Pay0004311 (gene) Melon (Payzawat) v1

Overview
NamePay0004311
Typegene
OrganismCucumis melo L. var. inodorus cv. Payzawat (Melon (Payzawat) v1)
DescriptionRibonuclease H
Locationchr01: 14770798 .. 14771330 (-)
RNA-Seq ExpressionPay0004311
SyntenyPay0004311
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: polypeptideexonCDS
Hold the cursor over a type above to highlight its positions in the sequence below.
ATGAATGGGGCAGTTGAGGCAGCTAACAAAAATATTAAAAGAATCATTGAGAAAATGACAATAACACACAAAGATTGGCATGAAATGCTACCGTTTGCACTGCATGGATATCGCACGTCAGTTCGTACTTCAACTGGGGCAACACCATTTTCTTTAGTTTATGGTATGGAAGCTGTTTTACCTTTAAAAGTTGAGATACCTTCATTGAGAGTTCTCATGGAAGCTAAGTTAGATGAAGCTGAATGGATACGAGGTCGTTATGAGCAGTTGAATTTCGTTGAAGAAAAAAGGTTAGCAGCATTAAATCATGGGCAACTTTACCAAAGAAGACTAATGCGAGCATACAATAAGAAAGTGCATCCTCGAAGCTTTCGTTTCAAAAGGATCATCGAGGAAAATGGACTCCTAATTATGAAGGTCCATTTGTAGTGAAAAAAGCTTTTTCAGGAGGAGTTCTACTTTTGACTAATAAGGATGGCAATGAGTTAAAAAATCCTGTGAATTCAGATTATGTTCGAAGATATTATACATGA

mRNA sequence

ATGAATGGGGCAGTTGAGGCAGCTAACAAAAATATTAAAAGAATCATTGAGAAAATGACAATAACACACAAAGATTGGCATGAAATGCTACCGTTTGCACTGCATGGATATCGCACGTCAGTTCGTACTTCAACTGGGGCAACACCATTTTCTTTAGTTTATGGTATGGAAGCTGTTTTACCTTTAAAAGTTGAGATACCTTCATTGAGAGTTCTCATGGAAGCTAAGTTAGATGAAGCTGAATGGATACGAGGTCGTTATGAGCAGTTGAATTTCGTTGAAGAAAAAAGGTTAGCAGCATTAAATCATGGGCAACTTTACCAAAGAAGACTAATGCGAGCATACAATAAGAAAGATCATCGAGGAAAATGGACTCCTAATTATGAAGGTCCATTTGTAGTGAAAAAAGCTTTTTCAGGAGGAGTTCTACTTTTGACTAATAAGGATGGCAATGAGTTAAAAAATCCTGTGAATTCAGATTATGTTCGAAGATATTATACATGA

Coding sequence (CDS)

ATGAATGGGGCAGTTGAGGCAGCTAACAAAAATATTAAAAGAATCATTGAGAAAATGACAATAACACACAAAGATTGGCATGAAATGCTACCGTTTGCACTGCATGGATATCGCACGTCAGTTCGTACTTCAACTGGGGCAACACCATTTTCTTTAGTTTATGGTATGGAAGCTGTTTTACCTTTAAAAGTTGAGATACCTTCATTGAGAGTTCTCATGGAAGCTAAGTTAGATGAAGCTGAATGGATACGAGGTCGTTATGAGCAGTTGAATTTCGTTGAAGAAAAAAGGTTAGCAGCATTAAATCATGGGCAACTTTACCAAAGAAGACTAATGCGAGCATACAATAAGAAAGATCATCGAGGAAAATGGACTCCTAATTATGAAGGTCCATTTGTAGTGAAAAAAGCTTTTTCAGGAGGAGTTCTACTTTTGACTAATAAGGATGGCAATGAGTTAAAAAATCCTGTGAATTCAGATTATGTTCGAAGATATTATACATGA

Protein sequence

MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVLPLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNKKDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNSDYVRRYYT
Homology
BLAST of Pay0004311 vs. ExPASy TrEMBL
Match: A0A5A7T7R4 (Ribonuclease H OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold277G002820 PE=4 SV=1)

HSP 1 Score: 313.9 bits (803), Expect = 4.0e-82
Identity = 160/187 (85.56%), Postives = 162/187 (86.63%), Query Frame = 0

Query: 1    MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
            MNGAVEAANKNIKRIIEKMTIT+KDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL
Sbjct: 1751 MNGAVEAANKNIKRIIEKMTITYKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 1810

Query: 61   PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
            PL+VEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNH QLYQRRLMRAYNK   
Sbjct: 1811 PLEVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHVQLYQRRLMRAYNKKVH 1870

Query: 121  ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                              KDHRGKWTPNYEGPFVVKKAFSGG LLLTN DG ELKNPVNS
Sbjct: 1871 PRSFREGDLVLKRILPFQKDHRGKWTPNYEGPFVVKKAFSGGALLLTNMDGIELKNPVNS 1930

BLAST of Pay0004311 vs. ExPASy TrEMBL
Match: A0A5D3CXE2 (RNA-directed DNA polymerase (Reverse transcriptase), Ribonuclease H OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold21G003720 PE=4 SV=1)

HSP 1 Score: 303.5 bits (776), Expect = 5.4e-79
Identity = 155/187 (82.89%), Postives = 158/187 (84.49%), Query Frame = 0

Query: 1   MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
           MN AVEAANKNIKRIIEKMTIT+KDWHEMLPFALHGYRTSVRTSTGAT FSLVYGME VL
Sbjct: 23  MNEAVEAANKNIKRIIEKMTITYKDWHEMLPFALHGYRTSVRTSTGATQFSLVYGMEIVL 82

Query: 61  PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
           PL+VEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLA LNHGQLYQRRLMRAYNK   
Sbjct: 83  PLEVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLATLNHGQLYQRRLMRAYNKKVH 142

Query: 121 ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                             KDHRGKWTPNYEGPFVVKKAFSG  LLLTN DG ELKNP+NS
Sbjct: 143 PRSFREGDLILKRILPFQKDHRGKWTPNYEGPFVVKKAFSGRALLLTNMDGVELKNPMNS 202

BLAST of Pay0004311 vs. ExPASy TrEMBL
Match: A0A5A7T1D0 (RNA-directed DNA polymerase OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold57G002530 PE=4 SV=1)

HSP 1 Score: 296.2 bits (757), Expect = 8.6e-77
Identity = 150/187 (80.21%), Postives = 155/187 (82.89%), Query Frame = 0

Query: 1   MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
           MNG VE ANKNIKRIIEKMTIT+KDWHEMLPFALHGYRTSVRTSTGA PF LVYGME VL
Sbjct: 182 MNGTVEEANKNIKRIIEKMTITYKDWHEMLPFALHGYRTSVRTSTGAKPFFLVYGMEVVL 241

Query: 61  PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
           PL+VE PSLRVL+EAKLDEAEWIRGRYEQLNFVEEK+L ALNH QLYQRRLMRAYNK   
Sbjct: 242 PLEVETPSLRVLIEAKLDEAEWIRGRYEQLNFVEEKQLTALNHRQLYQRRLMRAYNKKVH 301

Query: 121 ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                             KDHRGKWTPNYEGPFVVKKAFSGG LLLTN DG ELK+PVNS
Sbjct: 302 TRSFREGDLVLKRILPFQKDHRGKWTPNYEGPFVVKKAFSGGALLLTNMDGVELKSPVNS 361

BLAST of Pay0004311 vs. ExPASy TrEMBL
Match: A0A5D3E1A3 (RNA-directed DNA polymerase OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold1228G00260 PE=4 SV=1)

HSP 1 Score: 292.4 bits (747), Expect = 1.2e-75
Identity = 149/187 (79.68%), Postives = 153/187 (81.82%), Query Frame = 0

Query: 1   MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
           MNG VE ANKNIKRIIEKMTIT+KDWHEMLPFALHGYRTSVRTSTGA PF LVYGME VL
Sbjct: 182 MNGTVEEANKNIKRIIEKMTITYKDWHEMLPFALHGYRTSVRTSTGAKPFFLVYGMEVVL 241

Query: 61  PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
           PL+VE PSLRVL+EAKLDEAEWIRGRYEQLNFVEEK+L ALNH QLYQRRLMRAYNK   
Sbjct: 242 PLEVETPSLRVLIEAKLDEAEWIRGRYEQLNFVEEKQLTALNHRQLYQRRLMRAYNKKVH 301

Query: 121 ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                             KDHRGKWTPNYEGPFVVKKAFS G LLLTN D  ELKNPVNS
Sbjct: 302 TRSFREGDLVLKRILPFQKDHRGKWTPNYEGPFVVKKAFSEGALLLTNMDDVELKNPVNS 361

BLAST of Pay0004311 vs. ExPASy TrEMBL
Match: A0A6J1D7C7 (Ribonuclease H OS=Momordica charantia OX=3673 GN=LOC111018303 PE=4 SV=1)

HSP 1 Score: 284.3 bits (726), Expect = 3.4e-73
Identity = 138/187 (73.80%), Postives = 155/187 (82.89%), Query Frame = 0

Query: 1    MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
            MNGAVEAANKNIKRI+EKMT+T++DWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL
Sbjct: 1481 MNGAVEAANKNIKRIVEKMTVTYRDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 1540

Query: 61   PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
            P++VEIPSLRV+MEAKL EAEW++ RYEQLNFVEEKRL AL  GQLYQRR+M+AY+K   
Sbjct: 1541 PIEVEIPSLRVIMEAKLQEAEWVQRRYEQLNFVEEKRLTALYRGQLYQRRMMKAYDKKVH 1600

Query: 121  ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                              KDHRGKWTPNYEGPFV+KKAFSGG L+L N DG E  NP+NS
Sbjct: 1601 SRRFREGDLVLKRILPLQKDHRGKWTPNYEGPFVLKKAFSGGALVLANMDGTEFLNPINS 1660

BLAST of Pay0004311 vs. NCBI nr
Match: KAA0037621.1 (uncharacterized protein E6C27_scaffold277G002820 [Cucumis melo var. makuwa])

HSP 1 Score: 313.9 bits (803), Expect = 8.2e-82
Identity = 160/187 (85.56%), Postives = 162/187 (86.63%), Query Frame = 0

Query: 1    MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
            MNGAVEAANKNIKRIIEKMTIT+KDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL
Sbjct: 1751 MNGAVEAANKNIKRIIEKMTITYKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 1810

Query: 61   PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
            PL+VEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNH QLYQRRLMRAYNK   
Sbjct: 1811 PLEVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHVQLYQRRLMRAYNKKVH 1870

Query: 121  ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                              KDHRGKWTPNYEGPFVVKKAFSGG LLLTN DG ELKNPVNS
Sbjct: 1871 PRSFREGDLVLKRILPFQKDHRGKWTPNYEGPFVVKKAFSGGALLLTNMDGIELKNPVNS 1930

BLAST of Pay0004311 vs. NCBI nr
Match: XP_031738551.1 (LOW QUALITY PROTEIN: uncharacterized protein LOC101203611 [Cucumis sativus])

HSP 1 Score: 308.9 bits (790), Expect = 2.6e-80
Identity = 155/187 (82.89%), Postives = 161/187 (86.10%), Query Frame = 0

Query: 1    MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
            MNGAVEAANKNIKRIIEKMT T+KDWHE+LPFALHGYRTSVRTSTGATPFSLVYGMEAVL
Sbjct: 2448 MNGAVEAANKNIKRIIEKMTTTYKDWHEILPFALHGYRTSVRTSTGATPFSLVYGMEAVL 2507

Query: 61   PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
            PL+VEIPSLRVLMEAKLDEAEWIRGRYEQLNF+EEKRL AL+HGQLYQ+RLMRAYNK   
Sbjct: 2508 PLEVEIPSLRVLMEAKLDEAEWIRGRYEQLNFIEEKRLTALSHGQLYQKRLMRAYNKKVH 2567

Query: 121  ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                              KDHRGKWTPNYEGPFVVKKAFSGG LLLTN DG ELKNPVNS
Sbjct: 2568 PRSFREGDLVLKRILPFLKDHRGKWTPNYEGPFVVKKAFSGGALLLTNMDGVELKNPVNS 2627

BLAST of Pay0004311 vs. NCBI nr
Match: XP_031741309.1 (LOW QUALITY PROTEIN: uncharacterized protein LOC105435093 [Cucumis sativus])

HSP 1 Score: 308.9 bits (790), Expect = 2.6e-80
Identity = 155/187 (82.89%), Postives = 161/187 (86.10%), Query Frame = 0

Query: 1    MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
            MNGAVEAANKNIKRIIEKMT T+KDWHE+LPFALHGYRTSVRTSTGATPFSLVYGMEAVL
Sbjct: 2101 MNGAVEAANKNIKRIIEKMTTTYKDWHEILPFALHGYRTSVRTSTGATPFSLVYGMEAVL 2160

Query: 61   PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
            PL+VEIPSLRVLMEAKLDEAEWIRGRYEQLNF+EEKRL AL+HGQLYQ+RLMRAYNK   
Sbjct: 2161 PLEVEIPSLRVLMEAKLDEAEWIRGRYEQLNFIEEKRLTALSHGQLYQKRLMRAYNKKVH 2220

Query: 121  ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                              KDHRGKWTPNYEGPFVVKKAFSGG LLLTN DG ELKNPVNS
Sbjct: 2221 PRSFREGDLVLKRILPFLKDHRGKWTPNYEGPFVVKKAFSGGALLLTNMDGVELKNPVNS 2280

BLAST of Pay0004311 vs. NCBI nr
Match: XP_031737561.1 (LOW QUALITY PROTEIN: uncharacterized protein LOC116402452 [Cucumis sativus])

HSP 1 Score: 308.9 bits (790), Expect = 2.6e-80
Identity = 155/187 (82.89%), Postives = 161/187 (86.10%), Query Frame = 0

Query: 1    MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
            MNGAVEAANKNIKRIIEKMT T+KDWHE+LPFALHGYRTSVRTSTGATPFSLVYGMEAVL
Sbjct: 2103 MNGAVEAANKNIKRIIEKMTTTYKDWHEILPFALHGYRTSVRTSTGATPFSLVYGMEAVL 2162

Query: 61   PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
            PL+VEIPSLRVLMEAKLDEAEWIRGRYEQLNF+EEKRL AL+HGQLYQ+RLMRAYNK   
Sbjct: 2163 PLEVEIPSLRVLMEAKLDEAEWIRGRYEQLNFIEEKRLTALSHGQLYQKRLMRAYNKKVH 2222

Query: 121  ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                              KDHRGKWTPNYEGPFVVKKAFSGG LLLTN DG ELKNPVNS
Sbjct: 2223 PRSFREGDLVLKRILPFLKDHRGKWTPNYEGPFVVKKAFSGGALLLTNMDGVELKNPVNS 2282

BLAST of Pay0004311 vs. NCBI nr
Match: XP_031738857.1 (LOW QUALITY PROTEIN: uncharacterized protein LOC116402780 [Cucumis sativus])

HSP 1 Score: 308.9 bits (790), Expect = 2.6e-80
Identity = 155/187 (82.89%), Postives = 161/187 (86.10%), Query Frame = 0

Query: 1    MNGAVEAANKNIKRIIEKMTITHKDWHEMLPFALHGYRTSVRTSTGATPFSLVYGMEAVL 60
            MNGAVEAANKNIKRIIEKMT T+KDWHE+LPFALHGYRTSVRTSTGATPFSLVYGMEAVL
Sbjct: 2116 MNGAVEAANKNIKRIIEKMTTTYKDWHEILPFALHGYRTSVRTSTGATPFSLVYGMEAVL 2175

Query: 61   PLKVEIPSLRVLMEAKLDEAEWIRGRYEQLNFVEEKRLAALNHGQLYQRRLMRAYNK--- 120
            PL+VEIPSLRVLMEAKLDEAEWIRGRYEQLNF+EEKRL AL+HGQLYQ+RLMRAYNK   
Sbjct: 2176 PLEVEIPSLRVLMEAKLDEAEWIRGRYEQLNFIEEKRLTALSHGQLYQKRLMRAYNKKVH 2235

Query: 121  ------------------KDHRGKWTPNYEGPFVVKKAFSGGVLLLTNKDGNELKNPVNS 167
                              KDHRGKWTPNYEGPFVVKKAFSGG LLLTN DG ELKNPVNS
Sbjct: 2236 PRSFREGDLVLKRILPFLKDHRGKWTPNYEGPFVVKKAFSGGALLLTNMDGVELKNPVNS 2295

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
Match NameE-valueIdentityDescription
A0A5A7T7R44.0e-8285.56Ribonuclease H OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold277G00282... [more]
A0A5D3CXE25.4e-7982.89RNA-directed DNA polymerase (Reverse transcriptase), Ribonuclease H OS=Cucumis m... [more]
A0A5A7T1D08.6e-7780.21RNA-directed DNA polymerase OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaf... [more]
A0A5D3E1A31.2e-7579.68RNA-directed DNA polymerase OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaf... [more]
A0A6J1D7C73.4e-7373.80Ribonuclease H OS=Momordica charantia OX=3673 GN=LOC111018303 PE=4 SV=1[more]
Match NameE-valueIdentityDescription
KAA0037621.18.2e-8285.56uncharacterized protein E6C27_scaffold277G002820 [Cucumis melo var. makuwa][more]
XP_031738551.12.6e-8082.89LOW QUALITY PROTEIN: uncharacterized protein LOC101203611 [Cucumis sativus][more]
XP_031741309.12.6e-8082.89LOW QUALITY PROTEIN: uncharacterized protein LOC105435093 [Cucumis sativus][more]
XP_031737561.12.6e-8082.89LOW QUALITY PROTEIN: uncharacterized protein LOC116402452 [Cucumis sativus][more]
XP_031738857.12.6e-8082.89LOW QUALITY PROTEIN: uncharacterized protein LOC116402780 [Cucumis sativus][more]
Match NameE-valueIdentityDescription
InterPro
Analysis Name: InterPro Annotations of Melon (Payzawat) v1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR036397Ribonuclease H superfamilyGENE3D3.30.420.10coord: 1..94
e-value: 2.9E-16
score: 61.4
NoneNo IPR availablePANTHERPTHR24559TRANSPOSON TY3-I GAG-POL POLYPROTEINcoord: 2..139
NoneNo IPR availablePANTHERPTHR24559:SF342SUBFAMILY NOT NAMEDcoord: 2..139
IPR012337Ribonuclease H-like superfamilySUPERFAMILY53098Ribonuclease H-likecoord: 2..62

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Pay0004311.1Pay0004311.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0015074 DNA integration
biological_process GO:0006310 DNA recombination
biological_process GO:0006278 RNA-dependent DNA biosynthetic process
biological_process GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
cellular_component GO:0030430 host cell cytoplasm
cellular_component GO:0005634 nucleus
molecular_function GO:0003887 DNA-directed DNA polymerase activity
molecular_function GO:0003723 RNA binding
molecular_function GO:0003964 RNA-directed DNA polymerase activity
molecular_function GO:0004523 RNA-DNA hybrid ribonuclease activity
molecular_function GO:0003676 nucleic acid binding