTTCATTATTTCAATGAAATTCGTCTTTGTTGCCTTGTCAACAAAAAGATGTCCATTTTTCCCGCAGGGACCCGCCCCGCCGTTTAAGCGGGGAACGAGGATAAAATTTTCTCCGTTGGCTAAACGGGGACGGGAACAGGGAATACATTCCCCATCCCCGACCCCGACCTCGTCCCCGCCCCGCTCCCCGTCCCAATTAATTTATTTAATTTTAAATATATATATATTTGTATACATCTAATAAACCATAAGTCTAAAATTTTATCAAATATCATTTTATTTTTCTAAGAAAATTGAAAAAATGCCTCTTAACTATAAATCTCTAAAGAATAATTAACCATTTAAAAACATTTTTTTTTTAAAAAAGAAAGGAATTAGTTAATAGAAGGGAAAAATACACTTTTGGTCCCTCAGTTTATAAGTGAGTTTCTATTAAGTCCTCGAATTTCAAAATCGAACAATCAATTCCCTTAATTTAAGAAAATAGTTCAATTGAGTCCTTCGACGTTAACCACCGTTAATTATTTAACGAATTGCTGATGTGACAATTTTTAATATTAACATAATAATTTTTTAAAATAAAAATAATGATTATTATCATTAAAATAAAAATAATTATTAAAAAAAACATCCTCTTTCATTTTCTCTTTCTCTATCCTCTTTCTCCTTCTCTCTCCCTCATCCGATTCTTCTTCCTCTCTCTTCTCTCTCCTTTTCCTTCTCCTTCATTCCCTCTCTTTCTTGAAACCTTCTCATCTTCAACCTACAGAAATTCCACAAACTCCATTTCAGAGCAAGAATATTTTTTTTTCTTTTTCTCCTTTCCTTTGCATTTCTCTCTCCAAACCGTCTTCATCGACTCCATATACGTCCATCTCAAAACTCCCCTCCGCCGGGCTGACCTTCACCTCTTATTTCTTTTTATTTTCTTCTTCTTCTTTTCAAATTTGGGGTTGAAATCTCTAAATCCACCCTTTTTCTCCCATTATTATTCTTTTCAAATATGGGTTTAAAACCCAGATCTGAAACTATTGGAACAACGTCGAGAGTACTGGTCACGAACCCCACATCTACGCCTAGTTTCAACTCTTCCTATTCCTTTTCATCTTCGCTTGCTCTCAACTCTCTCCAAATATGTTTGTGATTTTAAGAGGGCTTATGGAGATAGGTTCGATTTGCTTGGATGGAAAGACACATAGAGGAGAGAGAACAAAGAGGAATGGACGGAAGGGCACACAGAGGAGAGAGAAGAGGAAGGGAGAAGGTGTTGGAGAGAGAAAGAAAATATTTTATTTTTATTTTTATTATAATGATAATTATTATTTTTATTTAGAATTGATTATTTTAATACTAAAAATTGCCACATCAAAATGCCGTTAAATAATTAACAGTGCTTAACGTCGAAGGACTCAATTGAACTATTTTCTTAAATTAAGGGACTTAATTGTTCGATTTTGAAACTCGAGGACTCAATAGAAATCCACCTGCAAACTGAGGGACCAAAAATGTATTTTTCCCTTAATAGAATTTAGAAAAATAAAATTCTAAACGGGGAATTATTCCCAGTGGGGAACCCGATCCCCGCGAATTTCCCACAGGGAATCTCCGCCCCGTTCCCCGTGAAATGACAAAAAGTATTGATGCTGAATCTTGAGAGAACATTGAGAGTTTTATCCACATCTCTTTGATCTCTCCTCGGCCTACCACAATTAAGCAAGAACCGAGAGTAATACCAGATTAGAAAACGTAAGACTGAAGATTTAAATGACTAAAAACTTCTTTATTGAAACAAGAACTGTAAATCTGAAATAAATTGGGTTGTGACGAACTTTGGAAGGTCGACAAACACCCATTGAACGTTTACAACTTAAATATAAGTAAAAGGAATAAAATCTAAGTGCTTAACTGAGACTACAATCACTAAACGAGTTCTTCTAATTTCAAACCGCAGGACAAAAAGACAGACATAAACCAAAATTTAGCATGCTGCAAAACGAATACAGGAAAAACAACGTGCCTTCTTTAGCTTTTTCCGTCCTTATTTATAGAGGGTCGTGCTGCTAGGGTTTTCTTTTACTGCTCTTCCATCTCTCGCAATCATAACAATCATCCCTCTTTTGACCGTGATTTCCGTTTTCTTTAAATTCCGGAAAATCTGCTTAGCTGCTAGGCAATTGCGTTGGCTTTGCGTCCCTGCATTCAAATTGAATAACGTAGTTCTTTTCTTAACCTCTTTTTTGTTTTATTACAAGAACTTAGCATTTCTTCTCATCTTTAATTCTTAATGGTTATTTATCCTTATATATGCCTCATTTGAGAGTACCATAACTTTCACAATTCACTTTATTCAATAACATATTTACTGAATAAAACACATTTATTGCAAAATAGAATATACATTCAGTTTACGAAACCATGAGTTTTAGGACATAAAACCCAACAGATCCATCTGCCAAAGTAATATTAGCAAGAGATGTAGATGAAGAAAGAATGGAAAACAAATTGGGATTACCTGTCATATGGTCGATAGCACCAGAGTCTATGACCCATTTGGTAGAAGAGGAGAGAAGACAATGATTCATGTAACCTGACCCAACAATGGCTGTAATAGGGGTATGCGCAAATGATGAAGAAAATGCTTTTAATGATTTCTGGTATTGTTGAAATTTAGTAGACTCGACCATAGAATTAACAAATGGGTTCTTAGATGAACCATGAGTGGGTTGAGGCTGCGCTTGAATCACATTAGACATCACTATAAGTTCTCGTTCTGCCATAGGTCAATGATGAATGTAAAACCACAGAATCAACTCTAAAACCACAAAATTAGACCCAAATTGCTACAGAATTGCTGAAACTTCTAAATAACAGTCATACTAGGGTTTTAAATCAGAATCACAACAAACCCTAAAGTTTTCAAATGAGGTATGATTCTAAACACCACAAACTGGATCCTATATGCCCCAAACCAACACAGCAACATAAAGAGGACTTAATGACGATCAAACCCACAAAAGACGGAGCAGAAACCGGCGCCGCACGTGCCTCCACACGTTGGCGCGTGAATCTGGTGGCAAAAGCTACCGACAGCGTGTGAGGCCCTCACGCAGGATATTTTCCAGCCAAAATTGGGATACTTGTTGATCGGCGGCTGGGCTTTCGAATGGGGTGGGCGGTGACAAAAAAATCCTCCAGTGACAGACCTCAACGCGCGGCGTTGGTGGCGGCTTCCGACAAAAATAGTGGCTACGACGATGGATTCTGACGGTTGTAGAGGTTCTAATGGTAGTGGGATGAACAAACCACGCAACGAAGGACTTAAACCTCCAACAGGTGTTCCAAATCTCAAACCCTAATGGTTCCAAATCCCTAAGGACAACAAAAGAACCCTAATTACTATTGATAACCCTAGGTCTCTGATACCATGTTATTGTGAGATCAAAATATGAGAGTCTTCTATTCATTCTATACAATAGAGTCAAATATATATAGGAATACATGAAAGCCCTAAACTAATAAATGTAAAATGACAATAAAGGACAAAATGATGTAACAGTGTTTTATGTTGTTTTTACCCAAGGGTTTTCTGTTATTTTAAATAGCTTGTTATTTAGGAAAGTTACCTACTGTTAGTTGGTTTTTACCTTGGGATTATTATTGTCTACCATGGGGGGTTATTTTATGGTTAGTTAGCCATCTCTTGTATAGCCATCTCTTGTATAAATACCCTTTGGGGTGATTTGTTTTAGATATAATAAAATCTTTGGTATTTGAGTTACATCAAATTGGTATCAGAGCTCCAAGATTCGGGGCATCAATGGCTGGAAGGAAACCTACCCCTATACTATCGGGAGAGGTATCGACCACCGGACAAGAAGCGGAGACCCAAAGCACAGCCCTCTCACCTAACTCCACAACTAGACGCTTGTCGCTTCCGGTTGAGAATCTTTATTGAAAACATTCAAAGGAATGTGGGCGAGATCCATCAAATGATCGAAACTATGACACAAAGAATAGAACAACTTGTTGTCAATCAAGGCAGACAAGGAGAACCAAGAAACCAAGGGGAAACCAACCAAGAAGGAAGAAACCAGCAGAGGAGACATCCGTTTCAAGGAAATTTCCTAGAACGACTGAATAACAACCAAGAAAGAATTCAAGAACAAGCTCTCCCGAGAAGAAACCCCCAAGATTTTGAATCGTCCAGTGAAGAAGAAGAGATTATGGCACAAGAAGAAGAAAGAAGATTCATGGGCAACCATCAAGCTCAAGGTGATGCAAGTGATTATAGGTTCAAGATAGAACTTCCAAGCTTTAATGGCAAAAGGGACATTGAAGCTTTTCTTGATTGGATCAAGAATGTCGAGAATTTTTTTAATGTCACTAATACGCTGACACACAAGAAAGTAAAATTAGTTGCTCTCAAGTTAAAAGGGGGAGCCTCGGCTTGGTGGGAACAAATTGAAGTTAATAGAAGAAGATTCAGGAAAAGACCTATTAGAACTTGGGAAAGAATGAAGAGACTACTAAAAGATCGATTTCTTCCGGCCAATTATGAACAACTATTATATGATCAATATCAAAATTGCAGACAAGATAATCGCTCCATTCATATATATACATGAAGAATTTCATCACCTAGGAGCCCGCACAAACCTTGCCGAAAGTGAGAACCATCTCGTGGCACGATACATTGGTGGTCTTCGAACAGATATTAAGGAAAAAATCAAATTACAGCAGGTTAGTTTTTTATCGGATGCAATTACCCTTGCCGAAACAATAGAAGAAATGCGGAATAGTCAATACCGAAGAAATACAAGACAATCTTCGTGGGAATCAGTTCAGAAAACTATGGCATCATCTTCAAAAACTCCAACCCGTGGTTCAAGTGGATCAAATCCAAAGTCAAAAGTCTCAGATCAAGAACAAGAACCTCAAACAAAGAAAGCTCAAGAACTACAACCTAGAAAACAGCAAGAAAATCAAGGGAAAAGGCAGACAAATGCGTATAGTCGACCAAATATGGGTAAGTGTTATCGATGTGGTTCAAACAGGACATTTGTCCAATGAATGACCTCAGAGAAGAGCAATTGCAATCCTAGAGGAGGAAGAAGATGACCAAGAGGGATATGACACAGACGACTACCAAGAAGATCAAACAATAATCCCTCCAGATGAAGGAGATCAACTTTCTTGTATCATTCAAAGACTCTTACTAACACCAACGAAAGACATCAACCCTCAAAAGACATTCCCTATTCAAAACTCGCTGCACAATAAATGGAAAGGTATGTAATGTAATTATCGATAGTGGAAGTAGCGAAAATATAGTATCAAAAAAGCTTGTGACATCTTTGAATTTGAAGACAAACCCACATCCAAACCCATACAAAGTTAGTTGGATTAAGAAAGGAGGTGAAACTTTGGTTTCAGAAGTTTGCACCGTTCCTATCTCCATGGGAAATTTCTATAAAGATCAATTGGTTTGCGATGTTCTTGATATGGATGTTTGTCACATCTTACTTGGCCGACCATGGCAATTTGATAGACAAACATTACATAAACGACGTGAAAATACATATGAATTCCAGTGGATAGATAAGAAAGTAATACTTGTTCCAATCCCTAAACTCCCTGAAAAAGCAAAAGGACACCTTGGAAGCAATAAAGGACAATTATTTACTTTCCTTAGCGGGAAACAGTTCATGGCTCAATCAGAAAAAATTATTCTAGGGTTAGTAGTTTCGGGGCAATCAAAACAAGATGAACAAGTTAGCTTTCCGAATGAGATTAGGGAACTGTTGACAAAAACCCCACAACTCACAAAAGAGCCATGCGATTTGCCACCCCTGAGGGACATCCAACATCAAATTGATCTTATTCCAGGATCAATCATCCCTAATCTCCCACATTACAAGATGAGCCCCAAAGAATATGAAATTCTCCATGAACACATTCAAAATTTACTTGAGAAAGGACATATTAAACAAAGCATTAGTCCTTGTGTTGTTCCTGCTTTATTAACACCAAAAAAGGATGGAACTTGGAGATTATGTGTGGACAGTAGGGCGATTAACAAAATAACCGTTAAATATCGCTTCCCTATTCCTCGAATTAATGATCTTTTAGATCAATTGGGGGGTTCAACAATTTTTTCCAAAGTGGATCTCCGAAGTGGCTATCACCAAATAAGAATCAAACCAGGTGATGAATGGAAGACTGCATTCAAAACAAATGAAGGCTTGTTCGAATGGTTGGTGATGCCGTTTGGACTATCAAATGCTCCAAGCACATTCATGAGATTAATGAACCAGGTACTTCATCATTTTCTCAATAAATTCATTGTAGTATACTTTGATGACATCTTAGTTTATAGCAAAACCTATGACGAACATCTTGATCATTTAACTAAGCTGTTCCAAACTTGGGATAAAAATAAACTATATTAACCCTAAAAAGTGCACTTTTCTTGTCCAAGAAATATCATTTTTAGGTTTTCTAATTGGAGCCTATGGCATAAAAATGGACCCTAAGAAGATAAAAGCAATTACCGATTGGCAAGAACCTAGGTCAGTAAAAGAAATTCAAGCTTTTATGGGTCTAGCATCTTTTTATAGAAAGTTTATTCGGAATTTCAGCACTATTTCTGCTCCTTTGACTAACTGTCTTTGAAAAAATTCGTTCAATTGGAGTCATCCACAACAACAAAGCTTTGAAAAACTTAAAGAAAAATTAAGTCAGAGCCCTGTCCTACAATTTCCAAACTTTACAATACCTTTTGAAGTCGCTGTGGATGCTTGTGGGATAGGAATAGGAGGGGTACTTTCTCAAAATGGACACCCAATTGAATTTTTTAGTGAAAAACTTAGCCCTTCAAGGCAAAATTGGAGCACTTATGAATAGGAGTTATACTCTTTTGTGAGGGCATTAAAACAGTGGGAACATTACCTTCTTTATAAAGAATTCATATTCCTCACTGATCACTTCTCTCTCAAATACTTACAAGCTCAAAAATCCATTAGTAGAATGCATGCTAGATGGATTAATTTTTTACAACGATTTGATTTTGTTATTCAACATCAATCTGGAAAATCTAACAAGGTGGCTGCAGTAGGAAAACATATTTGCTAACTTTACTTGCAGGAGAAGTTGTGGCATTCGAGCACATTAAGGAACTTTATGCAACTGATTCCGACTTTGAAGAAATATGGGTAACGTGTTCAACAAATTCATCGTTCAATGATTTTCACATACTGGAAGACTTTCTATTCAAAGGGGATCAATTATGTATTCCCCATACATCAATTAGAGAAGCTCGAATCAAAGAATTGCATTCGGGTGGCTTGGCTGGCCATTTTGGTCAGAATAAAACATTGGAATTGGTCACCTCTCGGTTCTATTGGCCCCAAATAAGAAAAGATGTCCAGAATTTTGTCAAACATTGTATGGTTTGTCAAACAGCAAAAGGCTCTTCGACCAATGCTGGAATGTATACACCTCTACCTATCCCTAACAATATATGGGAAGACTTATCCATGGACTTTATACTTGGCCTACCAAAAACTCAAAGAGGATTTGATTCTGTCGTAGTGGTTGTCGACCGCTTCAGTAAGATGACACATTTTATCGCATGTAAGAAAACTAATGACGCGGTCTATATAGCAAACATATTCTTTCGAGATGTGGTTCGATTACATGGAATACCTAAAACCATAGTCTCGGATAGAGATGTTAAATTCCTAAGCCATTTTTGGCGATCTTTATGGAAAAAATTTGACACAACGCTAAAATACAACACGACTAGCCACCCACAAACTGAGGTCACCAATTGAACTCTTGGTAATTTGATTCGTTGTTTAAGTGGCTCTCGCCCAAAACAATGGGATTTGGCATTGGCCCAAGCCGAATTTGCATTCAACCACATGAGGAATCGATCCACAGGGAAGTGCCCATTCGAGGTTGTTTACACGCGTGTCCCTAGACTTACTGTGGACTTAGCTAACCTCCCTATTTCTATAAATGTCAATCAGGAAGCTGAAATAATGGCTGAAAAGATTGCAACCTTACATGAAGAAGTCCAGACACATTTGGAGGAGGCAACTTCACGGTATAAAGATTCGGCGGATGTGCATAGAAGACATGTTGATTATGCAATTGGGGACTTGGTCATGGTTCATCTTCGCAAATCTCGATATCCTGTAGGAACTTATAATAAGTTGAAGAGTAAAAAACTTGGACCTTTTAGAGTTTTGGAGAAGTTTGGTGATAATGCTTACAAGATTGAGCTACCTTCGGAGTTTCATATTAACCCAGTATTTAATGTGGCAGATATCCATCCTTATTTTGCACCAGATTCTTTCACTTTGGCAACATAAACTCGTGGTCGAGTTATCTTAGGGAGGGTGGATTATGATGTAACTACTTGAGTGTTTTATGTTATTTTTATCCAAGGGTTTTCTGTTATTTTAAATAGCTTGTTATTTAGGAAAGTTACCTACTGTTTGTTGGTTTTTACCTTGGGGTTATTATTGTTTACCATGGGGGGTTATTTTATGGTTAGTTGGCCATCTCTTGTATAGCCATCTCTTGTATAAATACCCTTTGGGGTGATTTGTTTTAGATATAATAAAATCTTTGGTATTTGAGTTACATCACAAAAGGTTAATAAGCTTCTAAATACACATATATACTATAACAATACTCTCTTCTCCATTATCTATTATCACTTGAGCCATGCTTTTTTTTGACCTCTCGCTTTTGGACAACCAAAAAATTTCGTGGGTTTAGAATGCATCTTACACATTGAAAGATTAATAATTATGTTGAAAGCAGACGTCATCCTTTCCTTATAGGAAATGGCTCAGGTCATTCAATTAAATCCAATGATTTATCCATGTTTTCTTATGCATTGAAATCTTTGTAATTACTTTCCTTTGTTTCAATTTTTACTACTGTTGCTGCCTTGTTTCTCTTAGTTTATCATCTGCTTCTATAGGAGAAAGACAAGAAATAGTACTAGCCGTTACAATGAAGTTTTAGGGTTTGAAATATTTTGCTATCATGTTTTGTCACCATCCTTTTATTGAACATAAAGTAAAAAAAATGCACATTTTAAAATTGATTTAACTGCTCAACTTAATTCTTGATTTTACCTCTATTCCGATTATTTTGCTGCAGATTTTATTTCCATCAAGATTTTTCCTTCTAGAGAAAGCGTACTGGGTAATTTGCATGGTGATGATGTTGACATAAAAATCATCTAGTTTTATTAGAAATATTATGTGGCATGTTATTTTGGGTGATCATTTAGAACATAAGGATTCTTATGGGTTGGTGGAATGTGCTGCTAATAAAGTGGCAGTAAGTGATTTTATTTAGCTTCTTTTGAAAATCTAGTTATTGTAAGTGGAATTGAGAACTGTTAACTAAAAGCTGGTGCTAACTTTTTTGAATACACTGATGGTAAAGGATCTTCTGCTGCACTATATAGAAATTAGTCGAATTACCATTTTTTCATTGAACATGACATCGCGTTACGTGCAAAACAATTGTATAGAATGAATGAACGTAGTCAAGTACTGATCTCTCTCTCTCTCTCTCACACACACACACACACACATTTGTCATGCAATTTGGGATATCAAGAATAGTCTACGCATGACTTTAGCCTCTTTTTTCCCCTTTTTTGTGAATGACACAAGTATTTATGGAGTTTCCCGTCCCACATATCATTCACACCAACTCATTAGAACATTGATTTTATTTGACTTGATTGCTTCTTTGACCAGAGAAATTACCTGGATGTTTACCGCTTTGAATCATGGGGAGGTTCAACTATTCCAACTTACGTTTCTGGGCAACAGGTTTCTGTTCACTCATTACAATTTTATATTCATTAGTCTATCATGGTAGTCCTGCATATGGTTGCTTTTGTGCAAATCAACCACAATCATGCAAACACATGAGTTCATTCATTATTCATATATGGGGAACTTTCATGCAATAATTCGTTTTTGGATGACAAATCATACTTTCACCTAGAAAAGTGTTGGTTATTTTTTGGTGTAGTTAATTAGAATTTACTGTATTATATTGTTGGAATATTATTTCCTTATTTGTAAATGAGTGTTTGATGTAGCCTAAATGAGACTAAAGGAGATAATTCTCCAAGAATCAATCAAGGATCTTTATTAGAATGAAAATGGTGTAGAATACATGGGAGGGATTCTCTATTTATAAGGGATTAAAATACAAATGAGGGTAAAAAAGATTAACCTAGAGAATTTACTTAAGTTTACGTTAATCCTACCTTCATCATTCTATCCCTCCAAAAAAAAACTCGTCCTCGAGTTTTAAAAAGAAAATGGAAACAAAAGAAAACAAACAAAATAGAAACAAGCTTCATTCGATAGTTGCCAAATACTCCAACTGAAAATTGCTTTCTGAATTCATCAACTTGCCAACCCAGTTGGTCATTGCTTATCATCCTGAAAAATAATTCTTGAAATGCAAGTTCTTGAGTCAACTGCTTGTGGTATTGCCACAATTCCTCCAAATACACGAACTTGTTGACAAAAATAATTTGCAAAAGAGCAGACATGTGAAATTTGTGGAAGGTTTTCTTTAAACTCTCTCGATTTGTCGGCCAAACCAAAGAAGAAATTCTTGGTCCTTTAACTTCCTCCACAATGATAGAACTTTTTCCAAAATGACTTTCGAGAATTTGAGGTTCCCAATTCAATAATTGCAACTCAAACAAAATTTTCTCATGTAATAAGCCAACATTGGATGTTTGAGAGAATTTTCTTGTAAACCCTTTTGAAGTTTCCAATTCAACCATGTTGACTTTATTTGTAATTCTTCCAACGTTGACCTCACCGGTTTTGACACAATTCTCCTCAAATTCAACTTCATGGGTTTTGATTTCATAGTTCTCCACCTCTAAGGTGTCTTCCATGACAGTAAAAAGTTTATCCAAACAAAATAAAATTTCATCCTCACCATCAAAATATTCAATGAAATTCAAAAGAAATTCATCATCTATTTCATTTGAACTCATCTGATTGTTGTGAGAAATTGGTTTGGCTTCCTTCTCATTTTCCTTCTCAATTTCTTGTTCTGTTTGTACATATTCTTGAAAGATTAAAGAACTATGCCCGCTGGAGTCTTGCTCTTCAACTTCAAAGAACAATTGAGCCAAATAAAAAGAAGAGTCATCAACTGTCTGTATCAATTCTTTTTCAACTTCATCTTCCTCATCAAAATAATTTTCAAATTTTAGAAAACATTCCTCTTCTTTGCCGGAAAAATCAAAATTGTTAACATCAAATCCATGAAAAAATTCTTCTTCTTTGCTGGAAAATTTGGAATTTGGAACCAAGAAACCTTCATTTTGGCATTCTTGGAGTTTATCATGATGAAAAGGGTTTCTAATAAATCTTGGAAGGTGGGCTTTCTGTTTTTGCAACATTTCTTCTTGATCATCTCCACGATTTTGGTATATATCTCCATGGTAGAAATCTTCTCTTTTCGAACATTCATCATCTTGATTCATGAATCTTGAAAATTGATGTTCAAGAGGTCTTCCCGCTATATTTTCTTGAATCTTTATCATATGATCCATGAATTCTTCTTTGCGTTGAACTTGTTTTCCTTGAATTTTTTCCAAACGACGTCGGATTTTATCCATTCCCTTTTGAAATTCCTCCCAATTCATGGTTTGATCCGAATATTGATGTTTTCTTGAAAATGTTTCAGCCTCTGAATCACTTTCTAAATCATCCAAGTCCAAATTCTCACATCGATTTCTTGAAAAACTTATTTGATTAGATCGTAGAGCTCTTTCTTGATAATATCGGTTCGTTAGTTTGTCCCAAACTATATTGCTATCTTTGTCGGAATCGCTAGAATCACTAGAATCAAAATTCCAATGCGGATCTTGATTGATTCTTTGATAAAATCGAGCATGAGCAATGTTGTGATGTTGAAATTCCTCTTCTGAATCACTTGAATCAAAATTCCAGCAATGATTTTGAGAGTATTTTTTACTTTCTTGCCCATACCAACTGCTGTATTTTTTCTTGGTCATCTTCTTTGAACGGTAATTATTCATTCTTGCAAATTCTTGGAAAATTCTTCAAGTTTCTTGAATCTATAGGGTCCCCCCTAAATAAGGGTGTGTTGTTTGGCAACGAGCACAACTCACGAAGCTCCCTCTTGTGATCGGCGTCACCAAGAGTTTTCCGGTCTTCCACCGGCGGCAGTCAACGTTGGCCCAGGCGGTTGCTCTGATACCAAATTGATGTAGCCTAAATGAGACTAAAGGAGATAATTCTCCAAGAATCAATCAAGGATCTTTATTAGAATGAAATTTGTGTCGAATACATGGGAGGGATTCTCTATTTATAAGAGATTAAAATACAAATGAGGGTAAAAAAGATTAACCTAGAGAATTTACTTAAGTTTACCCTAATCCTACCTTCATCAGTGTTTCTTCTCTTTAAGAAACCCTTTCTTCTTATAATAAAATATGCAAAAAATTATTTCTCTTATTTTGCTCATGGGATAAGAGACAAAAACCCTAATTTTTTAGAAACCCTAAAATTAACCCTAACCTTAGCCGCCAATGGCTCGTATTACCCAACGCCACTTACAAATAGAACTATCTACCCCTGGGCATCACTACCTCACACACACAAGACCTCAACTTCTCGATATGTGACGCCATTGCTGCTGACTTCGACTTCTGTTGCTGCCCTCGACGTCAACTTCCACGATCTGTCCAACATCTCTTATGGCTAAAATAAATTGATATGCCCTTGTAATCTTTCATTTTTTCTCAATAACTAAACTTAAGCCATAGCTAAACTTGCAAATGTCCGCCATCTCCTTTCATGTTGAGCAATCTCTTAAAATCAACTTTTAACTGAGCATTAACTTCAAACCTAACATACACTTAAGAGAAGGCTTCTTTCTTCTTTAATTTTGGCCTTTTGAGTGAGGAGGTTGAACTTAGCATTTCTTTTGCAGAACAAGTATCTTCCTTTAATTTAGAGGAGTTGATAACTATATCCCCTTTGGCTGTTTCTTTTACAGTTTGTTCCAACAACATTAACTCTTGATTCAGGAGTCACAAGACCACCTCCCCTTCTGAGTGAAGCTGATTTGCTCTCTTGTATGGATAAGGTAAGTAAGATGTCTTTTCCAGCTGAGCTTATCAAATTCTGGGGTTTGAACCTTTATGTTTGACTAGAATTTAAATTTATATTGCAATCGAGTGGTGAAGGCTTTATTTTTGATCAAGTTCTTTTTTGTTTGTTATTTAAAAGGAGGGAATTGGTACAGATGCAACAATGCATGACCACATCAAGAAGTTGCTGGATAGATTTTATGCAACAAAGGACACAAACACTCGTTTCATGCCAACTAACCTGGTAATGAGCTTGGATTTTGTCCAGTACTCATTTTCTTCCTTATTCTCCTATCATTTCTAAATGTGATTTATAAGATGAATGTTATCAATGTTACCATTAATGCATGAGATAATGAGTCGAAACTAAATGGACTAGTTATTGTCCTAGGATGTGAGGGATCTTGGGGATAGGGGTAACTGTAAGTTGGTTTAAAAGGTGTTATAGTAGGAGAGGCCATACCTAGTCATTTCATGTCTTGGAATGTGAGGGATAACCGTAGGTTGATTAAAGAGGTGTTATTGCAGAGACATTTTTGTTGAGATTAAACAGACTAGTTATTGTCGAGAGTTGATTAAAAGTATCTAGAGTAGAAGAAGAGTGGAGTGGGAAGGTTCGAGGTGGTTGTGGCCTCTGGGGGTATCTTTGTTGGATGAAGCTTCTTTTCCATCCTTGGAAGTTGTGAAGGGTATTTATTCTGTGTCGGTTTTCTTTAGTTTGTTTGGTAGCAGGGTGGGTGGGTGTACAATCCCCTAAGCCTAAGGGTAGGAAAGTCTTCGAAGAGGAGCTTGGTGGGTTGTCTGTGCCTTGTTGGTGTGTTGGAGGTGATTTTAATGTGGTTGGAACTCTTTCGGAGAAAGCTTCTTGAAGAAGGATGACTATGTCTATGAGGGGGTTTAATAGTTTCAGTGAGGAGTGACGTCTCTTTGATTCATTATTAGTGAAATGGAGCTTTACCTGGTCTAATAGTTTAGCTCAACCTAGAATAGATAGGTTTCTATTGTTAGGTGATTGGATGAACCTTTGCAGGTTGGTTCGTCAGTGTCTAGGGCTCAGGATTACCTCTAACCATTGCCTGTTTGTCTTACAACGGGGTTTTTCTATGTGGGGTCCTTGCCCCTTTTGATTTGAGAATATGTGGATGTCTCACCCCTTCTTTAAGTCTTCTCTAGAGGTTTATTGGTCGGAGCTTTCCAGTTCGTGAGAAAGCTTTGTGCTCATTGTAAAATAGAATGGAGAAAAATATATGTTCTATTCACATTAGAGTTCTATGACATATATATAGGTATACAAAGAAACCCTAATACTAAAAGAATGTACAATTACGATAAAGGACAACAATATATATTATAACACTCCCCCTCAAGCTGGAGCAAAAATGTCGAACATGCCAACTTGTTACATAGATAATTTATTCTTTCTCCATTTAAGGCTTTAGTAAGTTATTCTCCCAATTGCTCTCCAGTCTTCACATATCCTGTGGACACCAATCCTCGTTGTATTTTCTCACGAATAAACTGACAGTCCACTTCAATATATTTAGTTCTCTCATGAAACACTGGGTTAGAAGCAATGTGAAGTGCAACTGATTATCACACCACAATTTAGTTGACATAGACATACTAAATCCAATCTCAGACATTAATTGATGTATCTATAGTATTTCACACATAGATTGCGACATAGCTCTATATTCTGACTTAACACTCGAACGTGATACCACATTCTGCTTCTTACTCTTCCACGACACTAAATTTCCTCCTACAAAGATACAATATCCAAATGTTGATCTTCTATCTTCGTTAGATCTTGCCCAATCAGAATCAGAAAAACATTCAATCTTTGTATGACCGTGATCTTTAATGGTGCTAGATCCAAGAACAGAAGATGTTGAACCATCTGCCAAAGTGACTGCTGGAAAAGGTGCATAGGACAAAAAGGTACAAAATAGGCTAGAATTACCTATCTTGTGAGCTGTGGCACCAGAGTCGATGACCCATTTGGTGGAAGATGTAAGGAGACAATGATTCTTACCTAATTAGTTGCAATAGGATTTGATGATGAAGATGCTTGTAATGAGTCCTGGTATGACTGGAATTTAGCAAAATCGTCTGTAGAAATAGTTACCGTCCTCTCAGGTGTATCATTTGTAGATGCAAGCTAAGCTACTTGAGGCCTTTGCCCCCTATTCAACAACTTCCAACAATCACGTTTCATGTGACTCGACTTACGACAATAGTTACATATAATCTCTTGTGACTCTTGTCGTCAATGATCAAAACCAAGTTTCTGATAATCAGAACCAAGTCTCTGATGACCCGACTTACCATTCATTTCTTTAGTAACCTTAGGATCATTGCAACTAACTAAAGCACTGTTGGACTGAGAAACAGACGAACCTGACGAAGACTTTTTTGTGCGAAGAACTCTACTAAAAGCTTCGTCCAAAGAGGGGATCTCAGAATCTGAGAGAATTTGTGATTTGGCCATATCAAATTCAGAGGAGAGACCATTAAGAAAGCTCATGACACTCATCTTTTCTCTTTGAGCTTGTTGAACCTTTATGTCTGTACTAAATGGGAGTAAAGTATTAAATTCTGCACGTCTTCTTAACTTGCATAAAATAATTCGTGACAGATTGGTCTCCCTGTTTCGCATGAAAAAGAGCGGTGCAGACTTCATAGATTCGGTTAACTTGCTCTTTTCCTGAATATAAGAATTCTAAAAATCCGAGCAGTTATTTAACAGAATCACAGTGATTTACCAATCCAACCACTTCACTCTCAATTGTATTCTTGATTTGAATATACAATCGAGCGTCATCGCGCAACCAAGTCCTCCTTGTGTCATCCTTTGGTGGATCCTAATCGATATGATCATCCATCTCAGTGCTTCACAAATAGAACCTAATTGTTCGACTCCAATCATAATAGTTTGAACCATTCAACTTATGCTCCGTGATCTTTGATGAGAGGGGAACCATTTTGGGTTTAACTATAGGTTCTAGCTCAACCATCATTAAAGAAACAGTAGGTGAACATCAAGTAAAGCAGAAAACAAATCTGAATAGTACCAAAAAGTGGCTTAATCTCACCTAAAAGCAAAAATTCGAGACAAACCAAGGGGCTAATGCTGAATCCAAGGTGACAGACAGACTGGAAATACCAAAAGGAGACAAACCCAAGCGACGACAGACTAATCGACACTCTCACGCGCTCCCATGCGTCGCCGCGTGGCGGTGAAGACATTAACTTCCGGCAACGCGTGAGCCTCACGCACGACAACTTCTGTCGAACGACGACAACGATTCTCCTTCCCTGACGACGACACTCCTCCTAAGTTAGGTGGTGTCGACAAACGACCACCCTAAGATGATGACCCAAACTTCAAACCTTAACCTTATTTAGGAGAAAGAAACCCTAATTGCCAAATGCAAACCCTAAACCCTAGGGACTTCTTTGATACCATGTAAAACAAAATGGAGAAAAATATATGTTCTATTCACATTAGAGTTCTATGACATATTGAGCAAAATAATAGATTTAATAATCTGTATATTATTTTGAGAAGAGAAAGGGTTCTTAAGAGACCACCCATTTATAGATATGGAATTTACAACTAACGAAAATAAAATTCCAGCAATCTACAATAAAGATACAATAAAAATATTATTTAGCTAAAAAAGAAAATAGCTAAACCAACACTCCCCCTCAAGCTGGTTTGAAGATATCTTCCATTGCCAGTTTGCTGATCATCTTGTCAATCTGTGATTTTGGGAGTCCTTTTGTGAATACATCAACGATTTGCTCAGCCGTAGGCAGGTAAGGAATGCATATTACACCTGTATCAATTTTCTTCTTTATAAAGTGTTTATCAACCTCAATGTGTTTTGTCCTATCATGAAGGACTGGATTGTGGGCAATTGAAATTGCAGCTTTATTGTCACAGTAAATACGTATAGGTGCCTTTGGAAAGAATTTCACTTCTTCCAAGAGTCTCCTTATCCACATGCCCTCACAAATACCATGTGCTAAGACTCTAAACTCAGCTTCAACACTGCTTCTGGCCACTACATTTTGTTTTTTACTTCGCCAGGTAACTAGATTCCCTCCAACAAACGTACAGTAACCAGAAGTAGATCTTCTATCTATGGTACTACCAACCCAGTCCGCATCAGTGTAAACTTCAACATGTAGATGGTCATGCTTCTTAAACAATATACATTTTCATGGTGTACCTTTCAAGTACCTTAGGATTCTATAAACAACTTCAAAATGAGTAGGTCCGGGAGCATGCATAAACTTACTTACCATACTAACAGCAAAAGAGATGTCAGGGCGTGTGTGAGACAAATAAATTAGTCTTCCCACAAGTCTCTGATATTTTTCTCTGTCTTTTACCACTTTCTCTGTTGCAGTTTGTAATTTTAAGTTTGGTTCAATGGGTGTCTCAGCAGTTCTACAACCAAGTAATCCCATTTCTTCAAGTAAGTCAATGATATACTTCCTTTGATTAACAAGGATGCCCTGTTCTGACCTAGCAAATTCCATTTCTAGGAAGTATTTTAGGGTTCCCAGGTCTTTGATTTGGAATTCATTAGCTAGTCTTTTCTTCAGATCAATCAATTCTGTCTCATCATTCCCTGTAAGGATAATATCATCAATATATACTATTAGAACAACAACTTTGTCCTTCCCAGTATGTTTGTAAAAAATAGTATGATCTGCTTGGCTTTGAAGAAATCCATAGCTTGTGACAATTTTTCCAAATCGTTCAAACCACGCTTTAGGAGACTGTTTAAGGCCGTATAGAGCCTTTTTTAACTTGCATACTTTGTTAATCCCCAGATTTTCCTCAAAAGCAGGTGGTAAACTCATGAATACCTCTTCTTCAAGTTCCCCATTGAGAAAAGCATTCTTGACATCAAGTTGATAAATTGGCCAATCTGCATTTACAACAATGGATAACAGAACTCTAATGGAGTTAATTTTAGCAACTGGAGCAAATGTTTCTTGATAATCAATTCCATAGGTCTGAGTGAATCCTTTAGCAACAAATCTGATTTTGTACCTTTCAACACTTCCATCGGCCTTGCACTTAATATAGTAAACACCCATTTGCACCCTACTGTTTTCTTATTCTTTGGTAATTCTACAACGTCCATGTGCAATTCTGCTTAAGAGCATTCATCTCCTCCATAATTGCTAATTTCCACTTCGAGTCATCTAGGGCCATTCCTTGGAACAAACAAATTTGTTATCCTAGAGGTAAAGGCTCTATGGCTATCTGACAGTCTATGGTAAGATGGATAGTTTGCAATAGGATATTTAAGGCAATTTCGAGTACCTTTCCTATGGGCTATTGGAATGTCAAGATCATATATTTCAGGTGAACGATTCGATGAAGAAATGAGATTAGGAGGTATGTTACCTAAATCTTCGGGATCATTCATCGGGGTATTAGATTGGTCTTGTGATAAGTTCACTGTCTGGTCTCGATTCTTTTGACTTGTTGCAAACCTGAAGTTCAGTATTTGTATCAGTTTGTAGTGTTTCTCCCCCTGAACACAAATTTTCCATACTTGGCATTGGAGAACTAGAACTGGAAGTCTCAGAGCTAGTAATGCTAGGAAGAGGGGAGGTATCCCAAAAATTATCTTCTAAGGTAGTTATCTCCTCCTGAAGAGAAGTTTTGTTAAAGAAAGGTTGATTTTCCCAAAAAGACACATCTAGACTTTCGAAGTACTTTTGGTTCAAGGGATCAAAACATTTGTAGGCCTTTTTGTGGGAGACATACCCTAAAAAGATGCATTTCACTGCTCGAGGATCTAATTTAGATCGTGAGAAACTAGGTACATGTACACAGGCAGTACATCCAAACACCTTAATGTGTTGATCAGAAAACAAACGAACATTGGGAAAAAAGGTTTTGAAGTGGTCCAGAGGTGTTTTAAAATCCAAAATTTTTGTAGGCATTCGGTTTATAAGATAGGCAACAGTGAGTATAGATTCACCCCATAAATAAGAAGGGACATTCATAGAAAACATAAGGGCACGAGCAACATCAAGTAAATGACGATTTTTCCGTTCAGCAATGCCATTTTGTTGGGGTGTATCTCTACATATAGATTGATGAAAAATTCCTTTAGCTTGCAAAAAATCATTTACTGTTCATTGAAATACTCAGTGCCATTATCAGAGTGCAAAATACTAATTTTAGTATGAAATTGAGTTTCAATCATGTTATAAAACCGAATAAAAGTATCTTTCACCTCTGATTTTTTTGTTAACAAATAAATCCAAGTTAAACGAGTGTGTTCATCAATAAAAGTAACAAACCATCGTTTCCCACTATGTGTTAAAACTTTAGAGGGACTCCACACATCACTATGAATTAAGTAAAAAGGTGCGGAAGTCTTGTAAGGTTTGGGCAAGTAAGGAGATCTATGATGCTTTGCAAAAATACAACTTTGACACTGAAAAACAGAGCAATCAATTCAATTCCTTTAAGCAATTTTGGAAACAAATACTTTAAATAGAAAAAACTGGGATGTCCTAGTCTACGATGCCAAAGCATGATAGTTTCTTGAACAGAAGGAGAACTAACACCACATAAGCCCTGAACTTTTTTATGACTAGTTGGAGACTCATCAAAATAGTAGAGGCCATCGAGCATCTTAGCACGCCCAATCATCTCCCCCGAATCCTGATCCTGAAAGGTGCAATGAGAGTCAAAAAAGGTAACACGACAATTAGCGTCCTTTGAGATTTTACTCACAGACAACAAATTACAAGCTAATTTTGGGGCATGAAGGACAAAATGTAGAGTAATATGTGAAGTCAAACGAATAATTCCTTTACCTGCAATAGAATTAAAACTACCATCTGCAATTCGAATTTTTTCATTGCAATACATAGGAGAGTATGAGTCAAATAGTTTTGAGGAACCAATCATGTGATTAGAGGCTCCGGAATCTATAATCCACGAAGAGGAGTTAAAACAAGAGAGGGCTTTAGGAGAATTACCTGTTTGTGCCAAAGAAACACTAGGATTACCAGAAGATGAAGTAGCCTTTAGCAGCTTCAGAAGTTGATCAACTTGCTCTTTGCTAAATGGGCTGGAGTCAACATCATTAGCACTGGAAGATTGTTGATTGCTACTTTTCTCACTTTGCTTAGAACTCTTCCAATTTGCAGGTTTTCCGTGCAGTTTCCAACAAGTATCCCGAGTATGTCGGGGTTTATTACAGTGGTCACACCAGACACAAGGTTTTTCATGGTTCTTGTTTGATTGATCGGAGGCCTTGTAGGTTGTAGCTTCAACCACTAAAGCTGAACTTTCAACGGAATCGATAGACTTCTTTCCAATCATCACATTCCGACGACTTTCTTCTCTACGCACTTCGGAAAACACTTCGCTGATAGTTGGCAAGGTGGTCTTACCAAGTATTCTGCCTCTAACCTCATCAAATTCAACATTGAGACCTACCAGAAATTTATAAATACGACCATCTTCTACGAGTTTCCTGTAGTGTTTCTGATCATCTGTAGACTTCCATTCATATGAATCAAACAGATCGAGATCTTGCCAGATCCTCTTTAGGGAATGAAAATATTGCGTAATTGAGTTACCTCCTTGTCATATGTCGCCTATCTTGAGATTCAGCTCAAATACTTGTGACTGATTACCCATATCTGAATACATCTCCGTCACACTATCCCATAGTTCTTGTGCAGTAGCATAGCACCTATAGTTAGAACTAATGTCTTCCACCATTGAATTGACTAGCCACGTCATCACCATGGAGTTTTCAGCATCCCACACAACAACCAAAGGATCATCTTTGGCGGGTGCAATTTTGTCTCCAGTAAGATATCCAATCTTCCCTTGTCCACGAATATACATTCGAACACTTTGAGACCAACAAAGAAAGTTGTCTCCATTAAGCCGAATGGTTGTAATTTGGACAGTAGGACTGTTGGAATGGGTGCGATTATCTGCAACTTTAACAATGGAAGACTTGTTTTCTAACATTTTTCCAAAAAAAAATTAATAATGACCAACAACCCAAAAAATACAAAACAGAACAAGAAAGTTTCAAGAAACCCTATTGGGGATTCTCGAAGAGTCGAGCAACACAGTACAGAACAACAAACAAAAGAAGACACCGAAGATGACTGGCCGACGGACTATCGGAGACTGACCGACGGTACAGACGGCGTCGACTCTCGAAGTGAAGTGATTGGCTGACGGTTCACACGACGTCGACGTGAATCGAAGGGGCTGCACATGGTGGAGCGGTTCTGTCTGAGGGGAGGCGTCAACGTGAATCAGAGGGTTGCGGCTGGCCGACGTGGACTGGGTTGCGCACGACGTGAAGTGGCTGCGACTCGCGGAAGGGAATGCCGCGCGCCTCGTCACACACTGCGCGAAGGGGTTGCGCCGCGGTGGTTCTGCGCCAAGGAAGAAGGGTAGCGCGCGCATTTACTTACGCATGATGTAAGTTAGGGTTAGGGTTTTTGGAAAAATTAGGGTTGCTCTGATACCATGAGCAAAATAATAGATTTAATAATCTGTATATTATTTTGAGAAGAGAAAGAGTTCTTAAGAGACCACCCATTTACAGATATGGAATTTACAACTAAGGAAAATAAAATTCCAGCAATCTACAATAAAGATACAATAAAGATATTATTTAGCTAAAAAGGAAGTAGCTAAACCAACACATATATATAGGTATACAAAGAAACCCTAATACTATAAGAATGTACAATTACGATAAAGGACAATAATATATATTATAACACTCATAAGGCCTCATTTTGAAGTCTTGGAATAGGGAAGTTTTTGAGGGCATTAGAGTTCAGAAGTGTGAAATTTTGGAGATGTTTAGCTTTGGATAGTGGTGTAGCCTAAAGAGACTAAGGAGATAATTCTGTAAGAATCTAAACCAAGTTAGGGACTCACTATTTATACATAAGAAGACAGTAGAATAAGAAGACAGTAGAATGGAGCTAACCTAGGAATTACCTAAGGTTAACCTAATTCTCTCTAAATCAATTCTATCCCTCCCCAAAAAAACTTGTCTTCAAGTTCTAAAAAGGAAAAAGGAAGATTGGTGGAAACAAGTAAATTGTGACTAAGTTTTATCATTTTTTTTGACAAGGAAACAAAACAATTTCATTGATATAATGAAATAAAGCATTACAGGAGAAAATCATAACAAAACCCCAGTGAAAGAGAACAAAAGGCGAACTAATAACAAATAAATGGAAGAGAACTAATGTTTCATAATAAAGGGGATCCACGAAAAACATAAATCTGAAATCGAGTAAACCCTCGAAGTCCTTAGAAAGAATACACCAGGAGGACGCCTTCAAATGAATGGAATCAAATCTTTTGACCCAATCCATCGCTTTGTCTTGGAAAATCCTCTGATTCCTTTCGTACCAAATGTCTGACAGTAATGCTTTGACTCCGCATCTTCACAAGATCCTAGCCTTGGATGGTAAGGAAACTCCAGATAAAAGACCATAAACGTTGTCTGCTACATTACTAGAGAAAGCCCATCTGAAGTTGAAGGAGCTAAACAACTTTGCCCAACACTTAATCGAATAGCTACAGTTACAGAATAGATGGAATGCAGACTCCTGAGAGCTATAGCAAAGACAACACACAAAGGGCTGCAACATCATTGAGGCTTGCTTTTTTTGTAAGACTTCTGAAGTATTAAGCTTCCCAGCAAACATGATCCACATCAACACATTTACCCTTCTTGGACAAAGAGGACACCAAAGAGCCTGAAAAAATGACTTATCTATCGTCGAACCTTCCCCATAGTGAGAAACTAATGAACGAACTGAGAAATAACCCCAGGCTCGATGGACCAAGATCTTCCATCTTCCTTAATTGTCAATTTTTGGTCCCTAAGAGACCCCAAAAGGGAGACAAATTCCTCCTCCTCCTCCAAATTTCTTCGAAAAGAAAAGTTCCAAGCTGAAATTTCAGAATCCCAGCAATCAGCTACATAACCCTCCTTATTGTTGACAACTGAGTATAGTAGGGAAAAAGAGGCTTTCAACACTCTTTCACCTAGCCACAAGTCCTCCCAAAACTGAATTCTAAGACCATTCCCAAGCCGCAACCTCACCAACCCCCGCACTTTATTCCAATGCTTAACTATATTAAACCAAGGGCTTCTCATACTGTGTCCTCTAGCCACTAAGGGGTTCCAACCATCTTTTGCAACACCATGTATGCTTGTAATCACCCGTCTCCACAAAGCCGATTCCTCAAACCCAAACCTCCAACCCCATTTAGCCAATAAGGCCTTATTCTTCCTTCTCAGATTTCCAAGGCCAAGCTGCCCCAAGGATTGGTCTTGCGAAACTAAATCCCATCAACTAGGTGGTTAAGCTTAGAGCCACTTCTTTCTTCCCAAAAGAAATTTATGATTATTCCTTCCATTTTGCGAACTACTCCAACTGGTACTTCGAAGACAGAAAAATAGTACAAGGGGAGACTGTCAAGAATTGAAGAACAAAGGGTCATACGCCCTCCCCTTGAGAGATTAAATTTCTTCCACTTATCAATCTTTTTACTAAAGGAGTCAATCAACTGCTGCCAAAACTCAACCTTCTTAGGATGTCCTCCCAGAGGTAACCCCAAGTATTGCATTGGAAAATGTTCAGCCTTGCAACCCATTTGTTTGCCATTAGCAAAACCTCCGAATCCTGAAAATTTACACCAGCTAAGGCCGATTTTAACTAATTGACTCGTAGCCCAGAACAAGTTTCAAATAAGGCAATGGTCTGAACCAAAACATCCATCATAACATCATCATCTTTGTAGAAGAGCAAAGTATAATCAGCGAACTGCAACACAGAGACATGAACTTGGTTTTTCCCCACAACAAAACCTTCAAACATCCTTTGTTCATACATTTTATTAATTAAAGAGGAGAGGACCTCCGAGTCTAACAAATATAGGAAAGGGGAAAGGGGGTCCCCTTGCCTCAGACCCCTTGAGGCCTTGATTCTGCCCCTTGGTCTTCCATTGATAAAGACTGAAAACATCGGGTCCTTAATGCAACCCATCATCCATTGAACCCAAGTGGAATCAAACCCTTTCAAACACAAAACCTCTTCGAGGAACTCCCAATCAATGCTGTCAAAAACTTTCTCAATGTCAATTTTTAACACCCATCCCTTTCTCTTCTTAACTCGATACTCCTCCATTATTTCATTTGCAATCAAAATCGGATCAAGTATTTGTCTTCCTGGGATGAAGGCACTTTGGAATCTAAAACAATAGAAGACATGACTGTCCTCATTCTTTCCGCCAGTACCTTGGCCAAAATCTTATACGAAGAAGCAATCAAATTGATTGGCCGAAAATCCTTAACCGTAATGGCTAAGTCCTTTTTTTGAATTAAGCATATGAAATTCTCCTTTTGAACTGCGTTAATTTTTCCATTGGAATGAAACTCATCAAAGAATCTAACCAAATCACCTTTTAAAAGCTTCCAGAACTTGAGGTAGAACTCAGTAGTAAATCCATCCGGTCCCGGGCCTTGTTACTTCCGAGCCCTTTAATGGCTTTCAATATTTCATCAGCCGAGAAAAGGGCAACCAGCAAGGCATTCTGTTCTGAATTAACCATTCCCCAAGTGAGCGAGACTGGAACAAACCTTTTGCCATCAATTTTGGAGTATAATCTGTCGAAATAAGTAATTATTTCATTTTCTATATCATTTGCCAATGTAAGCACATCTCCCCCCCGTACTCTGGAGCTCCACAATCAACCTTTTTCTCTTTTTTGCCGCTAAAAATCTGTGAAAGAACCCTGTATTCTCATCCCCCTCCTTTAGCCATTTCAATTTACTCTTTTGAATTAAGTCCCTTTCCTCCAAGAGATAAAAGTTAGCCAAATCCCCTATTGCAGCAGCTTTGGCCGAACATTCCAAGGGAGAAAGAAGTGAATGATCAGCTTTCGAGTCAAGCCAATTGATTTCCTCTAGCAAGTCCGATTCCTTCTTTTTTTTTTTTTTCTGCTTTTCAAACTCTCCATACCTTTTTTCAACCACTTCCTTAACCTTGCTAAGCTTTAATGCAATAACAAACCCTGCCCATCCATAAGCCTTGTTATTTCTCAAGGAACGTTCAATCTTTTTCACACACTCCACATTTTCTAGCCAAGAGTTATAAAACCGAAAGGGGACAGGGCCCCATTGAAATACACCAACCTCTAACATCAAAGGAAAATGATCTGAAAAGACCCTAGCTTGCCTGGAGGCCCTTGTGTTTTCAAAAATGGCATCCCACTCCATATTTATGAAAAATCTGTCGATAAGCAATCTTGTATTTTCGTCCTTCGGCTTGGACCAAGTAAAAGTTCCATTTGAGAGGGGAATTTCCAGCAACCCAAGTTCATCAATAAGCTTGTTAAACTTGCTCATTCCTTTGGTCACCCTCCTCATCGGTACCCTTTTTCATGTATCCATCTAATAACATTAAAATCTCCTCCCATACACCATGGTCCTTCACAATAAAAGGAAAGGGAACGCCACTCCTCCCACAAGAACTTCCTCTCCTGATAGTGATTAGGCCCATAAAAATTGGACATCCAAAAACACTTTCCTTGTAAGGAAAGCACATTCACAGATAATGAGTAACCTCCCTTCAAGACCTCTTTAACCGATACTTTAAGCTCATCCCACATCACCAACAACCCTCCAGATCTACCAAAGGCTTCCACATGAGCCCAGCCAATGTCTCTTGAACTTCATAGTGACCTAATCACATTATCATCCACAATCATGAGCTTCGTCTCTTGAATAAGAACCAAATCCGGGCAAATTCGCTGAAGAAATCTCTTGAGGCTGATTCTCTTTGAATTATCCCAACCCCCTTGGATTTCATGACATAATTTTCATTTTGAAGCCAAAATCGCTTGACTTGGCACGATTTCCTTAAGTTGCAATCCACTGTTTTTTAAAAGCTTGCTAAACCGAGCTAACTCAGTCGGACCCTCAGGAGCTACCTTATTATCTTCCTTTCCCAACTGGCTCCGAGAGGCCTATAGATCAAAAAAATCCTGAAGATTGATTGCAGGGGATGTAACTTCAGCTTCTTTATGCTTCAATCTTTTCACAAAATCCAAATCAGAACTGCTTAATACTACCACCAAACCTGAGTTCAAGGACCCCGAGACCGAAGAAGGAGAGAGAGAACACTGTTTTAAAGGAGAGTGAGGCTGGAAAGAAGCTTTGACAAAAATCACATTAGTTGGTCCCAAATGACACTCTTCCATATTAATTAATGGAGAACAAGCAACAACACTAGATGTTACTTGATTTTCCAAAAATCCAATGGAAGACTGCTGCAAGTTGTCGTTCTGTTCTAAGAAATCCGGAAAACTTTCATCAAAATGACCTTCTAGATTCAAGATGTCCTTCCCACCTCTTCTTGAATAATATTTCCCACAGAAAACGTCTTTGACTTCCTTCGTACTGATTGGATTTACTGAGGAAAAAAGAGGCTCCCCACTAACTGTATCCAAATCTCGCAAATGACCAACTGCCGGATCAAAACTTCTCAAATCTTCCCCTGTACTTAGTTGATGATTAGGTGAAGATAAGTCATTCTGATTCTGTTGCTTTAATAAGGGGCGGGAGCTTGGCCGAGAGTCATTGTTCAGCTTCTCAATACAACCATTGGACTCCCCTGCAATTAATTCCACCAATTCCGAAGTGTCCTCAAACAATTCATTGACTCCCTCCAAAGCGTTTCCTTGACCTTCAATTTCCCAATTAAAGTCTGTAGAAACAAGAGCCTCGGGCTCTCTAGATGCATTGGACCTATCCCCCTCATTAGTAGTGACATTTAATCTTACCTTGGAAGCCAATGGACCAGCCAGTGAATCAACACCCAATTCATCATCCATTACTTGTTGAATTCTGAGCAAGTCTAAGGGATTGGTAACATCCCCCGAAGTCAAATGATCCGACAGTCTACTAGGAGGAGAGATAACCCCCAAGGCTTCGAAAGTTAATGAATCTCACCAACTAATGGGTCCCTAATAGGAATTGAAATTGGCCAGAAACCACAGAGGTTTGAGGAGACCTTTATTCTTGCCCTTGATAGTTCTAGAAAGTTTGAGGTGTCCAATGATATGTCTTCAAGTCCTCCAAAGTATAATCCAATTCCTTCGAACACCTCTCTCCTCCATAATCTCAAAAGTAGGTTATTTATCGCAATCCACCCTCCATAACCAATCATAACTGAGGGGGAGCTATGAAGCTTGTCATCCCATTTTTCAACTTTTAGATGAAGATTGTTGATTATTTGCCATTGCCCCCCATTTATATCTGAAGGCTCCTCTTCAAAAAGAATCATAGCCTTGTCACACATGAATGGATTTATTTGTAGGTTCACCATGAAATGAGTTTGCAGGGCATTCTTGATCACCTCCTAACTGATATGAGCAAACAATCTAGACACGACCCATATCCTATCGAAATCAACAAAAACGACCTCCTTCTCCTTACGGATCCAATACTTATCCTGAATCACCTCATGAGTCCCTTTGTTTTCCATTATCGAAGAGAACATCCTAGAAGGAGAATCAAATCTAGAAACCTTGTTCCCAACCAAGTTCAAAGAGTTTAAGGATACAGAGGGGAAGGAGGATGGCGAATTTAAACGAAGGAAGTCACCCAACATGTCTCTAAATTCCATCCAACCCGTGGAGAACAATCCAAGAGGCACCGAGAAGACCCGACGTTCCCCTGACGGAGGCCAAAGCATATACCCTCCGCAACCCAACCGACCCTTTTTCTAACCTTAAGTAGCCCAATCGTTGCACCTTCATCCTTGAAGATGCAAGATTTGACATCTGCCGCCAAATCCACAAACCAACCATGGAATTGCTTCACGTGAACGAGAGACATAGGAATTGGGCGGTTTGAAGATCCTTCTTGCAAATATAGGTCAGTCAAATTCCCCCCGACACTAAGTTCCGAAGTCCCGATACAACAACTGCACTTCTTTACCTGAGACGTTGGAGCCCTGACAAAAAGAATCGACATGGTTAGGGAAGACCTATCGCTTTCCTCTTTGAATCTGAAGAGTCACCAAAACGGTGTAGGGAAGGGGGAATAAGATGGCAAAAGACAGAGGTGAAGAGGCAGAGGGACGGACAGAAACGCCGACAATGGGGCGGGAAGGGTAATCGAAGATAGTAAGGTTCTGACTAAGAAAGCCACGAAGTTATCGAAGGCGGTAGGGTTGGGCGAAGGGAAGAGAGAGAAGATGTCGGGCTTTCACCTGCGTGGTCGGAGGCGAAGGGGAAGGGGTGGTCAAAGGCGAGGCGAAGGGGAAGGGGTTGGTCGGAGGCGAGGTGAAGGGGCGAAACGAGAGGGCTAGTCTCATGGAATACCGGGGGATTGGGGGATTTCTCTAAAAGGACAAGTCTGAAAAATGCTTTATGAAGCTTTGTACTGTTACAGTGTTGATATAAGAAACAAACGATGGGTTTATTGATGCTTTTATCGGGTATTCAGATGTCTGCAATGGCTTGATTGTTGTGGAGAAATGAGGTCAAGACACTGTTTTCAGATCTTTGGCTTGCGAGAAATCAAAAAATGTTAGGATAAGGAGATGGATTGGGATAGAAGATTTAATGCAATTCTTTTGTAAGCTTCTACTTGGTGTGTTCTTTCCAAGGATTTTGCTAATTATTCTATTTCTGATTTACGCCTTTCTTGGAAGCCCTTCTTATCTTGTATCTGATGGTTTGTAAGCTAGTTTTGGTTTATTGGTTATGTATAAGGTTTAGATGCTTTTATTTTGGGTTTTCTAGGTTATGTCTCATGTTGTTTTGGATATTTCTTGTTCTTTTTTGTTTGTTGTATTTTGAGCATTAGTCTCATTTCATTATTTCAATAAATCTCGTTTGTTACCTTGTCAAAAAAAAAGTAAATTGTTCAAATGGTTGATGATCAAAGGCTGACTCCAAAAACTGATGCCACTCTTTTCGATGATTTGAAAAGCCGCCACTGAAAACTGCCTTTGAAATTCATCACGCCAACAAAGAAGACCCAACTGGTGATTGTTGAACATAAGGAACAAAAATATTCTTGAAATGCAAGTACTGGAGTCAGCTTGTGGTACCGTAATCACTCCTCCAAACACAATCTTGTGCATAAAAATAATTTTCAAAGGATCATTATCAAATATCCCAAGCATTTCGTGGCTCAAAAAGATTGAAGAGGGCTGGTTCATGTTTACTTCAGCTGGTTTGGGTAAGTGCTGGAAAAAAATAGATGTGAGGAGGTGTGTGAGACAAGTAAATGAGTCTTCCCACAAGTCTCTGATATCTTTCTCTTTCTTTTACTTCTTTCTCGGTGACAGTTTCGGCGGTGAGACAATAAAGTTAGGGTTAGGATTTTGAAAAAAATTAGAGTTGCTCTTATACCATGAGCTAAATAAGAGGAATAATTATTTCTGTATATTATTATGAGGAGAATAAGGGTAACACCCATTTACAAATATGGAATTTTCAAGGAAAAAGATTCCAGTGGTATAATACAATAAATGTAATAATTAATAATTAGCTACAAAAGGAAATAACTAAACCAACAGGTACCTTGTCTAAAAAAAATTAATTCAAAAGATGAGTGAAATTGTTGTTATATATGTTTTTTTTGAGGTTAGTATATGTTAAATCACCAATCAACCCAAAAGCTTAAACTTATAGGCTATGGTAAATTTAATTATATCAACACTCTCCCTCACTTGTGGGGTTGAAAATTTGAACAAAGGTCCAAACAAATGGAAATCAATATTAATTGGGAGAAAACGACTTTACATGGATTTTAACACAGGACCTCTTGCTCTGATATCTTGTTAAATCACCAATCAACCAAAAAGTTTAAGCTTACAGGTAAATTTAATTATATCAACAGTATAGAATTGGGAGAACACATGAGAAGCTCTCATCATATCATCCTTGGAGGGAAAAAAGGGCAAGTGTTAAATGGATAATGCAAAGTTTTCTACTTAGAAATGGAAACCTTGAACATTAAATTTGTCCCGGTTTGTGCTTGTTCTTTTAGTTTCGTTAACTCCAGTAGGTTTTTTGTGCTACTAGGGTCGATGAGAAGACTTTGGAATGATGTGTGGTAATGGTAAAATTTAGGGAGTTTGTTCCACATTCGCTTTGTGCTACTAGAATCAATGAAAAGACTTCAGCTTTTTTCCAGAAAAGAACCTTGATTTACTAATCGCAACTCATTTCATCCACCAACCCTCGTATCTTCTAAAACATTTGGAGTTTTTAGCCAACAATTCTCAAATATGAAAGGAGTTCCCATCTTACATTACTAAAATGGAGGATAATAAAAAAGTGGTGGACTGGCTAAACATTTGGAGAAAGGGTTGTGAAACTTATCCAACCACCCTTTTGTGAGGAGAAATCTGGATAGCTGGGAATAAATTGGAACTCCCTCAAATTAGACCCTGTAAAAGAGGTATTGGGGAATGGATATCGATGATTTCTAAAGAAGTAATGAACTTGTCGAGCTTCCTCTTACTAGCTGTGTATCTTCTTATGTCTGATTTTTTATTGTAAATGACATTATAATGTTCTCTTAGGAGCCAAATTGGATAGCATAAACATTGCAAGTCCCAAAGCTCAACCCAAAGTTTGACCTCTTTCTTCTAAATCCTACAAAACCACCCAGTGAAGTCATCGACTATAGAAAAAGCCACTTAAAGGGAGTAACCATCATAGTCTCTGAAATATTCACTGAATAGTCTCTCCACATGATACAAAATCTCCTAATGAGCCAATAGTATTGAAACCAAACTATTGGATACAAATCCTCCTAATGAGCCAATAGTACACAAATTCTCCACATGTAAATTGATTACTCCCTTTTGTAACTACAATTTATCTTCTTTCATGACCAATTGGAAACGTTTTTTTGTAATTTATTGGATAGGAACTCACCCTTTTGTAATTTCATCATATTAATGAAATGTTACTGTTTCCTATAAAAAAAAAAGTATCCAAACCAAACCAAATCGTGCATGCCTCTGGACCTTCTCATCGACTTTATCAGTTTAAGTGAAATTGAATCGAGTTTGGTTTCAGAAAGAATAGGCACATCCAAATTACATTTGTAATTCACATCTTTAACCACAAACCTCTTAGCTTGGGAATCTCTTGGCTTGGAATCTAGACCCTTGACATTTTAAGAGATGATCAATAAAGAGTCTGACATCCCTTTGAAAGGACGCCCTCCATATTTATATCTAGCTTTATCATAATTGATGAAGCTCTGTAAATTTCTCAATTCCCTTTTACCGTTTTCCCTTTTGTTTCACAGCTAGCTCTCCTCGCACTCCTCTATTTCAGGGGAATGAGGCCAAAATTGTTCTTTTCTTTCAAGCCATTTTGCTATAGCTGGATCCTTCCAATTGAAATCCCCTTTTTCTCCATAACTAAAGGGGATTTGTTCCTTCCGCCCACATTTGTGAAGTTTTATGGAGCGTAAAGATGCCTAAGAAGTGTAAAATGTTCATTTGGTCTTTTCCTGTCTCCTCCTTCATTGGATATATGCAGTTGAAACCTTGACTCTCTTTAGGGACTTTCCTTGTCCAAGATTTTTCACCCTCACTTCCACCCACTCGATAACCCTTTTATGTGTTTCTAATTTACTCTAGCAAAGATGGCCTGGCAGATATTTCTTAGAATATTCAGTTCCTTTGGGGGTGTCCATGTATAGTTATTTTAGTGATATTCTTTTATTTCTTACTTTATTGGATTAGATTTCTTACATTATCTTTGAGGAGCTTTTGAAGTACTTTATCGTTTACATTCTTTCTCTAACATCATTTAGTTTTCTCTGTTTCTTGTAAAAATTTACTATTCTTTCAGGGTGAGGCTCTGGTTATGGGATATGACGACATGGGGTGAGTACTTTTCTCTAGGGTATTATATAGATGATGAGTTAAAACAAACACCCTTCACCATATAGAAGTTTTTTTTAGCAATAAACAAAACTTTTTCATTGGATAAACAAAAGAGACTAATGCTCAAAAGAGTTGTGCTCAAAAGATACAAACTCTACAAGGGAGTGAAAAAAGAACAAAACAGACGATGAAAAAGAAAATTAAGAAAGATAAACCTCAAAACTCCCTTCCTAGTTATCATCAAATAAACTGACTATCCTTATGGAGCTATAAATGATAGTGGCCTAGTAGCTTGTGGTTTAGATATTTGCTGTAGAAAATAAGATAAAATGCTTTCTGACTATGCTCTGTTAGATTCTATCACCATTGAAAGCCTGAAGGTCTTCTACATTTATATATTAATACGTACTTTATGAACATTCAAGCCCCGTTTGATAACCATTTGGTTTTTGAAAATTAAGCTTGTTTTCTCCCAATGTCTCTATAATGAGTTTCATTTTTCTTAAGGAAACATTTGAATCTTAGCCAACTTAAAAAAAAAGAGTTTTCGAAAACTACTTTTTAGTTTTCAAAAGTTGGTTTGGTTTTTGAAAACATAGATAAAAAGTAGATAACAAAGCAAGGAAACCCATCGATGGAAGTAGTATTTATAGGGTTAATTTTCAAAAACCAAAAATAAAAAAATAGTTATCAAATGGGGCTAAGTTATTTTTTCTGATATGAAATTCAGAAACTAATTTAACTTATATCAGTACTAATGAAATGAAGAAAGCGTATGTTTGGGGAGTATAATGGCAGATTGCAACCACATTTTAAAGCATGACAAAATATGTGATCCAATCATTTGTAGTAAAATTCTGAAGGAAATTCCCTTTGCAATGGAGATTATTTTAATCGTGGTATGGTTTGTTATAATTAGACTGTTATAATATATATTATTATGTATATTTGTCATTTATAGTAATTGTACATCCTTTAGTATTAGGGTTTCTTTGTATATCTATATATATGTGTTAGCGACTCTAATGTGAATACAACAAATAATTTTTCTCAATACTCAATTACATGGATTAGTGCCCGCCCCTAGGATTTTAGACTTTGAATTTGGCAAGGGTTTTCTCTCCCAAGTGAGGTTAAGGTTTAAAGTTTGGATCATTGCGTTAGGGAGGACATTTGTCGACACCACCAACCTCAGGAGTGCCGCTGTCAGCAGAGGAGTTTCGCTGTTCACCATTCATTGGAAGCATCCGCGCATGAGCCGTACGCGCCGACATTTGAGACCTCCAATTAGTGCCACTGCCTGGGTTTGTCTCGGCTTGAGGATTCCGGTCGTTCTGTGCCTTTAGATTCGACAATAATCCCTTGGTTTGTCTCGGGTTTTGGATTTGGTTGAGATTAAGTTGTTTTTTTGGTACTGTTCAAATCTGTCTTTGATTCACTTGAAGTTTATCTGCATTTTCTTTAATAATGGCTGAGCTGAAACCTATGGTTGTACCTACTTTGGTTCCCTTTTCGTCAAAAATCACGGAGCATAAGTTGAATGACTCAATTATTATGATTGGAGTTGAACAATTTGCTTATATATACGAAGCACTGAGATGGATGATCATATCGATCGGGATCTGCCAGAGGATGACACAAGGAAGACTTGGTTGCGTGATGATTCTCGATTGTATATTCAAATCAAGAATTTGATTGAGTGAATGACTCAAATTATTATGATTGAGTCGAACAATTTGCTTCTATTTACGAAGCACTGAGATAGATGATCATATCGATCAGGATCCACCAGAGGATGACACAAGGAATACTTGGTTGCGTGATGACGCTCGATTGTATATTCAAATCAAGAGTTCGATTGAGTGAAGTAGTTGGATTGGTAAATCATTGTCATTCTGTAAAAGAAGTGCTCGGATTTTTAGAATTCTTATATAGAAAAAAAGCAAGTTAATAGAATGTATGAAGTTTGCGCAACCCTCTATCATGCGATACAGGGAGACCAATCCGTTATGAATTATTTTATGCAAGTTAAGAAGACGTGTGCAGAATTTAATACTTGACTCCCATTTAGTACCAACATAAAGGTTCAACAAGTTCAAAGAGAAAAGATGGATGTCATGAGTTTTCCGAATGGTCTTTCCTTTGAATTTGATATGGCTAAATCACAAATTCTCTCGGGCTCCGAGATCTCTTCTTTGGACGAAGCTTTTAGTAGAGTCTTCCGTACAAAAAATTCTTTGTCTATTTCTCAGTCTAATAGTGCTCTCATTAGTTGGAATGATCCTAAGGTCAGTGAAGGAATGAATACCAACAATGAAAGGCTTGGTTCTGATCATCAATGACAAGATTCACAAGAGATTATATGTAACTATTGTCGTAAGTCGGGTCACATGAAACGAGGTTGTTGGAAGTTGTTGAATAAGGGGCAAAGACCTCAAGTAGCTCAGCTTGTGTCTACGAATGATACATCTGAGAGGTTGGTTACTATTTCTGCAGGCAATTCGCTAAATTCCAATTGTGCCAGGACTCATTGCATGCATCTTCTTCATCGAATCCTATTGCAATTATGGCTTTATTGTCTTCTTACATCTTCCACCAAATGTGTCATCGACTTTGGTGCCACAACTCATATGATAGGTAATTCTAGTTTATTTTGTACCTCTTTGTCATCTGTACCTTTTTCATTTGTCACTTTGGCAGATGGTTTGACGTCTTCTATTCTCTGATATGTCGCCATTAATCTCACACCCTTGCTTCCTTTGTAGTTTGTCTTGCATTTGCCTAGACTCCTGCTTAATTTGCTTTCTGTTAGTAAGCTCACTCATGACCTTAATTGTTTTATCTCATTTCTTTCTGGCTATTGGTTGTTTCAGGATCGTATGATGAAGAAGATTATTGGTAAAATGTATGAGTCTGAAGGGATTCACATTTTTTATCAGCAGATACTAAAAGCTATGGCCTGCTCTGGTGTTGCATCTCCGTTTGAAGTCCATTGTCATTTAGGTCATTCGTTTTTGTCTGTGTTAAAGAAAATTCATCAGTTTCATTTTTTGTCTTCGTTGAATTGTAAGTCCGGTCAATTTGCAAAATTTCATTGTGTTAGTTCGAGTCCTAGAGTCCATAAATGAGTTAGTGCTTCATTTGAATTAGTTCAATCTGATGTCTAGGGTCCTTATCCTATAGTGTCCAGAACTGGATTTCGATATTTTATTACTTTTGTTGACGATTATTCTCATATGACTTGGTTATATTTATTGAAAAGTCATTTTGAGTTGCTTATTCACTTTTGTACTTTCCATGCTGAGATTTAGAATCAGTTTAATGGCTCTGTTAAAAATTAACGAACTAATAACGCTGGTGAATATTTTTCTTACATGTTGGGATCTTACTTGTGTACAAATGACATTCTTCATCAATCTTCTTGCGCTGATAATCCATCCCGAAATAGGGTCGCTGAATGAAAAAATCGACATTAACTTGAAACGGGTAGAGCATTATCCTTTCAAATGCATGTTCCAAAACATTTTTAGGCAGATGCAGTTTTCACAGGTTGTTTTTTGATAAACAGAATGCCTTCCTTAGTTCTTAATGGTGAAATCCCCTATCGTGATCTCTGTCCAACTAAATCTTTGTTCCCAATGCATCCAAAATATTTGGTTGCACTTGTTCGCTCGAGATGTTAGTCCTCATCATATGTTATAATATATATATTGTTGTCTTTTATCGTAATTGTACATTCTTTAGTCTTAGGGTTTCCTTGTATACCTATATATATTTGTCATACACCTCAAATGTGAATAGAACGAATATTATTCTTTCTCAATTCTGTGTTACATGGTATTAGAGCTTCCCTAGGGTTTAGGGTTTGCATTTGAAAATTAGGGTTTCTTCCTCCTAAGTAAGCTTAGGGTTTGAAGTTCGGGTCATCATCTTAGGGTGGTCGTTTGTCGACACCCTTACCTGAGGAGGAGCGTCGCCGTCAGAGAAGGAGAATCGCCATCGCCGTTCGCTGGAAGCTGCCGTGAGTGTACCTCATGCGCCGCTCGAAGGATCTGTCTTCGCCGCCATGCGCCAGCGCGTGGGAGCTCCGATCAGCGAGCGGTCGCCTAGGTTTGTCTCCGTTCGTGTTTTTCGGCCTGTCTGTCACCCCGGATTCGACACTAGCCTCATCGTTTGTCTCGGTTTCTTCATTTGGGTGAGATTAGGGCACTTTTTGGTACTGATCAGGATTTTCTGTTTCCTTGAAGTTAACCTACAGTTTTGTTTTAATAATGACTCAGATGAAACCTATAGTTGTATCCAAAATGGTTCCCTTCTCGTCAAAGATCACGGAACATAAGTTGAATGGTTCAAACTATTATGATTGGGGTCGAACAATTAGGTTCTATTTACGAAGCACTAAGATGGATGATCATATCGATCATGATCCACCAGAGGACGATACAAGGAGGACTTGGTTGTGTGATGACGCTCGTTTGTATATTCAAATCAAGAATTGAATTGAGAGTGAGGTGGTTGGATTGGTAAATCACTGTGATTCTGTAAAAGAACTGCTCGAATTTTTAGAATTCTTATACTCAAGAAAAGAGCAAGTTAATCGAATGTATGAAGTCTGCACAACTCTTTTTCATGCGAAACGGGGAGACCGATCTGTCACTAATTATTTTATGCAAGTTAAGAAGACATGTGCAGAATTTAACACTTTACTCCCATTTAGTACAGTCATAAAAGTTCAACAAGGTCAAAGAGAAAAGATGGGTGTCATGAGCTTTATTAATGGTGTTTCCTCTGAATTTGATACGGCAAAATCACAAATTCTCTCAGGATCCGAGTTTCCCTTTTTGGATGAAGTTTTTAGTAGAGTTCTCCGTACAGAGAATTCTTCGTCCGATTCTTCTGTTTCTCAGTCCAACAGTGCTTTAGTTAGTCGCAATGATCCTAAGGTCACTAAAGGAATGAATGGTAAGCCGGGTCATCAGAGACTTGGTTCTGATCATCAGAGACATGGTTCCGTTGTCAGGAACCATCAGAGACTTGGTTCTGATCATCATCGACGACAAGAGTCACAAGAGATTATATGTAACTATTGTCGTAAGCCGGGTCACAAGAAACGTGACTGTTGGAAGTTCTTGAATAGGGGGCAAAGACTTGGAGTAGCTCAACTTGCGTCTACAAATGATACACTTGAGAGAACAGTAACTATTTCTGCAGACGATTTTGCTAGATTGCAGTCGTACTAGGACTCATTACAAGCATCTTCTTCATTAAACCCCATTGCAACTATTGCTGAATCAGGTAATAATCATTGTCTCCTTACATCTTCCACGAAATGGGTCATCGACTCTAGTGCCACAGCTCACATGACAGGTAATTCTAGCCTATTTTGTACCTCTTTGTTCTCTGCACCTTTTCCCTCTGTAACTTTAGCAGATGGTTCGACATCTTCTGTTCTTGGATTTGACACCATTAACCTCACACCCTCGCTCTCTTTATCTTCTGTCTTTCATTTGCCTCGACTTTTGTTTAATTTGATTTCTGTTAGTAAAATCACTCATGACCTTAATTGTCTTATCTATTCTTTCTTGGTTATTGCTTGTTTCAGGATCGTATGACGAAGAAGATTATTGGTAAAGGATATGAGTCTGAAAGCCTTTACATTTTTGATTAGCAGATACCGAAAGTTGTGGCATGCTCTGGTGTTGCATCTCCGTTTGAGGCCTATTGTTGTTTAGGTCATCCATCTTTGCCCGTGTTAAAGAAAATGTATCCAAAGTTTCTTTCTTTGTCTTCGTTGGATTGTGAGTCGTGTCTGTTTGCAAAATTTCATCGTCTTAGTTCGAGTCCTAGTCCTGTAATGCCCAAAACTAGATTTCGATATTTTGTTTACTTTTGTCGACGATTTAGTGCTCCGTTTGAATTAGTTCATTCTGATATCTGGGGTCCCTGTCCTGTAATGCCCAAAACTAGATTTCGATATTTTGTTTACTTTTGTCGACGATTTTTCACGTTTGACTTGGTTATATTTAATGAAGAGTCGTTTTGAGTTACTTACTTATTTTTTCAATTTCCATGTTGAGATTCAGAATCAGTTTAATGTTTCTGTTAAAATTTTGCGAACTGATAATGCGGGTGAATATTTTTCTAACATGTTGGGATCTTACCTGTGTACAAATGACATTCTTTATCAATCCTTTTGCGCTGATACTCCATCCCAAAATGGGGTCGCTGAACGAAAAAATCGACACTTGAAACAACTAGAGCTTTATCCTTTCAAATGAATTTTCCAAAGCAATTTTGGGCAGTTGCAGTTTCCACAACTTGTTTTTTGATAAATAGAATGCCTTCCTCAGTTCTTCATGGTGAGATCCCTTATCGTGTCCTTTGTCCAACTAAATTTTTATTCCCAATTGCACCCAAAATCTTTGGTTGCACTTGTTTTGCTCGAGATATCAGTTCTCATCGTACGAAGTTAGATACTAAGTCCTTAAAATGCATCTTTCTGTGTTATTCTCGTGTTCAAAAGAGGTATCGTTGTTATTGTCCTAGTCTTAACAAGTATCTTGTCTCTCCTGATGTTACGCTTCTTGAGGATTTACCCTTTACCCCATCATCGTCGAGTACATGTCAGGGGGAGGATGACACACTCATCTATGAGATTGTCTCTCTTTCATCTCTCCCTACTCTGTCTCCTTCAACACCTATCCCTCAGCGTCTGCCTATTACTCAAGTTTACACCAGACGAATACCACAACAACCTTCAGACACATGTCCTATACCAGAAGATTCTTCGGCATCTGATCCAGGAACTTGTGATGAGCTCCCCATTGCCCTTCGTAAAGGTAAAAGCACCTGCACTTACCCTATTGCTTGTTGTGTATCTTATCACCAATTGTCACAACTTACATATTCTTTCGTTACATCCCTTGATTCTACTTGTCTTCCTGTTCATGAAGCTTTATCTCATTCTGGCTGGCGTAATGCAATGATAGAAGAGATGCATGCTTTATATGATAATGGTACTTGGGATTTGGTATCTCGTCCTGCAGGAAAGAAGGCTATTGGATGTAAATGAGTTTTTGCCATTAAAGTTAATCTTGACGGAGCCGTTGCTCACTTGAAAGCCCGCCTAGTTGCTAAAGGTTATGCTCAGACTTATGGGATAGATTATTCTGACACATTCTCTCCGGTTGCTAAATTAACTTCTATTCGATTATTTATTTCCATGACTGCTACTCACGGTTGGCCCTTGCATCAGCTAGATATTAAGAATGTCTTTCTCCATTGTGATCTTCAGAAGTATATATGGAGCAACCACTTGGTTTTGTTGCTCAGGGGAGAGTAATTTGAAAAAGCAGTGACGAGTCATGGATTTCTTCAAAGCCAAGAAAATCATACCATTTTCTATAAACATACTGTGAATGATAAAATTGTTGTTTTGATAGTATATGTTGATGACATTATCCTCACAGGAAGTGACGAGGCAGAGTTCACTAACCTTAAGAAATAACTAGCTAATGAGTTCCAAATTAAGGATCTCGGAATCCTGAAGTATTTCCTAGGAATGGAATTTGCTAGATCGAAAGAGGGTATTCTTGTTAATCAAAGGAAGTATATTATTGACTTACTTGAAGAGACAAGATTACTTGGCTGCAGAATGACATAAACCCCCTATTGAGCCAAATTTGAAATTGCAGAGTGCAACAGAAAAAGAAGTAAAAGACAGAGAAAGATATCAAAGACTTGTGGGGAGACTGATCTACCTGTCTCACACACGTCCAAATATCTCCTTTGCAGTTAGTATGGTAAGTTAATTTATGCATGCTCTAGGACCAACCATGATGTTGAGGCGCATCCGGGCGCTCGCCTGAGGCGCAAGGCGAGGCCATTCTGTGGATATGTGCCTCACCATTGCACGAGACGATGGCCTTCAATGAGGCGTTCGCCTCTGTTGTGCTCGGCAGTGGCAGCGCCTTAGACGCAGGCAATGGCCTGCGATTTTCTGCAGGTTTATCTGTTTTTTTGTTTTTTTTTAAAAGCTTAACTTAATTCTCAAGTAACCGTAAATAGTCCGCCCACATACAAGCCCACCTATATGCATGCAGAGTTGCCGTTTCTTTATTTATTTAATGAAAACGACAACTCTCCATATTTCCATCTATCGACAATAAAGCTATCGAATCGACTCCAATCCCTTCCCCTTCGATTCGAATTCAACCTTTATAATGATTTCTTTATACAGCTTCATCGACATAACCTTCACCTTTCACCTTTCTATTCGAATTCCTACTGCTTAACAGATTTGTTGGTTCATTGATTCATTATTTCATAATTTTCTTCTGGATGACTTTAGCCATTTGGTTGATGTATTAAGTTTTTAAGGATTTTTCATTTTATATGATATTTACTATACAATTTATGTTGTATATATTATTTATTTATATATTTAATTATTGTACCTCGCATCACTCGAGCAACGCCTTTTTGTCACCTCTCGCCTTTTGGCGATCAAATGGCTTATCGCCCTGAGGTGCATCTTGCGCTTTGAAAACACTGGGACCAACTCATTTTGAGGCCGTCTATAGAATTCTAAGGTACTTGAAGGGTACTTCGGGAAAAAGTATATTGTTTAAGAAGCATGGTCAGCAGGTTGAAGTTTACACTGACGCTGATTGGGCAGGTAGTACAATAGATAGACGATCTACCTCTAGTTACTGTTCCTTTGTTGGGGAATTTAGTTACCTGGCGGAGTAAAAAACAAAATGTGGTAGCCAGAAGTAGTGTTGAAGCTGAGTTTAGGGCTCTAGCTCATGGTATTTGTGAGGGTATATGGATGAAGAGACTATTGGAAGAATTGAAATTTTGTCCAAAAGCTCCCATGCATATTTATTGTGACAATAAGACAGCAATCTCAATTACTCACAATCCAATCCTTCATGATAGGACAAAACACGTTGAGGTTGATAAACATTTTATAAAAGAAAAAATTGATGTGGGGATTATATACATTCCATATCTGCCTACCACAGAGCAAGTTGTAGATGTATTAACAAAAGGGCTCCCAAAATCACAGTTTGACAAGATGATCAACAAGTTGGCAATGGAAGATATCTTCACACCAGCTTGAGGGGGAGTGTTGGTTTAGTTATTTCCTTTTGTAGCTAATTATTATTTATTGCATTTATTGTATTATATTGTTGGAATTTTGTTTCCTTCCTTGTAAATTCCATATTTGTTTCTTTAAGAATCCCTATTCTCATTATAGCAATATACAGAAAAATAATTCCTCTTATTTTGCTCAAGGATTATAATTATTTTTCATAGCAAATGAAATTTCAATAGAAGAAACGATTATAGAGATAGGCAGCCTGTCCTATTAAGACAAAGGACGCCGTCAATTGTAATGACTCAAAAACTGCTTAAATATCTTAGAGAATTAATATCCTTCTACCATACTACTTTTCTCATTCGTTACCTTTCTGTATAGGTCCATAATTCTACTTCTAAACAGCTTTCTCTTTTATTATTCTTTTTTGCCTAGGTATAAACTGTGGAAACCTCACCTTAGAGCCGTCATGGAGCACGAGATGAAAGCAGTTAGTGAGGGCACTAAGAGAAAAGATGAAGTGTTGGCTACATCCTTGCAGCAGATGAAAGATTGCTTCTTAGATGTAAGAATTAATTGTGTTAACAAATTTTCATCATGAATTAATTTTTGATTTGTTTCTGCGATGACATGCCAATTTCTAAAAAAGTAGGACATGGCACGTTGGGACACATTATGGATAAATAATAATAATAATAATATACTCCATTCTAAAATCATAAAAATACTACAAAATCATTTTATATTTTTTAAAACTAACTAAACTAAGGCTAGCCCGTGTTCAGAGTACGCTGCTTTCAGATTACGCTGAGAAACGACTCGCCACTAAATGTGATAAAGGTAGACGTTATCGTGTGGACCCAATTGACTGTTACAATTAACACGTACGGGATGGTCATTTGGATGGTATCGTCAATCTTCAAACACGACAGTGCACCTGCAGGGAGTTTGATTTGTATGAAATCCCTTGTTCTCATGGTATCATGGCCGCTAGAAAGCGCAACATTGCTCCGTCGATCCTTTGCAACAAAAGTTATAATGTTGAAGCTCTTCAAGCGGTGTATCAAAAACCAATATGCCCCTTGGTCACATATTTGAATGGTCGAAGCCATCTGGATATGTAGATGTTCAGATATGACCACCGAAACGTGTTGTCAGGGTCGGACGACGAAGGGTGCAAAGGATTCCTTCTAGTGGAGAGCATAGGCAACCTAAAAAATGTGGTCGGTGTGGTAATGTCGGACACAATCGACAATCATGTAATCAACCACTCAACACTATGAACTTCAACCGACCAGATGAATCATAAGGTATTCATTATGAATTCTAAGTTAATGTTTTAATAATCTTTTTGAAGTATTTCGATTTACATACTGTTCTATCTATCAAAAACAGACTCCAGATCTGACCGCTCTCGTAGGACCGCTCACGTTGGATCGCTCTAGTTGGACCGCTCACCTGCTGTTGACATCTTTATTTATTTTTTAAATGTAAACTTGAAGCAAATACATAAATATAACATGTAAATACATATATTCAATGTAATATATGAACAAAACAATTTACATAATATGTATATAGTGTAAATTTACATAAGGTAAGAGTATTGTAAAGTTACATATGGATTTAAATAAAAAAAATGCAGACCCAGACCATGAATTGGGATCTGTCTGCATCGGTTACAAGATATTCAATCCACTTCGCACAAAATATACCGCAGTCAATGGAGTTCTGCTGCAAATCTTCACATCTTGATCGAAGCAATTGCCATCTATCCGTTCGTAACTCATCCTTGTCACGTTGGACGTCACAATAATACAGTAGTGATGGGAGTGTATACGTCAAGGGCTCTAGAAACTTATTGACTTCTTCGATCTTGAGATACGATGGATAGGAATCAAAAAGCATAATACAACCTCTGTTCATATCCAAATATAACAAAAACCAATGCTCTTTCAGGTTTGTTGGACAGAACACAAAATCCATCTCACTCCATGCCGGTTTGTAATCATCATGCAGACCTTGGACGTATTCGGTGTACGTATCGTCTGTACTCCAAACCATAGCAGCTTTGAGTTTGAGTTTATTCTTTATTTTCTGGAATAGACTATTTTTGCCTCGTGCATTTAGATGAGACTGCAAACTCATAATAGAATAACTCAGACAATGATATGTACTTAATCTTATAGAACTAAGTAAAAACATATCCAATTAACTTACCAATATCCCAAATGGAAGAATGGTAAATTTGTTTATGCACATATCGGGTCGTGCGGACAACTTTTTCTTCACGAACATACATAATGTGTTCATAGTCTACAAAAAAAAAAACATGAAGATGGACATTCACGGTAGAATAAACATTCATAAAGCCATAATATACCACTTACGTCACACTCGACCCATGAGCTCGGCGTAAGGAGATCAATGAAGAACTTCTTCCCCATGAGCTCGGCTTCGAATATCTTAACATTCACGTCATGTGCAGGATTGTATTGCACGGCCGACGCATGAAGTATCGTGATCCTACCAAGGATAGGGTATTTGGCCTTCTTACGCTCTGGTGTATGGATATTCTCGGTAGTTTGACTTGCTATCTTGTCGCTAGGCGAATAACGACGTGATGCTGTTCTTTTGCGACTTCCCTTCCTCGCAACTGCTTCAATAGAAGGTCCGCAAACAGCAATAGGGACGGTGACGTCAACATTTTCGATCTCCAAATTGGGTTCATTCGCTCCCCCAACCACAACTGATGTCGTTACTTTGTTTAGACTATCCAATATCGTAGCTGCATCTGTATCGGGATTATCTAAATCATATGGATAGTCCATTAGGGATAACATGAGCTCAGTGTGGATGGTGGAGGCATCAGTTGTTGACTTCTCGGCCAATACCTTCTTTGAAATGATGGCAAGGGATGTTTCAGGATGACGGCGGAAGTGGTGGATGACTCGGGTTGTGGGATGGATGTATTAGTTGTTGATGGTTCGGGTGGTGGGATGGAGGTGAATTCTTCGGATGGTGGGATGCTGGTGGTAGTGGTGGTTGGATCCGGTTGTGAGATAGTGGTCAATGTATCGGTGGAGTCTGGGATAGGGGTGAATTCTGTGATAGTGGTGGAGTCTGGGATAGGGGTGGATTCATCGACTGGTGTCTCGGGTTGGGGGACAGTGGTGGATGGCTCGGGTGGTGGGATGACGGTGGTAGTGGGCGATGGATCGGTGGCGGGTGGAGATGTCTCTGGTGCAGGTGGAGATTTCTCGGGTGCGGATGGAATGAGAGTGGGGGGTGGGTCAGGTACGGGTGTGGTGATCCACTTCCATATTGCAACCATCATCCTGCAATATGTGCAATCCATATAATTAATAATATGTAGGTATGAACATAACAATAAGTATATTATGCAACGACATTATGTAACGTACCTTGTTCATTCTATGAATGAAGTCACGAATATATATCAAATGGGTTTTAACCTCACCCACATCTATTCTCATTTCTTCTCGCAAATCCATTATGTCTTATTTCGCCTTCTACAGACTTCTCAATACCATCGACACGCATGTCTATACCCCGAAGGTATTCAATTTCTGATGCTCCAGTGTGTATACCGGTGGATCGAGTATGGACCGGAGGCATAACATGTGAGCGGATAGGGGATCTGATAGGGAGCGGAGAAAGGATCTGACAGGGGACATGTGCTCCTGATGTGGGACCCCGATAGTGTCCCTATCTTCCTCATTATTAATGTTGTCGTTGTTGGTTATTCTCTTTATTTATTAATAAGGAAATATTAGCTATTCCCTTATTTGTCAATAAATATTTCCTTGTATTTGCCATAATATAGATGCTGTGTTTTTATTTCCTTGTATGTAAATATAGGTTTCTCCTATATAAGAAACCTTGTACCTTCATTGTAAGATATAGAAAATATTTCTACTCTTATTATTTTCTACATGGTATCAGAGCAGAAACCCTAACTCTGTTCAAACCCTAATTCCCTTTTTTTTAAAACCCTAATTCCTTTCGTTTTTCACGAGCAACATTGAAGAACCGGCAAAGACCCATACACAGTGAAGGACCTGCGAAGAATAACCTGCAAAGAAGACCCACGAAGAACCGGTGAAGCATACCCACTGCCGTCCCACGAAGTACCGACCCGCGAAGCATACCCACGAATCCAGCGGCTTTGTCTACGATTCTTCACCCGCGAGCTGGTCGGATTTCCTTCAAAGGTCGCGCCATTGATCCATTGCCGCCGGACCCTCCTTCTAGCGCCAAGAAACATCGCCATCAAGCTCACCATCATCGCTGTCGGTCTCCCACCGCCGCTTGTTGCTTCCCGCTTCCTTACGTATAATTTTTGTTTTTCACCAAAGGAGTTTCGCTTTTGCTTGGTTTGTTGTTACCGTGTGGTGTTCTCCAACGAGAATGTCGGACAATAAGTTCTTGCCATTGTAAAACCCTCGATGGTCGGATCCACTCCAACAAATCCGTTGTCCAAATTACAACCATTCGACTTAATGGCGATAACTTCCTTCGTTGGTCGCAAAGTGTTCAAATGTACATCCGAGGACAAGGGAAGATTGGATACCTTCATCGAGACAAATCCATACCGCAGTAAGACGATCCTCGTTCACGTGTATTTGATGGGATCTTTGAAAACTCCATGGTGATGACTCGGTTAGTAAATTCCATGGTAGAAGAAATAAGTTCTAACTATATGTGCTACTCTCACTGCTAAGGAATTGTGGGAAAATGTGACTCGGATGTATTCTCGACTGGAAATCAATCACAAGTGTTTGAACTCAATCTTAAACTCGGGTGATATACGACGGGAAATAATTACATTACACAATACTTTCATTTGTTAAAACGAATTTGGCGGACTTGGATTTATTTGATACGTATGAGTGGAAGTCAACCGATGATCAAAGGCACTACAGAAAGTTGTGGAAGACGGGCGGATTTATAAATTCCTCGCAGACTCAACGTTGAATTCGATGAGGTTAGAGGGGCGAATATTGGGAAAAAGCAGACTCCCAAATATTAATGATGTGTTTTCTGAAGTTCGCAGGGAAGAGAGTCGCAGAAGCGTTATGATCGGCAAAAAGGTCATTGATTCAGTTGAAAGTTCGGCTCTAGCAGTTGAAGCTACAACACATAAGGCATCAAATCAGGCACCCAGAAATAATGATAAGCCTCGAGTTTGGTGTGATTACTGCAACAAGCCTCGACATACTCGTGAAACAGTGAAACTTCACAGAAACTCGCTAATCGGAAGAGTAATAAGCATGGCCCCACTTCATCCGATGACGGAGTATAAATCAACACTCATCCGTAATCAATCATCATTCTCTCGCTAATATTGCTGATTCTAATCCATTTAGCAAGGAGCAAGTCGATCAACTCCTGAAGCTGCTAAAGGTCAATTCATCATTGGGTAATCCCAGTGTTTCTTTGGCACAAACAGGTACTTGTCCTCAAGCCCTTTCTTGTCTTACTTCCTCCCCATGGATCATAGATTCCGGGCTTCATCACATGACCAGCCTCCTCAAAGTTATTTGAATCATACTCTCCGATGTAATCAGAACGAAAAATTCGAATTGCAGATTTTTAGTTTTAATTCCATTGCAGGGAAAGGAACTATTAGACTATCCTAAAAAATTAATCTATATTATGTATTGCATGTTCCAAAACTAGAATGCAATTTGTTATCTGTAAGTAAAATATCTAAGGATCCTAATTGTCGTGTCATCTTCTGTGATTCCCATTGTGTTTTTCAAGATCAGGGGTCGGGGGAGATGATTGGGCGTGCTAGAATGCTTGAAGGTCTCTACTATTTTGAGGAACCCTCGACTAGTCATAAAACAGTTCAAGGCTTGAGTAGTGTTTGTTCTTCCCCTGTTAAAGAAACTATAATGCTTTGGCATCGTAGATTAGGGCATCCCAGTTTTTTCTATTTAAAGTATCTGTTTCCAAATTTATTTAAAGGTATTGATTGCTCCATTTTTCAGTGTGAAAGCTGTATTTTTGCAAAAAATCACAGATCAACTTATTCACCCAACCCTTACAAAGCATCTACTCCTTTTTACCTAATTCATAGTGATGTTTGGGGACCTTCTAAAATTTTAACTCATAGTGGAAAACGGTGGTTTGTCACCTTTATTGATGACCATACCAGGTTAACCTTGATTTATTTGCTAAAAAACAAGTCAGATGTGAAAGATATTTTTATCCAGTTTTATAACATGGTTGAAACTCAATTCCAAACTAAAATTAGCATTTTGCATTCTGATAATGGAAAAGAGTATTTCAATGAACATTTAAATGAATTCTTTAAAATCAAAGGTATTTTTCACCAATCGACGTGTCGTGACACTCCCCAACAAAATAGCATTGCTGAAAGAAAAAATAGACACTTACTTGATGTTGCTCGTGCACTTATGTTTTCTATGCATGTTCCTAATTATTTGTGGGGAGAAGCTATTCTCACGGCAACGTATCTTATTAATCGAATGCCTTCAAAAACTTTGGATTTTAAGACACCCCTGAATCATTTTAAAACCTTTTTTCCCTCTGTTCGCTTATTTTCTGATTTGCCTATCAAGGTTTTTGGGTGTACAACATATGTTCACCTTCCTAACATTTGTCGGTCTAAACTTGAGCCTAGGGCTTCTAAATGTATTTTCGTTGGATATGTTTCAAACAAGAAAGCATACAAATGTTTTGACCCCATACAGAAAAAATATGTTGAAAGCATGGATGTTTCATTCTTGGAAGATCAATCCTTTTTTCAGCCAAATTATCTTCAGGGGGAGATGGTATCTAATTTAGAAGATAATTTCTGGGATACGTCTCCTCTACCCACACTCATTAGCCCTGAGGTTACAAACTCTAATTCTCTAATGCCAAGTGTGGAAAACTCTTCTCCATCCAACAGAAAAAATATGTTGAAAGCATGGATGTTTTAACCGCATGACTTCATCGTTTTCATCTCCTCCATTCACCTCCCTATGAAGGATGTGATGGACTAGTGGACTGTTGAATATGAGGTCCACATCAACGAGGGGACCGAATACTGTCCGCCTGGACAGTTCGAGTTGTGTACGTGTCAACTTCTGCCTCAATACCTTATTAGCACTGGTGATGTGTGCTAAAATAGAGGCTTGTCCTGGTACGAACACCTTAAATTGAAAACAGTTTACAGAAGGTACGAAATTCATTCTGTACAATAGAGGAACGCTCTATCTGACTCGTTCACTATAACTCGTTCTCATACACTTTCGCCGTTTTCTTCCTTCAAATTAGTACAATCGCAACCATAAACCCTAGCAACGTAAGCTCTATTCTCCCTATAAACTCGATATAATACATGTATCTCTAAGACAAACAATAACATTCACAAAACGAAACCAGCATCGCAAAATCACGCACTTACGAACAAAAAAAATTCAAATCACAACGAAGAATAACGCAATATCGTACCGTGACGGCTGGCGGCAGCAGTCGGTCGTGCGACAGAGCTCGTTAGAGAGAGAGAGAGCTAGAACTTAGAGAGAGGGAGTCCGAACTTAAGAGAGACAGTGAAATGAGAAACCCCTTTTATATGAAATGTTGCTCGCTCTCGCTTACTCGCTCTGGTTCATTTGCTCACGGTTGATCGCCCTCGTTAATTCGCTCTCGACAACTCGCATTCATTGACGCGCTTACTCGTTTATTATTAATTTATTCTAAAATGTATTAATCCCTGATTCGGGGAACCAATCGACGCAATAATGAGTGGTCAGACCTTTTTAATTTCGACCGTTTAGTTATTAGTATTAATAGACAAAGAGACTAATACAAATTTTATCATAACACACAATTAAGCTATCTTCATCTTCTTCATCCTCCTCAGCATGAATTCCAACACAACCGATTTCAGTCTGAAAAAACTACATCCGACAACATTGCCAGAGAGGTTTCTTCTCTCACTCCACCTGGTGAACAGTCATTGGAGGATGGTTTCTTCAACTATCCTGGAGAACCCCCGAGCAAGTCATCGGAGGAATCCTCTAAGGAGTCCTCAGAGGACTCAAGTCATCGGAGGAGTCCTCAAAGGACTCGCTTGAGTGCTCCGAAGTCCCGTTTGGGGACTCTGAGCTTACTCCCCACGCATGCGAACCATCACAACCTCCCCTTGTCGAACAGGCGCCGTCAGAATATTCAGTCAACATTCCTACACAACGCCCCAAAAAGAAGGCCAGACAAGATGCACCATTAGTCATAATCGACTCCTCGACTGAGTCGGACTAGGGGACGAAATGACCTTTCTATATTTTCTATATTTTGTTTTTGTTTTGTAATTTTCAATATCAAGTCCCGTTTGTTTTTGTTCAACTTTTATACATATCTCCTGTTGCATATTCTGTTTCAAAATTGCAACAGTAGTGTTAAGCGATCGAGTGCGAGTGAGCGAGTAATGCTAAGTGATCGAGTGCGAGTGAGCGAGTAGTGCTAATCGAGCGAGTGGGAAAGAGCGAGTAGTGCTAAGAGTGCGAGTGAGCGAGTGCGAGTAAGCGAGTTGGAGTAAGCGCTCGAGTTTAAGAGCGAGGAGTGCTTCGAGTGCGAGTGAGCGAGAGCAAGTAAGCGAGTACGAGTGAGCGAGAGCGAGTACGAGTGAGCGAGAGCGAGCAAGCGAGTACGAGTGAGCGAGTGCGAGTAATCGAGTACAAGTAAGCGAGACGCGAGTCCGAGTAAGCGAGTCCCATTGAACGAGTGTGAGTGAACGTTCGCGTATAACTGGGATGCCCTTCGGCGTAATTTTGCGCGCATTGCCACGTCAGAATAGGTCAGTTTTCATTATATTTGAGCGCCAGGTCATTTCGCATTAAATATATTAAAAAAGGATCTTCCGTACAAAAACCCCCCGATATCATGTAAATCATCAATTAACCAAAAAACTTAAGCTGATAGGTTATGGCGAATTTAATTATATCAACACCAACAACATCATCTTTTACACTTTTACAAAACAAGTATACTGAATGCTATATATACGAAATACTTTTGCGTTTAATTGAATCTTAAGAAACAAAAAGTTAATTGGCTCTTAAGAAAGGAAAAATTAATTTACTTCTTACTTTATTATAGAGGATTCTCAATGCCTGTAAACATTGTAATTTTAGGTGTGCTTAGAGTTCAACCTTAACATGTTCTAAAATTGAAATGGCTATTTAGTTTATTGTTCTAAGAAGCGTGAAAGATCTATTGTATTTATGCTGTGCCTTTTTTTTTTTTTCTCTTTTTCTGCGTTTTTCCCTTTTCATAAAAGCTTGGAAATATCTGCAGGCAAGGTTGAATAAGCTAAAACTTCTTGAAGCCATGGAGGTTTTCTTTGAGAGGTATTTCTATATTAGCTTATCAAATGTTGTTTTTCTATTTTCTTTTATATGTTAATGTAACCCTTTTCACTTATGCAGATCTAATGGTTCTGGCGGGGATGAAAATCATGCAGTTGGAGAAGTTGTCCGTCGATGTGGACTGTGTCAGGACTCAGATATGGTGCTTAAAAGAAACAGGGTAATGATTTATAAATTATGTTCATGGAAAATTAGATCTTTCAGGGCAATAAATCATAAACCCTTTCAAATCAAAGTGAATTTGTCCATACTTCTTTATATCTATTTCATTATAAAACCTTTGGAAATTGGAAGCATTTCTTTTTGAAGGGGATCATCGCCACATCTATTTTATTATCTATCATCTTTTTGGATGAGCACAACAAACTTTGAAATATAAGATTTTGATGTTAGTTCTTTCTTGGTGTAAATGCTTCCATATATATATATATATATTTTTAACAAGAAGCGAAACTTTTTATTGAAGAAATGCACAAGAGAGTGAAACAAAAATCAGTAAGAGTAATAAACTTCCAAAAGGGAGAAAATAAAGAGAAGATAAAGGAGATTAGGGAAAAATAAAAGCATCCCAATTTAAACATATACTTTGAAGAGAAAACCCATAACAAAGGTTAGAGTGAGAACACCAAATTCCAACTTTTAAAAGTTTACTTCAGTACTTCAATTTTGACTTCTTATTTTCTCCATTTTTATCCTTTGTCATTACCAAAAATTAAGTCTAATAATTGTACAATTATAATGATATCTTGAAATGCCTAGAATTAGAAATCAAGTATATTGAGGACTATTGGCTACTGTTTTCCCTTTTTTCCCCCTAATAAAATTAGAAAATTTACATGAATTTAACACTAGGCCATTAGGCTAGTTTGGCTTCTTTCGAGATGTTTTTGTAGGATTGTCTTTTGGTTTTGGTTCTCTAGTTTGTCTTGCCCTTGTGTATTCTTTCATTTATTTTGAATGAAAAACTTGGTTCTTTGAAGTTTGAATAAAGAAACATTTTTCCATCATCATTTTCTTCTCTCTTTGTTATGAGAAAAAAATTGGTTTTAGAAACTATAAACGCTAAAGCTGGTCAAAATTATAAGAGGCTAAATAACTGAATGGTCACTAATGTTTTAAGTAATTCTCAATTTGATCAATCTTTTAACATTTTATGACTTTAGTAGGTTGAAATTAACTTTGTCCTAATTTTTGAGTTCTTACTTTATTCATTTTTATTATTTATAGTAATCATATTGAATAGTTTACTTTGACACACTGCAGGATGGAAATTACATGGTTGGATGTTTGGGCTTTCCCCAGGTGTGATCATCTTCCATGATGGGTGCCACTTATTATAAATAGGATGTTGGCATATTAATTTTCCATGAAGAATTAGGAATTTGATTGTTATTTTTTGCATCCCTGCTATCCCCTCCCTTCATTTAACACACACTCACAAATACATGCATTAGTTGGTCTTTTAGTCTAGAAAATGATATCTTACGGTCACGAAGTCCTTTAAGCCAAGCAGTATTAACTCTGTTAATTGAATGTCATCGTGGTTAAATTCTTATTTTTCACATTATGTATGTTCTTTTGGTAGCTTCTATTTTATAGCAGTTGAATTATATTTCCATCATTATTGTAGAAGATTGTACTTTCGAATAAAGGTTAAGGATGGTAAATGCTCCTAAATTACATGCACTTGTAGAAGGTACACGTAACTAGGGAGCTCGTACTACTATTTATATCTGTTAAGACATAAGCTACAATCCCTATTATCTTTTCTGCTACAGTTGAGGTTTGGCAGAGGTCATTGTCTAGTCTTGTCTGTATTAATACTTTGTACTCTTAGTGTACTTTACTTTCTTTAGCTCTATTCTTTAAAGGCTTGTATTTGGCTCCTAAAAGAGATTCATCGAATAACAAAGAAAGATACACAGAAGCTTTCTCTTCTCCCTGCTCTGTTTCTCTGTTTCTCATTTCTTCCAGGAACTCAATTTGGTATCAGAGCCATATGGCCAACACCAATGAATCCTCGACTTCAGAAAATCCCCTCATCCATTCTCCTGTCCTTAAGACCCCAGGACCAGTCCATCTTCAAAAGGATCCAAATGCTTTTCAAGTAAGGTGCGTGTCTGTGTCAGTGGGAAATCCTCCTTTTGTTAACCTTCGTAACCAGGTCACCTCCATTAAACTGGACAGGAACAACTTTCTGCTGTGGCAAAACATCGCTTTACCTCTCCTCAGAAGCTACAAGCTTGAAGGGAACCTTACTGGACAATCAATCTGCCCAGAAATGTCCATTGTCATACCACCCTCTGAAGAAATGGTTCTCAATTGCCTATTCATTTTACTGGAAGTTCTTTTTTACTCTAAAAAACTAGAAATTTAAAAGATTTACTACATGTCACACAAATTAGTAAGAACCTTATTAGCATTTTACGATTGACTTTGGATAATGCTGTGACTGTTGAATTTTATGACTCATTTTGTGTTATCAAGGACAAGGGAACGGGGAAGGTTCTTCTGGAAGGGAGTCTTAAGGATGGGCTATATTAAATCCCTATGTTGACAGCCTCTTCACACAAGAATATGCAAGAAGTCTCAAGAAAGAGAGTCACGTTTGTTGCTTTTGTTTCTAGTCTTTGTGGTAAGAACCAGAGTGATTCTATGATGTTGACATCACCTGGTAGTCATCACATTTTGTATTGTTCTAAAGACACTTGGCACAATCGGCTTGGCCATCCATCTATTAGAACTCTATCTCAGTTGCTGACTTCTTGTAATTTGAAAACTAGAATGAATGAAAAAGTATCATTTTGTGAGGCTTGTCAGTATGGAAAATCTCATCGGTTACCCTTTTCTGACTCTCATTCTCGTGCCACCAAACCGTTGGAACTGATTCATATTGATTTATGGGGACCAACTCCTATGACTTCAACTAATGGTTATAAGTACTATATTAGTTTTCTTGATGATTTCTCACAGGTCACATGGATTTTTCCTCTGAAAGTTAAAAGTGATACCGCTTCTGTGTTTAAATAGTTCAAGCCTCAGGTTGAAAACTTGTTTGAATCCAATATTAAAACTGTCAGATGTGATGAAAGAGGTGAATTGAGACCACTCTTTCATTTTGCTTCTGAGGTAGGAATTCGAATTCAATTGGCTTGCCCTCACACCTCAGCTCAAAATGGAAGAATCGAAAGAAAGCATAGGCATATTGTGGAAACAGGCCTAACTCTTTTGGCTCAAGCTCACATGCCCTTAACCGATTGGTGGGATGCTTTTCACACTGTAGTCTATCTTATTAACCTACTTCCTACTGTTGTCCTTGATGGGGAAGTACCCTACACGGTGTTGCATCAAAAAACACCTGACTACAACTGTTTAAGAGTCTTTGGTTCAGCATGTCACCCCTGTCTTCGCCCATATCAACAACACAAGTTCGAATTTCACACCGCAAGGTGTGTTTTTATTGGGTATAGCACTAATCATCGTGGTTACAGGTGCGTCAGCTCCTCTGGCAGAGTTTATGTCTCTAGACATGTTTGCTTTGATGAAAACTGTTTTCCCTTTGCTGACAACTTCATGGATCAACCTTCATCTACCCCTGTCTCCTCTCTTAACATTCTTACATGGCTACCTATCTCTACCAATCCCCATGACCCCTTTGCTCTTTTCTCAAGCCATCCCCCATATCGCCCACCTATCCACTCCACTGATATCACCTCCACCCAACCTCCCTCGGGCATCTCACTTGCATCCTCCCCATCCTCTAACGCACCAATCCACCTTATCCTCTCCTACCACTTATCCCATGTCTTCTCCCTCATCATCCTCTCCTACCGCTTCCTTACCTATCTCCAACCCCCCTCACCATCCCATGATCACTAGGGCCAAGGCTGGAATAACCAAACCTAAACAGTTTTTTGGTTGCTTATCTAATATCTCTTCTCCCATTGATTGGTCCTTACTTGAACCCACTCGGTTTGCTGATGCTGCTGCTGTTCCTTCCTAGAAAATGGCTATGGATGATGAATTTGTTGCCTTAATGCGTAACCACACTTGGGATCTTGTTTCCGCTGCTCAGGTCAATCTTTGGTTGGTAATAAGTGGGTGTACAAGCTCAAGCGCAATGCAGATGGTGACATTACTCGGTACAAGGCACGTTTAGTTGCCAAAGGTTTCTCACAAACTCCAGGGGTTGACTTTCACGAAACTTACAGTCCAGTTGTCAAGCCTACTTCCATACGGTTGGTACTCACTTGCCGTAACTTGGAACTGGTCGGTTAGACAGTTAGATGTCAATAATGCCTTCCTCAATGGCTCCCTCCGTGAGACTGTTTATATGCCCCAACCTCAGGGATATGTTGATCCACATTTCCCTCATTATTTGTGTCGTCTGAATCGAGCTCTTTATGGCCTAAAACAAGCCCCACGGGCATGGTATGACCGCTTGTGCACCACTCTCTTACAATGGCAGTTTCTTCAGTCTAAGGCCGACTCCTCATTGTTCTTTTGTCACCAAGGTAACCATTTACTCATCATCCTCGTCTATGTTGATAATCTCCTTATTACAGGGTCTAACATCTCCATGGTTACTAATCTCATTGGTCGACTTCAACACACATTCGTGCTACGTGATCTAGGCCCTCGCCACTACTTCTTAGGCATTCAAGTGACTCGGTCTCCCTCTGGTTTTATCCTTTCTCAGGATGCCTACCTACGTGATCTGCTAGTTCGATTGCATATGCAGTTTTTGAAGGCTGCTCCCACCCCTATTACTGGAGCCTCTTCCGTCACCTCCCCAGCTCAAGAACCTTTCTCTGATCTTGTGCTCTATCGAAGCATCATTGGCTCTCTTCACTATGCTCTTCTTACTCGCCCAGACATAGCCTTTGCCGTGAACAAACTCAGTCAACAGTCTCAGGCTCCGACCATTGCCTACTGGCAGGCTCTCAAGCACGTCTTGCACTACCTCAAAGGCTCTCTGCATCTTGGCCTTGCAATTCAGCCCGTTGCCGCCCTTACTCTCACGGGTTTTTCTGAATGCCGACTGGGCTGCCTGCTCTATCGATCGTCGGTCTGTGGGCGGTTATTGTGTCTTCTTTGGCTCCACCTTAATCTCGTGGTCCTCCAAAAAGCAACAAGTTGTTGCTCGATCCAGCACTGAATCTGAATATCGTGCTAGCAAATGTTTCCTGTGAACTTCGATGGACCACATCCTTGTTATCTGAATTGCGTGTTCTGCTTGCTGCTCCTCCCATTACCTGGTGTGACAATGTGAGTGTCGCTGCCATTGCTCGCAATCCTGTCGTCCATGCTCGTACCAAACACATTGAAATTGATGTTCACTTTGTTCGTGATCAAGTTCTTCGTCATCAGCTTGATATTGGTGTTGATATAATTAAATTTGCCATAACCTATCAGCTTAAGCTTTGGGGTTAATTGGTGATTTACATGGTATCAGAGCAGGAGGTCCTGTGTTCGAACCCTGGTGAAGTCGTTTTCTCCCAATTAATATTGATTTGTACTTGTTGGGCCTTTGGTCAAATTTCCGAGCCCACAAGTTAGGGGAAGTGTTTAATTTCCACTTGTTGGGCCTTTGTTTAAATTTGTAAACCCACAAGTGAGGGGGAGTGTTGGTGTTGATATAATTAAATTTGTCATAACCTATCAGCTTAAGCTTTTGGGTTAATTGGTGATTTACATTCGTTATATTCCATCCCTTGATCAACTCGTTGATTGCCTCACCAAACCTCTTCCTATCACTCAGTTTCATTATCTTCGCGACTATTAGATTATATGGGGTTCCATCTCAAAACCAATTGGCAATGAGAGGAGTAACCCACATATCTTATATAATGTGAGGTTTCTCTCCACTTTACCAATGTGAGATCCTCAACATGCCCCCTCAAGATGGTGCCTCTTTGGGTTCACCATTCTTGGATCGGATCCCAATTTCAATTTTTGGACCGAATACCCGTTTGGGTTTAATGGGCTCTGATACCATATTAATGCTAAAGTATGAGAGAATCAGTATGTTCTATTCCATTCACTCAAGATATATATATATACAAGTATACAGGGTTAACCTAAATAGAAGAGCGTAAAAAGACAATAAAGGACACCCTTAGAGTTATATTAACAAAATACAATTATACTAATATAAGGACTCTAACACTCCCCTCAAGTTGGAGCATATATATCCATCATGCACAACTTGTTGAGAGGTAATCAATTCGTGTCTGCTCAATGCTTTGGTGAAGATATCTCCTAATTGCTCTCCGCCTCTTCACATATCCCGTCGATATCAAACCTTGTTGTATCTTCTCACGCATAAAAATGACAATCAACTTCAATGTGTTTAGTTCTCTCATGAAATACTTTGGATTAGATGCTATATGTAGAGTCGCTTGATTATCACACCACAATTTGGTCGTGTTGTGATATCAAATCCCAATTCAATAAGAAGTTGACGTATCCAAACTAATTCACGCATGAGATTGTGCCATTGCTCTCATATTCGACTCAAAGACTTGATCGTGAAACCACATTTTGTTTCTTACTCTTCCAAGAAACCGAATTACCACCAACGAATACACAATATCCTCGACGTTGACCTTCTATCTTCCTTAGATCCCCGCCCAATCAAGATCCGAGAAACATTCAATGTTCATATGCCCATAGCTCTTATATAATAAACCACGCCCGTGAGCGCTTTCAAATAACACAAAATCTGCTCCATCGCAGCCAATGATCAATTGTAGGAGAAGACATGTACTTGGCTCACAATACTCACCGAATAAGCTATGTCCGGTCGAGTTCTTTGTAAGATAATTGAGTTTTCCCACCAACCTCCTATATCGCTCGTGATCTTTCAATAATTCTCCATCATTTGTGAGTTGTACATTAGGCATCATCGGGGTACTACATGGCTTAGCCCCTAACTTCCCTGTTTTACCAACAAGTCAATAACATACTTTCTCTGTGATAGCATGATTCCCTTCTTGCTTCTCATTACCTCAATTCCTAGAAAGTATTTCAACATTCCCAAATCTTTCGTGTGGAATTGACTATGGAGAAAGGTCTTGAGAGATTGGATGCCCAATGTATCATCTCCTGTAATCACAATATCGTTAACATACACAACCAACAGATGACACCACTCTCGCATCGCTTGTAAACACACGAAATGATCTGATTTGCTCTTTCTCATTCCAAAGCTTTCAATCACCGAGTGAATTTCCCAAACCATGCTCGTGGACTCGCTTTAATCCATACAAGGATTTACGAAGGCGACATACCTTTCCCTTCTCCCCCCGAGCAACAAACCACGGAGGTTGCTCCATATACACCTCTTCCCCAAGAATCATCATGAAGAAAGGCATTTTTAATATCAAGTTGATGCAATGGCGGTGATGAATCGATGCTAATGAAATGAATAACTTTGTGTAAGTCATTTTAGCAACAGGAGAAAATGTATCGAATAGTCAATCCCATAAGTTTGTGCGTAGCCTTTAGCAACAAGGCGAGCTTTCAATCGAGCAACAGATCCATCCGGATTGACTTTAACCGCAAAGACCCACTTACAACCAATAGATTTCTTTCTGCGCAGGAAGAGACACTAAATCCCAAGTACAATTGTCATCTAAGGCGCGGTCATCTCTCCACCATTGCAAAGACGCCAACCGTGATGAGACAAAGCTTCAGAATGGCAGATTAGGAATGCAGATATAGATTGGAGGATGCAATGAATGAACAAGTAGAAGATGACAAATGGTTATATGAAACAAAAGAGGAAATAGGATATGTGCATTGACGCTTTACCTTTACGGCGTGCAATAGGAAGATCATCGTTTGTTCCTGAATCCAATGACGAAGAAGCCTCTGGTACAGGGCATGCATCCGAAGGAGGTCGTCGTCGAGAATAAACCTGAGTGATAGGTGGGTTAATACAAACGGATGGAGATGGAGAAGAAGCACCAGAAGACTCACAAGAGGAGAAAATTGTATAAACAAGAAAATCATCCTCGCCCTCTCGATGCTCCCCCGACACGTATTCAAGATGAAGTAAAGAAAGAAGAATCTTCAAAGAACGTGACATCAGGAGAGACAAAGTAACGATCAAGACTAGGAGAATAGCACCGATACCCTTTTTGGACACGAGAATAACCAAGGAAGACACATTTTAAAGATTTCGGATCGAGTTTGGTGAGAAGAGGGCGAACATCTCGAACAAAGCAAGTACAACCAAAGATTTTCGGTGGGAGAGAGAACGCAGGAGGTGGGGCACAAAATACGATAAGGTATCTCACCTTTAAGAACCGAAACGAGGGCATACGATTGATTAAGAAACAAGCCGTCAATATAGCATCAACCCAAAATTGTTTGGGGACATTCATCCAAAACATTAAGGCTCTTGTTGTTTCAAGGAGATGGCGATTCTTTCGCTCGCAACTCCATTTTGAGACGGAGTATCAACACATGAGGATTGATGTAGAATGCCATGTTCACTTAGATAAGAACTAAGAGCATGAGAAAAGTATTCCTTAGCATTATCACTTTGCGTAACTTTAAGAGAACCATGATATTGAGTACAATTTCAGCATGAAAATTGCGAAAATGAGAAAGTAACTCGAAACGATTCTTCATTAAATATAACCACGTGACACGAGAAAATCATCGACAAATGTAACAAAGTACCAAACCCTCGCTTAGACTCAACAGACAAGGACCCCAAACATCAGAATGAACTAACTCAAATGGAGCATTAGCTCGTTTATTGACTCTAGGATACATACTTAGACGATGAAATTTAGCAAACTGACATGACTCGCAATCTAACGAAGACAAGTGATTAAATTGAGGACGAAGACTCTTCAAGACAGAAAAAGATGGATGACCCAAACGACAATGTTCTTCAAAAGGAGAGGTCACCAGAGAGCATGGAACGATCGTGGATATGTGTGGTTCAAAAATATAGAGACCTCCCGATTCGTGTTCTTTTACCAATAGTCTTCTTCACAAAAGATCCTCGAAATAAACAATAACCAGGAAAGAATAAGACACAACAATTTAGATCTCGAGTGAGCTTACTAATCAAATCAAGTTAAAGGAGAATCATGTAAACTTAAAAACAGAAAACAAGGAAATTGACTTGGTAAGATTGACGTGCCCGACCTTAAAACAGGAGAGAGGTGGTCCCATCACTATATAGTAACATTAGGTGAAGATTTATACGGATGAGATATGAGAGAATAAATTTGGATTACCATCATATGATCGAGAGCGCTGAGTCTATGACCCATTTGGAAGAGGAGGAAAGAAGACACGTAGATGTATTACCTGTGTCAGCAATGACAGTAATAGGAGTGGAGGATGACGCCTTTAGCAACTCTTGATACTGGTGGAACTTAGCAAACTCCTTTGCAGAAATCGAGATAGATTTATCGGGATTATCAGGTGTAGAGGCAACATGCGCAGATGGAAACCTCTGGCCTCTATTCAACAATCGTCTGCAATCACGCTTCATATGACCAGGCTTATGCCAGTAGTGACAAACAATATCGCCTGAGTTTGCTCTTTGAGTGTTCGAATTACCTTTATATGCATTGGGTCCAACCTCTCTGTTTCCTTTGTACTCACCTGTCTGTCCAACCAAGGCACTGTTTGACTCAGGTGGCAAGGTTACCTGCGACTTCTCAGTACGAAGTATGCGAGTATAAGCATCTTCCAATGAGGAGATGTCAGAGCTAGATAGAACTTGATCTTTTGCCATATCATATTTAGAAGCGAGACCAACTAAAAAACTCATGATGAACAGTTGTTCACGTTGTGTAGTTTCAACTTTCACATCATTACTAATAGGCAACAAGGCATTAAACTCTGCATATGATGTTTTGCACTCCATAAAGTAACTAGTCAGAGATTTCTCACCTTGATCAGGTTGAAAGAGAGTTTTGCATACATCAAACACTCAGACTAATATTCCTTTTCCAGAGTAAAGGAATTCCAAATATTCCAAGAGCTCGTGAACAGATTCACAATGATTAACCAACCCTACGATGTTGCTCTCAATAGAGTTCTTTATTTGTAGAATAAGCCTAGAATCATCGCATAACCAATTTTTTCTAGTATCATCAGTCGGTGGTGAATTTCCAGTGACATGATCATCCATATCGAGACTTCGAATGTAGTGACGAATGTTTGTCCGCCATGCATAAAAATTAGACCCATTAAGCTTATGTTCTGTAATCTTTGACACCATAGGGATCATCTCCGTCATCACCATACCTTTCTTGTCAGCCATAACTAAAGAAAAGAAAAAAAGGACCACAAAAAACAGATTGAAAGGCCCAAAACAGAATTGTACCAAAAAACCCTAGATTGCCAAAGAAGGGTGTCTCAAACCGACCCTAAACCGAGAGGGATATGACCCCAACAAGCACACCACTAGAAAGAGTATGCAAAACCGAGCGAAACCAAAAAAAAAACAGCAGATTTCCATATTAGATTGTATGGGGTTCCATCTCAAAACCAATTGGCAATGAGAGGAGTAACCCACGTATCTTATATAATGTGAGGTTTCTCTCCACTTTACCAATGTGGGATCCTCAACAGCGACAAACTTGGCCGCGTTTGAGGGGGGATGTTTAGACATAAGCTACAGTCCCTATTATCTTTTCTGCTACAGTTGAGGTTTCGCAGAGGTCATTGTCTAGTCTTGTCTGTATTAATACTTTGTACTCTTAGTGTACTTTACTTTCTTTAGCTCTATTCTTTAAAGGCTTGTATTTGGCTCCTAAAAGAGATTGATCGAATAACAAAGCAAGATACACCGAAGCTTTCTCTTCTCCCTGCTCCGTTTCTCTGTTTCTCATTTCTTCCAGGAACTCAATTATATCAACACTTATTTTAAATGTTCAAGAAGAATTGGCACGAGTCTTAAGGAACTTTATGCCGAAATATCAATTTTCCTTTTGATCAAATTCAAAAAGGTTGAAACATTTTCAATGCCAATGCACATAAATGTTCTTGTAGTTATTTTAGAATGGCATTGTTAACTGCAATCTCAAAGTGGCCTTTATGAACACACATCCCAAAGAAAGTTGACGCTACTATAAGTTTTTGAGTATTGTCATATCAGTGCAGTCTTACTGTTGGTTGTTTCCTTGTTGGTTGTTTCCTTTTGTAATTAATCAGTATTTATTGTACTATTTGTATTGCTGTTGGATAAAAAAAGGTATTGCGAAAGCAATAATCAAATCAAAATCTCAATGTTTGTTGAACAAATAGAGAAAATTGAAAAATGAGAGAGTGGAATCCAATAAATGAATAGTCTTTTATTGAAATAGAAAATATTGGTGATGCATCCTTCACATGGAAGTTCGTCCTTTTATAGGTACGAGGAATTGACACTCATTTAATTTTTCAACATTAAAAGCATTAGAAACTTACAAACTTAAAAAACAAAATTTAAAAGACAAAAAACCGAAATGTGTTAAATCTGACTTTTAAAAGAAAAAACATAAAACATTAATTGAAAAACTTAACGTAATTAAAAAAGAAAAAACTCATAACTCAACACTCCTCCTTGAGGTTTTTCTTTGTGACGCCCAGCTTTTGGCGTAGAAATACAAACTGCCTATGTGGTAGAGCTTTTGTTAGAATGTCGGCAAGTTGTTCTTCAGAACTACAAAAAAGGAGTTTTATTTTGCCTTCTTTCTCTGCTTCTCTCAATAAATGAAATTTGACTTTGATGTGCTTTGTTCTATCATGTTGTACTGGATTGGAGGCAATAGCAATAGCAGACTTGTTATCACGTAACAAATTGGTAGGTTCTTGAGTTCAAATCCCAAATCACTAAGCAATTTGCGGCCATATTGCTTGATTTATACTGATGATCAAATTGAAATATATTCACTTTCAGATGGAGATTGAGCCACTACTTCTTGTTTTCTTGAATTCCAAGAGAAAAAACATAACTGGAAGTGCTTTTAGAATCATCAACACAACCAACCCAATCACTGTCGGAATATCCAGTTAATTTCAAATTACCTGTAAATTCAAACCAAATTCCAAAATCAAGAGTACCCTTTAAGTATCTGAGAACTCTTTTAGCAATACCAAAATGAATTTCACTAGGTGAATTCATATATCTTGAGAGCAAACTTGCAGCAAACATCAAGTCTGGCCTGGATGTTGTCAAATACAAGAGACTTCCTACTAAAGTTCTATAATTTGTAGGATTAGAAAGCTTCTCACTATCATTTTTTGATACTTTCAAGTTTGTCGCTAAAGGAGTGGAAACAACTTTACATGTTTCCATTTTAAATTTCTTCAAAATTCCTTGAGCATACTTTCTTTGGGCAATAAAAATACCCTTATCTTCTTGAAGAATTTCCATACCTAGAAAATAATGCATGTGACCAAGATCTGACATCTCAAACATCTTTTCCATCTCGATTTTAAAATCTTGTAGCATTTGATAATCATTTCCGGTCACAAGCATATCATCAACATAAAGGGAAAGAATAAGTTGATTAGAGATGTTACCAACCTTAACATAAAGAGTAGTTTCGCTCATACTCCTCCTGAAGCCTTGAAGAAGCAAGTAGGAATCAATTTTACTATACCAAGCACGTGGTGCCTGCTTCAATCCATAGAGAGCTTTCTTCAAACGGTATACTTTGTTTTCTTGGTCTTCATCCACGAACCTTTCAGGTTGGTTCACATAAATCTCCTCCTCAAGATCACCATTCAAAAAAGCTGATTTGACATCTAGATGGAATATTTTCCACCCCAAATGTGCAGCTAAAGCAATAATCAATCGTATTGTGTCATGTCGTGCAACTGGAGCAAATGTATCTCCATAATCAACTCCAGGTTGTTGTACATAACCTTTTACCACTAACCTTGCTTTATATTTGTTGACCGAACCATCACAATTATTCTTCACTCTGAACACCCATTTCACTCCCAAGGCGTTCTTTCCTCGTGATTGCTCTACAATCTCCCATGTATTATTTTTATTGATCATCTCCAATTCTTCTTTCATAGTAGCAATCCATTCAGTAGATTGTGAAGTTTCATAATAACTATTTGGTTCAACAATAACAAGATTACAACTTTCATATACATCAACAAGTGATCTTACCTTGTAATTTGGATTATCACCCGTTGCATCAACAAGATCATCATCATTTGAAAGAGGATATTGGCCATCTCGATCATTAGAATCAATTGAATCAAAGGAGGATTCATTTTGTTCTAAGATTTCAAAATTGATGGATGAATCTCTCACAATTTTTTGCTCCTCAAAATCCCAATAAGAATCTTCATCAACAATGACATCACAACTCAAGATAATCTTTTCCGAGTTCAAATCAAAAATTCTGTACCCTTTTGAATCAGCAACATAGCCAATAAATACTCCCTTAATTGTCTTCTCATCAAGTTTAGATCTCTTAATAGAAGGAACAAAAGAGTAACAAATAGATCCAAAAATCTTCAAGTTCTTAACTGAAGGTTTTCTACCTGACCAAGCTTCATAAGGAGTTTTGTCCTCAACTGCCCTTGTAGGCAGTCTATTGAGCAAGTAAACAACAAGACATACAAATTTTCCCCCAAAATTTCTTTGGTAATTTTTTTCCAAAGAGTAGACATCTTGCCATCTCCATCACAGTTCTGTTTTTTCTTTCCGATACACCATTCTGTTGTGGTGTATGAGGCAATGGACAGCTGGTGTTGGATTCCCAAATCTTCACAAAACTTGTCAAATTGCTTGGAAGTATATTCCTTCCCGTTTTTTGTTCTCAAAGTTTTGAGCTTACAACCACTTTGAGTTTCAACCAAATTTACAAACATTTTGAAAATTTGAAAAACTTGAGTTCTCTCGACCAAAAAATATACCAAAGTCATCCTGGTAAGATCATCAATAAAAAAGATAAAATATTTATTATTCCCAATAGATGAATTTTGCATGGGACCGCAAACATCACTGTGCACTAATTCAAGCTTGTCTTTGGCTCTAAAGTTGCCACCTTTGGGAAAAGGTAATCTGTGCATCTTCCCTTCTTGGCAACTTTCACAAATCTGATCAAATGAGGTAAAATTGGAAAAATCATCAACCATATTAGTAGAATGCAAAATTTTCAAAGCTTTGTTGTTATAGTGACCAAAGCGATGATGCCACTTCTTGCTATCTTCTACTTTGACATTTAGTGCATGATGACATAAAGAGTCACCATTCAAAAAGAAAGCATTTCCAACCATGTTGACCCTTGCAATCTCTACTCCTTGTGGGTCATAAATAACACAAACTTGGTCCTTGAAAACCACGGAAAATTTGTTATGCAACAATTGAGCAATACTGAGCAAGTTTTGAGATAATCTTGGAACATATAAGACATTGGATATTTTCTTTTCACCTTGCTTAGTATGCATAATGGCAGTACCTTTACCTTCCGCTAGTACCGTCTCGCCATGTCCAAGGACCACCTTAGACTGTATAGATCTGTCAATTTGGCTAAAAAGATTGATATCTTTAGTCATATGAGTAGTGCATCCACTATCAATAAGCCATGAGGTTGACTTGTTGTCATTGGTATGAGATGCCATAAACAAAAATTTGTTTCATGATATTATTGTGGGCACAATTCGCTTGTTCTTGAGGATGTTGGATTTGGGTTTTCTTGGCATAGCAAAACTTCTCTGTATGACCATCCTTGTTGCAATATTCACAATGATAGACTTGCTTGTTTTTGGACCAACAATTTTTCTCAGTATGATTGGTCTTTTTACAATAACGACAAGGAGGAAATTTACCTTTCTTTGATGCTCCTCCTTTTCCCTTGCTCCCCTGATCTTTGGTCTCTCGTCTATCATCTTCTGCAACAGGTTTCTTGCCTTTAGACTTGGCATGAAATGCACCCTCAACATGCTCTTCATTGCGTATTGTATCCCTTTGTTATTGAGCTTGTAATTTGCTAATTAACTCAGCTATAGACAGAGTAGTCAAATCAGAAGACTCCTCTATGGCTGAGATCTTTGATTCAAATTTATTGGGAACACTAACCATTATTTTTTCCACAACTCTTTGATCTGGAAAATTTTCACCAGATAGTCTTATCTGATTTACGATGGTCATCACTTTTGTTGTGTAGTCCCTCACAGAATCTGAATCTTTCATTTTCAACATCTCAAACTCTCTCTTGAGAGTCAATAATTTGACAGCCTTCACCCTCGCGCTTCCTTCAAATTCCTCATGCAATTTATCCCAAGCTTGTTTTGTTGTTTTACAATCAATGATCCTAGCAAAAATAGGATCTGATAAAGCGGCATGAATAACGGATAAAGCTTTCGGCTATTTCAATTTCTCCTCTTCGTGTAGTCTTATCTGATTCAACGTCGGATTTTCTCCTAATGGTTGAGGATCAACATTAGTTGAGACAGATTCCCAAAGGCCAAGTGCCATGAGGTAGGATTGCATTTTAACAACCCAAAATTGATAGTTTTCACCATTAAAATGTGGAGGAGAGGTTACACCAAAATTAGAAGACATTTTTCAAATACAAAAATTGAACTTCTCACTCTCAAATAAAAACACAACCCTTTAAATCTAAGGCTCTAATGCCACTGTTGGATAAAAAAAGGTATTGTGAAAGCAATAATCAAATCAAAGTCTCAATGTTGTTGAACAAATAGAGAAAATTGAAAAATGAGAGAGTGGAATCCAATAAATGAATAGTCTTTTATTGAAATAGAAAATATTGGTGATGCATCTTTCACATGGAAGTTCGTTCTTTTATAGGTACGAGGAATTGACACTCATTTAATTTTTCAACATTAAAAGCATTAGAAACTTACAAACTTAAAAAACAAAATTTAAAAGACAAAAAAACGAAATGTGTTAAATCTGACTTTTAAAAGAAAAAACATAAAACATTAATTGAAAAACTTAACGTAATTAAAAAAGAAAAAACTCATAACTCAACAATATTACTGAAATATTTTTTCTTTATTTGTAAATGGTTTTTCTTTTTTTTTTTTTTTTTTAAAAACGACAATCTTTTCATTGAAAGGATGAAAAGAAATACAGGAAAAAAAAAGAACAAAAAGCAAAAGTACAATAACCAAAATAAATAACAAAATTAAGAAAGAAAGGCATGCCAATTTAAGGAAATATCACGAACAGAAAACCCCTCAAAGTCTGTGGAAAGAACACACCAGGCAGAAGATTTGAGAACAATTGACTCAAAACGAAACGACCATCCAACGAATTTATCCACAAAAGTACGTTGATTCCTCTCGAACCAAATTTCCGAAAGAATAGCTTTGACCGCGTTATTCCAAAGAATAACAACTTTAGAGCAACCCGACGACCCCACCAGCATCTGAATCACATTATCTTGTATAGAGTTCGAGAAACCCCAACTAACATTAAAGATACTGAAGAGACTGTGCCAACACTTAATCCCAAATTCACACTGGAACATCAAATGAAACAGAGACTCGCTTGCCTTAAAACACATCACACAAACCGACGGTTGTAACTAGAAAGATGGCATCTTTCGGTGCAAAACCTCAGCTGAATTTAATTTCCCGTTCAGAAGGATCCACACAAAAACCTTTGATTCTTTTCGGGCTCTTAAATCGCCAAACAACCCTATAGATCAATTTATCCATAGGCGAACAATCCATCAAATGAGAGACCAACGATTTAACACTAAACTGTCCATATAAGTCCAATCTCCAGCCTTTAATAACACCCCTTACAGAGAGTTTAACCCTTTCCAAGGATACCAACAAGTGTTGAAATTCCACAATTTCTCTATCTTTCAACAGCCGCTGGAACGAAATAAACTCCCAAAAATCCGACACCCAACCCTTCTGATTGTTTGAAAATGGGTGTTTCTTCTATTTAAGAACCCCTTTCTTCTCATAATAATATACCAAAAATTTATCTATCCTAAACTTATATGGTATCAGAGCAGAAACCCTAAAATTTAACCCTAATCTTTGTGTTGTGATCGCGCCGCTGTCGACAACCCTATTCAATGTCGACTATAGACGCAAACTTATCGCCCGACCCATCTCACAGAAGAAACACACGTCAAACCCATTGCAAATCGACCAACATGTTACTGCTTCTCTACAAATCTTTGAGCATCGACCAACCAACGATTGCTCGGTCAGTCGCTGCTGTCTATATTGTCAGAAAGTCGCGTCTTCACCGATGAACTGCAATGGGTTCGATTTCTTCAACTGTCGTGGGTTAGACCAACCATTCACGTTTGAGTTATGTTTCGTGATTTTTTTTTCTCGACTGCGGTGTCTTTTTTGAGTTTAGTTCTATTATTATTATTTTTTCCTCCTAGATTTGTCATTTTTAGCATTAATGGTCGAAAACAACTCCATTGCTAAAGTCTCAGAAAGCCGCATCCATCCTACCAGCCCTACTGTTCAGATTACAACCATTCGACTCAATGGAGACAATTTCCTTCGTTGGTGCCAAAGTGTTCGAATGTATATTCGTGGACAAGGGAAGATTGGCTATCTTACTGGAGATAAAATAGTGCCTCCAAAAGATGATCCTTTATTTATCGTGTGGAATGCTGAAAATTCCATGATTATGACTTGGCTAGTCAATTCCATGGTAGAAGATATTAGAGGTAATTATATGTGTTACTCTGCTGAGAAGGAACTATGGGATAGCGTGACTCAAATGTATTCAAATTTGGGAAATCATTCACAAGTATTTGAGTTGAATCTGAAATTGGGTGACATACGACAGGGAGAAAACTCAATTACACAGTATGTTCACTCCTTAAAGAGGATTTCGCAAGATCTTGAAAACTTTGGTACATATGAATGGAAGTCTATTGCACTACAGGAAAACAGTGGCGGATGGTCGCATTTATAAATTCTTGACCGGACTCAATGTTGAATTTGATGAGGTTAGAGGCACAATGTTTGTAAAACAATCCTCCCAAACATTAATGACGTTTGTTTTTGAAGTACGCAAGGAAGAGAGTTGTCGGAATGTTATGATTGGGAAGAAACCAGTTGATTCATTTGAAAGTTCTGTTTTGGTGGTCGAAGCTACTGCACACAAGGCTTATGATCAACCCAACAAGAACCACGAAAAGCCTCGTGTCTTGTGTGATTATTGGAACAAACCCCGACATACTCGTGATACATGTTGGAAGCTTAATGGAAAACCTGCAAATTGGAAGAGTACTGGACAAAGTGTGCAAAATATGAAAAGATAATATTTTCTCTCTATTCATTAAGTGAGATTAGGGTTTCTTAAATAGAAGAAATACCCATGTACATAAGGAAATAAATTTACAACAATATATTACATTAAGTACGAATATTCTATTGAGCTAAGTAAGGAAAAACATCCCTAAATAACCAACACTCCCCCTCAAGCTGGCTTGAAAATATCTTCCATGGCTATCTTGTTGATCATCTTGTCAAACTGCAATTTAGGAAGCCCTTTTAGCAATTTGCTCTGTAGTAGGAAGGTAGGGAATGCAGATTACTCCTGAATCGATTTTTTCTTTTATAAAATGTTTATCCACCTCAATATGTTTTGTCCTATCGTGAAGGACTGGATTGTGAGCTATGAAAATTGTTGCCTTGTTGTCACAATAGATACGTGTGGGGCCACTCTGAGTAAACTTCAAATCTTCCAACAATCTCCTTATCCTTATGCCTTCACAGATGCCATGAGCTAAGGCCCGAAGTTCAGCTTCAACGCTACTTCTAGCTACTACGCTCTGTTTCTTGCTTCGCCAAGTAACCAATTTTTCCCCTGCAAAGGAACAGTAACCTGAGGTAGATCTTCTTTCTGTTGTACTGCCTGCCCAGTCAGCATCTGTATATACTTCAACATGCAGGTGACCATGTTTCTTAAACAATATTCCTTTCTCAAGAGTACCTTTTAGGTATCTCAAAATTCTATAGATTGCTTCAAAATGAGTAGGTCCTAGGGCATGCATAAACTGACTTACCATACTAATTGCAAATGCAATGTCAGGATGAGTGTGTGAGAAGTAAATGAGTCTTCCCACAAGTCTCTGATATTTTTCTTTATCTTTTACTTTTTTTCTATTGCAACTTGCAATTTTAGATTACGCTCTATTGGCGTTTTTGCTGTTCTACAACCCAGTAAGCCTGTCTCTTCGAATAAGTCAATGATATATTTCCTTTGATTGACCAAAATACCATCCTTCGATCTAGCAAATTCCATTCCTAGGAAATATTTCAAGTCTCCCAAATCTTTGATTTGAAATTCATCGGCAAGTTTTTCTTTCAAGATAGTTAGGCCTGCCTCGTCGTCTTCTGTAAGAATAATGTCATCCATATAAACTATTAGAATGGCAACCTTGTTATTTTCAATATGTTTATAGAAGATGGTATGGTCTGCTTGACTTTGAAGGAAACCATAGCTCGTGACTGCTTTGGCAAATCTTTCAAACCAAGCTCTAGGGGATTGTTTTAGACCATATAAAGATTTCTTCAATCTACATACTTTGTTACTTCCTAAAGCTTCCTCAAAACCAGGGGGCAAATTCATAAATACCTCTTCTTCAAGTTCACCATTGAGAAACGCATTTTTGACATCAAGTTGATTAAGAGGTCAGTCTGCATTAACAACAACATATAACAAAACTCTAATGGAGTTGATTTTAGCCACGGGGGCAAATGTTTTTTGATAGTCAATTTCATAAGTTTGAGTGAAGCCTTTAGCAACAAGTCTGGGTTTATATCTTTCAACGCTCCCGTTAGCTTTGCACTTTATATTGAACACCCATTTGCATTCGACTGTTTTCTTATCTCTTAGTAATTCTACGATGTCCCATGTCTGATTTTGTTCAAGAGCATTCATCCCTTCCATTACTGCTAACTTCCAATTTAAGTCATTTAGTGCTTCCTGTATATTCCTTGGAACAACCAAATTTGTTATCCTAGAGACAAAGGTTTTAGGACTATCAGAAAGCCTATGATAAGACAAGTAATTGGCAATAGGGTATTTAATACAGTTTCGAGTACCTTTTCTATGGGTTATTGGAATGTCAAGATCAGATGTATCAGATAAAACGTTATGGATAGGTGAAGAGATGGAGGTACCTGGATCTTCAGCATCATTCATCAGAGCATTGGATTGGTCTCGTGTTAAGTCAACTATCTAGTCTTGGTTCCTTCGATGTATTGCCCTTCGAGTATAAACCTGAAGTTCAGGATATCGATTACTTTGTAGTGTTTCTCCCCCTGAAGGAGTATTCTCTTTGCCTGGCACGGGACTAGAAGTAGTTCCCTCAGGATAAATGATATTAGGCAGAGGAGAAGTGTCCCAAAAATTATCTTCTAAGTTAGAGATCTCCCCCTGAAGAGAAGGTTTGGTGAAAAATGATTGATTTTCCAAGAAAGACACGTCCATACTTTCAAAGTATTTCTTAGACAAGGGATCAAAACATTCTTCTTGTGCGGGACATGACCTAGGAAGATACATTTGACAACCCTAGGATCAAGTTTGTAGAAGAAAAAGAGTCGTTAACAAAAACAGTGCAACCAAAAACTTTGATGGGTAAATCAGAGAATGCCCGGACTGCGGGGAAGAAGATTTTAAAATGATCAAGGGGGGTTTTAAAATCTAGTATTTTCGTGGGCATCCTATTAATTAGATAAGTAGCAGTAAAAACAACGTCACCCCATAAATAAGAAGGCACATGCATGGAAAGCATAAGAGCACGAACAACATCTAGCAAATGTCTATTTTTCCTTTCCGCAATACCATTTTGTTGCGATGCATGTAGATTGATGCACTATACCTTTATCTTGGAAAAAGTTAGTTAAACAAGTATTGAAGTACTCAGTACCATTATCAGAGTGCAGAATGCTAATTTTGGTCTGAAATTGGTTTTCAATCATATTGTAAAAACGAATAAAAACCTCTTTTACTCTGACTTTTTGGTTAACAGATACACCCAAGTTAGACGAGTATGGTCATCAATAAAGGTAACAAACCACCGTTTTCTACTAAGTGTCAAAACTTTTGAGGGTCCCCAAACATCACTGTGAATTAAATAAAAAGGTTTAGAAGCCTTATAAGAACTAACACTACTTAAGCCCTGAACTTTTTATGACTTGAAGGTTGTTCATCAAAGTAGTAGAGACCATCAAGCATCCTAGCACATCCAATCATCTCCACCGATTCCTGATCCTGAAAGATACAGTGGATTTCAAAGTAAGTAACACGACAGTTAGCATCTTTAGAGATTTTGCTAACAGATAACAAGTTACAAGCAAGTTTTGGAACATGAAGTACAGAGTGTAAGGTAATGTGTGAAGTTAGGGTGATAGTTCCTTTTCCAGCAATATAAGAGATACTACCATCAGCTATTCGAATTTTTTCATTACAATATATAGGAGAGTATGACTCAAAAAGATTGGAGAAACTAGTCATATGATCGGAGGCTCCTGAATCTATAATCCAAGGAGATGAATTTAGAGAGCAAAGGGCTTGAGGACAGTTACTTGTTTGTGCCAAGGAAACACTAGGATTACCAGATGATGAATTGGTCTTCAGCAGTTTCCGGAGTTGATTGATTTGCTCCTTACTGAACGGACTGGAGTCAACAACATTAGCAGTGGAGGAATGTTGACTTATGGCCTTCTCACCTTGTCGGGTACTTTTCCAATTTGCAGGTTTTTCATGTAGCTTCCAACACGTCTCACGAGTGTGTCGGGGTTTGTTGCAGTGTTCACACCATACACGCGGCATTTCATGGGTTTTGTTTGATTGAACAGAAACCTTTTGTGCAGTAGTTTCTACTATTAAAGCAGAATTTTCAACTAAGTCAACCTGTTTTTTTCCCATCATAACATTTCGACAACTCTCCTCCCTGCGCACTTCAGAAAATACATCGTTAATAGTTGGTAGGTTAGTTTTACCGAGTACTCTACCACCTCATCAAATTCAACATTGAGGCCGGCTAAGAATTTGTAAATACGACCATCTTCAACAATTTTCCTGTAGTGCTTCTGATCCTCGGTAGACTTCCATTCATAGGTGTCAAACAGGTCCAAGTCTTGCCAAATCTTTTTTAGAGAGTGAAAGTATTGAGTAACAGAGTTACCTCCTTGTCGTATGTCGCTTAATCTTAGATTTAGTTCAAACGTTTGTGACTTGTTGCCCAAATATGAATACATTTCAATCACGCTCTCCCAAAGTTCTTTTGCACTAGTGTAACACATATACTTACAACTTATGTCTTCTTCCATAGAATTAACGAGCCAGGTCATTACCATGGAATTTTCAGCATCCCATCCGGCAAATAAAGGGTCGTCTTGGGTGGGTGCCACTTTATCTCCAGTGAGGTAGCCAATCTTTCCTTATCCCCGAATATACATACGCACACTTTGGGACCAACGAAGGAAATTTTCACCATTAAGCCTAATGGTGGTGATTTGAACAGAATTGGAATGAATACGATGATCCAATGCTTTAACAATTGAAGATTTATTTTATGTCATCTTTGCTGCAAAAACAGTGACCAAAGAGACAAAATCCAACTACTAAACACAGTAGTTTAACACAGAAAAAATAAAACCAGCAGTCTATTCCCAGAAAAAAATGACCAAAAAAAGGTAGATGAAGAAAAAAGGGAACTTGTACATCCCTTGCCGGCGATGGCGGAGACAGAACCGGGCGGCAGCGGCGACGACAGAGGCTGGCAGCGGTTGCTTGTTGACTGCTAGGGTTAGGGTTTTTTATTTTAGTCTAAACAATTAGGGTTAGGATTTTTCTCTGATACCATGTGCAAAATATGAAGAGATAATATTTTCTCTATATTCATTAAGTGGGATTAGGGTTTCTTAAATAGAAGAATATGAAGAGATAATATTTTCTCTATATTCATTAAGTGGGATTAGGGTTTCTTAAATAGAAGAAATACCCATGTACATAAGAAAATAAATTTACAGCAATATATTACATTAAGTACGAATATTCTATTGAGATAAATAAGGAAAACATCCCTAAATAACCAAAACTATCATTGCATCCATTGTTATTCATCTTTTGATTCTAATCTCATTCCCATCATAAAGATCACGTTGAAATCTTGAAAAAGCAAAAAAAAAAAAAAAAAAAATCCAGGATTGTTTCAGGTTGAGTTCTTGAATTGTTCATGCCTATTTGTATTCATTTAGTTTCAAATTGCATGAATTTGTTGAGGTTCATATCAGTTTTCAATTAAATCTTGTTGAGACTGTCCAAATTCCTAACGGCAGAATTTAGTGTCTAAAATGGCTCTTCAAACTCGCTGATAACGTCCGAATTTGCTTAATTGATGTGAAGAGAAAAGTTAGATCAGACTGTTATCTTTCAAAGATAAGAAAGAAGTTTTATCAAATTCGTAATGTAGTACGTTCGTTTTTAGAATTCCAATTATGTGCGCAGTTTTATCCGAAAATTCCAGCACCTTTCTTATTTGTTCTTTTCATTGTCCTCTTTGTTTTCTTTGTTCTAAATTGTTGTTATTTCAAAATTATCTTGTCTTGGCTGATTTGTAAAACTCACTATTGCCAGAATCTCTTGAACCACATATTAGCTTACCCAATATCATCATTTAGTCGCTTTCTCAAGTAGTCCACCTTTGTGTGATAAACACGAGTGTTCCGAGTGTAAAAACGTAAGTGATTGTGAGGTCCATTTCTTATCATTTTACATTCTTTTACAGCATGTATCATCGAGGACGAAGACATCATGAGGCCTACAATAATTACGATCCATTTTGGAAGAATTTTCGATAGGATCTAGTTGAGCTACAACAATCCATAAATTACATGGTTGAATTGTGTCAAGAAATGAATTTGTGAGATCAAGCCATAAAGGGACAAGTTGCACAACCATATCAAAATGGTGAAGATTGTCCATTGCCTCAAGAGAATGCCCAACAAATTCAAACTGAAAGTGACCGTCAAAAGTCAAAAGAGAGAGAAATATGGTGAGATTATTATAGAAGAAAAGGAGGTACTCGAGGTATGTGTTGAGAATGATGTGAAGCTAAACCTCTTGAAAATTTTGTGAAGACCGAAGAGAATAAGAAAATAGAGAAGAGAAGAAAGTGTGAAAATGAGATGGTAGAAAAAATTGAGCTGAAAGAAAAACAAAAGGGATGTAAAAAAAAGTGTTTAAGCAAAAAAAATCATGAGAGTAAGGTTCATTTTAAAACTAACGTTTTCTTCCGATATCTACCTAGTGTTTTTGATTGTTCATCAAAGATAGATTGGATTAAGTTTGAAGTTATCGATCAACAACCAAGAGAGAGGATTAATGCACTAAGAAGATTGGCACAAGGTCCAACAGAAGAAATTCCAATCCAAGCGTTTGAACTAGTTCGAGATAATGACTACAAAGTTGCTTTACAACAAGATCCTTTAGATTCGAGGACGAATCTTCTCGAAGAAGGGGAGAATGATAAGAATCATGATGTTTCACACTTCCCAACTTGACCTATTACACGCGCCAAAACTAAGAAGCTTAAACAAGCATTCTTTATTCACATACAAAATTGGATAGGTTCAGCTCAACCTCCATTTCATATGCTGCAAATTGATCCAAGAGCGCATGACGATGTGAAGGTCAACGTTTGCAAGATTGACGTTGTGCTAGCATTTTAAAGACTTATTTGTTATTTTTAATCATGGACTTTTGATTGTAATTTTTGAACTTGTGGGGTTCCAAAATATGGTTTCAAAATTAGACTTTAATTGAGGGGAGTTACTAAGTAGGCCAATTATGGTCATTAATACTTGTAGGTTTTATTTTTGGGGAACTGAAAGGTTGAGAGTTTTATTCATTTTTAGGCTATAAAAAGTCACATCCTAGCCATGTAAAACTCAGATTGTGATGAATGAAATTTGATCTCTCAAGTTCGAGAGTTGTTTTCTTAGAAATTCATTTCTAAGATTTCTTGCAATTCTTGTGATAGATTGCATTTTGAGTCATTCAATCAAGCCTTGATCACGTTTGATTGTGGAATGACTCAATCTAGAACAAGATTTCCAATCTTGCTTCTAGATCTTTGATCATAAGAGGTAATCGATTTCTAGTATTTTCTCTTGGTTGATTCTAATTTGTATAGGGAGGTGTTAATCTCTTCAATGGTTCTTGCTAATTCATAACCTGGATCTTTGGTTGAGAATTAAGGTTGCCTTATCATTTTGGTATCAGAGTATAGGAACTCAAGAGAAGTTAGGTGGGAGCATGTGGTAGCCTTTGGCAGATTAGAAGGCTTGTTATTAATATGGGTTGTGTCAAATTTTTCGATTGTGGGAGTGTTGAAAGGTTGGGAAGGTTGGGTTGTGGATTTTTGGGATGTTAGGGTGTTGGCATGGAGTTTTTCCTTTCAAAGAAGTTTGAAAGTGGATGAAATTTCTGAGTCGATCATTTTGATTTTACTAAAGGAGTTGAAGCCTGTTTTAAGAGAGGGTTGGAGATCTTGGTCTTTCGATTCCTCAGGAAGGTTTTCTGGTTGTTCTTTGGTTAGCTATGATGGAGTTGGGTCGGCCTTAGATAAGCTTATGTTATCTCCAAATGCTTGCTTGTTGTGGAGAAATGATATTAAAGCTTTGTTATTTTGTTGGTTTTTTTCTAATTTTTCCTCTCTCTTTGTATTTTGAGCATTAGTCTCATTGTATTTTGAGCATTAGTCTCATTTCTTTTTATCAATGAAATCTCTTTTGTTGCCTTATTAAAAAAAAAAGATGAAGAAAAATATCAAAGACTTGTGGGAAGAGTCATTTACTTGTCTCATACACGTCCCGACATCGCTTTTGCAGTTAGTATGGTAAGTCAGTTCATGCATGCTCCAGGACAGACACATTTTGAAGTTGTCTATAGAATCCTTAAATACTTGAAAGGTACTCCAGGAAAAGGTATACTATTTAAAAAACATGGGCATCTGCATGTTGAAGTTTACACTGATGCTAATTGGGCAGGCAACACCACATATAGAAGATCTATTTCTGGTTACTGCTCATTTGTTGGAGGGAATCTAGTTACTTGGCGAAGCAAAAAACAAAGTGTGGTGGTCAGGAGTAGTGTTGAAGTTGAATTTAGGGTCTTAGCCCATGGTATTTGTGAGGATATATGGATAAAGAGACTGGTGGAAGAATTGAAATTCTCTCAAAAGATGTCCATGCATATTTATTGTGACAACAAGGCAGCAATTTCCATTGCCTACAATCCAGTTGGCGAAGCAAAAAACAAAGTGTAGTAATATGCATTCTGTTGGTTATTTCCTTATTTGTTAATAAGACTATTCTATATTTACTATATTATCTGTATTATAGGCGCTGGAATATTTTTTTCCTTTTCTGTAAATGTAGGTTTATCCTATATAAGAAACCCTTTATTCTCATTGTGAATATACAGAATAATATATTCTACTCTTGATATTTTCTACATGGTATCAGAGCAGGAACCCTAATTCTGTCAGAAACCGTAATATCTTTTTCTCACACCAAAAAAAAAACCCTAGCCGCCGCTTTCTACCCATCGTCGGCCGCTCCTCGAGTGTCACCGTTGATAACATCCTTGTCGGTCGTTTCAGTGCCTTGAATTCGAAGAACCTTGCCAAAAACAATCAGTCACGATAAGAATATTCTGTATTTACTATATTATCTGTATTATAGGTGCTGGAATATTTTTTCCTTTTCCGTAAATGTAGGTTTCTCCTATATAAGAAACCCTTTATTCTCATAGTGCATATACAAAATAATATATTCTACTCTTGATATTTTCTACACATTCCATATCTCCCTACTATGAAGCAAATTGTTGATGTGTTAACAAAAGGGCTCCCAAGATTACAATTTGATAAGATGATCAACAAACTGGCAATGGAAGATATTTTCAACCAGCTTGAATGGGAGCGTTGGTTGTTTCTTTTTGTAATTAATCAGTATTTATTGTATTATTTGTATTGTATTGCTGGAATATTTTTTCCTTATTTGTAAATGGGTATTTCTTCTATTTAAGAACCCCTTTCTTCTTATAATAATATGCGAAAAATTTATCTGTCCTAAACTTATGCTGTGAGTAACTTTTTTAGTGAGAAAATATAAATTTTTGTGTAAGTGACTACCACAACGGCACTACCCCTATTTATGTGTCAGGTAGTTGTTTAACGTATATTATCTAAAAATTTCCAGTGTAGAAATGTTGTCTGGCTCCCAGGATCCATTGCAGAAGCAGCAGTAACCTCTGATTGTTGCAACTCGTGCACCCCAGGTTTCTGTCTTTGCCTAGCTTCGACTTCATTTCTGTATTTTTCCTAAAAGGATAAGAAATAACCTTAGTGTAAACAACATTACATGATTGCATCTACTATGGTTGGATTGAAGGGGCCTTGTTAGAAAATGAATGACAAAATTATGTGCAACCATAATGCACATATGCATGTTGGATTCCAGTTTTTTATCATAAAAAAAAAATACAACCCGAAAAGGAGTTTTGTTTTAGCAGATTGCATGATGCTGTAATGTTAAATGCCTTTGTCAGGCTGTTTTAGAAAATGATATGTTTCATGTTCTTGTCGTGTCATATCCAAAGTTATTATCTAGACTTGTCATTAATTAGGGAATTAGTTAATGTTCTTTTCTATTTTCTTATAATGTGGTCAACGTTCAGTACAGTTTCTATGATTTTTCTCTATAGAGTTTAGGGAATGATGAATGTCTTTTATTTTCTGAAAAATCTTCAAATAGGTCCTGTTTACTTGATCCAATTTAAGTTTCGTCAGCTGGAAATACCACCAAACTACAATGCTAACCACTTGGGTACGTACTACTTTAATCATGGGACTTCAATTTGAGGTTTTGTTAAGCATCAGCTATCTTGTCTTTATGATAGAATTTTGTACTGTAAATCTATTTGAGGACATCTTTTTATATGCACTATGGATATTACATGGGAGTTACACAGATATTCATATTTTCGTTAAGAGATTGCATGTCTATTCTCCCTTGAAAAGGAATGAATGATATATATATGCATACTTTTTTCTGCTGTACATACTACATATTAAGATTGCAGAATCTAAGATTTTTTTCCATTCTTGTTCATGCGTTATCATTGTCGAGAAAGAATATCTACTAATCTGGAGAATTGGTCAATTTGGTTAACACGGAGTTGTTTAAGACTAGTTCATCATTAGTTGCTTTAGGGTTTATGCTTCTGCAATAAATACAACTTTTGTATTTCACTTGGTTGTAATTTTAATGCAGCCTAAAGTTATAACTCTTGTTAACTGTAGACAGAATGTATAAAGTGTTTTCTGTATTGATTTGATAAGAATTAGGTATTGATTTGATAAGAATTAGGGTTAGAGATACCCATTTACACATATGGAATTTACAAGTAAGGAAATAAATCCAGCCATATAATGCAATGCAATAAATGATAATTATCTACAAAAGGAAATAAATAAACCAAATAAACCAACACTCCCCCTCAAGCTGGTGTGAAGATGTCTTCCATTGCCAGCTTGCTGATCATCTTGTCAAACTGTGTTTTCGGAAGCCCTTTTGTTAATACATCTGTAATTTGCTCTGTCGTAGGCAGATATGGAATGCATATAACACCTGCATCAATCTTTTCTTTTATAAAATGTTTATCAACTTCAATGTGTTTTGTCCTGTCATGAAGAACTGGGTTGTGAGCAATTGAAATTGCTGTCTTATTATCACAATAAATACGTATGGATTGTTCTTGAAAGAATTTCAATTCTTCCAATAGTCTCTTTATCCATATACCCTCACAAATACCATGAGCTAGGGCCCTATACTCAGCTTCAGCACTGCTTTTGGCCACTACACTTTGTTTTTTACTCCGCCATGTAACTAGATTTCCTCCAACAAAGGAACAGTAACCCGAGGTAGATCGTCTATTTGTCGTACTACCTGCTCAATCAGCATCAGTGTAAACTTCAACCTGTAGGTTACCATACTTCTTAAACAATACGCTTTTGCCTGGTGTACCTTTCAAGATAAAGGTATCGTTCATCAACCTACTTGTCGGGATACTCCTCTCATTGCCAATTGGTTTTGAGATGGAACCCAAACGGATATTCGGTCAAAAAAAAATTGAAATTGGGATCATGGTGAACCTAAAGAGATACCATCTTGAGGGGGCATGTTGAGTATCCCACATTGGAAAAGTGGAGAGTAACCTCACAATATATAAGATATATGAGTTACTCCTTTCATTGCCAATTGGTTTTGAGATGGAACCTCATATAATCTAATATGGTATCAGAGCAACTTACCTAATAAATATAATGCCTAGTAAGATCTTGAATTTTAAAACTCCCATTGATTGCTTTAAAACTGTTTTTCCTACATCTCGTATATATTCTGATTTGCCTCTCAAAGTTTTTGGTGTACTACTTATGTTCACATACCTAGTCAATTTCGGTCAAAACTTGATCAGAGAGCTATTAAATGTATTTTTTTGGGTTGCTCTTCAAGTAAAAAAGGCTATAAATGTTTTGATCCCCAAGCAAAAAAACTTTTTGTAAGTATGGATGTGTCTTTTGTAGAAAATCAACCATATTTTACCTGAAGTTCTCTCCAGGGGGAGAAACAAAATTTGGAAGATAACTTTTGGGATATCTCTACTACTCTTCCTAGTCTTGTTTGTCCTATTGTTACTAGTCCTTCGATGTCAAGTGTAGAAACTTCTCAATTAGGGGGAGAAATACTACAGAATGATCCTCCTGATCAAGTTCCCGAGTTTAAGTTTTATACTAGAAGAAAATTCAATCAAAAGAACCAAGACCAGATAGTTTATCTTTCACAAAACCAATCTGAGACTTCGATGAATGAAACTGAAAATCTTGGTAATCCTCCTATTCCTACTCCTTCAACTATTCAAAATACTGTGTCAATTGTGTCTGTGTGTCAATTGTGTCTGATCTTGATGTTCCTATAGCCATTAGAAAAGGTACTCGAAGTTGTACCAAATATCCTATTGCAAACTACATGTCATATCATAATTTGTCAAATAGTCATAAAGCTTTCACATCTAGGATAAATGACTTATTTGTTCCAAGGAATATACATGAGACCTTAGAAGATCCAAATTGGAAAGTAGTAGTTCTGGAGGAGATGAATGCACTAAAACAAAATGGGACTTGGGAAATAGTAGAAGTGTCAAAAGATAAGAAACCAGTAGGTTGTAAATGGGTATTTACCATAAAATGTAATGCAGATGGTAGTATTGAGAGATATAAGGCCAGATTGGTAGCTAAAGACTTCACTCAAACATATGGGATTGATTATCAAGAAATGCTTGCTCCTGTTGCTAAAATTAACTCTATTAGAGTTCTTTTGTCACTTACAGTCAATTCAGAGTGGCCACTTTACCAATTGGACGTGATGCATTTCTCAATGGCGATCTTGGAGGAGGTTTTTATGAGCTTACCACCAGGTTTTGAAAGAGAACTCGGATGTAGTAAAATTTGCAAATTAAAGAAATCCCTTTATGGTCTTAAACAATCTCCAAGAGCTTGGTTTGAGCGTTTTGGAAAAGTTGTGTCTAACTATGGATTTCTTTGGAGTCAAGCAGATCATACTATATTTTATAAACACTCTGAGAATAAGAAAATCTCAATTTTGACTGTCTATGTAGATGATATTATTCTTACAGGTGATGATGAAATTGGTCTAGCTGAACTTAAGAAATATCTTGCAAGTGAATTTCAAATCAATGACTTGGGATCATTGAAATATTTTTTAGGGATGGAGTTTGCAAGATCGAAGAAAGGTATCTTTGTTAATCAAAGAAAGTACGTCCTTGATTTACTTGAAGAAACTAAATTACTTGGTTGCAAGGTCGCAGAAACTCCTATTGAACCGCATCTAAAGATACAAGTAGCAAAACCAGAAGAAAAAAAGGATAAAGAACGATACCAAAGATTGGTTGGAAGGTTAATTTATCTACCTCATACACGTCCTGTTATTGCATATGCCGTAGGTATGGTAAGTCAGTTTATGCATGCGCACGAAACTACTCATTTTGAAGTTGTCTATAGAATTTTGAGATATCTAAAAGCGACTCCTGGAAAAGGAAATTTATTCAAAAAGCATAATCACTTCCAAATAGAAGTTTATACCGATGCAGATTGGGCAGGAAGTACTACAGATAGAAGATCCACCTCTGGTTATTGTTCCTTTGTTGGAGGAAACCTAGTTACTTGGAGGAGTAAAAAAAAAATGTAGTGGCTAGGAGTAGTGCTGAAGCAGTGTTTAGAGCTCTAGTCCATGGAATTTGTGAGGGGATATGGATCAAAAGGATACTTGAAGAATTAAAGGTTCCTCTGAAGATGCCCATACGAGTTTATTGTAACAATAAAGTTGTCATCTCTATTGCGAGTTTATTGTGACAATAAAACTACCATCTCTATGCATCAATATGCATTTCTTATCTTGCTACTACCGAGCAAATTGTTGATATACTAACTAAAGGACTTCCAAAGAGGCAATTCGACATATTGATTGACAAGCTGGCTATGGAAGACATATTTACCCGCTTGAGGGGGAGTGTTGGAATTTTTGTTATTTAGGAATGTTTTTGTATAAATATTAAGTGTAGAATATTTTGTATTTATTATATTCATTTTATTTCCATATTTGTAATTGGTCTTTCTCTTATATAAGTGGACCTATATTGCGCATATTTGATAAGGAATAAAATCTTTATGCTCTCAATGTAACGACCCTAAATTTGAGACAAACCTACGTTAGGGAAGTTACTCCGTCACACCGTTCGCGCCGAAATTTCAGCAACATAACGGCATAATAAGGAGAAAACCAAAATTTTTTCCTGGAATCTAGCAAGTAGAAAACCTTCAAATAGTTTCAAATAATGCCCAACATCCACCAAACTACAATCAAAGAATGGGTTGGGCTACAACCAGAGTTCCAAAGCACAATATCTTGGGCAAACGAACACGCAGCAGAGAGACAACTCAACCAGAATGAAAATTACTATCTAAGAAGTTCAGGAGACAACATAGTGTTGCGCGACCAAACAAATAAAACAAAAACTAAAACATGACCATTTCAAACAAAACTCTAAGCTAAAAGAACACAAGAAGGAACAGGGTCCCACAGCCTCGCCGGATCGTCATCATCGTCAACCGTCTCATGGTTTCTTACCTGCAACCAAAAACAACGAAGTAGATGGGTGAGTATAAAAATACTCAGTAAGCAACCCACTCACGTCCAAACGAGCTAACATGCAAACAAAACAAGACTCAACTTCTAAACTCACTCAACCCCAAACAGGTCTCACATTTAGCACACTTCACCCTGAGCCCTCCTGCGGTAATAACTCGAGCTCTACCTTCGGTCCTGGAACTTTGATTGACGATGCAATGAGAGAAAGAAACTCTCACGCCACTACACACTGGCATAGAGCAGAGCAGGTACGTATCCTACACGCCCTATGGGGAATTGCCCCTAAGCCAGCACAGGATAATGGAAAGCAACCACTCCCTGACGGGGACGTACCCCAGGCTCTCACAACGCAACACGCTAGCATAGTGCAATGAGGTACGTAACCAACACGCCCTATGAGGAATCGACCCTAAGCTAGCACGGGATTATGGAAAGCAACCACTCCCAAATCTCATGGGGACGCACCCTAGTCTCACGAGCCTAACATATATCGTCAACCTAGAGGTTCCGACTCGCTCAGGCGTAACTCAGGGTTTAGTAAGTGCTGGGTTTTGCGCTTCATAAGGTTATTTAGGGTTTTAACTAGACATTTCCAAAATCCTCGACCCATTCTCAAGAGTTCCAAACTCGGCAAGGTTCTCACTTTCAACCAACAGCTCAAACTACCCAAAATCCACTTTCAGACCACACTCAGTTAGACGTCCGACTTAGCCTTACCCTAAGCCCACACAGGTTTGCTCAGCTCCTTGCTTCACGTTGGTAAACGCCTCCCTAACTAGCATTCTGACATAGCCCAGACCCGCCCCGCAGGACGCTCATAAGCTATGTCTCACTCCGAGTCTGTTGCCACACTCATAATGGCTCACCTCGAAGCATTCTCGTCTTTGGTCTGTTGCCATGACTACCATGGCACCACAAGACATCAATGCCCCTGGTCTGCTGCCACACACACGGTGACCCACCACGAGACATCGTCAATACACATGCTCCATGCTAGTTTCTCGCCACACAAGGTTATAGGATAACGTCACATAAATAAGGAGTAAGGTAGGGACTACTAGCCTGAGGGGTTCCATAACACAACTCTCTTGACTTGGTACTAAGACCATAATCGAAGATACATAGTAACAATCATGCGAATGCTACAAACTGCATATCGCTTATGATCCTCAACCACACATGCACGAACTCAATCACGGTCGAAACCAACCCCTTTAACATACATGTCAACACAAGGTTTCAACCCACCAACCATGCAAACAAGCTCTCTCACTTATGAGCTCGCTTCCTGAATCAAGTTGGCTACCTACATCGATTCGAGGATCCATGAAACAACTACTTCCTTCAACAGTCAAACGCAAGCTCGCCTAACACAGTTCGAAGGAAAACACTGACCACTAGCGTAGCCTAGGGCTCGCCTTTAACACCCAACCAAGTTAGTTATAGCATTCCAAATAGCTCAAACACAAGCTGCATCCAATGGTCACGTTTGGCCCAAACCACCGTAACCGAAGCTTTAGTTGCAACCTCGAACCCTTAAACAAGAATAGCCTCACGCTTAGGCGACCTTAAGCCCAACACAGAAATCCTCCACTCGGTATAGCCAACTACACCGTGCCCGCCACACCCATACTAATCCAGTATGTGTAGTTCCAAACCATCGCCGACATAACCCAACCTCAACCAACCCCTAACATAGACAAACTCTTAAGCTACCATGTTAGCGCCAAACATTTAGCCCCTAGTTCCACATTGGCCTCATGCCTTTAGGCCTTTTAACACAAACGACCCCATACAATCCCTTCGACCAACAACGTATCGTAAGGCACAATTTCGAACATACTATCACAATTCGCAAGGGGTCTCACATAGTCAAAGCAACAATAACTTATCGGGCTTAATTCCAAATGACTACTTACCTTGATAGCTAAGGTTCGGGAGTTCGATCCCGAGTTTCACGCGCTTCCTTAACACGCACGAGCCCCTATTCAATAAACAAAGACCTTAAAACCACGCTTCTAACAATCATACACGAACTAATTTGACTTAAATGACCAAACTAATGCATGGAGACTTAAAATGGAATCGAAAAAAAAACGAAGTCGACCGGTTATACCTATCCGACGGCGGCGGCGGCGACGGAATCCGGCAAGTGGCGGCGGCAACAGCTTCCGGCGAGTGGCGGCGCGTGGAGCACAAATCTGAGATGCCCGTGGCCCGATCTATTCAAAAATCAACATCCAAACGATGAGAACTGGATTAAAAACTCGAGAACCGATCGAACCAAACCAAAGGTTCCTTTTGAAAAACTTACCGTTGAAGGCTACGGCGGCCGAGAAGGGAACGACAACCAAGGATTTGGCGTGGTCGTTGGGTGCGGCGGCGAACAATTGGATCGGAGCGGCTGAGCGACAGTCTGGCGGTGATGGACGATGCCTGCGGGTTGCTGGACGCCGGCGAGGAGACGCGTTGACAAAGGAGAAGGCTCGAAGTCAACTGGTCTGCTTGCGAGTTGACGTTGCGACGGGGAGAAGGGGAAACTCGGTTGTGTGTGCCTGACGGCGTGGCTGGCCGTTGAAAGACGGAAGGAAGAAAGTGGAGTGGCTCGGCGGTGAGGGGAAGAAAAGGAGAAAGTCGAAGATGGGGGGGCAGCACGCGTGAAAACGCAAAACTTCTTTTCTTTTTTTTTTTTCTTTTTATTACTTTCTAAAACCTTATTTTCCTTTTCAAAAAAAAAAAAACTTTTCCTTAATTACTTTACACTTAATACCAAACTTATGAAGCGAGACCAAAAAGAATTAACTTCAAGAATTTAGTAGATTCCTGGAAAGTACCGGGCGTTACACTCAAAATCAGCATTTTTCTTTCCTGTTTTTTCCCTTGATCTGTATACTAAATTCTTTGTTCTTTAATTGTTTGATCAGGTTGTATAGGTGGTTGCGATGATATTCTTCGGCAGTTGACAGAAATCTGTGGTACTGGATCTCGCATGTCAGGCATGTATCTTTTCTGCAGTTATTTCTTCAAAATATCTGAGATGTGCAGGTTTCTGTTTTTTGGAGTTTAGAATCATAGAAACAGTATGAACTTGTAAGCTTATTGCGGATAAATTGTCTACATTTACTATTTCATTAAGATGTCCTGAAGCTTGTTTAGTTGTTGAAAGTTTCTTCTACGTCACACTTCAGCTAAAGAATAATTAACCGAATCCTCCCTGCCTGTTTTTACCTTGTCCAGTTTCTGGGAGTAACAGTGGGTTATTTATCGAATGTTGAATGCTGTTCATTTCACAATCTGAGTAAGATAGTTGGATTGAACTTGACGCAATCTCCTTTAAGAATAAGTATTGATCAACGGTCTCATTATCTGTTTGATAAAAGCACGATTTAGAAGAAGGGAAATAATCCATATGGCCCAAGAAATTAAAAAAAAAATCCTTTTGCAAACTTATATGATAATTTTATATTTTGCACATTCAAATTATGTTTTCCAGCTAGAGGTCGAGGAACTTCATCATCAAATGTGCAACGAGGTAACACCGGGCAAAGTGTATGCATTTTCTGCCAACAAGTAGGCCATTCCTCAAACGATTGCCCTTCACAGGTTGTAGGTTCCAGAAGTGCTCGTTGTTGGCAAAGTGGTAAGCGGGACTTTCTGTTGTCTATAACGAACAGTTGCTACCTTTTTCGGAAATTGTAATGGGTAGCAAAATATGGGTTCTTATTTGCAAATATAGAAAGTTTTTTAAAAAAATTGCAAATATAGCAAATATGTTAAATAACATTTTTTAATTTTCATTTTACCCTTAATTGAAGCCTAATAGACTTTTATCACTGTACAGAATCCGTCGGTGATTGACTTCTATCCCTGATAGATTCTTATTTGCAAATATAACAAATATTTTAAATAACATTTTGTAATTTTCATTTTACCCTTGATTGAAGCCTAATAGATTTTTATTACTGTTCAGAATCTGTTGGTGATAGACTTCTATCCCTGATAGACTCTTATGACAGTTAGAACTCTACTGGAAGGATTGAAGTCATCTTAATAGACACTTATCACAATTAGGAGTCTATTAGTGATAAATTTTTATCATTAATAGATTCTTATCACAATTAGAAGTTTATGAGTGATTGAATGTGGTATAATTCAATTTTGAAACAACGCTTGGAGTAGGCTGGTAGACTTTTATCATAGTTAGGATTCTATCAATGATAGATTTCTAACACTGATAGACTCTTATTACAGTTAGGATTCTATAGTGATAGAATATGATAGAATGCAATACATGAAGTAGATTTGATGTTCTATGACTGATAGAATCTTATCACAATTTGAAGTCTATCAGTGTTAAACTCTAATAGACTGTAAAATTGAAGTAAGACTTGAAGTAGTATGCTTGTAGAATTTTATCATAGCAGGAGTCTATCAGTGTTAAACTTCTATTAGTGATAGACTTCAATCACACATTCTAGCTTATTCAAGGATGAAAATTAACCTTTATTAATCCTAGTTGATTCAAGATTCAAAATTCTAGTAATTCAGATGGTAGCAATTAACATATATGCTTCCATCAGTGATAGACTTCAATCATGCACTACTCCTAATGATAGTGGTAGAAGTCTATAAATAATGAACTTCCATAAAAAGTAAGAAACAACACATATAGAAGTCTATCAGTGATAGTGATAGACTTATATCACTGATAAACTTTTATTACAAGACAGTGATTGAAGTCTAATAGAAAAAATTGAACTTTGGACATCGATTGAACCTAGGATTTTTAGTTGATCGACTAAAAATTGGAGAAAGGAAGAAGAAATCACAAAAAAAATACAAAAAATCAAAGATAGTTTGAGGAAGAAATGAAGGAAAATGAATCACAATTTTCATTCGGGCTAAAAGTCATGTGCATGGACTTTTTAGTAATTTAAATGCAAATTTGCTATATTTGCAATATTTTAGGCCCATTTGCTATTTGCCCAAGTGTCCCTACATTTTTTAAATAATTTTAGATTATTTAAAAAATAATCATTGTGAGAAGACTTACTTTTTTTAATCTATTGCCCAAGTGGCTTTTAGATTTATTTTATGCTATGTGTGTATGTTAAATGCTGTAAACTTAAAGTATTTACTTTCAAATGCGTAATTTTTCTTCGGGTTCGCATAGCCACGAGCTCACAATTCATGAAGGAACTAATTTGCTTATTTATTTATTTATTTTATCATAATCATTGTGAGAATCTAACAAATGTTAGTCATCTACGGAAATTTTGAACTTCTGAAATTGCGGATCATCTTTGCATGTTTTCAGATTCCTTTTGCTGTTATTGATAAATTTCGAACCAACAGGTTTTAATTTTTAATGTTTTTATGTTTTGTTGGCAGGGGAATCTTCAGTTTCATGTAGTACCTGTGGTACACCATGCGTCTTACGGACAGCAAATACTGCCAATAATAGGGGAAGAAAATTCTACAAATGTCAATCTCAAGAGTGCAATTTTTTCATGTACGCAGCCCCTTTAAATTTGTTTTGGTCTCTTAGATTTTTTTTTTTAACATTACGTTAACATAAAAACTCAAGGATTTGACAATAATTATAACCTACCATGATATTAGAGTCAAAATTTCCTTCCAGTCAGAAAACAACAGTTCATGCGTAGATCTGACAATATAAGTTAAATACTTCTATGACTCAACCAAATAGCTCAACATTTTAGTTTAGTTTAGTTTATTTTAAAGAATTATGTCGAACTGTTTCACAATACCATAGTTCTGTTCAATAAGGAGAACACGCTTTTCACATTAAATTCCTTGGATTCCTATTGAAGCTGTTGATATTATCTAAATACCTCTCTGTTAACATAAATGTAAATAATGCATCCTTTTGCAGATGGGAAGACAACGTAGACAATGGCAATGGAGGACATAATGCTCCACGGTCAAATGTCAGGAGCTCAGGCTCAGCGGCATCTAATCCAAACCCTGGTCGAAACATTGGGCGTGGTCGCGGTCGCGGTCGCGGTCACGGTCAGATTGCAGCAACATTCGTGTCTGCAACTGGTGAGCCAATATCTGATAGAAGATGTTTTGTTTGTGGTGATCCATCACACTTTGCAAATGTTTGCCCAAATCGTGGTGCTTGA

mRNA sequence

ATGTCCGGCGGCCGTCCGATCACCGTTCTCAATGTAGCAGAGAAGCCATCGGTGGCGAAATCTGTGGCCACCATACTCTCCAGGAACCAGGGCCTTCGAGTTCGCGACGGTCGTTCTCGCTACAACAAGATTTTCGAGTTCAACTACGCCATTCGAGGCCAGTCTTGCAATATGCTCGTCACCTCCGTCACAGGTCATTTGATGGAGCTCGAGTTCGAAGAACGGTACCGCAAATGGCATTCCTGTGACCCAGCCGAGCTTTTCCATGCTCCCGTCCGCAAATTTGTCCCCGAGGACAAGATGGATATAAAGAGGACATTGGAACAAGAAGCTAGAAGGTGTCAATGGCTCGTCCTCTGGCTTGATTGTGATAGAGAAGGAGAAAATATTGCCTTTGAAGTCGTGGAAGTTTGCACAGCAGTGAATTGTCATCTTAACATTAAGAGGGCCCACTTCTCTGCTTTGATCGAAAGGGATATTCACGAAGCTGTGCAAAATCTTGTCCAACCAAATAAATGGTTTGCTGATGCGGTTGATGCTAGACAAGAAATTGATCTAAGAATTGGTGCTTCTTTTACTAGGTTCCAAACTATGCTGTTGAAAGATGCATTTAATATTGATTCTGTCACAGATGACAAAAATGTTATTTTGAGTTATGGGCCTTGTCAGTTTCCTACTCTTGGTTTTGTTGTTGAGCGGTACTGGGAGATTCAATCCCATGAGCCAGAAGAATTTTGGACGATCAACTGTTCGCACAATTCTGATGATGGAATTTCTACATTTAATTGGACGAGAGGGAATCTATTTGATTATACTTGTGCTGTTTTGCTCTATGAAATGTGTGTACAAGAATCGACTGCTACGGTTGTAAATGTTAGACGACAAGAGACGTTAAAGTATCCTCCTCATCCATTGAATACAATTGAACTTGAAAAACGAGCTTCACGGTACTTCCGAATGAGTTCTGAACACACTATGAAGGTGGCCGAAGATCTGTACCAAGCAGGTTTCATTAGTTATCCTCGTACAGAGACTGATTGCTTTTCTCAAAGGACCGATCTTCATGCGATTGTGCAAGAACAACAAGAACACCAAATATGGGGAGCCTATGCACAAAGGTTGCTGGATCCTGGATCAGGACTTTGGAGGAATCCTAGTGGTGGTGGCCATGATGACAAAGCCCATCCACCTATTCACCCAACGAAGTTCTCTGCTGGGGAACGCAGATGGAGCCAAGATCATCATAGAGTGTATGAGCTAGTCGTTCGCCATTTTCTGGCATGTGTCTCACAGCCAGCTGTAGGTGCTGTGACCACTGTTGAAATTGATATTGCTGGTGAATTGTTTTCTACATCTGGGAGAATGATACTAGCATTTGTTCCAACAACATTAACTCTTGATTCAGGAGTCACAAGACCACCTCCCCTTCTGAGTGAAGCTGATTTGCTCTCTTGTATGGATAAGGAGGGAATTGGTACAGATGCAACAATGCATGACCACATCAAGAAGTTGCTGGATAGATTTTATGCAACAAAGGACACAAACACTCGTTTCATGCCAACTAACCTGGGTGAGGCTCTGGTTATGGGATATGACGACATGGGGTATAAACTGTGGAAACCTCACCTTAGAGCCGTCATGGAGCACGAGATGAAAGCAGTTAGTGAGGGCACTAAGAGAAAAGATGAAGTGTTGGCTACATCCTTGCAGCAGATGAAAGATTGCTTCTTAGATGCAAGGTTGAATAAGCTAAAACTTCTTGAAGCCATGGAGGTTTTCTTTGAGAGATCTAATGGTTCTGGCGGGGATGAAAATCATGCAGTTGGAGAAGTTGTCCGTCGATGTGGACTGTGTCAGGACTCAGATATGGTGCTTAAAAGAAACAGGTGTAGAAATGTTGTCTGGCTCCCAGGATCCATTGCAGAAGCAGCAGTAACCTCTGATTGTTGCAACTCGTGCACCCCAGGTCCTGTTTACTTGATCCAATTTAAGTTTCGTCAGCTGGAAATACCACCAAACTACAATGCTAACCACTTGGGTTGTATAGGTGGTTGCGATGATATTCTTCGGCAGTTGACAGAAATCTGTGGTACTGGATCTCGCATGTCAGCTAGAGGTCGAGGAACTTCATCATCAAATGTGCAACGAGGTAACACCGGGCAAAGTGTATGCATTTTCTGCCAACAAGTAGGCCATTCCTCAAACGATTGCCCTTCACAGGTTGTAGGTTCCAGAAGTGCTCGTTGTTGGCAAAGTGGGGAATCTTCAGTTTCATGTAGTACCTGTGGTACACCATGCGTCTTACGGACAGCAAATACTGCCAATAATAGGGGAAGAAAATTCTACAAATGTCAATCTCAAGAGTGCAATTTTTTCATATGGGAAGACAACGTAGACAATGGCAATGGAGGACATAATGCTCCACGGTCAAATGTCAGGAGCTCAGGCTCAGCGGCATCTAATCCAAACCCTGGTCGAAACATTGGGCGTGGTCGCGGTCGCGGTCGCGGTCACGGTCAGATTGCAGCAACATTCGTGTCTGCAACTGGTGAGCCAATATCTGATAGAAGATGTTTTGTTTGTGGTGATCCATCACACTTTGCAAATGTTTGCCCAAATCGTGGTGCTTGA

Coding sequence (CDS)

ATGTCCGGCGGCCGTCCGATCACCGTTCTCAATGTAGCAGAGAAGCCATCGGTGGCGAAATCTGTGGCCACCATACTCTCCAGGAACCAGGGCCTTCGAGTTCGCGACGGTCGTTCTCGCTACAACAAGATTTTCGAGTTCAACTACGCCATTCGAGGCCAGTCTTGCAATATGCTCGTCACCTCCGTCACAGGTCATTTGATGGAGCTCGAGTTCGAAGAACGGTACCGCAAATGGCATTCCTGTGACCCAGCCGAGCTTTTCCATGCTCCCGTCCGCAAATTTGTCCCCGAGGACAAGATGGATATAAAGAGGACATTGGAACAAGAAGCTAGAAGGTGTCAATGGCTCGTCCTCTGGCTTGATTGTGATAGAGAAGGAGAAAATATTGCCTTTGAAGTCGTGGAAGTTTGCACAGCAGTGAATTGTCATCTTAACATTAAGAGGGCCCACTTCTCTGCTTTGATCGAAAGGGATATTCACGAAGCTGTGCAAAATCTTGTCCAACCAAATAAATGGTTTGCTGATGCGGTTGATGCTAGACAAGAAATTGATCTAAGAATTGGTGCTTCTTTTACTAGGTTCCAAACTATGCTGTTGAAAGATGCATTTAATATTGATTCTGTCACAGATGACAAAAATGTTATTTTGAGTTATGGGCCTTGTCAGTTTCCTACTCTTGGTTTTGTTGTTGAGCGGTACTGGGAGATTCAATCCCATGAGCCAGAAGAATTTTGGACGATCAACTGTTCGCACAATTCTGATGATGGAATTTCTACATTTAATTGGACGAGAGGGAATCTATTTGATTATACTTGTGCTGTTTTGCTCTATGAAATGTGTGTACAAGAATCGACTGCTACGGTTGTAAATGTTAGACGACAAGAGACGTTAAAGTATCCTCCTCATCCATTGAATACAATTGAACTTGAAAAACGAGCTTCACGGTACTTCCGAATGAGTTCTGAACACACTATGAAGGTGGCCGAAGATCTGTACCAAGCAGGTTTCATTAGTTATCCTCGTACAGAGACTGATTGCTTTTCTCAAAGGACCGATCTTCATGCGATTGTGCAAGAACAACAAGAACACCAAATATGGGGAGCCTATGCACAAAGGTTGCTGGATCCTGGATCAGGACTTTGGAGGAATCCTAGTGGTGGTGGCCATGATGACAAAGCCCATCCACCTATTCACCCAACGAAGTTCTCTGCTGGGGAACGCAGATGGAGCCAAGATCATCATAGAGTGTATGAGCTAGTCGTTCGCCATTTTCTGGCATGTGTCTCACAGCCAGCTGTAGGTGCTGTGACCACTGTTGAAATTGATATTGCTGGTGAATTGTTTTCTACATCTGGGAGAATGATACTAGCATTTGTTCCAACAACATTAACTCTTGATTCAGGAGTCACAAGACCACCTCCCCTTCTGAGTGAAGCTGATTTGCTCTCTTGTATGGATAAGGAGGGAATTGGTACAGATGCAACAATGCATGACCACATCAAGAAGTTGCTGGATAGATTTTATGCAACAAAGGACACAAACACTCGTTTCATGCCAACTAACCTGGGTGAGGCTCTGGTTATGGGATATGACGACATGGGGTATAAACTGTGGAAACCTCACCTTAGAGCCGTCATGGAGCACGAGATGAAAGCAGTTAGTGAGGGCACTAAGAGAAAAGATGAAGTGTTGGCTACATCCTTGCAGCAGATGAAAGATTGCTTCTTAGATGCAAGGTTGAATAAGCTAAAACTTCTTGAAGCCATGGAGGTTTTCTTTGAGAGATCTAATGGTTCTGGCGGGGATGAAAATCATGCAGTTGGAGAAGTTGTCCGTCGATGTGGACTGTGTCAGGACTCAGATATGGTGCTTAAAAGAAACAGGTGTAGAAATGTTGTCTGGCTCCCAGGATCCATTGCAGAAGCAGCAGTAACCTCTGATTGTTGCAACTCGTGCACCCCAGGTCCTGTTTACTTGATCCAATTTAAGTTTCGTCAGCTGGAAATACCACCAAACTACAATGCTAACCACTTGGGTTGTATAGGTGGTTGCGATGATATTCTTCGGCAGTTGACAGAAATCTGTGGTACTGGATCTCGCATGTCAGCTAGAGGTCGAGGAACTTCATCATCAAATGTGCAACGAGGTAACACCGGGCAAAGTGTATGCATTTTCTGCCAACAAGTAGGCCATTCCTCAAACGATTGCCCTTCACAGGTTGTAGGTTCCAGAAGTGCTCGTTGTTGGCAAAGTGGGGAATCTTCAGTTTCATGTAGTACCTGTGGTACACCATGCGTCTTACGGACAGCAAATACTGCCAATAATAGGGGAAGAAAATTCTACAAATGTCAATCTCAAGAGTGCAATTTTTTCATATGGGAAGACAACGTAGACAATGGCAATGGAGGACATAATGCTCCACGGTCAAATGTCAGGAGCTCAGGCTCAGCGGCATCTAATCCAAACCCTGGTCGAAACATTGGGCGTGGTCGCGGTCGCGGTCGCGGTCACGGTCAGATTGCAGCAACATTCGTGTCTGCAACTGGTGAGCCAATATCTGATAGAAGATGTTTTGTTTGTGGTGATCCATCACACTTTGCAAATGTTTGCCCAAATCGTGGTGCTTGA

Protein sequence

MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNRCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCGDPSHFANVCPNRGA

Homology

[Close]

BLAST of Tan0004448 vs. ExPASy Swiss-Prot
Match: Q9LVP1 (DNA topoisomerase 3-alpha OS=Arabidopsis thaliana OX=3702 GN=TOP3A PE=1 SV=1)

HSP 1 Score: 1254.2 bits (3244), Expect = 0.0e+00
Identity = 626/925 (67.68%), Postives = 723/925 (78.16%), Query Frame = 0


Query: 3   GGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTS 62
           GG P+TVLNVAEKPSVAKSVA ILSR    R R+GRSRYNKIFEF+YAI GQ C ML+TS
Sbjct: 5   GGGPVTVLNVAEKPSVAKSVAGILSRGT-FRTREGRSRYNKIFEFDYAINGQPCRMLMTS 64

Query: 63  VTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLD 122
           V GHLMELEF +RYRKWHSCDPA+L+ APV K VPEDK DIK+TLE+EAR+  WLVLWLD
Sbjct: 65  VIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLD 124

Query: 123 CDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQ 182
           CDREGENIAFEVV+VC AV  +L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQ
Sbjct: 125 CDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQ 184

Query: 183 EIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEP 242
           EIDLRIGASFTRFQTMLL+D F IDS  ++++ ++SYGPCQFPTLGF+VERYWEIQ+HEP
Sbjct: 185 EIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEP 244

Query: 243 EEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNV-RRQETLKYP 302
           EEFWTINCSH S++G++TFNW RG+LFDY  AV+LYEMCV+E TATV+NV   +E  KYP
Sbjct: 245 EEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYP 304

Query: 303 PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQ 362
           P+PLNTIELEKRASRYFR+SSEHTMKVAE+LYQAGFISYPRTETD FS RTDL A+V+EQ
Sbjct: 305 PYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQ 364

Query: 363 QEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELV 422
             H  WG+YAQRLL+P  GLWRNP+ GGHDDKAHPPIHPTKFS+GE  WS+DH  VYELV
Sbjct: 365 TRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELV 424

Query: 423 VRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA----------------------- 482
           VRH+LACVSQPAV A TTVEIDIAGE FS SGR ILA                       
Sbjct: 425 VRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKG 484

Query: 483 --FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNT 542
             F+PTTLTLD+ VTRPPPLL EADLLSCMDK GIGTDATMHDHIKKLLDR YATKD NT
Sbjct: 485 QQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANT 544

Query: 543 RFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF 602
           RF PTNLGEALVMGYDDMGY+LWKP+LRA+MEH+M  VS G K K EVL T LQQMK CF
Sbjct: 545 RFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACF 604

Query: 603 LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------- 662
           LDAR+ K KLLEAM +FFERSN +   E+   GEVVRRC LC +SDM L++NR       
Sbjct: 605 LDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVG 664

Query: 663 ------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIG 722
                 CRN VWLPG   EA+VT++ C SC PGPVY I FKFRQ+ IPP ++ NHLGC+G
Sbjct: 665 CMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLGCVG 724

Query: 723 GCDDILRQLTEICGTGSRMSARGR-GTS-SSNVQRGNTGQS-VCIFCQQVGHSSNDCPSQ 782
           GCDDIL+QL +ICGTGSR  AR   GT+ S+N+Q  NT QS VCI CQQ GH+S +CPS+
Sbjct: 725 GCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNTRQSNVCIHCQQRGHASTNCPSR 784

Query: 783 VVGSRSARCW----QSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWED 842
           V  SR++R      ++ ES+VSC+TCG+ CVLRTANT  NRGR+F+ C +Q C+FF WED
Sbjct: 785 VPASRNSRPTATNPRNDESTVSCNTCGSQCVLRTANTEANRGRQFFSCPTQGCSFFAWED 844

Query: 843 NVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIA-------ATFVSAT 875
           +++N +G          ++ + +++   GR   RGRGRG   GQ +        +FVSAT
Sbjct: 845 SINNSSG----------NATTGSNSGGSGRRGSRGRGRGGRGGQSSGGRRGSGTSFVSAT 904

[Close]

BLAST of Tan0004448 vs. ExPASy Swiss-Prot
Match: C7J0A2 (DNA topoisomerase 3-alpha OS=Oryza sativa subsp. japonica OX=39947 GN=TOP3A PE=3 SV=1)

HSP 1 Score: 1192.9 bits (3085), Expect = 0.0e+00
Identity = 601/925 (64.97%), Postives = 708/925 (76.54%), Query Frame = 0


Query: 3   GGRPITVLNVAEKPSVAKSVATILSR-NQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVT 62
           GG  I VLNVAEKPSVAKSVA ILSR + G+R R+GRSRYN++FEF+Y+I G++C+MLVT
Sbjct: 6   GGGAIRVLNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEFDYSIGGRACHMLVT 65

Query: 63  SVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWL 122
           SVTGHLMELEF++R+R+WHSCDPA+LFHAPVRK VP+DK DIKRTLE+EAR+CQWLVLWL
Sbjct: 66  SVTGHLMELEFDDRFRRWHSCDPADLFHAPVRKSVPQDKQDIKRTLEEEARKCQWLVLWL 125

Query: 123 DCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDAR 182
           DCDREGENIA+EV+++C   N  LNI RA FSALI+R+IHEAVQ+L +PNK FADAVDAR
Sbjct: 126 DCDREGENIAYEVIDICAGANSRLNIWRARFSALIDREIHEAVQHLDRPNKLFADAVDAR 185

Query: 183 QEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHE 242
           QEIDLRIGASFTRFQTMLLKDAF +D   DD+N+ILSYGPCQFPTLGF+VER+WEIQ+HE
Sbjct: 186 QEIDLRIGASFTRFQTMLLKDAFVLDDTGDDRNIILSYGPCQFPTLGFIVERFWEIQAHE 245

Query: 243 PEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYP 302
           PEEFWTINCSH SD+G ++F W RG+LFDY+ AV++YEMCV+E  ATV NVR QE LKYP
Sbjct: 246 PEEFWTINCSHTSDEGTASFGWIRGHLFDYSSAVVIYEMCVEEPMATVQNVRNQEKLKYP 305

Query: 303 PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQ 362
           P+PL+TIEL+KRASRYFRMSSEHTMKVAE+LYQAGFISYPRTETD FS  TDLH+IV EQ
Sbjct: 306 PYPLSTIELQKRASRYFRMSSEHTMKVAEELYQAGFISYPRTETDNFSPNTDLHSIVHEQ 365

Query: 363 QEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELV 422
             H  WG YAQRLLDP + LWRNPS GGHDDKAHPPIHPTKFSAGE  W+ +H ++YELV
Sbjct: 366 VAHPNWGTYAQRLLDPEARLWRNPSNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELV 425

Query: 423 VRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA----------------------- 482
           VRHFLAC SQPAVGA TTVEIDIAGE F+ SGR++LA                       
Sbjct: 426 VRHFLACCSQPAVGAETTVEIDIAGEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIG 485

Query: 483 --FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNT 542
             FVPTTLTLDSG+TRPPPLL+EADLL CMDK GIGTDATMHDHIKKLLDR YATKD NT
Sbjct: 486 QQFVPTTLTLDSGMTRPPPLLAEADLLGCMDKAGIGTDATMHDHIKKLLDRCYATKDANT 545

Query: 543 RFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF 602
           RF PTNLGEALVMGYD+MGY+LWKP+LR++ME +MK+VS GTK K EVL   LQQMK CF
Sbjct: 546 RFSPTNLGEALVMGYDEMGYELWKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACF 605

Query: 603 LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRN-------- 662
           LDAR NK+KL +AM  FF RS+    +  +++ E VR C  C +S+M LK+         
Sbjct: 606 LDARANKVKLFDAMGTFFARSSRPVNETQNSI-ETVRPCAACNESEMFLKQRPTGEFMVG 665

Query: 663 -----RCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIG 722
                +CRNVVWLP S++ AAVT   C +C PGPVY IQFKFR+ +IPPN++ +HLGCIG
Sbjct: 666 CRGFPQCRNVVWLPRSLSGAAVTDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIG 725

Query: 723 GCDDILRQLTEICGTGSRMS----ARGRGTSSSNVQRGNTGQSV-CIFCQQVGHSSNDCP 782
           GCDDIL++L E+   GS       AR +  ++S V++G++ Q +   F   V  ++   P
Sbjct: 726 GCDDILKELMELSRFGSHSQTATPARNQSQTASGVRQGSSRQDLHTSFHPAVQFTNGQTP 785

Query: 783 -SQVVGSRSARCWQSGESS--VSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWE 842
                G RS     SG +S  V C++C  PCVLRTANT  NRGRKFYKCQ+  C FF WE
Sbjct: 786 VVNPQGFRSTHTQSSGNASGQVQCTSCREPCVLRTANTEANRGRKFYKCQNLACGFFAWE 845

Query: 843 DNVDN----GNGGH-NAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATG 876
           D+V+N    G GG     RS+ R S ++AS    G   GRGR RGRG       FV+ATG
Sbjct: 846 DDVENSAPRGRGGRGRGGRSSSRQSSASASAGRRGGTQGRGR-RGRGRNADGMMFVAATG 905

[Close]

BLAST of Tan0004448 vs. ExPASy Swiss-Prot
Match: Q13472 (DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1)

HSP 1 Score: 644.8 bits (1662), Expect = 1.4e-183
Identity = 369/876 (42.12%), Postives = 514/876 (58.68%), Query Frame = 0


Query: 9   VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLM 68
           VL VAEK   AK +A +LS N  +R R+G S++NKI+EF+Y + GQ+  M++TSV+GHL+
Sbjct: 36  VLCVAEKNDAAKGIADLLS-NGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLL 95

Query: 69  ELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREGE 128
             +F+ ++RKW SC+P  LF A + K+ PE+ +DIK+TLE+E R+CQ LV+W DCDREGE
Sbjct: 96  AHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 155

Query: 129 NIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRI 188
           NI FE++ VC AV  +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRI
Sbjct: 156 NIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRI 215

Query: 189 GASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTI 248
           GA+FTRFQT+ L+  F    V  ++  ++SYG CQFPTLGFVVER+  IQ+  PE F  I
Sbjct: 216 GAAFTRFQTLRLQRIF--PEVLAEQ--LISYGSCQFPTLGFVVERFKAIQAFVPEIFHRI 275

Query: 249 NCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTI 308
             +H+  DGI  FNW R  LF++T  ++LY++CV++  ATVV VR +   K+ P  L+T+
Sbjct: 276 KVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTV 335

Query: 309 ELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWG 368
           ELEK ASR  R++++ TM++AE LY  G+ISYPRTET+ F +  +L  +V++Q     WG
Sbjct: 336 ELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWG 395

Query: 369 AYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLAC 428
           A+AQ +L+ G      P  G   D+AHPPIHPTK++        D  R+YE +VRHFLAC
Sbjct: 396 AFAQSILERGG---PTPRNGNKSDQAHPPIHPTKYT---NNLQGDEQRLYEFIVRHFLAC 455

Query: 429 VSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTT 488
            SQ A G  TTVEIDIA E F   G MILA                         F P+T
Sbjct: 456 CSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPST 515

Query: 489 LTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNL 548
           + +  G T PP LL+EADL++ M+K GIGTDAT  +HI+ +  R Y     + RF+P +L
Sbjct: 516 VEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHL 575

Query: 549 GEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNK 608
           G  LV GYD MGY++ KP LRA +E ++K + +G K K  VL   +Q+ K  F++A    
Sbjct: 576 GMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKA 635

Query: 609 LKLLEAMEVFFERSNGSGGDEN--HAVGEVVRRCGLCQDSDMVLKRNR------------ 668
            KL EA+  +F         E+   A+ E +R+C  C + DMVLK  +            
Sbjct: 636 KKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQC-NKDMVLKTKKNGGFYLSCMGFP 695

Query: 669 -CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDI 728
            CR+ VWLP S+ EA+  S  C  C P PVY ++ KF++  +PP      + CIGGCDD 
Sbjct: 696 ECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDT 755

Query: 729 LRQLTEICGTGSRMSA---RGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSR 788
           LR++ ++  +G    A    GR  ++ ++ R +  Q       Q   S     S+ +   
Sbjct: 756 LREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQH-----PQPADSRQTGSSKALAQT 815

Query: 789 SARCWQSGESSVSCSTCGTPCVLRTANTAN-NRGRKFYKCQSQECNFFIWEDNVDNGNGG 840
                 +GES+     CG   VL T      NRGR+F+KC    CNFF+W D+ + G GG
Sbjct: 816 LPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGG 875

[Close]

BLAST of Tan0004448 vs. ExPASy Swiss-Prot
Match: O70157 (DNA topoisomerase 3-alpha OS=Mus musculus OX=10090 GN=Top3a PE=2 SV=1)

HSP 1 Score: 634.8 bits (1636), Expect = 1.4e-180
Identity = 371/907 (40.90%), Postives = 525/907 (57.88%), Query Frame = 0


Query: 9   VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLM 68
           VL VAEK   AK +A +LS N  +R ++G S++NKI+EF+Y + GQ+  M++TSV+GHL+
Sbjct: 36  VLCVAEKNDAAKGIADLLS-NGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLL 95

Query: 69  ELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREGE 128
             +F+ ++RKW SC+P  LF A + K+ PE+ +DIK+TLE+E   CQ LV+W DCDREGE
Sbjct: 96  AHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGE 155

Query: 129 NIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRI 188
           NI FE++ VC AV  +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRI
Sbjct: 156 NIGFEIIHVCKAVKPNLRVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRI 215

Query: 189 GASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTI 248
           GA+FTRFQT+ L+  F    V  ++  ++SYG CQFPTLGFVVER+  IQ+  PE F  I
Sbjct: 216 GAAFTRFQTLRLQRIF--PEVLAEQ--LISYGSCQFPTLGFVVERFKAIQAFVPEVFHKI 275

Query: 249 NCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTI 308
             +H+  DG   FNW R  LF++T  ++LY++C+++  ATVV VR +   K+ P  L+T+
Sbjct: 276 KVTHDHKDGTVEFNWKRYRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTV 335

Query: 309 ELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWG 368
           ELEK ASR  R++++ TM++AE LY  G+ISYPRTET+ F +  +L A+V++Q     WG
Sbjct: 336 ELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWG 395

Query: 369 AYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLAC 428
           A+AQ +L+ G      P  G   D+AHPPIHPTK+++G      D  R+YE +VRHFLAC
Sbjct: 396 AFAQTILERGG---PTPRNGSKSDQAHPPIHPTKYTSG---LQGDDRRLYEFIVRHFLAC 455

Query: 429 VSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTT 488
            SQ A G  TTVEIDIA E F   G +ILA                         F P+T
Sbjct: 456 CSQDAQGQETTVEIDIAQERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPST 515

Query: 489 LTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNL 548
           + +  G T PP LL+EADL++ M+K GIGTDAT  +HI+ +  R Y    ++ RF+P +L
Sbjct: 516 VEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHL 575

Query: 549 GEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNK 608
           G  LV GYD MGY++ KP LRA +E ++K + EG K K +VL   +Q+ K  F++A    
Sbjct: 576 GMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKA 635

Query: 609 LKLLEAMEVFF-ERSNGSGGDENH-AVGEVVRRCGLCQDSDMVLKRNR------------ 668
            KL EA+  +  ER+  +  +E + A+ E VR+C  C + DMVLK  +            
Sbjct: 636 KKLDEALSQYLGERTEMAQQEEIYPAMPEPVRKCPQC-NKDMVLKTKKSGGFYLSCMGFP 695

Query: 669 -CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDI 728
            CR+ VW P S+ EA+  +  C+ C P PVY ++ KF++  +PP      +GCIGGCD+ 
Sbjct: 696 ECRSAVWFPDSVLEASRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGCDET 755

Query: 729 LRQLTEICGTGSRMSARGRGTSSSNVQRG---NTGQSVCIFCQQVGHSSNDCPSQVVGSR 788
           L+   EI G     +       S ++Q     N   S      Q   + +  PS+ V   
Sbjct: 756 LK---EIFGLRFPRALPRASQPSGHLQASQALNRMDSSQHNLSQPLVNRHTRPSKTVAQA 815

Query: 789 SARCWQSGESSVSCSTCGTPCVLRTANTAN-NRGRKFYKCQSQECNFFIWEDNVDNGNGG 848
                 +GES+     CG   VL T      N+GR FYKC + +CNFF+W D+  +  GG
Sbjct: 816 LLPPTTAGESNSVTCNCGREAVLLTVRKQGPNQGRHFYKCSNGDCNFFLWADSSHSTGGG 875

Query: 849 -----HNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRG--HGQIAATFVSATGEPISDRR 865
                   P S+V    S  S+ +   ++G     G     GQ A T       P   R+
Sbjct: 876 TPTSASGPPGSSVGCPSSVGSHMDGFGSLGSDSDGGTPCLCGQPAVTRTVQKDGPNKGRQ 927

[Close]

BLAST of Tan0004448 vs. ExPASy Swiss-Prot
Match: Q8T2T7 (DNA topoisomerase 3 OS=Dictyostelium discoideum OX=44689 GN=top3 PE=3 SV=1)

HSP 1 Score: 538.9 bits (1387), Expect = 1.1e-151
Identity = 297/663 (44.80%), Postives = 404/663 (60.94%), Query Frame = 0


Query: 9   VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRG-QSCNMLVTSVTGHL 68
           +LNVAEKPS AK +A ILS N+   VR+G S+YNK+++F Y I     C M  TSVTGHL
Sbjct: 5   ILNVAEKPSAAKEIAAILS-NKRATVREGFSKYNKLWDFKYNILNFNDCEMTFTSVTGHL 64

Query: 69  MELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREG 128
           ME++  E+++ W SCDP +LF AP+RK VP DK  +K+TLE+E ++   L+LWLDCDREG
Sbjct: 65  MEIDVVEQFKPWASCDPIQLFDAPIRKTVPSDKEPLKKTLEREIKKADILILWLDCDREG 124

Query: 129 ENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLR 188
           ENIAFEV+EVC          RAHFSA+I R+I  A +NL +PN+  + AVD R EIDLR
Sbjct: 125 ENIAFEVLEVCKNAKKKFEFYRAHFSAIIPREIDRACKNLAKPNEKDSIAVDTRMEIDLR 184

Query: 189 IGASFTRFQTMLLKDAFNIDSVTDDK---------------------NVILSYGPCQFPT 248
           IGA+FTRFQT+ LK  F I S +D++                       I+SYGPCQFPT
Sbjct: 185 IGAAFTRFQTLYLK-KFKIISNSDNQPKTTTPANGNILNNSNNNSSGKEIISYGPCQFPT 244

Query: 249 LGFVVERYWEIQSHEPEEFWTINCSHNSDDGIS------TFNWTRGNLFDYTCAVLLYEM 308
           LGFVVERY+ I + +PE+FW ++  H   D  S      TF+W R  LFDYT A +LYE 
Sbjct: 245 LGFVVERYFRIVNFKPEDFWHLSVVHEKMDTSSGKMIPVTFSWCRNRLFDYTAAFILYEK 304

Query: 309 CVQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISY 368
           C+  + ATVV+V  +E+ +Y P PL TIEL+K AS+  R+SS  TM+ AE+LY  G ISY
Sbjct: 305 CLDNTEATVVDVTSKES-RYRPVPLTTIELQKAASKKLRISSVQTMQYAEELYTKGLISY 364

Query: 369 PRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP 428
           PRTETD F   TDL  ++  Q  +  WGAYA RL++    ++  P  G ++D +HPPIHP
Sbjct: 365 PRTETDSFQAGTDLKGLIGNQASNPEWGAYASRLINNNQFVY--PKSGKNNDNSHPPIHP 424

Query: 429 TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMIL--- 488
           T  + G    S +  ++Y+ + R FLAC S+ +V A TTV IDI GE FS +G M+L   
Sbjct: 425 TSSATG---LSGNLKKIYDFITRRFLACCSEESVFANTTVTIDIQGERFSETGTMVLKLG 484

Query: 489 ----------------------AFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDA 548
                                  F P  + L  G T  P  ++EA+LL+ MD   IGTDA
Sbjct: 485 YLEVYPFDKRNDKLIPTYQKGERFTPKRIDLTKGTTVAPHYITEAELLTAMDNNKIGTDA 544

Query: 549 TMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVS 608
           TM  HI+ + DRFY  K+ + +F+P+NLG +LV  Y+ MG++  KP+LRA +E ++  +S
Sbjct: 545 TMATHIQTIQDRFYVKKNESNQFVPSNLGVSLVASYELMGFEFSKPNLRAAIEADVDKIS 604

Query: 609 EGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRC 619
            G K K EVL +++++ K  +  A  N      +   ++E ++  GG+    V +   RC
Sbjct: 605 RGQKTKQEVLLSTIEKYKQLYQLANQNINCFDRSFREYYEPADPKGGEFRVLVSQ-FSRC 658

[Close]

BLAST of Tan0004448 vs. NCBI nr
Match: XP_038904102.1 (DNA topoisomerase 3-alpha isoform X2 [Benincasa hispida])

HSP 1 Score: 1692.6 bits (4382), Expect = 0.0e+00
Identity = 821/889 (92.35%), Postives = 842/889 (94.71%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+V
Sbjct: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMIV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMELEFEERYRKWHSCDP +LFHAPVRK VPEDKMDIKRTLEQEARRCQWL+LW
Sbjct: 61  TSVTGHLMELEFEERYRKWHSCDPVQLFHAPVRKVVPEDKMDIKRTLEQEARRCQWLILW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTAVNRHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQTMLLKDAFNIDSV DD+N++LSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVVDDRNIVLSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+ YEMCVQE TATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSGDGISTFSWTRGNLFDYTCAVVFYEMCVQEPTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQE
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEA 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEA
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEA 480

Query: 481 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWK 540
           DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGY LWK
Sbjct: 481 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDANTRFTPTNLGEALVMGYDDMGYNLWK 540

Query: 541 PHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGS 600
           PHLRA+MEHEMKAVSEGTKRKDEVLAT LQQMK CFLDAR+NK KLLEAMEVFFERSNGS
Sbjct: 541 PHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKSCFLDARVNKQKLLEAMEVFFERSNGS 600

Query: 601 GGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTS 660
           GGDEN AVGEVV+RCGLCQDS+MVLKRNR             CRNVVWLPGSIAEAAVTS
Sbjct: 601 GGDENRAVGEVVQRCGLCQDSNMVLKRNRDGNYMVGCLAFPQCRNVVWLPGSIAEAAVTS 660

Query: 661 DCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGR 720
           DCCN CTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSR+SARGR
Sbjct: 661 DCCNLCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSARGR 720

Query: 721 GTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCV 780
           GTSSS+VQR NT QSVCIFCQQVGHSSNDCPSQVVGSRSA   QSGE SVSCS CGTPCV
Sbjct: 721 GTSSSSVQRDNTRQSVCIFCQQVGHSSNDCPSQVVGSRSAHRRQSGEYSVSCSNCGTPCV 780

Query: 781 LRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRN 840
           LRTANT NNRGRKFYKCQSQECNFF+WEDNVDN NGG++A RSN+R+SGSAA NPNPGRN
Sbjct: 781 LRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNSNGGNSASRSNIRTSGSAAPNPNPGRN 840

Query: 841 IGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCGDPSHFANVCPNRGA 877
              GRGRGRG  +IAATFVSATGEPISDRRCFVCGD SHFANVCPNRGA
Sbjct: 841 --TGRGRGRGWSRIAATFVSATGEPISDRRCFVCGDASHFANVCPNRGA 887

[Close]

BLAST of Tan0004448 vs. NCBI nr
Match: XP_038904101.1 (DNA topoisomerase 3-alpha isoform X1 [Benincasa hispida])

HSP 1 Score: 1678.7 bits (4346), Expect = 0.0e+00
Identity = 821/914 (89.82%), Postives = 842/914 (92.12%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+V
Sbjct: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMIV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMELEFEERYRKWHSCDP +LFHAPVRK VPEDKMDIKRTLEQEARRCQWL+LW
Sbjct: 61  TSVTGHLMELEFEERYRKWHSCDPVQLFHAPVRKVVPEDKMDIKRTLEQEARRCQWLILW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTAVNRHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQTMLLKDAFNIDSV DD+N++LSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVVDDRNIVLSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+ YEMCVQE TATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSGDGISTFSWTRGNLFDYTCAVVFYEMCVQEPTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQE
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PTNLGEALVMGYDDMGY LWKPHLRA+MEHEMKAVSEGTKRKDEVLAT LQQMK C
Sbjct: 541 TRFTPTNLGEALVMGYDDMGYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKSC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+RCGLCQDS+MVLKRNR      
Sbjct: 601 FLDARVNKQKLLEAMEVFFERSNGSGGDENRAVGEVVQRCGLCQDSNMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEAAVTSDCCN CTPGPVYLIQFKFRQLEIPPNYNANHLGCI
Sbjct: 661 GCLAFPQCRNVVWLPGSIAEAAVTSDCCNLCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVV 780
           GGCDDILRQLTEICGTGSR+SARGRGTSSS+VQR NT QSVCIFCQQVGHSSNDCPSQVV
Sbjct: 721 GGCDDILRQLTEICGTGSRVSARGRGTSSSSVQRDNTRQSVCIFCQQVGHSSNDCPSQVV 780

Query: 781 GSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGN 840
           GSRSA   QSGE SVSCS CGTPCVLRTANT NNRGRKFYKCQSQECNFF+WEDNVDN N
Sbjct: 781 GSRSAHRRQSGEYSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNSN 840

Query: 841 GGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCG 877
           GG++A RSN+R+SGSAA NPNPGRN   GRGRGRG  +IAATFVSATGEPISDRRCFVCG
Sbjct: 841 GGNSASRSNIRTSGSAAPNPNPGRN--TGRGRGRGWSRIAATFVSATGEPISDRRCFVCG 900

[Close]

BLAST of Tan0004448 vs. NCBI nr
Match: XP_022154286.1 (DNA topoisomerase 3-alpha [Momordica charantia])

HSP 1 Score: 1671.4 bits (4327), Expect = 0.0e+00
Identity = 822/915 (89.84%), Postives = 843/915 (92.13%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           MSGGRPITVLNVAEKPSVAK+VATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV
Sbjct: 1   MSGGRPITVLNVAEKPSVAKAVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMELEFEERYRKWHSCDPA+LFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW
Sbjct: 61  TSVTGHLMELEFEERYRKWHSCDPADLFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVV+VCTAVN HL IKRAHFSALIERDIHEAVQNLVQPN+WFADAVDA
Sbjct: 121 LDCDREGENIAFEVVDVCTAVNRHLTIKRAHFSALIERDIHEAVQNLVQPNQWFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQTMLLKDAF IDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTMLLKDAFVIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNSDDGISTF+WTRG+LFDYTCAV+LYEMCVQESTATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSDDGISTFSWTRGHLFDYTCAVVLYEMCVQESTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETD FSQRTDLH IVQE
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDGFSQRTDLHVIVQE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQ HQIWGAYAQRLLDPGSGLWRNPS GGHDDKAHPPIHPTKFSAGER WSQDHH++YEL
Sbjct: 361 QQSHQIWGAYAQRLLDPGSGLWRNPSSGGHDDKAHPPIHPTKFSAGERGWSQDHHKLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDLN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PTNLGEALVMGYDDMGYKLWKP+LRAVMEHEMKAVSEGTKRK EVLA SLQQMK C
Sbjct: 541 TRFTPTNLGEALVMGYDDMGYKLWKPNLRAVMEHEMKAVSEGTKRKAEVLAASLQQMKTC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDARLNKLKLLEAMEVFFERSNGSGGDE+H VG VVRRCGLCQDSDMVLKRNR      
Sbjct: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDEHHTVGVVVRRCGLCQDSDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEAAVT DCCNSCTPGPVYLIQFKFR LEIPPNYNANHLGCI
Sbjct: 661 GCLGFPQCRNVVWLPGSIAEAAVTFDCCNSCTPGPVYLIQFKFRPLEIPPNYNANHLGCI 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRG-TSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQV 780
           GGCDDILRQLTEICGTGSRMS RGRG TSSS+ QRGNTGQ VCI CQQVGHSSNDCPSQV
Sbjct: 721 GGCDDILRQLTEICGTGSRMSGRGRGVTSSSSAQRGNTGQGVCIHCQQVGHSSNDCPSQV 780

Query: 781 VGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNG 840
           VGSRSAR  QSGESSVSCS CGTPCVLRTANTANNRGRKFY CQSQ+CNFF+WEDN+D+G
Sbjct: 781 VGSRSARRRQSGESSVSCSNCGTPCVLRTANTANNRGRKFYSCQSQDCNFFVWEDNIDSG 840

Query: 841 NGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVC 877
           NGG++APRSN+R S S ASNPNPG+N G GRGRGRG+  IA TFVSATGEPISDRRCFVC
Sbjct: 841 NGGNSAPRSNIRGSASVASNPNPGQNTGHGRGRGRGN--IAMTFVSATGEPISDRRCFVC 900

[Close]

BLAST of Tan0004448 vs. NCBI nr
Match: XP_022982837.1 (DNA topoisomerase 3-alpha isoform X1 [Cucurbita maxima])

HSP 1 Score: 1664.0 bits (4308), Expect = 0.0e+00
Identity = 817/916 (89.19%), Postives = 843/916 (92.03%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           M+GGRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLV
Sbjct: 1   MAGGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMELEFEERYRKWHSCDP ELF+APVRK VPEDKMDIKRTLEQEARRCQWLVLW
Sbjct: 61  TSVTGHLMELEFEERYRKWHSCDPVELFNAPVRKLVPEDKMDIKRTLEQEARRCQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCT VN HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTTVNRHLNIKRAHFSALIERDIHEAVQNLVQPNKYFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQTMLLKDAFNIDSV DD+NV+LSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVGDDRNVVLSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+LYEMCV+ESTATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSGDGISTFSWTRGNLFDYTCAVVLYEMCVEESTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQE
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYAS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PTNLGEALVMGYDDMGYKLWKPHLRA+MEHEMKAVSEG KRKDEVLAT LQQMK C
Sbjct: 541 TRFTPTNLGEALVMGYDDMGYKLWKPHLRALMEHEMKAVSEGIKRKDEVLATCLQQMKSC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDAR NK KL EAMEVFFERSNGSGGDENHAVGEVV+RC LCQDSDMVLKRNR      
Sbjct: 601 FLDARFNKQKLFEAMEVFFERSNGSGGDENHAVGEVVQRCRLCQDSDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLIQFKFRQLEIPPNYN NHLGCI
Sbjct: 661 GCLGFPQCRNVVWLPGSIAEAAVTSNRCNSCTPGPVYLIQFKFRQLEIPPNYNPNHLGCI 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVV 780
           GGCDDILRQLTEICGTGSR+SARGRGTSSS+VQRGNT QSVC+FCQQ+ HSSNDCPSQVV
Sbjct: 721 GGCDDILRQLTEICGTGSRISARGRGTSSSSVQRGNTAQSVCVFCQQLDHSSNDCPSQVV 780

Query: 781 GSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGN 840
           GSRSAR  Q+GESS SCS CGTPCVLRTANT NNRGRKFYKCQSQECNFF WED+VD+ N
Sbjct: 781 GSRSARHRQTGESSFSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFAWEDSVDSVN 840

Query: 841 GGHNAPRSNVRSSGSAASNPNPGRNIGRGR--GRGRGHGQIAATFVSATGEPISDRRCFV 877
           GG++A +SN+RSS SAASN NPGRN GRGR  G+G+G GQIAATFVSATGEPISDRRCFV
Sbjct: 841 GGNSAAQSNIRSSASAASNTNPGRNTGRGRGWGQGQGQGQIAATFVSATGEPISDRRCFV 900

[Close]

BLAST of Tan0004448 vs. NCBI nr
Match: XP_008443145.1 (PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Cucumis melo])

HSP 1 Score: 1663.7 bits (4307), Expect = 0.0e+00
Identity = 816/922 (88.50%), Postives = 843/922 (91.43%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+V
Sbjct: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMIV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMEL FEERYRKW+SCDP +LFHAPV KFVPEDK+DIKRTLEQEARR QWLVLW
Sbjct: 61  TSVTGHLMELAFEERYRKWYSCDPVQLFHAPVHKFVPEDKLDIKRTLEQEARRSQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTAVNHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQT+LLKDAFNIDSVTDD+N++LSYGPCQFPTLGFVVERYWEIQ+H
Sbjct: 181 RQEIDLRIGASFTRFQTLLLKDAFNIDSVTDDRNIVLSYGPCQFPTLGFVVERYWEIQAH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNSDDGISTF+WTRGNLFDYTCAV+ YEMCVQESTATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCVQESTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IV+E
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVRE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDP SGLWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPESGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PT+LGEALVMGYDDMGY LWKPHLRA+MEHEMKAVSEGTKRKDEVLA+ LQQMK+C
Sbjct: 541 TRFTPTSLGEALVMGYDDMGYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLASCLQQMKNC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+ CGLCQ+SDMVLKRNR      
Sbjct: 601 FLDARVNKQKLLEAMEVFFERSNGSGGDENRAVGEVVQLCGLCQESDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEA VTSD C  CTPGPVYLIQFKFRQLEIPPNYNANHLGC+
Sbjct: 661 GCLAFPQCRNVVWLPGSIAEATVTSDRCTLCTPGPVYLIQFKFRQLEIPPNYNANHLGCV 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVV 780
           GGCDDILRQLTEICGTGSR+SARGRGTSSSNVQR N GQSVCIFCQQVGHSSNDCPSQ V
Sbjct: 721 GGCDDILRQLTEICGTGSRVSARGRGTSSSNVQRDNPGQSVCIFCQQVGHSSNDCPSQSV 780

Query: 781 GSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGN 840
           GS SAR  QSGESSVSCS+CGTPCVLRTANT NNRGRKFYKCQSQECNFF+WEDNVDN N
Sbjct: 781 GSGSARGRQSGESSVSCSSCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNVN 840

Query: 841 GGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGR--------GHGQIAATFVSATGEPIS 877
           GG++A RSNVRSSGSA SNPNPG+N GRGRGR R        G GQIAATFVSATGEPIS
Sbjct: 841 GGNSAQRSNVRSSGSAPSNPNPGQNTGRGRGRSRGRGRGRDLGQGQIAATFVSATGEPIS 900

[Close]

BLAST of Tan0004448 vs. ExPASy TrEMBL
Match: A0A6J1DNA0 (DNA topoisomerase OS=Momordica charantia OX=3673 GN=LOC111021577 PE=3 SV=1)

HSP 1 Score: 1671.4 bits (4327), Expect = 0.0e+00
Identity = 822/915 (89.84%), Postives = 843/915 (92.13%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           MSGGRPITVLNVAEKPSVAK+VATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV
Sbjct: 1   MSGGRPITVLNVAEKPSVAKAVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMELEFEERYRKWHSCDPA+LFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW
Sbjct: 61  TSVTGHLMELEFEERYRKWHSCDPADLFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVV+VCTAVN HL IKRAHFSALIERDIHEAVQNLVQPN+WFADAVDA
Sbjct: 121 LDCDREGENIAFEVVDVCTAVNRHLTIKRAHFSALIERDIHEAVQNLVQPNQWFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQTMLLKDAF IDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTMLLKDAFVIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNSDDGISTF+WTRG+LFDYTCAV+LYEMCVQESTATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSDDGISTFSWTRGHLFDYTCAVVLYEMCVQESTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETD FSQRTDLH IVQE
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDGFSQRTDLHVIVQE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQ HQIWGAYAQRLLDPGSGLWRNPS GGHDDKAHPPIHPTKFSAGER WSQDHH++YEL
Sbjct: 361 QQSHQIWGAYAQRLLDPGSGLWRNPSSGGHDDKAHPPIHPTKFSAGERGWSQDHHKLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDLN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PTNLGEALVMGYDDMGYKLWKP+LRAVMEHEMKAVSEGTKRK EVLA SLQQMK C
Sbjct: 541 TRFTPTNLGEALVMGYDDMGYKLWKPNLRAVMEHEMKAVSEGTKRKAEVLAASLQQMKTC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDARLNKLKLLEAMEVFFERSNGSGGDE+H VG VVRRCGLCQDSDMVLKRNR      
Sbjct: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDEHHTVGVVVRRCGLCQDSDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEAAVT DCCNSCTPGPVYLIQFKFR LEIPPNYNANHLGCI
Sbjct: 661 GCLGFPQCRNVVWLPGSIAEAAVTFDCCNSCTPGPVYLIQFKFRPLEIPPNYNANHLGCI 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRG-TSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQV 780
           GGCDDILRQLTEICGTGSRMS RGRG TSSS+ QRGNTGQ VCI CQQVGHSSNDCPSQV
Sbjct: 721 GGCDDILRQLTEICGTGSRMSGRGRGVTSSSSAQRGNTGQGVCIHCQQVGHSSNDCPSQV 780

Query: 781 VGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNG 840
           VGSRSAR  QSGESSVSCS CGTPCVLRTANTANNRGRKFY CQSQ+CNFF+WEDN+D+G
Sbjct: 781 VGSRSARRRQSGESSVSCSNCGTPCVLRTANTANNRGRKFYSCQSQDCNFFVWEDNIDSG 840

Query: 841 NGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVC 877
           NGG++APRSN+R S S ASNPNPG+N G GRGRGRG+  IA TFVSATGEPISDRRCFVC
Sbjct: 841 NGGNSAPRSNIRGSASVASNPNPGQNTGHGRGRGRGN--IAMTFVSATGEPISDRRCFVC 900

[Close]

BLAST of Tan0004448 vs. ExPASy TrEMBL
Match: A0A6J1IXM8 (DNA topoisomerase OS=Cucurbita maxima OX=3661 GN=LOC111481572 PE=3 SV=1)

HSP 1 Score: 1664.0 bits (4308), Expect = 0.0e+00
Identity = 817/916 (89.19%), Postives = 843/916 (92.03%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           M+GGRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLV
Sbjct: 1   MAGGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMELEFEERYRKWHSCDP ELF+APVRK VPEDKMDIKRTLEQEARRCQWLVLW
Sbjct: 61  TSVTGHLMELEFEERYRKWHSCDPVELFNAPVRKLVPEDKMDIKRTLEQEARRCQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCT VN HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTTVNRHLNIKRAHFSALIERDIHEAVQNLVQPNKYFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQTMLLKDAFNIDSV DD+NV+LSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVGDDRNVVLSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+LYEMCV+ESTATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSGDGISTFSWTRGNLFDYTCAVVLYEMCVEESTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQE
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYAS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PTNLGEALVMGYDDMGYKLWKPHLRA+MEHEMKAVSEG KRKDEVLAT LQQMK C
Sbjct: 541 TRFTPTNLGEALVMGYDDMGYKLWKPHLRALMEHEMKAVSEGIKRKDEVLATCLQQMKSC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDAR NK KL EAMEVFFERSNGSGGDENHAVGEVV+RC LCQDSDMVLKRNR      
Sbjct: 601 FLDARFNKQKLFEAMEVFFERSNGSGGDENHAVGEVVQRCRLCQDSDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLIQFKFRQLEIPPNYN NHLGCI
Sbjct: 661 GCLGFPQCRNVVWLPGSIAEAAVTSNRCNSCTPGPVYLIQFKFRQLEIPPNYNPNHLGCI 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVV 780
           GGCDDILRQLTEICGTGSR+SARGRGTSSS+VQRGNT QSVC+FCQQ+ HSSNDCPSQVV
Sbjct: 721 GGCDDILRQLTEICGTGSRISARGRGTSSSSVQRGNTAQSVCVFCQQLDHSSNDCPSQVV 780

Query: 781 GSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGN 840
           GSRSAR  Q+GESS SCS CGTPCVLRTANT NNRGRKFYKCQSQECNFF WED+VD+ N
Sbjct: 781 GSRSARHRQTGESSFSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFAWEDSVDSVN 840

Query: 841 GGHNAPRSNVRSSGSAASNPNPGRNIGRGR--GRGRGHGQIAATFVSATGEPISDRRCFV 877
           GG++A +SN+RSS SAASN NPGRN GRGR  G+G+G GQIAATFVSATGEPISDRRCFV
Sbjct: 841 GGNSAAQSNIRSSASAASNTNPGRNTGRGRGWGQGQGQGQIAATFVSATGEPISDRRCFV 900

[Close]

BLAST of Tan0004448 vs. ExPASy TrEMBL
Match: A0A1S3B7B9 (DNA topoisomerase OS=Cucumis melo OX=3656 GN=LOC103486821 PE=3 SV=1)

HSP 1 Score: 1663.7 bits (4307), Expect = 0.0e+00
Identity = 816/922 (88.50%), Postives = 843/922 (91.43%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+V
Sbjct: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMIV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMEL FEERYRKW+SCDP +LFHAPV KFVPEDK+DIKRTLEQEARR QWLVLW
Sbjct: 61  TSVTGHLMELAFEERYRKWYSCDPVQLFHAPVHKFVPEDKLDIKRTLEQEARRSQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTAVNHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQT+LLKDAFNIDSVTDD+N++LSYGPCQFPTLGFVVERYWEIQ+H
Sbjct: 181 RQEIDLRIGASFTRFQTLLLKDAFNIDSVTDDRNIVLSYGPCQFPTLGFVVERYWEIQAH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNSDDGISTF+WTRGNLFDYTCAV+ YEMCVQESTATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCVQESTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IV+E
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVRE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDP SGLWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPESGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PT+LGEALVMGYDDMGY LWKPHLRA+MEHEMKAVSEGTKRKDEVLA+ LQQMK+C
Sbjct: 541 TRFTPTSLGEALVMGYDDMGYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLASCLQQMKNC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+ CGLCQ+SDMVLKRNR      
Sbjct: 601 FLDARVNKQKLLEAMEVFFERSNGSGGDENRAVGEVVQLCGLCQESDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEA VTSD C  CTPGPVYLIQFKFRQLEIPPNYNANHLGC+
Sbjct: 661 GCLAFPQCRNVVWLPGSIAEATVTSDRCTLCTPGPVYLIQFKFRQLEIPPNYNANHLGCV 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVV 780
           GGCDDILRQLTEICGTGSR+SARGRGTSSSNVQR N GQSVCIFCQQVGHSSNDCPSQ V
Sbjct: 721 GGCDDILRQLTEICGTGSRVSARGRGTSSSNVQRDNPGQSVCIFCQQVGHSSNDCPSQSV 780

Query: 781 GSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGN 840
           GS SAR  QSGESSVSCS+CGTPCVLRTANT NNRGRKFYKCQSQECNFF+WEDNVDN N
Sbjct: 781 GSGSARGRQSGESSVSCSSCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNVN 840

Query: 841 GGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGR--------GHGQIAATFVSATGEPIS 877
           GG++A RSNVRSSGSA SNPNPG+N GRGRGR R        G GQIAATFVSATGEPIS
Sbjct: 841 GGNSAQRSNVRSSGSAPSNPNPGQNTGRGRGRSRGRGRGRDLGQGQIAATFVSATGEPIS 900

[Close]

BLAST of Tan0004448 vs. ExPASy TrEMBL
Match: A0A6J1F0T9 (DNA topoisomerase OS=Cucurbita moschata OX=3662 GN=LOC111441350 PE=3 SV=1)

HSP 1 Score: 1661.4 bits (4301), Expect = 0.0e+00
Identity = 816/916 (89.08%), Postives = 842/916 (91.92%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           M+GGRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLV
Sbjct: 1   MAGGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMELEFEERYRKWHSCDP ELF+APVRK VPEDKMDIKRTLEQEA RCQWLVLW
Sbjct: 61  TSVTGHLMELEFEERYRKWHSCDPVELFNAPVRKLVPEDKMDIKRTLEQEAIRCQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCT VN HLNIKRAHFSALIERDIHEAVQNLVQPNK++ADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTMVNRHLNIKRAHFSALIERDIHEAVQNLVQPNKYYADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQTMLLKDAFNIDSV DD+NV+LSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVGDDRNVVLSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+LYEMCV+ESTATVVNV+RQETLKY
Sbjct: 241 EPEEFWTINCSHNSGDGISTFSWTRGNLFDYTCAVVLYEMCVEESTATVVNVKRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQE
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYAS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PTNLGEALVMGYDDMGYKLWKPHLRA+MEHEMKAVSEG KRKDEVLAT LQQMK C
Sbjct: 541 TRFTPTNLGEALVMGYDDMGYKLWKPHLRALMEHEMKAVSEGIKRKDEVLATCLQQMKSC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDAR NK KL EAMEVFFERSNGSGGDENHAVGEVV+RC LCQDSDMVLKRNR      
Sbjct: 601 FLDARFNKQKLFEAMEVFFERSNGSGGDENHAVGEVVQRCRLCQDSDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLIQFKFRQLEIPPNYN NHLGCI
Sbjct: 661 GCLGFPQCRNVVWLPGSIAEAAVTSNRCNSCTPGPVYLIQFKFRQLEIPPNYNPNHLGCI 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVV 780
           GGCDDILRQLTEICGTGSR+SARGRGTSSS+VQRGNT QSVC+FCQQ+ HSSNDCPSQVV
Sbjct: 721 GGCDDILRQLTEICGTGSRISARGRGTSSSSVQRGNTAQSVCVFCQQLDHSSNDCPSQVV 780

Query: 781 GSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGN 840
           GSRSAR  Q+GESS SCS CGTPCVLRTANT NNRGRKFYKCQSQECNFF WED+VD+ N
Sbjct: 781 GSRSARRRQTGESSFSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFAWEDSVDSVN 840

Query: 841 GGHNAPRSNVRSSGSAASNPNPGRNIGRGRGR--GRGHGQIAATFVSATGEPISDRRCFV 877
           GG++A RSN+RSSGSAASN NPGRN GRGRGR  G+G GQIAATFVSA GEPISDRRCFV
Sbjct: 841 GGNSAARSNIRSSGSAASNTNPGRNTGRGRGRGQGQGQGQIAATFVSAIGEPISDRRCFV 900

[Close]

BLAST of Tan0004448 vs. ExPASy TrEMBL
Match: A0A0A0LBG7 (DNA topoisomerase OS=Cucumis sativus OX=3659 GN=Csa_3G813290 PE=3 SV=1)

HSP 1 Score: 1659.8 bits (4297), Expect = 0.0e+00
Identity = 815/924 (88.20%), Postives = 842/924 (91.13%), Query Frame = 0


Query: 1   MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLV 60
           MSGGR ITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+V
Sbjct: 1   MSGGRSITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMIV 60

Query: 61  TSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLW 120
           TSVTGHLMEL FEERYRKWHSCDP +LFHAPV KFVPEDK+DIKRTLEQE+RR QWLVLW
Sbjct: 61  TSVTGHLMELAFEERYRKWHSCDPVQLFHAPVHKFVPEDKLDIKRTLEQESRRAQWLVLW 120

Query: 121 LDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDA 180
           LDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIH+AVQNLVQPNKWFADAVDA
Sbjct: 121 LDCDREGENIAFEVVEVCTAVNHHLNIKRAHFSALIERDIHDAVQNLVQPNKWFADAVDA 180

Query: 181 RQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSH 240
           RQEIDLRIGASFTRFQT+LLKDAFNIDSVTDD+N++LSYGPCQFPTLGFVVERYWEIQSH
Sbjct: 181 RQEIDLRIGASFTRFQTLLLKDAFNIDSVTDDRNIVLSYGPCQFPTLGFVVERYWEIQSH 240

Query: 241 EPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY 300
           EPEEFWTINCSHNSDDGISTF+WTRGNLFDYTCAV+ YEMCVQESTATVVNVRRQETLKY
Sbjct: 241 EPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCVQESTATVVNVRRQETLKY 300

Query: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQE 360
           PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IV+E
Sbjct: 301 PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVRE 360

Query: 361 QQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYEL 420
           QQEHQIWGAYAQRLLDP S LWRNPSGGGHDDKAHPPIHPTKFSAGER WSQDHHR+YEL
Sbjct: 361 QQEHQIWGAYAQRLLDPESRLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYEL 420

Query: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA---------------------- 480
           VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                      
Sbjct: 421 VVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVS 480

Query: 481 ---FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTN 540
              FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD N
Sbjct: 481 GQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAN 540

Query: 541 TRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC 600
           TRF PTNLGEALVMGYDDMGY LWKP+LRA+MEHEMKAVSEGTKRKDEVLA+ LQQMK C
Sbjct: 541 TRFTPTNLGEALVMGYDDMGYNLWKPNLRAIMEHEMKAVSEGTKRKDEVLASCLQQMKTC 600

Query: 601 FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------ 660
           FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+ CGLCQDSDMVLKRNR      
Sbjct: 601 FLDARVNKQKLLEAMEVFFERSNGSGGDENRAVGEVVQLCGLCQDSDMVLKRNRDGNYMV 660

Query: 661 -------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCI 720
                  CRNVVWLPGSIAEA VTSD C  CTPGPVYLIQFKFRQLEIPPNYNANHLGC+
Sbjct: 661 GCLGFPQCRNVVWLPGSIAEATVTSDRCTLCTPGPVYLIQFKFRQLEIPPNYNANHLGCV 720

Query: 721 GGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVV 780
           GGCDDILRQLTEICGTGSR+SARGRGTSSSNVQR N GQSVCIFCQQVGHSSNDCPSQ V
Sbjct: 721 GGCDDILRQLTEICGTGSRVSARGRGTSSSNVQRDNPGQSVCIFCQQVGHSSNDCPSQSV 780

Query: 781 GSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGN 840
           GSRSA+  QSGESSVSCS+CG+PCVLRTANTANNRGRKFYKCQSQECNFF+WEDNVDNGN
Sbjct: 781 GSRSAQRRQSGESSVSCSSCGSPCVLRTANTANNRGRKFYKCQSQECNFFVWEDNVDNGN 840

Query: 841 GGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRG----------RGHGQIAATFVSATGEP 877
           GG++  RSNVRSSGSA SN NPG+N GRGRGRG          RG GQIAATFVSATGEP
Sbjct: 841 GGNSVQRSNVRSSGSAPSNLNPGQNTGRGRGRGRGRGRDRDRDRGQGQIAATFVSATGEP 900

[Close]

BLAST of Tan0004448 vs. TAIR 10
Match: AT5G63920.1 (topoisomerase 3alpha )

HSP 1 Score: 1254.2 bits (3244), Expect = 0.0e+00
Identity = 626/925 (67.68%), Postives = 723/925 (78.16%), Query Frame = 0


Query: 3   GGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTS 62
           GG P+TVLNVAEKPSVAKSVA ILSR    R R+GRSRYNKIFEF+YAI GQ C ML+TS
Sbjct: 5   GGGPVTVLNVAEKPSVAKSVAGILSRGT-FRTREGRSRYNKIFEFDYAINGQPCRMLMTS 64

Query: 63  VTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLD 122
           V GHLMELEF +RYRKWHSCDPA+L+ APV K VPEDK DIK+TLE+EAR+  WLVLWLD
Sbjct: 65  VIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLD 124

Query: 123 CDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQ 182
           CDREGENIAFEVV+VC AV  +L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQ
Sbjct: 125 CDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQ 184

Query: 183 EIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEP 242
           EIDLRIGASFTRFQTMLL+D F IDS  ++++ ++SYGPCQFPTLGF+VERYWEIQ+HEP
Sbjct: 185 EIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEP 244

Query: 243 EEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNV-RRQETLKYP 302
           EEFWTINCSH S++G++TFNW RG+LFDY  AV+LYEMCV+E TATV+NV   +E  KYP
Sbjct: 245 EEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYP 304

Query: 303 PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQ 362
           P+PLNTIELEKRASRYFR+SSEHTMKVAE+LYQAGFISYPRTETD FS RTDL A+V+EQ
Sbjct: 305 PYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQ 364

Query: 363 QEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELV 422
             H  WG+YAQRLL+P  GLWRNP+ GGHDDKAHPPIHPTKFS+GE  WS+DH  VYELV
Sbjct: 365 TRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELV 424

Query: 423 VRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA----------------------- 482
           VRH+LACVSQPAV A TTVEIDIAGE FS SGR ILA                       
Sbjct: 425 VRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKG 484

Query: 483 --FVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNT 542
             F+PTTLTLD+ VTRPPPLL EADLLSCMDK GIGTDATMHDHIKKLLDR YATKD NT
Sbjct: 485 QQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANT 544

Query: 543 RFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF 602
           RF PTNLGEALVMGYDDMGY+LWKP+LRA+MEH+M  VS G K K EVL T LQQMK CF
Sbjct: 545 RFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACF 604

Query: 603 LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR------- 662
           LDAR+ K KLLEAM +FFERSN +   E+   GEVVRRC LC +SDM L++NR       
Sbjct: 605 LDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVG 664

Query: 663 ------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIG 722
                 CRN VWLPG   EA+VT++ C SC PGPVY I FKFRQ+ IPP ++ NHLGC+G
Sbjct: 665 CMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLGCVG 724

Query: 723 GCDDILRQLTEICGTGSRMSARGR-GTS-SSNVQRGNTGQS-VCIFCQQVGHSSNDCPSQ 782
           GCDDIL+QL +ICGTGSR  AR   GT+ S+N+Q  NT QS VCI CQQ GH+S +CPS+
Sbjct: 725 GCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNTRQSNVCIHCQQRGHASTNCPSR 784

Query: 783 VVGSRSARCW----QSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWED 842
           V  SR++R      ++ ES+VSC+TCG+ CVLRTANT  NRGR+F+ C +Q C+FF WED
Sbjct: 785 VPASRNSRPTATNPRNDESTVSCNTCGSQCVLRTANTEANRGRQFFSCPTQGCSFFAWED 844

Query: 843 NVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIA-------ATFVSAT 875
           +++N +G          ++ + +++   GR   RGRGRG   GQ +        +FVSAT
Sbjct: 845 SINNSSG----------NATTGSNSGGSGRRGSRGRGRGGRGGQSSGGRRGSGTSFVSAT 904

[Close]

BLAST of Tan0004448 vs. TAIR 10
Match: AT2G32000.1 (DNA topoisomerase, type IA, core )

HSP 1 Score: 376.7 bits (966), Expect = 5.0e-104
Identity = 233/640 (36.41%), Postives = 341/640 (53.28%), Query Frame = 0


Query: 7   ITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGH 66
           + VL VAEKPS+A S+A++LS  Q +  R G +   ++ EF+   RG   +  VTSV GH
Sbjct: 5   LRVLMVAEKPSIALSIASVLSHGQ-MSTRRGST---EVHEFDGMFRGFKAHYRVTSVIGH 64

Query: 67  LMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDRE 126
           +  ++F E+Y+ W + DP +LF AP+ K     K  I R L  EAR C ++VLWLDCDRE
Sbjct: 65  VFSVDFPEKYQNWATIDPQDLFDAPIIKKESNPKAHICRHLSNEARGCSYMVLWLDCDRE 124

Query: 127 GENIAFEVVEVC--TAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEI 186
           GENI FEV+E       +    + RA FS++ E+DI +A+ NLV+PN+  A AVDARQEI
Sbjct: 125 GENICFEVIESTGFDMKDSKRKVYRARFSSVTEKDISKAMDNLVEPNRDEALAVDARQEI 184

Query: 187 DLRIGASFTRFQTMLLKDAF-NIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPE 246
           DL++G +F+RFQT   +  + N+D        ++SYGPCQ PTLGF V+RY  I + +PE
Sbjct: 185 DLKVGVAFSRFQTSYFQGKYQNLDC------RVISYGPCQTPTLGFCVQRYMHINTFKPE 244

Query: 247 EFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPH 306
           +FW +      D       W R  LFD   A +  ++ V+  TA V++V  ++ +K  P 
Sbjct: 245 KFWALRPYIRKDGYELQLEWERRRLFDLEAATVFQKLVVEGRTAKVMDVSEKQEVKGRPA 304

Query: 307 PLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQE 366
            LNT+ L K AS       +  M +AE LY  GFISYPRTE+  +    D    ++ Q  
Sbjct: 305 GLNTVNLLKVASSALGFGPQTAMHLAERLYTQGFISYPRTESTAYPSSFDFTDTLRAQVS 364

Query: 367 HQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVR 426
           + +WG Y QRLL  G  + ++    G D   HPPI P + +A E     D  R+Y+ V +
Sbjct: 365 NPVWGGYVQRLLSDGFHMPKS----GTDAGDHPPITPMR-AATEVMVGGDAWRLYQYVCQ 424

Query: 427 HFLACVSQPAVGAVTTVEIDIAGELFSTSGRMI-----LAFVPTT--------------- 486
           HFL  VS       T VE+ I GE F  +G+ +      A +P +               
Sbjct: 425 HFLGTVSPNCKYIRTKVELSIGGETFHCTGQRVTEKGFTAIMPWSAVDEKKLPSFLKGER 484

Query: 487 -----LTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRF 546
                + L  G T PP  L+E++L+S M+K GIGTDA++  HI  + +R Y    +  + 
Sbjct: 485 IEVLRVELYEGNTAPPDYLTESELISLMEKHGIGTDASIAVHINNIGERNYVQVQSGRKM 544

Query: 547 MPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLD 606
           +PT LG  L+ GY  +   L  P +R+ +E ++  V++G      V+   +QQ +  F  
Sbjct: 545 VPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSHVVQHVIQQFRRKF-- 604

Query: 607 ARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC 619
                ++ +E M+  FE       D     G  + +CG C
Sbjct: 605 --SYFVQQIEHMDALFEAQFSPLADS----GRALSKCGKC 621

[Close]

BLAST of Tan0004448 vs. TAIR 10
Match: AT2G32000.2 (DNA topoisomerase, type IA, core )

HSP 1 Score: 337.4 bits (864), Expect = 3.4e-92
Identity = 208/580 (35.86%), Postives = 304/580 (52.41%), Query Frame = 0


Query: 67  LMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDRE 126
           +M  +F E+Y+ W + DP +LF AP+ K     K  I R L  EAR C ++VLWLDCDRE
Sbjct: 34  VMFSDFPEKYQNWATIDPQDLFDAPIIKKESNPKAHICRHLSNEARGCSYMVLWLDCDRE 93

Query: 127 GENIAFEVVEVC--TAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEI 186
           GENI FEV+E       +    + RA FS++ E+DI +A+ NLV+PN+  A AVDARQEI
Sbjct: 94  GENICFEVIESTGFDMKDSKRKVYRARFSSVTEKDISKAMDNLVEPNRDEALAVDARQEI 153

Query: 187 DLRIGASFTRFQTMLLKDAF-NIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPE 246
           DL++G +F+RFQT   +  + N+D        ++SYGPCQ PTLGF V+RY  I + +PE
Sbjct: 154 DLKVGVAFSRFQTSYFQGKYQNLDC------RVISYGPCQTPTLGFCVQRYMHINTFKPE 213

Query: 247 EFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPH 306
           +FW +      D       W R  LFD   A +  ++ V+  TA V++V  ++ +K  P 
Sbjct: 214 KFWALRPYIRKDGYELQLEWERRRLFDLEAATVFQKLVVEGRTAKVMDVSEKQEVKGRPA 273

Query: 307 PLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQE 366
            LNT+ L K AS       +  M +AE LY  GFISYPRTE+  +    D    ++ Q  
Sbjct: 274 GLNTVNLLKVASSALGFGPQTAMHLAERLYTQGFISYPRTESTAYPSSFDFTDTLRAQVS 333

Query: 367 HQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVR 426
           + +WG Y QRLL  G  + ++    G D   HPPI P + +A E     D  R+Y+ V +
Sbjct: 334 NPVWGGYVQRLLSDGFHMPKS----GTDAGDHPPITPMR-AATEVMVGGDAWRLYQYVCQ 393

Query: 427 HFLACVSQPAVGAVTTVEIDIAGELFSTSGRMI-----LAFVPTT--------------- 486
           HFL  VS       T VE+ I GE F  +G+ +      A +P +               
Sbjct: 394 HFLGTVSPNCKYIRTKVELSIGGETFHCTGQRVTEKGFTAIMPWSAVDEKKLPSFLKGER 453

Query: 487 -----LTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRF 546
                + L  G T PP  L+E++L+S M+K GIGTDA++  HI  + +R Y    +  + 
Sbjct: 454 IEVLRVELYEGNTAPPDYLTESELISLMEKHGIGTDASIAVHINNIGERNYVQVQSGRKM 513

Query: 547 MPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLD 606
           +PT LG  L+ GY  +   L  P +R+ +E ++  V++G      V+   +QQ +  F  
Sbjct: 514 VPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSHVVQHVIQQFRRKF-- 573

Query: 607 ARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC 619
                ++ +E M+  FE       D     G  + +CG C
Sbjct: 574 --SYFVQQIEHMDALFEAQFSPLADS----GRALSKCGKC 594

[Close]

BLAST of Tan0004448 vs. TAIR 10
Match: AT4G31210.1 (DNA topoisomerase, type IA, core )

HSP 1 Score: 79.0 bits (193), Expect = 2.2e-14
Identity = 88/356 (24.72%), Postives = 143/356 (40.17%), Query Frame = 0


Query: 117 LVLWLDCDREGENIAFEVVEVCT---AVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKW 176
           L+L  D DREGE IA+ ++E+     A++  + + R  F  + E  I  A+Q+  + +  
Sbjct: 548 LILASDPDREGEAIAWHIIEMLQQQGALHESMTVARVVFHEITESAIKSALQSPREIDGD 607

Query: 177 FADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDK-NVILSYGPCQFPTLGFVVE 236
              A  AR+ +D  IG              FNI  +   K     S G  Q   L  V +
Sbjct: 608 LVHAYLARRALDYLIG--------------FNISPLLWRKLPGCPSAGRVQSAALALVCD 667

Query: 237 RYWEIQSHEPEEFWTINCSHNSDDGISTF-------NWTRGNLFDYTCAVLL--YEMCVQ 296
           R  EI   +P+E+WT+       D  +TF       N  R N    +        E  ++
Sbjct: 668 RESEIDGFKPQEYWTVGIKVKGKDNSATFSAHLTSLNSKRLNQLSISSEANAQDIEQRIK 727

Query: 297 ESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQ--------- 356
                V   +   T K PP P  T  L++ A+     S+ HTMK+A+ LY+         
Sbjct: 728 SEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFSTAHTMKLAQKLYEGVQLSDGKS 787

Query: 357 AGFISYPRTETDCFSQRT--DLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDD 416
           AG I+Y RT+    +     D+ ++V E+          ++                +  
Sbjct: 788 AGLITYMRTDGLHIADEAIKDIQSLVAERYGKNFTSDSPRKYFKKVK----------NAQ 847

Query: 417 KAHPPIHPTKF----SAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDI 445
           +AH  I PT      S        D  ++Y L+    +AC  +PA  ++  +++DI
Sbjct: 848 EAHEAIRPTDIRRLPSTIASLLDADSLKLYTLIWSRAVACQMEPA--SIAQIQLDI 877

[Close]

BLAST of Tan0004448 vs. TAIR 10
Match: AT5G13920.1 (GRF zinc finger / Zinc knuckle protein )

HSP 1 Score: 55.1 bits (131), Expect = 3.4e-07
Identity = 30/76 (39.47%), Postives = 37/76 (48.68%), Query Frame = 0


Query: 724 CIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYK 783
           C  C+Q GH  NDCP +               ++ C   G  C ++ ANT  N GRKFYK
Sbjct: 11  CFRCRQAGHWINDCPLK-------SYTDDPPPAIQCPCGGGFCEIKVANTRENPGRKFYK 70

Query: 784 C-QSQECNFFIWEDNV 799
           C  +Q C FF W D V
Sbjct: 71  CPTAQNCCFFKWCDKV 79

The following BLAST results are available for this feature:

BLAST of Tan0004448 vs. ExPASy Swiss-Prot


Match Name	E-value	Identity	Description
Q9LVP1	0.0e+00	67.68	DNA topoisomerase 3-alpha OS=Arabidopsis thaliana OX=3702 GN=TOP3A PE=1 SV=1	[more]
C7J0A2	0.0e+00	64.97	DNA topoisomerase 3-alpha OS=Oryza sativa subsp. japonica OX=39947 GN=TOP3A PE=3...	[more]
Q13472	1.4e-183	42.12	DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1	[more]
O70157	1.4e-180	40.90	DNA topoisomerase 3-alpha OS=Mus musculus OX=10090 GN=Top3a PE=2 SV=1	[more]
Q8T2T7	1.1e-151	44.80	DNA topoisomerase 3 OS=Dictyostelium discoideum OX=44689 GN=top3 PE=3 SV=1	[more]

BLAST of Tan0004448 vs. NCBI nr


Match Name	E-value	Identity	Description
XP_038904102.1	0.0e+00	92.35	DNA topoisomerase 3-alpha isoform X2 [Benincasa hispida]	[more]
XP_038904101.1	0.0e+00	89.82	DNA topoisomerase 3-alpha isoform X1 [Benincasa hispida]	[more]
XP_022154286.1	0.0e+00	89.84	DNA topoisomerase 3-alpha [Momordica charantia]	[more]
XP_022982837.1	0.0e+00	89.19	DNA topoisomerase 3-alpha isoform X1 [Cucurbita maxima]	[more]
XP_008443145.1	0.0e+00	88.50	PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Cucumis melo]	[more]

BLAST of Tan0004448 vs. ExPASy TrEMBL


Match Name	E-value	Identity	Description
A0A6J1DNA0	0.0e+00	89.84	DNA topoisomerase OS=Momordica charantia OX=3673 GN=LOC111021577 PE=3 SV=1	[more]
A0A6J1IXM8	0.0e+00	89.19	DNA topoisomerase OS=Cucurbita maxima OX=3661 GN=LOC111481572 PE=3 SV=1	[more]
A0A1S3B7B9	0.0e+00	88.50	DNA topoisomerase OS=Cucumis melo OX=3656 GN=LOC103486821 PE=3 SV=1	[more]
A0A6J1F0T9	0.0e+00	89.08	DNA topoisomerase OS=Cucurbita moschata OX=3662 GN=LOC111441350 PE=3 SV=1	[more]
A0A0A0LBG7	0.0e+00	88.20	DNA topoisomerase OS=Cucumis sativus OX=3659 GN=Csa_3G813290 PE=3 SV=1	[more]

BLAST of Tan0004448 vs. TAIR 10


Match Name	E-value	Identity	Description
AT5G63920.1	0.0e+00	67.68	topoisomerase 3alpha	[more]
AT2G32000.1	5.0e-104	36.41	DNA topoisomerase, type IA, core	[more]
AT2G32000.2	3.4e-92	35.86	DNA topoisomerase, type IA, core	[more]
AT4G31210.1	2.2e-14	24.72	DNA topoisomerase, type IA, core	[more]
AT5G13920.1	3.4e-07	39.47	GRF zinc finger / Zinc knuckle protein	[more]

InterPro

Analysis Name: InterPro Annotations of Snake gourd (anguina) v1
Date Performed: 2021-10-25

Position :

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x 1


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR013497	DNA topoisomerase, type IA, central	PRINTS	PR00417	PRTPISMRASEI	coord: 335..344 score: 51.59 coord: 490..504 score: 40.89 coord: 217..235 score: 41.4 coord: 117..130 score: 53.58 coord: 417..433 score: 36.81
IPR013497	DNA topoisomerase, type IA, central	PFAM	PF01131	Topoisom_bac	coord: 172..457 e-value: 1.3E-69 score: 235.3 coord: 463..565 e-value: 4.0E-26 score: 92.0
IPR013497	DNA topoisomerase, type IA, central	CDD	cd00186	TOP1Ac	coord: 174..576 e-value: 5.7299E-135 score: 405.835
IPR006171	TOPRIM domain	SMART	SM00493	toprim5	coord: 8..143 e-value: 1.2E-17 score: 74.6
IPR006171	TOPRIM domain	PFAM	PF01751	Toprim	coord: 10..154 e-value: 4.5E-17 score: 62.2
IPR006171	TOPRIM domain	PROSITE	PS50880	TOPRIM	coord: 8..153 score: 17.968521
IPR001878	Zinc finger, CCHC-type	SMART	SM00343	c2hcfinal6	coord: 857..873 e-value: 0.0089 score: 23.9 coord: 723..739 e-value: 0.0097 score: 23.6
IPR001878	Zinc finger, CCHC-type	PROSITE	PS50158	ZF_CCHC	coord: 856..873 score: 8.729682
IPR003601	DNA topoisomerase, type IA, domain 2	SMART	SM00436	topIban2	coord: 146..247 e-value: 2.2E-28 score: 110.3
IPR003602	DNA topoisomerase, type IA, DNA-binding domain	SMART	SM00437	topIaneu2	coord: 293..528 e-value: 2.9E-64 score: 229.5
None	No IPR available	GENE3D	3.40.50.140		coord: 4..170 e-value: 9.5E-61 score: 206.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 802..838
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 803..824
None	No IPR available	PANTHER	PTHR11390:SF21	DNA TOPOISOMERASE 3-ALPHA	coord: 8..663
IPR013826	DNA topoisomerase, type IA, central region, subdomain 3	GENE3D	1.10.290.10	Topoisomerase I, domain 4	coord: 301..431 e-value: 1.2E-34 score: 121.4
IPR010666	Zinc finger, GRF-type	PFAM	PF06839	zf-GRF	coord: 758..797 e-value: 1.4E-11 score: 44.3
IPR013824	DNA topoisomerase, type IA, central region, subdomain 1	GENE3D	1.10.460.10	Topoisomerase I, domain 2	coord: 172..264 e-value: 9.6E-27 score: 95.7
IPR013824	DNA topoisomerase, type IA, central region, subdomain 1	GENE3D	1.10.460.10	Topoisomerase I, domain 2	coord: 461..598 e-value: 4.1E-34 score: 119.8
IPR000380	DNA topoisomerase, type IA	PANTHER	PTHR11390	PROKARYOTIC DNA TOPOISOMERASE	coord: 8..663
IPR023406	DNA topoisomerase, type IA, active site	PROSITE	PS00396	TOPOISOMERASE_I_PROK	coord: 330..344
IPR034144	DNA topoisomerase 3-like, TOPRIM domain	CDD	cd03362	TOPRIM_TopoIA_TopoIII	coord: 8..167 e-value: 6.55537E-53 score: 179.351
IPR036875	Zinc finger, CCHC-type superfamily	SUPERFAMILY	57756	Retrovirus zinc finger-like domains	coord: 706..740
IPR036875	Zinc finger, CCHC-type superfamily	SUPERFAMILY	57756	Retrovirus zinc finger-like domains	coord: 851..874
IPR023405	DNA topoisomerase, type IA, core domain	SUPERFAMILY	56712	Prokaryotic type I DNA topoisomerase	coord: 9..575

Relationships

The following mRNA feature(s) are a part of this gene:


Feature Name	Unique Name	Type
Tan0004448.1	Tan0004448.1	mRNA

GO Annotation

GO Assignments

This gene is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006265	DNA topological change
cellular_component	GO:0005694	chromosome
cellular_component	GO:0005634	nucleus
molecular_function	GO:0003677	DNA binding
molecular_function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity
molecular_function	GO:0008270	zinc ion binding
molecular_function	GO:0003916	DNA topoisomerase activity
molecular_function	GO:0003676	nucleic acid binding