PI0019023 (gene) Melon (PI 482460) v1

Overview


Name	PI0019023
Type	gene
Organism	Cucumis metuliferus (Melon (PI 482460) v1)
Description	DNA-directed RNA polymerase subunit beta
Location	chr02: 20892249 .. 20893392 (+)
RNA-Seq Expression	PI0019023
Synteny	PI0019023

Sequences

The following sequences are available for this feature:

Gene sequence (with intron)

Legend: five_prime_UTRexonCDSpolypeptidethree_prime_UTR

Hold the cursor over a type above to highlight its positions in the sequence below.

CCTGTTTTGTCCAGAAACTCAACTTTTAACAAAGCAATCCTATATTTTTGTAATTCCCCCAAGAAATTTAATGGTAGAATTCGTACTCCCCACTTGTTCTCTGTTTTTAATGGAAAAAGGATGCGGCCGTAATTCATTTCCACCGGCACTCATTTCAGATTTTCCATAACTGTCCAACTTCAATTGACAATGGCGACGGTAGATTCAAGCTTTATCTTCATCCGTATCTCCGCCGTACCTCATCCCCTTTTGAACAACAACAACAATAATGGCAGAAAATTCGGAATCACGTCGGCAAAACGTACACAAGATTCCGATTCAGATTCCACTTCATCAATCCAACCAAATCAATTCAAATTTCCATCGCTGAGAGTATCAAATCCACTTCTCGCCCGATCTGTCGTTTCGGTTCTCGGATTAGGGTTCGTCGATGCAGGGTATGAAAATTTTACCTCTAATTAATTTCGATTTGAGAATTGCTCTGTTTTATTTTTGTTTTCACTGAAATTGAAGTCGAATTAGGGTTTGAAATGATTAGGTATAGCGGAGATTGGTCTAGAATTGGAGCGATTACGAAGGAAACTGAAGAATTGCTTAAGATTGGAGCTTTGTTGGTGGTTCCGTTTTGTGTATTTCTCATTTTTTCTTTCTCAAAATTTGATTCGGATTCTTCGTAAGTGTATGGATGATGGATTCCCCAAAATGGTTAGAAATAATCTCAATTTGAAGATGGTAGCTAAGCTAAAGTTGTTTCTTTGCTTAGAAGGGAGATTTTGAAGAACATGTACAAAATTCATTTACTGATATGCACATGTTTGATGTTGGTTTCCACTTCCATGTTTTAGACTTTAGTTGGTGTCACTAAGTTTGGAAATAATACATGAATGAGACGAAATCATATTTGAACGAGTTAAAATTTATGGATATAAAATTGTAGTTTAAACACTTATAAAATTTTAGTAGCTCGTTGGCTAAAGTGTGCGAAGGAGACAACCTTGTAAGCATGTTTCAATTGACTTGTATTTCCGTTTCTTGAAGTTGTTTGAGGCTACATTTGTTGTACACTTACAGTTTTTTTTTTTCTTTTTAGACCAACTCAACTATCGTTGAGCTAAACTCACTTTGGTGAGATTGGTGTTCGTAG

mRNA sequence

CCTGTTTTGTCCAGAAACTCAACTTTTAACAAAGCAATCCTATATTTTTGTAATTCCCCCAAGAAATTTAATGGTAGAATTCGTACTCCCCACTTGTTCTCTGTTTTTAATGGAAAAAGGATGCGGCCGTAATTCATTTCCACCGGCACTCATTTCAGATTTTCCATAACTGTCCAACTTCAATTGACAATGGCGACGGTAGATTCAAGCTTTATCTTCATCCGTATCTCCGCCGTACCTCATCCCCTTTTGAACAACAACAACAATAATGGCAGAAAATTCGGAATCACGTCGGCAAAACGTACACAAGATTCCGATTCAGATTCCACTTCATCAATCCAACCAAATCAATTCAAATTTCCATCGCTGAGAGTATCAAATCCACTTCTCGCCCGATCTGTCGTTTCGGTTCTCGGATTAGGGTTCGTCGATGCAGGGTATAGCGGAGATTGGTCTAGAATTGGAGCGATTACGAAGGAAACTGAAGAATTGCTTAAGATTGGAGCTTTGTTGGTGGTTCCGTTTTGTGTATTTCTCATTTTTTCTTTCTCAAAATTTGATTCGGATTCTTCGTAAGTGTATGGATGATGGATTCCCCAAAATGGTTAGAAATAATCTCAATTTGAAGATGGTAGCTAAGCTAAAGTTGTTTCTTTGCTTAGAAGGGAGATTTTGAAGAACATGTACAAAATTCATTTACTGATATGCACATGTTTGATGTTGGTTTCCACTTCCATGTTTTAGACTTTAGTTGGTGTCACTAAGTTTGGAAATAATACATGAATGAGACGAAATCATATTTGAACGAGTTAAAATTTATGGATATAAAATTGTAGTTTAAACACTTATAAAATTTTAGTAGCTCGTTGGCTAAAGTGTGCGAAGGAGACAACCTTGTAAGCATGTTTCAATTGACTTGTATTTCCGTTTCTTGAAGTTGTTTGAGGCTACATTTGTTGTACACTTACAGTTTTTTTTTTTCTTTTTAGACCAACTCAACTATCGTTGAGCTAAACTCACTTTGGTGAGATTGGTGTTCGTAG

Coding sequence (CDS)

ATGGCGACGGTAGATTCAAGCTTTATCTTCATCCGTATCTCCGCCGTACCTCATCCCCTTTTGAACAACAACAACAATAATGGCAGAAAATTCGGAATCACGTCGGCAAAACGTACACAAGATTCCGATTCAGATTCCACTTCATCAATCCAACCAAATCAATTCAAATTTCCATCGCTGAGAGTATCAAATCCACTTCTCGCCCGATCTGTCGTTTCGGTTCTCGGATTAGGGTTCGTCGATGCAGGGTATAGCGGAGATTGGTCTAGAATTGGAGCGATTACGAAGGAAACTGAAGAATTGCTTAAGATTGGAGCTTTGTTGGTGGTTCCGTTTTGTGTATTTCTCATTTTTTCTTTCTCAAAATTTGATTCGGATTCTTCGTAA

Protein sequence

MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSLRVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSFSKFDSDSS

Homology

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BLAST of PI0019023 vs. ExPASy TrEMBL
Match: A0A1S3B903 (uncharacterized protein LOC103487329 OS=Cucumis melo OX=3656 GN=LOC103487329 PE=4 SV=1)

HSP 1 Score: 228.4 bits (581), Expect = 1.7e-56
Identity = 121/129 (93.80%), Postives = 122/129 (94.57%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNN-NNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPS 60
           MA VDSSFIFI ISAVPHPLLNNN NNNGRKFGITSAKRTQ  DSDSTSS QPNQFKFPS
Sbjct: 1   MAMVDSSFIFIGISAVPHPLLNNNKNNNGRKFGITSAKRTQ--DSDSTSSTQPNQFKFPS 60

Query: 61  LRVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFS 120
           LRVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGA LVVPFCVFL+FS
Sbjct: 61  LRVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGAFLVVPFCVFLVFS 120

Query: 121 FSKFDSDSS 129
           FSKFDSDSS
Sbjct: 121 FSKFDSDSS 127

[Close]

BLAST of PI0019023 vs. ExPASy TrEMBL
Match: A0A0A0LWH4 (Uncharacterized protein OS=Cucumis sativus OX=3659 GN=Csa_1G257930 PE=4 SV=1)

HSP 1 Score: 226.1 bits (575), Expect = 8.3e-56
Identity = 117/128 (91.41%), Postives = 120/128 (93.75%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSL 60
           MA VDSSFIFI  S VPHPLL  NNNNGRKFGITSAKRTQDSDSDS SS QPNQFKFPSL
Sbjct: 1   MAMVDSSFIFIGFSPVPHPLL--NNNNGRKFGITSAKRTQDSDSDSASSTQPNQFKFPSL 60

Query: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSF 120
           RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETE+LLKIGALLVVPFCVFL+FSF
Sbjct: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEDLLKIGALLVVPFCVFLVFSF 120

Query: 121 SKFDSDSS 129
           SK+DSDSS
Sbjct: 121 SKYDSDSS 126

[Close]

BLAST of PI0019023 vs. ExPASy TrEMBL
Match: A0A6J1EZT4 (uncharacterized protein LOC111440861 OS=Cucurbita moschata OX=3662 GN=LOC111440861 PE=4 SV=1)

HSP 1 Score: 178.7 bits (452), Expect = 1.5e-41
Identity = 98/128 (76.56%), Postives = 106/128 (82.81%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSL 60
           M   DSSFIF  +SA+PHPLL  +NNN RKFG TSAKRT DSD     SI   Q KFPSL
Sbjct: 1   MPIADSSFIFTGLSALPHPLL-LSNNNARKFGTTSAKRTGDSD-----SISSTQLKFPSL 60

Query: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSF 120
           RV+NPLLARSVV+VLGLGFVDAGYSGDWSRIGAITKETE+LLKIGA LVVPFCVFLIFSF
Sbjct: 61  RVANPLLARSVVAVLGLGFVDAGYSGDWSRIGAITKETEDLLKIGAFLVVPFCVFLIFSF 120

Query: 121 SKFDSDSS 129
           S+  +DSS
Sbjct: 121 SE-QTDSS 121

[Close]

BLAST of PI0019023 vs. ExPASy TrEMBL
Match: A0A6J1KT82 (uncharacterized protein LOC111498016 OS=Cucurbita maxima OX=3661 GN=LOC111498016 PE=4 SV=1)

HSP 1 Score: 177.6 bits (449), Expect = 3.4e-41
Identity = 97/128 (75.78%), Postives = 105/128 (82.03%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSL 60
           M   DSSFIF  +SA+PHPL+  +NNN RKFG TSAKRT DSD     SI   Q KFPSL
Sbjct: 1   MPIADSSFIFTGLSALPHPLI-LSNNNARKFGTTSAKRTGDSD-----SISSTQLKFPSL 60

Query: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSF 120
           RVSNPLLARSVV+VLGLGFVDAGYSGDWSRIGAITKETE+ LKIGA LVVPFCVFLIFSF
Sbjct: 61  RVSNPLLARSVVAVLGLGFVDAGYSGDWSRIGAITKETEDFLKIGAFLVVPFCVFLIFSF 120

Query: 121 SKFDSDSS 129
           S+  +DSS
Sbjct: 121 SE-QTDSS 121

[Close]

BLAST of PI0019023 vs. ExPASy TrEMBL
Match: A0A6J1C0R6 (uncharacterized protein LOC111007301 OS=Momordica charantia OX=3673 GN=LOC111007301 PE=4 SV=1)

HSP 1 Score: 150.6 bits (379), Expect = 4.5e-33
Identity = 87/124 (70.16%), Postives = 95/124 (76.61%), Query Frame = 0


Query: 5   DSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSLRVSN 64
           DS+FIF   SAV   L N NN   R F    AKRT   DS +T S Q NQF+FPSLRV N
Sbjct: 3   DSTFIFSGPSAVSRSLFNVNNR--RNFRTALAKRT--DDSTATKSNQENQFEFPSLRVPN 62

Query: 65  PLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSFSKFD 124
           PL+AR VVSVLGLGFVDAGYSGDWSRIGAITKE+E+LLKIGA LVVPFCVFLI SF+K  
Sbjct: 63  PLVARFVVSVLGLGFVDAGYSGDWSRIGAITKESEDLLKIGAFLVVPFCVFLISSFAK-Q 121

Query: 125 SDSS 129
           +DSS
Sbjct: 123 TDSS 121

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BLAST of PI0019023 vs. NCBI nr
Match: XP_008443827.1 (PREDICTED: uncharacterized protein LOC103487329 [Cucumis melo])

HSP 1 Score: 228.4 bits (581), Expect = 3.5e-56
Identity = 121/129 (93.80%), Postives = 122/129 (94.57%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNN-NNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPS 60
           MA VDSSFIFI ISAVPHPLLNNN NNNGRKFGITSAKRTQ  DSDSTSS QPNQFKFPS
Sbjct: 1   MAMVDSSFIFIGISAVPHPLLNNNKNNNGRKFGITSAKRTQ--DSDSTSSTQPNQFKFPS 60

Query: 61  LRVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFS 120
           LRVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGA LVVPFCVFL+FS
Sbjct: 61  LRVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGAFLVVPFCVFLVFS 120

Query: 121 FSKFDSDSS 129
           FSKFDSDSS
Sbjct: 121 FSKFDSDSS 127

[Close]

BLAST of PI0019023 vs. NCBI nr
Match: XP_004146667.1 (uncharacterized protein LOC101206545 [Cucumis sativus] >KGN65187.1 hypothetical protein Csa_020133 [Cucumis sativus])

HSP 1 Score: 226.1 bits (575), Expect = 1.7e-55
Identity = 117/128 (91.41%), Postives = 120/128 (93.75%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSL 60
           MA VDSSFIFI  S VPHPLL  NNNNGRKFGITSAKRTQDSDSDS SS QPNQFKFPSL
Sbjct: 1   MAMVDSSFIFIGFSPVPHPLL--NNNNGRKFGITSAKRTQDSDSDSASSTQPNQFKFPSL 60

Query: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSF 120
           RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETE+LLKIGALLVVPFCVFL+FSF
Sbjct: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEDLLKIGALLVVPFCVFLVFSF 120

Query: 121 SKFDSDSS 129
           SK+DSDSS
Sbjct: 121 SKYDSDSS 126

[Close]

BLAST of PI0019023 vs. NCBI nr
Match: XP_038879768.1 (uncharacterized protein LOC120071517 [Benincasa hispida])

HSP 1 Score: 189.9 bits (481), Expect = 1.4e-44
Identity = 102/128 (79.69%), Postives = 111/128 (86.72%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSL 60
           MA V+SSFIFI +S VP+PL  +NNN+ RKF ITSAK T+DSDSDS SS    Q KFPSL
Sbjct: 27  MAMVNSSFIFIGVSTVPYPL--SNNNHSRKFRITSAKLTEDSDSDSKSS----QLKFPSL 86

Query: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSF 120
           RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIG ITKE+EELLKIGA LVVPFCVFL+FSF
Sbjct: 87  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGVITKESEELLKIGAFLVVPFCVFLVFSF 146

Query: 121 SKFDSDSS 129
           S+ DSDSS
Sbjct: 147 SRLDSDSS 148

[Close]

BLAST of PI0019023 vs. NCBI nr
Match: XP_023531156.1 (uncharacterized protein LOC111793484 [Cucurbita pepo subsp. pepo])

HSP 1 Score: 182.6 bits (462), Expect = 2.2e-42
Identity = 100/128 (78.12%), Postives = 109/128 (85.16%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSL 60
           M   DS+FIF  +SA+PHPLL  +NNN RKFG TSAKRT DSDSDS SS    Q KFPSL
Sbjct: 1   MPIADSTFIFTGLSALPHPLL-LSNNNARKFGTTSAKRTGDSDSDSISS---TQLKFPSL 60

Query: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSF 120
           RV+NPLLARSVV+VLGLGFVDAGYSGDWSRIGAITKETE+LLKIGA LVVPFCVFLIFSF
Sbjct: 61  RVANPLLARSVVAVLGLGFVDAGYSGDWSRIGAITKETEDLLKIGAFLVVPFCVFLIFSF 120

Query: 121 SKFDSDSS 129
           S+  +DSS
Sbjct: 121 SE-QTDSS 123

[Close]

BLAST of PI0019023 vs. NCBI nr
Match: XP_022933449.1 (uncharacterized protein LOC111440861 [Cucurbita moschata] >KAG6587801.1 hypothetical protein SDJN03_16366, partial [Cucurbita argyrosperma subsp. sororia] >KAG7035696.1 hypothetical protein SDJN02_02494, partial [Cucurbita argyrosperma subsp. argyrosperma])

HSP 1 Score: 178.7 bits (452), Expect = 3.2e-41
Identity = 98/128 (76.56%), Postives = 106/128 (82.81%), Query Frame = 0


Query: 1   MATVDSSFIFIRISAVPHPLLNNNNNNGRKFGITSAKRTQDSDSDSTSSIQPNQFKFPSL 60
           M   DSSFIF  +SA+PHPLL  +NNN RKFG TSAKRT DSD     SI   Q KFPSL
Sbjct: 1   MPIADSSFIFTGLSALPHPLL-LSNNNARKFGTTSAKRTGDSD-----SISSTQLKFPSL 60

Query: 61  RVSNPLLARSVVSVLGLGFVDAGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSF 120
           RV+NPLLARSVV+VLGLGFVDAGYSGDWSRIGAITKETE+LLKIGA LVVPFCVFLIFSF
Sbjct: 61  RVANPLLARSVVAVLGLGFVDAGYSGDWSRIGAITKETEDLLKIGAFLVVPFCVFLIFSF 120

Query: 121 SKFDSDSS 129
           S+  +DSS
Sbjct: 121 SE-QTDSS 121

[Close]

BLAST of PI0019023 vs. TAIR 10
Match: AT4G30845.1 (unknown protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; Has 16 Blast hits to 16 proteins in 8 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 16; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink). )

HSP 1 Score: 95.9 bits (237), Expect = 2.5e-20
Identity = 53/105 (50.48%), Postives = 71/105 (67.62%), Query Frame = 0


Query: 24  NNNNGRKF--GITSAKRTQDSDSDSTSSIQPNQFKFPSLRVSNPLLARSVVSVLGLGFVD 83
           N+N  R F  G+T   + +D  S+ ++  +P       ++V N ++ARS ++VL LGF+D
Sbjct: 15  NDNKLRSFANGVTIMSKRRDF-SEKSNEERP----ILRIKVPNTIVARSAIAVLSLGFID 74

Query: 84  AGYSGDWSRIGAITKETEELLKIGALLVVPFCVFLIFSFSKFDSD 127
           AGYSGDWSRIG I+KETEELLKI A LVVP C+FL  SFS   +D
Sbjct: 75  AGYSGDWSRIGVISKETEELLKIAAFLVVPLCIFLALSFSNDSTD 114

The following BLAST results are available for this feature:

BLAST of PI0019023 vs.


Match Name	E-value	Identity	Description

BLAST of PI0019023 vs. ExPASy TrEMBL


Match Name	E-value	Identity	Description
A0A1S3B903	1.7e-56	93.80	uncharacterized protein LOC103487329 OS=Cucumis melo OX=3656 GN=LOC103487329 PE=...	[more]
A0A0A0LWH4	8.3e-56	91.41	Uncharacterized protein OS=Cucumis sativus OX=3659 GN=Csa_1G257930 PE=4 SV=1	[more]
A0A6J1EZT4	1.5e-41	76.56	uncharacterized protein LOC111440861 OS=Cucurbita moschata OX=3662 GN=LOC1114408...	[more]
A0A6J1KT82	3.4e-41	75.78	uncharacterized protein LOC111498016 OS=Cucurbita maxima OX=3661 GN=LOC111498016...	[more]
A0A6J1C0R6	4.5e-33	70.16	uncharacterized protein LOC111007301 OS=Momordica charantia OX=3673 GN=LOC111007...	[more]

BLAST of PI0019023 vs. NCBI nr


Match Name	E-value	Identity	Description
XP_008443827.1	3.5e-56	93.80	PREDICTED: uncharacterized protein LOC103487329 [Cucumis melo]	[more]
XP_004146667.1	1.7e-55	91.41	uncharacterized protein LOC101206545 [Cucumis sativus] >KGN65187.1 hypothetical ...	[more]
XP_038879768.1	1.4e-44	79.69	uncharacterized protein LOC120071517 [Benincasa hispida]	[more]
XP_023531156.1	2.2e-42	78.13	uncharacterized protein LOC111793484 [Cucurbita pepo subsp. pepo]	[more]
XP_022933449.1	3.2e-41	76.56	uncharacterized protein LOC111440861 [Cucurbita moschata] >KAG6587801.1 hypothet...	[more]

BLAST of PI0019023 vs. TAIR 10


Match Name	E-value	Identity	Description
AT4G30845.1	2.5e-20	50.48	unknown protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biologic...	[more]

InterPro

Analysis Name: InterPro Annotations of Melon (PI 482460) v1
Date Performed: 2021-10-25


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 31..53
None	No IPR available	PANTHER	PTHR38389	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA	coord: 1..125

Relationships

The following mRNA feature(s) are a part of this gene:


Feature Name	Unique Name	Type
PI0019023.1	PI0019023.1	mRNA

GO Annotation

GO Assignments

This gene is annotated with the following GO terms.

Category	Term Accession	Term Name
cellular_component	GO:0016021	integral component of membrane