Pay0008280 (gene) Melon (Payzawat) v1

Overview
NamePay0008280
Typegene
OrganismCucumis melo L. var. inodorus cv. Payzawat (Melon (Payzawat) v1)
DescriptionComplex1_LYR domain-containing protein
Locationchr06: 5430826 .. 5433314 (+)
RNA-Seq ExpressionPay0008280
SyntenyPay0008280
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonfive_prime_UTRCDSpolypeptidethree_prime_UTR
Hold the cursor over a type above to highlight its positions in the sequence below.
ATCGACCCAACTCTTCAAATCAAATTCGGGAGTTTCGTTTGATTCTTGTTCGATTTTCTTCATCCTTTCCCTCTTTTTCCATACTCAAGCTCGTCACAAGCCACCAAGAGGAGCCGCCGGAGGAGGTAATAGATCTTTTATCTTGAATCCTTTTCATATTTAGTCACATATTCCGCTTCTTCGTGGACGAACTTCCCACGAGAAAGAGAACGATAAACCTGAAGGAACAGAAGGCAGAGATTAATGAGAATAATTAGAATAGACCCATTATGGCTGTATGAAATGGAATGATTGGGTGTGGGAGTCTTTAGTTGATCCAGCTTGAATTTATTAGTAACTTTCAATTTTATGTTTCAGCCGTAATAACTGTTTTCTTCCGTTTGATCCTTGTCTTTTTGACTCTTTGGTAGTTTCTCGTTGTAGCGAACTAATCATTTTAATGAATACAGAAGGTGTGTTAGTGAAACGGGCGGAAATGCCATCTCTACAGACTGCTCTACCTCCTGAGCTTGCTAATAATGTCATTAGGGTTGGTCCCCCTCCTATCCATTTTTTGCAATACAATTTTCTCCTCAAATTTTCTTAACTTTACATGTTGTATCATTGCAGCTTTACCGCGAGTGCCTTCGAAGGGCCAAGTTTGTTGGTCATCGGGTATGGATGTTCCCTTTGTTTTTTATTTTATCTAATCCAATGGCCCCATTCGAGTAATTTTGCATTTGAATAATTTAAAAAGGTTACTGATTCAATGAGAAGTGAAAAGTTAAAGCTTAATACTCCAGGTTAATTGCAATTATCCAATCAATGAGTTCATTCGTTTATTTCTTTATTTGCCATTTGGGTACTGTGCTGCATCAAGCCTATAGTTGAATTCGTGCAGGACATAACCTTACTGCAAAGCTATGTTCTCACTATTCATATCAATCAGTCAAAATATGACTATAGGAATTGAACAATCCACCGAAACATAGTATTTTGTATGTAAAAGCGCCTTTGCTACCTGCCTCCCATGATCATGTTTTAAGTATTTCCAGTGGCTAGGTTGTTGCGCTGGATGTAGAATGATTGCAGACTTGTTAATGGCAATGGAGTTTTAGATATTGGTACAACGAAAGACTATAGAGTTATTCTAAGAAGTTCATATTTTGTTTCTACTAACGTCAAGATTTACTAGTCAAGAAATATACATTACAAGTAGATATTTCTTCACCTTATTTAATGCTAATAATGCTTATAAGTCAAGGACGCAGTTGTACAACCTATAGAATAGATCTTGTTCAAGTAAGGTCATTAATGCTAATAATTTTCTGTATAAAGTTCACAATATTAGGTGTAAAATGGAAATCCCTATTCATTTCACCCGCACTTCAAAGTTAGAAATGATTTGAAAATTAATTGACGCACTCCATCTTGTTGACTGTGATATTAGGTTTCCTCTTTCCTTGACTGTATCCTCTCTTTTTTGCTGAATTAGGTTATAGTTCTTATCTGTTTTGACTTAAAAAATTGTGCTCACATTTCAAATTAGTTGTACCCAGTTACAGGAAGGTGTAGAGGATTCGACATTGGTTCTTTGACACTTGTTAAACTTGAATCCTATCAACTTCTTGCAGCAACATAACACCGAGCTTATTGTCGATATGGTGAGGCAACAATTCAAAAAGAACATGCATGAGACTGACCCAGAGAAGATTCAGAAGATGAAAGATGAGTATGTCTTATGATTGCCTTTTTTCCCTTGTTTCGTTCCTTCTCTTTTTCCACACTCTCTTTCGCAGCCGGAAGTCATATTAAAAAGAAATTTGTAGAAGAATACAAGTAGGAAAGGCATCCGATCAAACCCAAAGTGAAGAGACCACATTTATATTTTCTGATTAGAACTTGTGTGGGTATGGCCCTCACATTTCTGTGTATATAATTGTTTGTTTGCAGGGCTGCTAGGGGACTTATAAACCATATGCTATACGAACATGAGAGAATGTCAGGTCAAAAATTGAGCCAAAGTTCTTGATGTTATATCGAAAATGACATTGAGTGAAAGTTCACCATTGGAACTTCAGTCAGACATTGTAGGAATAAGATGGCTAATGATGAAAGTACTCCTCGGAGGTTGTTTTTGCGTTTCCTTGTTTATTTCTACTATTTGTTCAGAAATCGTCAAATTCTACGGTAGTTGGTGAACGTTTTTCCATCTACAATCTACATTTTATTGCGGAAAGTGGATGTCCAAGGAAGATATGGCATATTGCACATCTCTGATGTCGGGTTCTCTTTTTTAGTGTCTGTTGGTTTCGTGCACTTTGACTATTTTCGTGGAATTTTTTACTACACTCACCTAGTTGTTAAGGTAACTTAGACTATTATATCTTGTATGGATGGTTACTATGGTTTAAACTCGTTGTTTTTTAAGTTTTGTATGATTGGTATTTTTTTTTATGAGATTTATTATGGTAATTGTTAATGGAAATCCAAGGAGAAGAATTGTCGCC

mRNA sequence

ATCGACCCAACTCTTCAAATCAAATTCGGGAGTTTCGTTTGATTCTTGTTCGATTTTCTTCATCCTTTCCCTCTTTTTCCATACTCAAGCTCGTCACAAGCCACCAAGAGGAGCCGCCGGAGGAGAAGGTGTGTTAGTGAAACGGGCGGAAATGCCATCTCTACAGACTGCTCTACCTCCTGAGCTTGCTAATAATGTCATTAGGCTTTACCGCGAGTGCCTTCGAAGGGCCAAGTTTGTTGGTCATCGGCAACATAACACCGAGCTTATTGTCGATATGGTGAGGCAACAATTCAAAAAGAACATGCATGAGACTGACCCAGAGAAGATTCAGAAGATGAAAGATGAGGCTGCTAGGGGACTTATAAACCATATGCTATACGAACATGAGAGAATGTCAGGTCAAAAATTGAGCCAAAGTTCTTGATGTTATATCGAAAATGACATTGAGTGAAAGTTCACCATTGGAACTTCAGTCAGACATTGTAGGAATAAGATGGCTAATGATGAAAGTACTCCTCGGAGGTTGTTTTTGCGTTTCCTTGTTTATTTCTACTATTTGTTCAGAAATCGTCAAATTCTACGGTAGTTGGTGAACGTTTTTCCATCTACAATCTACATTTTATTGCGGAAAGTGGATGTCCAAGGAAGATATGGCATATTGCACATCTCTGATGTCGGGTTCTCTTTTTTAGTGTCTGTTGGTTTCGTGCACTTTGACTATTTTCGTGGAATTTTTTACTACACTCACCTAGTTGTTAAGGTAACTTAGACTATTATATCTTGTATGGATGGTTACTATGGTTTAAACTCGTTGTTTTTTAAGTTTTGTATGATTGGTATTTTTTTTTATGAGATTTATTATGGTAATTGTTAATGGAAATCCAAGGAGAAGAATTGTCGCC

Coding sequence (CDS)

ATGCCATCTCTACAGACTGCTCTACCTCCTGAGCTTGCTAATAATGTCATTAGGCTTTACCGCGAGTGCCTTCGAAGGGCCAAGTTTGTTGGTCATCGGCAACATAACACCGAGCTTATTGTCGATATGGTGAGGCAACAATTCAAAAAGAACATGCATGAGACTGACCCAGAGAAGATTCAGAAGATGAAAGATGAGGCTGCTAGGGGACTTATAAACCATATGCTATACGAACATGAGAGAATGTCAGGTCAAAAATTGAGCCAAAGTTCTTGA

Protein sequence

MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKIQKMKDEAARGLINHMLYEHERMSGQKLSQSS
Homology
BLAST of Pay0008280 vs. ExPASy TrEMBL
Match: A0A1S3AYB1 (uncharacterized protein LOC103483919 OS=Cucumis melo OX=3656 GN=LOC103483919 PE=4 SV=1)

HSP 1 Score: 182.6 bits (462), Expect = 7.5e-43
Identity = 91/91 (100.00%), Postives = 91/91 (100.00%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QKMKDEAARGLINHMLYEHERMSGQKLSQSS
Sbjct: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 91

BLAST of Pay0008280 vs. ExPASy TrEMBL
Match: A0A5A7UD86 (Complex1_LYR domain-containing protein OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold1769G00350 PE=4 SV=1)

HSP 1 Score: 182.6 bits (462), Expect = 7.5e-43
Identity = 91/91 (100.00%), Postives = 91/91 (100.00%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QKMKDEAARGLINHMLYEHERMSGQKLSQSS
Sbjct: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 91

BLAST of Pay0008280 vs. ExPASy TrEMBL
Match: A0A0A0L5F6 (Uncharacterized protein OS=Cucumis sativus OX=3659 GN=Csa_3G171030 PE=4 SV=1)

HSP 1 Score: 169.5 bits (428), Expect = 6.6e-39
Identity = 83/90 (92.22%), Postives = 87/90 (96.67%), Query Frame = 0

Query: 2   PSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKIQ 61
           P  +TALPPELANNVIRLYRECLRRAKF+GHRQHNTELIVDMVRQQFKKNMHETDPEKIQ
Sbjct: 84  PREKTALPPELANNVIRLYRECLRRAKFLGHRQHNTELIVDMVRQQFKKNMHETDPEKIQ 143

Query: 62  KMKDEAARGLINHMLYEHERMSGQKLSQSS 92
           KMKD+AARGLINHMLYEHERMSG+K SQSS
Sbjct: 144 KMKDDAARGLINHMLYEHERMSGKKFSQSS 173

BLAST of Pay0008280 vs. ExPASy TrEMBL
Match: A0A1U8AWB6 (uncharacterized protein LOC104607091 isoform X2 OS=Nelumbo nucifera OX=4432 GN=LOC104607091 PE=4 SV=1)

HSP 1 Score: 165.2 bits (417), Expect = 1.2e-37
Identity = 79/91 (86.81%), Postives = 88/91 (96.70%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRA+F+GHRQHNTEL+VDMVRQQFKK+MHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRARFIGHRQHNTELVVDMVRQQFKKHMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QK+KD+AARGLINH+LYE E+MSG+K S SS
Sbjct: 61 QKLKDDAARGLINHILYESEKMSGRKFSSSS 91

BLAST of Pay0008280 vs. ExPASy TrEMBL
Match: A0A6J1HLJ6 (uncharacterized protein LOC111464671 OS=Cucurbita moschata OX=3662 GN=LOC111464671 PE=4 SV=1)

HSP 1 Score: 164.9 bits (416), Expect = 1.6e-37
Identity = 78/91 (85.71%), Postives = 89/91 (97.80%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRAKF+GHRQHNT+L+V MV+QQF+KNMHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRAKFIGHRQHNTDLVVSMVKQQFRKNMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QK+KD+AARGLINH+LYE ER++G+KLSQSS
Sbjct: 61 QKLKDDAARGLINHILYESERLTGRKLSQSS 91

BLAST of Pay0008280 vs. NCBI nr
Match: XP_008438986.1 (PREDICTED: uncharacterized protein LOC103483919 [Cucumis melo] >XP_008438987.1 PREDICTED: uncharacterized protein LOC103483919 [Cucumis melo] >KAA0052166.1 Complex1_LYR domain-containing protein [Cucumis melo var. makuwa] >TYK05131.1 Complex1_LYR domain-containing protein [Cucumis melo var. makuwa])

HSP 1 Score: 182.6 bits (462), Expect = 1.6e-42
Identity = 91/91 (100.00%), Postives = 91/91 (100.00%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QKMKDEAARGLINHMLYEHERMSGQKLSQSS
Sbjct: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 91

BLAST of Pay0008280 vs. NCBI nr
Match: XP_004147626.1 (uncharacterized protein LOC101203751 [Cucumis sativus] >XP_011651093.1 uncharacterized protein LOC101203751 [Cucumis sativus] >KAE8650410.1 hypothetical protein Csa_010313 [Cucumis sativus])

HSP 1 Score: 177.2 bits (448), Expect = 6.5e-41
Identity = 87/91 (95.60%), Postives = 90/91 (98.90%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRAKF+GHRQHNTELIVDMVRQQFKKNMHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRAKFLGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QKMKD+AARGLINHMLYEHERMSG+K SQSS
Sbjct: 61 QKMKDDAARGLINHMLYEHERMSGKKFSQSS 91

BLAST of Pay0008280 vs. NCBI nr
Match: XP_031490696.1 (uncharacterized protein LOC116257839 isoform X2 [Nymphaea colorata])

HSP 1 Score: 166.0 bits (419), Expect = 1.5e-37
Identity = 80/90 (88.89%), Postives = 87/90 (96.67%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPP+LANNVIRLYRECLRRAKFVGHRQHN EL+VDMVRQQFKKNMHETDPEKI
Sbjct: 1  MPSLQTALPPDLANNVIRLYRECLRRAKFVGHRQHNVELVVDMVRQQFKKNMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQS 91
          QKMKD+AARGLINHML+E ER+SG+K S+S
Sbjct: 61 QKMKDDAARGLINHMLFESERLSGRKFSKS 90

BLAST of Pay0008280 vs. NCBI nr
Match: XP_010270901.1 (PREDICTED: uncharacterized protein LOC104607091 isoform X2 [Nelumbo nucifera] >DAD38383.1 TPA_asm: hypothetical protein HUJ06_009024 [Nelumbo nucifera])

HSP 1 Score: 165.2 bits (417), Expect = 2.6e-37
Identity = 79/91 (86.81%), Postives = 88/91 (96.70%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRA+F+GHRQHNTEL+VDMVRQQFKK+MHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRARFIGHRQHNTELVVDMVRQQFKKHMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QK+KD+AARGLINH+LYE E+MSG+K S SS
Sbjct: 61 QKLKDDAARGLINHILYESEKMSGRKFSSSS 91

BLAST of Pay0008280 vs. NCBI nr
Match: XP_022964695.1 (uncharacterized protein LOC111464671 [Cucurbita moschata])

HSP 1 Score: 164.9 bits (416), Expect = 3.4e-37
Identity = 78/91 (85.71%), Postives = 89/91 (97.80%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQTALPPELANNVIRLYRECLRRAKF+GHRQHNT+L+V MV+QQF+KNMHETDPEKI
Sbjct: 1  MPSLQTALPPELANNVIRLYRECLRRAKFIGHRQHNTDLVVSMVKQQFRKNMHETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QK+KD+AARGLINH+LYE ER++G+KLSQSS
Sbjct: 61 QKLKDDAARGLINHILYESERLTGRKLSQSS 91

BLAST of Pay0008280 vs. TAIR 10
Match: AT3G17300.1 (unknown protein; Has 48 Blast hits to 48 proteins in 21 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 40; Viruses - 0; Other Eukaryotes - 8 (source: NCBI BLink). )

HSP 1 Score: 149.1 bits (375), Expect = 1.8e-36
Identity = 71/91 (78.02%), Postives = 85/91 (93.41%), Query Frame = 0

Query: 1  MPSLQTALPPELANNVIRLYRECLRRAKFVGHRQHNTELIVDMVRQQFKKNMHETDPEKI 60
          MPSLQT+LPPELANNV+RLYRECLRRAKF+G +QHNTEL+V MVRQQFKK+M+ETDPEKI
Sbjct: 1  MPSLQTSLPPELANNVVRLYRECLRRAKFIGKQQHNTELVVGMVRQQFKKHMNETDPEKI 60

Query: 61 QKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QK+KD+AARGLINHML+E  +++G K+SQ S
Sbjct: 61 QKLKDDAARGLINHMLFESAKLTGGKVSQRS 91

BLAST of Pay0008280 vs. TAIR 10
Match: AT3G17300.2 (unknown protein; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; Has 35 Blast hits to 35 proteins in 14 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 34; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink). )

HSP 1 Score: 90.1 bits (222), Expect = 9.8e-19
Identity = 43/58 (74.14%), Postives = 53/58 (91.38%), Query Frame = 0

Query: 34 QHNTELIVDMVRQQFKKNMHETDPEKIQKMKDEAARGLINHMLYEHERMSGQKLSQSS 92
          QHNTEL+V MVRQQFKK+M+ETDPEKIQK+KD+AARGLINHML+E  +++G K+SQ S
Sbjct: 17 QHNTELVVGMVRQQFKKHMNETDPEKIQKLKDDAARGLINHMLFESAKLTGGKVSQRS 74

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
Match NameE-valueIdentityDescription
A0A1S3AYB17.5e-43100.00uncharacterized protein LOC103483919 OS=Cucumis melo OX=3656 GN=LOC103483919 PE=... [more]
A0A5A7UD867.5e-43100.00Complex1_LYR domain-containing protein OS=Cucumis melo var. makuwa OX=1194695 GN... [more]
A0A0A0L5F66.6e-3992.22Uncharacterized protein OS=Cucumis sativus OX=3659 GN=Csa_3G171030 PE=4 SV=1[more]
A0A1U8AWB61.2e-3786.81uncharacterized protein LOC104607091 isoform X2 OS=Nelumbo nucifera OX=4432 GN=L... [more]
A0A6J1HLJ61.6e-3785.71uncharacterized protein LOC111464671 OS=Cucurbita moschata OX=3662 GN=LOC1114646... [more]
Match NameE-valueIdentityDescription
XP_008438986.11.6e-42100.00PREDICTED: uncharacterized protein LOC103483919 [Cucumis melo] >XP_008438987.1 P... [more]
XP_004147626.16.5e-4195.60uncharacterized protein LOC101203751 [Cucumis sativus] >XP_011651093.1 uncharact... [more]
XP_031490696.11.5e-3788.89uncharacterized protein LOC116257839 isoform X2 [Nymphaea colorata][more]
XP_010270901.12.6e-3786.81PREDICTED: uncharacterized protein LOC104607091 isoform X2 [Nelumbo nucifera] >D... [more]
XP_022964695.13.4e-3785.71uncharacterized protein LOC111464671 [Cucurbita moschata][more]
Match NameE-valueIdentityDescription
AT3G17300.11.8e-3678.02unknown protein; Has 48 Blast hits to 48 proteins in 21 species: Archae - 0; Bac... [more]
AT3G17300.29.8e-1974.14unknown protein; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth ... [more]
InterPro
Analysis Name: InterPro Annotations of Melon (Payzawat) v1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR008011Complex 1 LYR proteinPFAMPF05347Complex1_LYRcoord: 16..67
e-value: 4.1E-11
score: 42.8
NoneNo IPR availablePANTHERPTHR47579COMPLEX 1 LYR PROTEINcoord: 1..91
NoneNo IPR availableCDDcd20251Complex1_LYR_SFcoord: 16..73
e-value: 5.61765E-18
score: 68.7257

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Pay0008280.1Pay0008280.1mRNA