Spg031287 (gene) Sponge gourd (cylindrica) v1

Overview
NameSpg031287
Typegene
OrganismLuffa cylindrica (Sponge gourd (cylindrica) v1)
Descriptionarabinogalactan peptide 20-like
Locationscaffold11: 43765684 .. 43766763 (+)
RNA-Seq ExpressionSpg031287
SyntenySpg031287
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: five_prime_UTRCDSpolypeptidethree_prime_UTR
Hold the cursor over a type above to highlight its positions in the sequence below.
AGCCCACGGATATTGGCATTGACGAATGCCACACTGGCTTTTGCCGGTTTCTTCTCCGTTCTCTCTCTTTTATAAAAACCAAATCACCACGTTATCCTCCGCCACTCTCTCTCTCTCTCTCTCTTCTTCTTCAACCTTTCATCAGAGCTTCGACGGACTGCAACAATGGCGTCCTCCCATTCCACTTCTAGGGCTTTCTCCGGCTTCTTCACATTCTTCGCTCTCCTCCTCTTCATTCTCTCGCCACTCGTTGACGCGCACTCTTCGGCCCCTGCTCCCCCTCCCGCTCCCGCAAGCGACGGTATCTAGATCCAACCTCCTTTCCATCTCCGGTTTATTTTTCTTTTCGCGTTCTTCTTTTTTCTTTTGTCTTCTTTGTCGGATGATGAAGAAGAATAATGTAGGTCTTTCGATTAGGGATTTCCGTTCTAGCACGAGCGATTACTTGCATTGCATTCTGAAATTCGGTTGGTTCGTAGGGAGATTTTCTGATTTGGAAGTGATTTGTTGATGGTTTTGTGCAAAATCAGGGACCTCCATAGACCAAGGGATTGCGTACGTGCTGATGCTGTTGGCGTTGGTTCTCACATACCTAATCCATCCTCTCGATGCGTCTTCCTACAACTTTTTTCTGAATTGAATTGTAGGATTGTAGCAATGTTGGCGCTGTTTTTGGGATTTGAAGATGCGTTTGTGGATAAATCATTGAAGGAAGTAGGGCCAACTTTCTTTCTCTCGTTGTGATAAAATGTAGGGTTGGAGAGGAATGTGCATATTGGGTTTGGCAAATTTTGATCAATTGTCTGATTGTTTATTCGATTACTTTTCTTTTCTTTCTTTTTTCCAATCATAATTTATTCATTGGATCCATTTTTCAAAGCTTTTCGAGTCTGCGACTTTGTTTGATTCCACCATTCTTTTTCTAATGTTATTGTCATCTTGAAGAGAATAGAATAGGGCCTTCACGTTGTGATTGAACTCTTCAAAAGTTTATCTAATTTCATCAATGGCCAAGCAAAACCTTCTGTAATTGTGTTTCTCTTCTCAAGAGGAGAGGCAAAAAACAATCAAAATAAGGAA

mRNA sequence

ATGGCGTCCTCCCATTCCACTTCTAGGGCTTTCTCCGGCTTCTTCACATTCTTCGCTCTCCTCCTCTTCATTCTCTCGCCACTCGTTGACGCGCACTCTTCGGCCCCTGCTCCCCCTCCCGCTCCCGCAAGCGACGGGACCTCCATAGACCAAGGGATTGCGTACGTGCTGATGCTGTTGGCGTTGGTTCTCACATACCTAATCCATCCTCTCGATGCGTCTTCCTACAACTTTTTTCTGAATTGA

Coding sequence (CDS)

ATGGCGTCCTCCCATTCCACTTCTAGGGCTTTCTCCGGCTTCTTCACATTCTTCGCTCTCCTCCTCTTCATTCTCTCGCCACTCGTTGACGCGCACTCTTCGGCCCCTGCTCCCCCTCCCGCTCCCGCAAGCGACGGGACCTCCATAGACCAAGGGATTGCGTACGTGCTGATGCTGTTGGCGTTGGTTCTCACATACCTAATCCATCCTCTCGATGCGTCTTCCTACAACTTTTTTCTGAATTGA

Protein sequence

MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLTYLIHPLDASSYNFFLN
Homology
BLAST of Spg031287 vs. NCBI nr
Match: XP_023528757.1 (arabinogalactan peptide 16-like [Cucurbita pepo subsp. pepo] >KAG7019041.1 Arabinogalactan peptide 16 [Cucurbita argyrosperma subsp. argyrosperma])

HSP 1 Score: 142.5 bits (358), Expect = 1.6e-30
Identity = 73/81 (90.12%), Postives = 77/81 (95.06%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLL 60
          MASS+STSRAFSG FTFF L+LFILSPLVDAHSS PAP PAPASDGTSIDQG+AYVLML+
Sbjct: 1  MASSNSTSRAFSGLFTFFTLILFILSPLVDAHSSVPAPAPAPASDGTSIDQGVAYVLMLV 60

Query: 61 ALVLTYLIHPLDASSYNFFLN 82
          ALVLTYLIHPLDASSYNFFLN
Sbjct: 61 ALVLTYLIHPLDASSYNFFLN 81

BLAST of Spg031287 vs. NCBI nr
Match: XP_022924337.1 (arabinogalactan peptide 16-like [Cucurbita moschata] >KAG6582645.1 Arabinogalactan protein 16, partial [Cucurbita argyrosperma subsp. sororia])

HSP 1 Score: 139.0 bits (349), Expect = 1.8e-29
Identity = 74/83 (89.16%), Postives = 78/83 (93.98%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSS--APAPPPAPASDGTSIDQGIAYVLM 60
          MASS+STSRAFSG FTFF L+LFILSPLVDAHSS  APAP PAPASDGTSIDQG+AYVLM
Sbjct: 1  MASSNSTSRAFSGLFTFFTLILFILSPLVDAHSSVPAPAPAPAPASDGTSIDQGVAYVLM 60

Query: 61 LLALVLTYLIHPLDASSYNFFLN 82
          L+ALVLTYLIHPLDASSYNFFLN
Sbjct: 61 LVALVLTYLIHPLDASSYNFFLN 83

BLAST of Spg031287 vs. NCBI nr
Match: XP_022147463.1 (arabinogalactan peptide 20-like [Momordica charantia])

HSP 1 Score: 137.5 bits (345), Expect = 5.1e-29
Identity = 73/81 (90.12%), Postives = 75/81 (92.59%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLL 60
          MASS STSRAFS  FT FAL+ FI+SPLVDAHSSAPAP PAPASDGTSIDQGIAYVLMLL
Sbjct: 1  MASSISTSRAFSSLFTAFALIFFIVSPLVDAHSSAPAPAPAPASDGTSIDQGIAYVLMLL 60

Query: 61 ALVLTYLIHPLDASSYNFFLN 82
          ALVLTYLIHPLDASSYNFFLN
Sbjct: 61 ALVLTYLIHPLDASSYNFFLN 81

BLAST of Spg031287 vs. NCBI nr
Match: XP_022979386.1 (arabinogalactan peptide 20-like [Cucurbita maxima])

HSP 1 Score: 131.7 bits (330), Expect = 2.8e-27
Identity = 70/83 (84.34%), Postives = 76/83 (91.57%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSS--APAPPPAPASDGTSIDQGIAYVLM 60
          MASS+ST RAFSG FTFF L+LFILSPL+DAHSS  +PAP PAPASDGTSIDQG+AYVLM
Sbjct: 1  MASSNSTFRAFSGLFTFFTLILFILSPLIDAHSSVPSPAPAPAPASDGTSIDQGVAYVLM 60

Query: 61 LLALVLTYLIHPLDASSYNFFLN 82
          L+ALVLTYLIHPLDASS NFFLN
Sbjct: 61 LVALVLTYLIHPLDASSNNFFLN 83

BLAST of Spg031287 vs. NCBI nr
Match: XP_038905636.1 (arabinogalactan protein 41-like [Benincasa hispida])

HSP 1 Score: 129.0 bits (323), Expect = 1.8e-26
Identity = 70/81 (86.42%), Postives = 74/81 (91.36%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLL 60
          M SS+STSRAFSG FTFFAL+ FILSPLVDA   APAP PAPASDGTSIDQGIAYVLML+
Sbjct: 1  MESSNSTSRAFSGLFTFFALIFFILSPLVDA---APAPAPAPASDGTSIDQGIAYVLMLV 60

Query: 61 ALVLTYLIHPLDASSYNFFLN 82
          ALVLTYLIHPLDASSY+FFLN
Sbjct: 61 ALVLTYLIHPLDASSYSFFLN 78

BLAST of Spg031287 vs. ExPASy Swiss-Prot
Match: Q9M373 (Arabinogalactan protein 20 OS=Arabidopsis thaliana OX=3702 GN=AGP20 PE=1 SV=1)

HSP 1 Score: 77.4 bits (189), Expect = 8.2e-14
Identity = 45/74 (60.81%), Postives = 52/74 (70.27%), Query Frame = 0

Query: 8  SRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLTYL 67
          SR        FA +  ++SP   A S APA  P+P SDGTSIDQGIAY+LM++ALVLTYL
Sbjct: 3  SRNSVAVIALFAFVFAVISPFAGAQSLAPA--PSPTSDGTSIDQGIAYLLMVVALVLTYL 62

Query: 68 IHPLDA--SSYNFF 80
          IHPLDA  SSY FF
Sbjct: 63 IHPLDASSSSYTFF 74

BLAST of Spg031287 vs. ExPASy Swiss-Prot
Match: O82337 (Arabinogalactan protein 16 OS=Arabidopsis thaliana OX=3702 GN=AGP16 PE=1 SV=1)

HSP 1 Score: 76.3 bits (186), Expect = 1.8e-13
Identity = 43/66 (65.15%), Postives = 51/66 (77.27%), Query Frame = 0

Query: 15 FTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLTYLIHPLDA- 74
          F  F+ +  ++  L  A S APA  PAP SDGTSIDQGIAY+LM++ALVLTYLIHPLDA 
Sbjct: 10 FALFSFVFAVILSLAGAQSLAPA--PAPTSDGTSIDQGIAYLLMVVALVLTYLIHPLDAS 69

Query: 75 SSYNFF 80
          SSY+FF
Sbjct: 70 SSYSFF 73

BLAST of Spg031287 vs. ExPASy Swiss-Prot
Match: Q8L9T8 (Arabinogalactan protein 41 OS=Arabidopsis thaliana OX=3702 GN=AGP41 PE=1 SV=1)

HSP 1 Score: 70.9 bits (172), Expect = 7.7e-12
Identity = 40/64 (62.50%), Postives = 48/64 (75.00%), Query Frame = 0

Query: 6  STSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLT 65
          S SR F G  T  +++  IL P+  AH+ + AP PAP SDGT+IDQGIAYVLML+ALVLT
Sbjct: 2  SGSRLFFGVSTIVSIIFAILLPM--AHAQSAAPAPAPTSDGTTIDQGIAYVLMLVALVLT 61

Query: 66 YLIH 70
          YLIH
Sbjct: 62 YLIH 63

BLAST of Spg031287 vs. ExPASy Swiss-Prot
Match: Q9FK16 (Arabinogalactan protein 22 OS=Arabidopsis thaliana OX=3702 GN=AGP22 PE=1 SV=1)

HSP 1 Score: 65.9 bits (159), Expect = 2.5e-10
Identity = 34/52 (65.38%), Postives = 41/52 (78.85%), Query Frame = 0

Query: 18 FALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLTYLIH 70
          F ++  IL P+  +HSS+PA  PAP SDGTSIDQGIAYVLM++AL LTY IH
Sbjct: 14 FVIISVILLPIAQSHSSSPA--PAPTSDGTSIDQGIAYVLMMVALALTYFIH 63

BLAST of Spg031287 vs. ExPASy TrEMBL
Match: A0A6J1E8M6 (arabinogalactan peptide 16-like OS=Cucurbita moschata OX=3662 GN=LOC111431859 PE=4 SV=1)

HSP 1 Score: 139.0 bits (349), Expect = 8.5e-30
Identity = 74/83 (89.16%), Postives = 78/83 (93.98%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSS--APAPPPAPASDGTSIDQGIAYVLM 60
          MASS+STSRAFSG FTFF L+LFILSPLVDAHSS  APAP PAPASDGTSIDQG+AYVLM
Sbjct: 1  MASSNSTSRAFSGLFTFFTLILFILSPLVDAHSSVPAPAPAPAPASDGTSIDQGVAYVLM 60

Query: 61 LLALVLTYLIHPLDASSYNFFLN 82
          L+ALVLTYLIHPLDASSYNFFLN
Sbjct: 61 LVALVLTYLIHPLDASSYNFFLN 83

BLAST of Spg031287 vs. ExPASy TrEMBL
Match: A0A6J1D1D7 (arabinogalactan peptide 20-like OS=Momordica charantia OX=3673 GN=LOC111016381 PE=4 SV=1)

HSP 1 Score: 137.5 bits (345), Expect = 2.5e-29
Identity = 73/81 (90.12%), Postives = 75/81 (92.59%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLL 60
          MASS STSRAFS  FT FAL+ FI+SPLVDAHSSAPAP PAPASDGTSIDQGIAYVLMLL
Sbjct: 1  MASSISTSRAFSSLFTAFALIFFIVSPLVDAHSSAPAPAPAPASDGTSIDQGIAYVLMLL 60

Query: 61 ALVLTYLIHPLDASSYNFFLN 82
          ALVLTYLIHPLDASSYNFFLN
Sbjct: 61 ALVLTYLIHPLDASSYNFFLN 81

BLAST of Spg031287 vs. ExPASy TrEMBL
Match: A0A6J1IQM6 (arabinogalactan peptide 20-like OS=Cucurbita maxima OX=3661 GN=LOC111479127 PE=4 SV=1)

HSP 1 Score: 131.7 bits (330), Expect = 1.4e-27
Identity = 70/83 (84.34%), Postives = 76/83 (91.57%), Query Frame = 0

Query: 1  MASSHSTSRAFSGFFTFFALLLFILSPLVDAHSS--APAPPPAPASDGTSIDQGIAYVLM 60
          MASS+ST RAFSG FTFF L+LFILSPL+DAHSS  +PAP PAPASDGTSIDQG+AYVLM
Sbjct: 1  MASSNSTFRAFSGLFTFFTLILFILSPLIDAHSSVPSPAPAPAPASDGTSIDQGVAYVLM 60

Query: 61 LLALVLTYLIHPLDASSYNFFLN 82
          L+ALVLTYLIHPLDASS NFFLN
Sbjct: 61 LVALVLTYLIHPLDASSNNFFLN 83

BLAST of Spg031287 vs. ExPASy TrEMBL
Match: A0A6J1IAU1 (arabinogalactan peptide 16-like OS=Cucurbita maxima OX=3661 GN=LOC111473327 PE=4 SV=1)

HSP 1 Score: 125.6 bits (314), Expect = 9.7e-26
Identity = 67/80 (83.75%), Postives = 70/80 (87.50%), Query Frame = 0

Query: 2  ASSHSTSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLA 61
          +SS ST  AFSGFFT FAL+ FIL PLV AHSSA AP PAPASDGTSIDQGIAYVLML+A
Sbjct: 3  SSSDSTPTAFSGFFTCFALIFFILLPLVHAHSSASAPAPAPASDGTSIDQGIAYVLMLMA 62

Query: 62 LVLTYLIHPLDASSYNFFLN 82
          LVLTYLIHPLDASSY FFLN
Sbjct: 63 LVLTYLIHPLDASSYQFFLN 82

BLAST of Spg031287 vs. ExPASy TrEMBL
Match: A0A6J1F1F2 (arabinogalactan peptide 20-like OS=Cucurbita moschata OX=3662 GN=LOC111441255 PE=4 SV=1)

HSP 1 Score: 125.6 bits (314), Expect = 9.7e-26
Identity = 67/79 (84.81%), Postives = 70/79 (88.61%), Query Frame = 0

Query: 2  ASSHSTSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLA 61
          +SS ST  AFSGFFT FAL+ FILSPLV AHSSA AP PAPASDGTSIDQGIAYVLML+A
Sbjct: 4  SSSDSTPTAFSGFFTCFALIFFILSPLVHAHSSASAPAPAPASDGTSIDQGIAYVLMLMA 63

Query: 62 LVLTYLIHPLDASSYNFFL 81
          LVLTYLIHPLDASSY FFL
Sbjct: 64 LVLTYLIHPLDASSYQFFL 82

BLAST of Spg031287 vs. TAIR 10
Match: AT3G61640.1 (arabinogalactan protein 20 )

HSP 1 Score: 77.4 bits (189), Expect = 5.8e-15
Identity = 45/74 (60.81%), Postives = 52/74 (70.27%), Query Frame = 0

Query: 8  SRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLTYL 67
          SR        FA +  ++SP   A S APA  P+P SDGTSIDQGIAY+LM++ALVLTYL
Sbjct: 3  SRNSVAVIALFAFVFAVISPFAGAQSLAPA--PSPTSDGTSIDQGIAYLLMVVALVLTYL 62

Query: 68 IHPLDA--SSYNFF 80
          IHPLDA  SSY FF
Sbjct: 63 IHPLDASSSSYTFF 74

BLAST of Spg031287 vs. TAIR 10
Match: AT2G46330.1 (arabinogalactan protein 16 )

HSP 1 Score: 76.3 bits (186), Expect = 1.3e-14
Identity = 43/66 (65.15%), Postives = 51/66 (77.27%), Query Frame = 0

Query: 15 FTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLTYLIHPLDA- 74
          F  F+ +  ++  L  A S APA  PAP SDGTSIDQGIAY+LM++ALVLTYLIHPLDA 
Sbjct: 10 FALFSFVFAVILSLAGAQSLAPA--PAPTSDGTSIDQGIAYLLMVVALVLTYLIHPLDAS 69

Query: 75 SSYNFF 80
          SSY+FF
Sbjct: 70 SSYSFF 73

BLAST of Spg031287 vs. TAIR 10
Match: AT5G24105.1 (arabinogalactan protein 41 )

HSP 1 Score: 70.9 bits (172), Expect = 5.5e-13
Identity = 40/64 (62.50%), Postives = 48/64 (75.00%), Query Frame = 0

Query: 6  STSRAFSGFFTFFALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLT 65
          S SR F G  T  +++  IL P+  AH+ + AP PAP SDGT+IDQGIAYVLML+ALVLT
Sbjct: 2  SGSRLFFGVSTIVSIIFAILLPM--AHAQSAAPAPAPTSDGTTIDQGIAYVLMLVALVLT 61

Query: 66 YLIH 70
          YLIH
Sbjct: 62 YLIH 63

BLAST of Spg031287 vs. TAIR 10
Match: AT5G53250.1 (arabinogalactan protein 22 )

HSP 1 Score: 65.9 bits (159), Expect = 1.8e-11
Identity = 34/52 (65.38%), Postives = 41/52 (78.85%), Query Frame = 0

Query: 18 FALLLFILSPLVDAHSSAPAPPPAPASDGTSIDQGIAYVLMLLALVLTYLIH 70
          F ++  IL P+  +HSS+PA  PAP SDGTSIDQGIAYVLM++AL LTY IH
Sbjct: 14 FVIISVILLPIAQSHSSSPA--PAPTSDGTSIDQGIAYVLMMVALALTYFIH 63

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
XP_023528757.11.6e-3090.12arabinogalactan peptide 16-like [Cucurbita pepo subsp. pepo] >KAG7019041.1 Arabi... [more]
XP_022924337.11.8e-2989.16arabinogalactan peptide 16-like [Cucurbita moschata] >KAG6582645.1 Arabinogalact... [more]
XP_022147463.15.1e-2990.12arabinogalactan peptide 20-like [Momordica charantia][more]
XP_022979386.12.8e-2784.34arabinogalactan peptide 20-like [Cucurbita maxima][more]
XP_038905636.11.8e-2686.42arabinogalactan protein 41-like [Benincasa hispida][more]
Match NameE-valueIdentityDescription
Q9M3738.2e-1460.81Arabinogalactan protein 20 OS=Arabidopsis thaliana OX=3702 GN=AGP20 PE=1 SV=1[more]
O823371.8e-1365.15Arabinogalactan protein 16 OS=Arabidopsis thaliana OX=3702 GN=AGP16 PE=1 SV=1[more]
Q8L9T87.7e-1262.50Arabinogalactan protein 41 OS=Arabidopsis thaliana OX=3702 GN=AGP41 PE=1 SV=1[more]
Q9FK162.5e-1065.38Arabinogalactan protein 22 OS=Arabidopsis thaliana OX=3702 GN=AGP22 PE=1 SV=1[more]
Match NameE-valueIdentityDescription
A0A6J1E8M68.5e-3089.16arabinogalactan peptide 16-like OS=Cucurbita moschata OX=3662 GN=LOC111431859 PE... [more]
A0A6J1D1D72.5e-2990.12arabinogalactan peptide 20-like OS=Momordica charantia OX=3673 GN=LOC111016381 P... [more]
A0A6J1IQM61.4e-2784.34arabinogalactan peptide 20-like OS=Cucurbita maxima OX=3661 GN=LOC111479127 PE=4... [more]
A0A6J1IAU19.7e-2683.75arabinogalactan peptide 16-like OS=Cucurbita maxima OX=3661 GN=LOC111473327 PE=4... [more]
A0A6J1F1F29.7e-2684.81arabinogalactan peptide 20-like OS=Cucurbita moschata OX=3662 GN=LOC111441255 PE... [more]
Match NameE-valueIdentityDescription
AT3G61640.15.8e-1560.81arabinogalactan protein 20 [more]
AT2G46330.11.3e-1465.15arabinogalactan protein 16 [more]
AT5G24105.15.5e-1362.50arabinogalactan protein 41 [more]
AT5G53250.11.8e-1165.38arabinogalactan protein 22 [more]
InterPro
Analysis Name: InterPro Annotations of Sponge gourd (cylindrica) v1
Date Performed: 2022-08-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009424Arabinogalactan protein 16/20/22/41PFAMPF06376AGPcoord: 35..69
e-value: 1.4E-18
score: 66.5
IPR009424Arabinogalactan protein 16/20/22/41PANTHERPTHR33374ARABINOGALACTAN PROTEIN 20coord: 7..76
NoneNo IPR availablePANTHERPTHR33374:SF38ARABINOGALACTAN PROTEIN 41coord: 7..76

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Spg031287.1Spg031287.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
cellular_component GO:0016021 integral component of membrane