Moc01g18370 (gene) Bitter gourd (OHB3-1) v2

Overview


Name	Moc01g18370
Type	gene
Organism	Momordica charantia cv. OHB3-1 (Bitter gourd (OHB3-1) v2)
Description	Reverse transcriptase domain-containing protein
Location	chr1: 12668524 .. 12668847 (+)
RNA-Seq Expression	Moc01g18370
Synteny	Moc01g18370

Sequences

The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonCDSpolypeptide

Hold the cursor over a type above to highlight its positions in the sequence below.

ATGGTGTCCCTCAAATTGGACACGAGCAAAGCCTACGATCGTATTGAGTGGATCTTCCTCGGGAAAGTTATGGCTAAAATGGGCTTCTGTGACAAATGGATTGAGCTTATTATGAATTGTGTGGAGTCCGTTAGCTTCTCAGTCCTTTTAAACGGGGTTCCAAGCAAGTCCTTCAAGCCTGGTAGAGGTCTTCGTCAAGGCGACCCACTCTCACCTTACTTATTCCTCTTATGCGTTGAAGGTCTTTCAACTCTTCTCAACACGGAGGAAAGAAATAATAACTTCTCAGGTTTGCATATTAATAAACATTGTCCTCCTATATGA

mRNA sequence

ATGGTGTCCCTCAAATTGGACACGAGCAAAGCCTACGATCGTATTGAGTGGATCTTCCTCGGGAAAGTTATGGCTAAAATGGGCTTCTGTGACAAATGGATTGAGCTTATTATGAATTGTGTGGAGTCCGTTAGCTTCTCAGTCCTTTTAAACGGGGTTCCAAGCAAGTCCTTCAAGCCTGGTAGAGGTCTTCGTCAAGGCGACCCACTCTCACCTTACTTATTCCTCTTATGCGTTGAAGGTCTTTCAACTCTTCTCAACACGGAGGAAAGAAATAATAACTTCTCAGGTTTGCATATTAATAAACATTGTCCTCCTATATGA

Coding sequence (CDS)

ATGGTGTCCCTCAAATTGGACACGAGCAAAGCCTACGATCGTATTGAGTGGATCTTCCTCGGGAAAGTTATGGCTAAAATGGGCTTCTGTGACAAATGGATTGAGCTTATTATGAATTGTGTGGAGTCCGTTAGCTTCTCAGTCCTTTTAAACGGGGTTCCAAGCAAGTCCTTCAAGCCTGGTAGAGGTCTTCGTCAAGGCGACCCACTCTCACCTTACTTATTCCTCTTATGCGTTGAAGGTCTTTCAACTCTTCTCAACACGGAGGAAAGAAATAATAACTTCTCAGGTTTGCATATTAATAAACATTGTCCTCCTATATGA

Protein sequence

MVSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPGRGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI

Homology

[Close]

BLAST of Moc01g18370 vs. NCBI nr
Match: XP_022157437.1 (uncharacterized protein LOC111024135 [Momordica charantia])

HSP 1 Score: 160.6 bits (405), Expect = 7.4e-36
Identity = 68/106 (64.15%), Postives = 85/106 (80.19%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           V++KLD SKAYDR+EW +L  +M KMGF ++W++LIMNCVESV F+VL+NGVP   F P 
Sbjct: 391 VAMKLDMSKAYDRVEWQYLRGIMVKMGFANRWVDLIMNCVESVRFAVLINGVPGDEFTPN 450

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
           RGLRQGDPLSPYLF++C EGLS L+N EE+  N + L IN+ CPPI
Sbjct: 451 RGLRQGDPLSPYLFIMCAEGLSALINDEEKKGNITRLKINRRCPPI 496

[Close]

BLAST of Moc01g18370 vs. NCBI nr
Match: XP_023878301.1 (uncharacterized protein LOC111990748 [Quercus suber])

HSP 1 Score: 142.5 bits (358), Expect = 2.1e-30
Identity = 60/106 (56.60%), Postives = 81/106 (76.42%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           +++KLD SKA+DR+EW F+ KVM +MGFC++W +L+M C+ SVS+S+L+NGV   +  P 
Sbjct: 535 MAIKLDMSKAFDRVEWGFIAKVMEQMGFCNRWRDLVMQCITSVSYSILINGVAHGNIYPS 594

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
           RGLRQGDPLSP LFLLC EGLS L+N   RN   +G+ IN+ CP +
Sbjct: 595 RGLRQGDPLSPSLFLLCAEGLSALINQAARNKLITGISINRGCPKV 640

[Close]

BLAST of Moc01g18370 vs. NCBI nr
Match: XP_035547368.1 (uncharacterized protein LOC118348906 [Juglans regia])

HSP 1 Score: 142.1 bits (357), Expect = 2.7e-30
Identity = 63/99 (63.64%), Postives = 78/99 (78.79%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           ++LKLD SKAYDR+EW FL  VM KMGF +KW+ LIMNCV+SVS+++++NG P  +F P 
Sbjct: 429 MALKLDISKAYDRVEWGFLRAVMVKMGFGEKWVALIMNCVQSVSYAIVVNGKPGNTFVPT 488

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHI 101
           RGLRQGDPLSPYLFLLCVEGLSTL+N  E      G+ +
Sbjct: 489 RGLRQGDPLSPYLFLLCVEGLSTLINHAESKGELKGVSV 527

[Close]

BLAST of Moc01g18370 vs. NCBI nr
Match: XP_030478262.1 (uncharacterized protein LOC115695328 [Cannabis sativa])

HSP 1 Score: 141.0 bits (354), Expect = 6.1e-30
Identity = 61/105 (58.10%), Postives = 79/105 (75.24%), Query Frame = 0


Query: 3   SLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPGR 62
           +LKLD SKA+DR+EW ++ +V+ +MGF D+W+ LIMNC+ S SFS +LNG      +P R
Sbjct: 98  ALKLDMSKAFDRVEWTYIKEVVRQMGFHDRWVSLIMNCLHSTSFSFMLNGEEVGHVQPSR 157

Query: 63  GLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
           GLRQGDPLSPYLFL+C EGLS LL +EE +NN  GL + +H P I
Sbjct: 158 GLRQGDPLSPYLFLICSEGLSRLLQSEESSNNLKGLRLTRHAPSI 202

[Close]

BLAST of Moc01g18370 vs. NCBI nr
Match: XP_018834507.1 (uncharacterized protein LOC109001610 [Juglans regia] >KAF5447955.1 hypothetical protein F2P56_033465 [Juglans regia])

HSP 1 Score: 141.0 bits (354), Expect = 6.1e-30
Identity = 65/99 (65.66%), Postives = 79/99 (79.80%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           ++LKLD SKAYD+IEW FL +VM KMGF  +WI+L+MNCVESVS+S+LLNG P   FKP 
Sbjct: 499 MALKLDMSKAYDKIEWKFLREVMIKMGFAQEWIQLVMNCVESVSYSILLNGSPQDLFKPT 558

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHI 101
           RG+RQGDPLSPYLF+LC E LS+LLN  E +   SG+ I
Sbjct: 559 RGIRQGDPLSPYLFILCAEVLSSLLNHAEFSRAISGVPI 597

[Close]

BLAST of Moc01g18370 vs. ExPASy Swiss-Prot
Match: P92555 (Uncharacterized mitochondrial protein AtMg01250 OS=Arabidopsis thaliana OX=3702 GN=AtMg01250 PE=4 SV=1)

HSP 1 Score: 64.3 bits (155), Expect = 9.5e-10
Identity = 27/59 (45.76%), Postives = 35/59 (59.32%), Query Frame = 0


Query: 49  LLNGVPSKSFKPGRGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
           ++NG P     P RGLRQGDPLSPYLF+LC E LS L    +      G+ ++ + P I
Sbjct: 13  IINGAPQGLVTPSRGLRQGDPLSPYLFILCTEVLSGLCRRAQEQGRLPGIRVSNNSPRI 71

[Close]

BLAST of Moc01g18370 vs. ExPASy Swiss-Prot
Match: P08548 (LINE-1 reverse transcriptase homolog OS=Nycticebus coucang OX=9470 PE=4 SV=1)

HSP 1 Score: 63.9 bits (154), Expect = 1.2e-09
Identity = 34/97 (35.05%), Postives = 54/97 (55.67%), Query Frame = 0


Query: 4   LKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPGRG 63
           L +D  KA+D I+  F+ + + K+G    +++LI       + +++LNGV  KSF    G
Sbjct: 596 LSIDAEKAFDNIQHPFMIRTLKKIGIEGTFLKLIEAIYSKPTANIILNGVKLKSFPLRSG 655

Query: 64  LRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHI 101
            RQG PLSP LF + +E L+  +  E+      G+HI
Sbjct: 656 TRQGCPLSPLLFNIVMEVLAIAIREEKA---IKGIHI 689

[Close]

BLAST of Moc01g18370 vs. ExPASy Swiss-Prot
Match: O00370 (LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens OX=9606 PE=1 SV=1)

HSP 1 Score: 60.1 bits (144), Expect = 1.8e-08
Identity = 30/101 (29.70%), Postives = 56/101 (55.45%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           V + +D  KA+D+I+  F+ K + K+G    ++++I    +  + +++LNG   ++F   
Sbjct: 595 VIISIDAEKAFDKIQQPFMLKTLNKLGIDGMYLKIIRAIYDKPTANIILNGQKLEAFPLK 654

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINK 103
            G RQG PLSP LF + +E L+  +  E+      G+ + K
Sbjct: 655 TGTRQGCPLSPLLFNIVLEVLARAIRQEK---EIKGIQLGK 692

[Close]

BLAST of Moc01g18370 vs. ExPASy Swiss-Prot
Match: P16423 (Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM OS=Drosophila melanogaster OX=7227 GN=pol PE=4 SV=1)

HSP 1 Score: 55.5 bits (132), Expect = 4.4e-07
Identity = 29/84 (34.52%), Postives = 45/84 (53.57%), Query Frame = 0


Query: 6   LDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPGRGLR 65
           LD SKA+D +    +   +   G    +++ + N  E    S+  +G  S+ F P RG++
Sbjct: 481 LDVSKAFDSLSHASIYDTLRAYGAPKGFVDYVQNTYEGGGTSLNGDGWSSEEFVPARGVK 540

Query: 66  QGDPLSPYLFLLCVEGLSTLLNTE 90
           QGDPLSP LF L ++ L   L +E
Sbjct: 541 QGDPLSPILFNLVMDRLLRTLPSE 564

[Close]

BLAST of Moc01g18370 vs. ExPASy Swiss-Prot
Match: P11369 (LINE-1 retrotransposable element ORF2 protein OS=Mus musculus OX=10090 GN=Pol PE=1 SV=2)

HSP 1 Score: 55.1 bits (131), Expect = 5.8e-07
Identity = 29/99 (29.29%), Postives = 51/99 (51.52%), Query Frame = 0


Query: 4   LKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPGRG 63
           + LD  KA+D+I+  F+ KV+ + G    ++ +I         ++ +NG   ++     G
Sbjct: 604 ISLDAEKAFDKIQHPFMIKVLERSGIQGPYLNMIKAIYSKPVANIKVNGEKLEAIPLKSG 663

Query: 64  LRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINK 103
            RQG PLSPYLF + +E L+  +  ++      G+ I K
Sbjct: 664 TRQGCPLSPYLFNIVLEVLARAIRQQK---EIKGIQIGK 699

[Close]

BLAST of Moc01g18370 vs. ExPASy TrEMBL
Match: A0A6J1DUG8 (uncharacterized protein LOC111024135 OS=Momordica charantia OX=3673 GN=LOC111024135 PE=4 SV=1)

HSP 1 Score: 160.6 bits (405), Expect = 3.6e-36
Identity = 68/106 (64.15%), Postives = 85/106 (80.19%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           V++KLD SKAYDR+EW +L  +M KMGF ++W++LIMNCVESV F+VL+NGVP   F P 
Sbjct: 391 VAMKLDMSKAYDRVEWQYLRGIMVKMGFANRWVDLIMNCVESVRFAVLINGVPGDEFTPN 450

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
           RGLRQGDPLSPYLF++C EGLS L+N EE+  N + L IN+ CPPI
Sbjct: 451 RGLRQGDPLSPYLFIMCAEGLSALINDEEKKGNITRLKINRRCPPI 496

[Close]

BLAST of Moc01g18370 vs. ExPASy TrEMBL
Match: A0A2N9FDP4 (Reverse transcriptase domain-containing protein OS=Fagus sylvatica OX=28930 GN=FSB_LOCUS13184 PE=4 SV=1)

HSP 1 Score: 142.5 bits (358), Expect = 1.0e-30
Identity = 65/106 (61.32%), Postives = 80/106 (75.47%), Query Frame = 0


Query: 2    VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
            ++LKLD SKAYDR+EWIFL +VMA+MGF  +WI L+M CV++ S+SVLLNG P+   KP 
Sbjct: 925  MALKLDMSKAYDRVEWIFLERVMARMGFASRWIRLLMTCVQTTSYSVLLNGEPTGYIKPT 984

Query: 62   RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
            RG+RQGDPLSPYLFLLC EGLS LL   ER     G+ I ++ P I
Sbjct: 985  RGIRQGDPLSPYLFLLCAEGLSALLCLAEREQQIHGVSICRNGPQI 1030

[Close]

BLAST of Moc01g18370 vs. ExPASy TrEMBL
Match: A0A6P9EU46 (uncharacterized protein LOC118348906 OS=Juglans regia OX=51240 GN=LOC118348906 PE=4 SV=1)

HSP 1 Score: 142.1 bits (357), Expect = 1.3e-30
Identity = 63/99 (63.64%), Postives = 78/99 (78.79%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           ++LKLD SKAYDR+EW FL  VM KMGF +KW+ LIMNCV+SVS+++++NG P  +F P 
Sbjct: 429 MALKLDISKAYDRVEWGFLRAVMVKMGFGEKWVALIMNCVQSVSYAIVVNGKPGNTFVPT 488

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHI 101
           RGLRQGDPLSPYLFLLCVEGLSTL+N  E      G+ +
Sbjct: 489 RGLRQGDPLSPYLFLLCVEGLSTLINHAESKGELKGVSV 527

[Close]

BLAST of Moc01g18370 vs. ExPASy TrEMBL
Match: A0A2I4FS81 (uncharacterized protein LOC109001610 OS=Juglans regia OX=51240 GN=LOC109001610 PE=4 SV=1)

HSP 1 Score: 141.0 bits (354), Expect = 3.0e-30
Identity = 65/99 (65.66%), Postives = 79/99 (79.80%), Query Frame = 0


Query: 2   VSLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPG 61
           ++LKLD SKAYD+IEW FL +VM KMGF  +WI+L+MNCVESVS+S+LLNG P   FKP 
Sbjct: 499 MALKLDMSKAYDKIEWKFLREVMIKMGFAQEWIQLVMNCVESVSYSILLNGSPQDLFKPT 558

Query: 62  RGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHI 101
           RG+RQGDPLSPYLF+LC E LS+LLN  E +   SG+ I
Sbjct: 559 RGIRQGDPLSPYLFILCAEVLSSLLNHAEFSRAISGVPI 597

[Close]

BLAST of Moc01g18370 vs. ExPASy TrEMBL
Match: A0A803NW04 (Uncharacterized protein OS=Cannabis sativa OX=3483 PE=4 SV=1)

HSP 1 Score: 140.6 bits (353), Expect = 3.9e-30
Identity = 65/105 (61.90%), Postives = 75/105 (71.43%), Query Frame = 0


Query: 3   SLKLDTSKAYDRIEWIFLGKVMAKMGFCDKWIELIMNCVESVSFSVLLNGVPSKSFKPGR 62
           +LKLD SKA+DR+EW +L  VM KMGF   WI LIM C+ S SFS  LNG    + KPGR
Sbjct: 495 ALKLDMSKAFDRVEWAYLAAVMEKMGFASTWISLIMKCLSSTSFSFSLNGEIVGNVKPGR 554

Query: 63  GLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
           GLRQGDPLSPYLFL+C EGLS LLN EE   N +GL + +H P I
Sbjct: 555 GLRQGDPLSPYLFLICFEGLSRLLNHEEDIGNLAGLRLTRHAPSI 599

[Close]

BLAST of Moc01g18370 vs. TAIR 10
Match: ATMG01250.1 (RNA-directed DNA polymerase (reverse transcriptase) )

HSP 1 Score: 64.3 bits (155), Expect = 6.8e-11
Identity = 27/59 (45.76%), Postives = 35/59 (59.32%), Query Frame = 0


Query: 49  LLNGVPSKSFKPGRGLRQGDPLSPYLFLLCVEGLSTLLNTEERNNNFSGLHINKHCPPI 108
           ++NG P     P RGLRQGDPLSPYLF+LC E LS L    +      G+ ++ + P I
Sbjct: 13  IINGAPQGLVTPSRGLRQGDPLSPYLFILCTEVLSGLCRRAQEQGRLPGIRVSNNSPRI 71

The following BLAST results are available for this feature:

BLAST of Moc01g18370 vs. NCBI nr


Match Name	E-value	Identity	Description
XP_022157437.1	7.4e-36	64.15	uncharacterized protein LOC111024135 [Momordica charantia]	[more]
XP_023878301.1	2.1e-30	56.60	uncharacterized protein LOC111990748 [Quercus suber]	[more]
XP_035547368.1	2.7e-30	63.64	uncharacterized protein LOC118348906 [Juglans regia]	[more]
XP_030478262.1	6.1e-30	58.10	uncharacterized protein LOC115695328 [Cannabis sativa]	[more]
XP_018834507.1	6.1e-30	65.66	uncharacterized protein LOC109001610 [Juglans regia] >KAF5447955.1 hypothetical ...	[more]

BLAST of Moc01g18370 vs. ExPASy Swiss-Prot


Match Name	E-value	Identity	Description
P92555	9.5e-10	45.76	Uncharacterized mitochondrial protein AtMg01250 OS=Arabidopsis thaliana OX=3702 ...	[more]
P08548	1.2e-09	35.05	LINE-1 reverse transcriptase homolog OS=Nycticebus coucang OX=9470 PE=4 SV=1	[more]
O00370	1.8e-08	29.70	LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens OX=9606 PE=1 SV=1	[more]
P16423	4.4e-07	34.52	Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM OS...	[more]
P11369	5.8e-07	29.29	LINE-1 retrotransposable element ORF2 protein OS=Mus musculus OX=10090 GN=Pol PE...	[more]

BLAST of Moc01g18370 vs. ExPASy TrEMBL


Match Name	E-value	Identity	Description
A0A6J1DUG8	3.6e-36	64.15	uncharacterized protein LOC111024135 OS=Momordica charantia OX=3673 GN=LOC111024...	[more]
A0A2N9FDP4	1.0e-30	61.32	Reverse transcriptase domain-containing protein OS=Fagus sylvatica OX=28930 GN=F...	[more]
A0A6P9EU46	1.3e-30	63.64	uncharacterized protein LOC118348906 OS=Juglans regia OX=51240 GN=LOC118348906 P...	[more]
A0A2I4FS81	3.0e-30	65.66	uncharacterized protein LOC109001610 OS=Juglans regia OX=51240 GN=LOC109001610 P...	[more]
A0A803NW04	3.9e-30	61.90	Uncharacterized protein OS=Cannabis sativa OX=3483 PE=4 SV=1	[more]

BLAST of Moc01g18370 vs. TAIR 10


Match Name	E-value	Identity	Description
ATMG01250.1	6.8e-11	45.76	RNA-directed DNA polymerase (reverse transcriptase)	[more]

InterPro

Analysis Name: InterPro Annotations of Bitter gourd (OHB3-1) v2
Date Performed: 2022-08-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000477	Reverse transcriptase domain	PFAM	PF00078	RVT_1	coord: 4..90 e-value: 1.0E-16 score: 61.2
IPR000477	Reverse transcriptase domain	PROSITE	PS50878	RT_POL	coord: 1..107 score: 9.306096
None	No IPR available	PANTHER	PTHR33116	REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED	coord: 3..95
None	No IPR available	PANTHER	PTHR33116:SF45	SUBFAMILY NOT NAMED	coord: 3..95
IPR043502	DNA/RNA polymerase superfamily	SUPERFAMILY	56672	DNA/RNA polymerases	coord: 3..81

Relationships

The following mRNA feature(s) are a part of this gene:


Feature Name	Unique Name	Type
Moc01g18370.1	Moc01g18370.1	mRNA

GO Annotation

GO Assignments

This gene is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006278	RNA-dependent DNA biosynthetic process
biological_process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
molecular_function	GO:0003676	nucleic acid binding
molecular_function	GO:0003964	RNA-directed DNA polymerase activity
molecular_function	GO:0004523	RNA-DNA hybrid ribonuclease activity