MC02g1240 (gene) Bitter gourd (Dali-11) v1

Overview
NameMC02g1240
Typegene
OrganismMomordica charantia cv. Dali-11 (Bitter gourd (Dali-11) v1)
DescriptionProteinase inhibitor-like
LocationMC02: 11351108 .. 11351454 (-)
RNA-Seq ExpressionMC02g1240
SyntenyMC02g1240
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: polypeptideCDS
Hold the cursor over a type above to highlight its positions in the sequence below.
CGTTATCCCCCTTGTGCTAGTGGTACTTGCACAGACGTTGTCTGTTGCACTTTGGGTCAAGGTGAGATTTCTCGCGCTCAAAACTTCTCTTTCCCTCTGAACACAACGATTTTTGTTTGTTTATTTTATTAATGTAAAACTTTGTGCATGCAGGACGTAAATTTAGATGGCCTGAAGTTATTGGAATGAAAGGAGGAGTAGCTAGAGTAATAATCGAAAGAGAAGCCCCATATGCCATAGTTGTTTATTTAGTACCAGGCATGGTCAGACTTAGTGATTTCTGTTGCAACCGTGTTTATGTTGTCCTTGATGAACGTGGTGTTGTCATCGATGTCTCCGTCATTGGT

mRNA sequence

CGTTATCCCCCTTGTGCTAGTGGTACTTGCACAGACGTTGTCTGTTGCACTTTGGGTCAAGGACGTAAATTTAGATGGCCTGAAGTTATTGGAATGAAAGGAGGAGTAGCTAGAGTAATAATCGAAAGAGAAGCCCCATATGCCATAGTTGTTTATTTAGTACCAGGCATGGTCAGACTTAGTGATTTCTGTTGCAACCGTGTTTATGTTGTCCTTGATGAACGTGGTGTTGTCATCGATGTCTCCGTCATTGGT

Coding sequence (CDS)

CGTTATCCCCCTTGTGCTAGTGGTACTTGCACAGACGTTGTCTGTTGCACTTTGGGTCAAGGACGTAAATTTAGATGGCCTGAAGTTATTGGAATGAAAGGAGGAGTAGCTAGAGTAATAATCGAAAGAGAAGCCCCATATGCCATAGTTGTTTATTTAGTACCAGGCATGGTCAGACTTAGTGATTTCTGTTGCAACCGTGTTTATGTTGTCCTTGATGAACGTGGTGTTGTCATCGATGTCTCCGTCATTGGT

Protein sequence

RYPPCASGTCTDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYVVLDERGVVIDVSVIG
Homology
BLAST of MC02g1240 vs. ExPASy Swiss-Prot
Match: P19873 (Inhibitor of trypsin and hageman factor OS=Cucurbita maxima OX=3661 PE=1 SV=1)

HSP 1 Score: 52.4 bits (124), Expect = 3.0e-06
Identity = 26/63 (41.27%), Postives = 37/63 (58.73%), Query Frame = 0

Query: 23 KFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYVVLDERGVVIDVS 82
          K  WP ++G+ G VA+ IIER+ P    V L  G     DF CNRV + +++RG+V+   
Sbjct: 6  KSSWPHLVGVGGSVAKAIIERQNPNVKAVILEEGTPVTKDFRCNRVRIWVNKRGLVVSPP 65

Query: 83 VIG 86
           IG
Sbjct: 66 RIG 68

BLAST of MC02g1240 vs. ExPASy Swiss-Prot
Match: P24076 (Glu S.griseus protease inhibitor OS=Momordica charantia OX=3673 PE=1 SV=1)

HSP 1 Score: 49.7 bits (117), Expect = 1.9e-05
Identity = 26/66 (39.39%), Postives = 38/66 (57.58%), Query Frame = 0

Query: 20 QGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYVVLDERGVVI 79
          QG++  WP+++G  G  A+ +IERE P    V +  G    +DF C+RV V + ERG+V 
Sbjct: 4  QGKR-SWPQLVGSTGAAAKAVIERENPRVRAVIVRVGSPVTADFRCDRVRVWVTERGIVA 63

Query: 80 DVSVIG 86
              IG
Sbjct: 64 RPPAIG 68

BLAST of MC02g1240 vs. ExPASy Swiss-Prot
Match: P82381 (Proteinase inhibitor OS=Linum usitatissimum OX=4006 PE=1 SV=1)

HSP 1 Score: 48.9 bits (115), Expect = 3.3e-05
Identity = 22/59 (37.29%), Postives = 33/59 (55.93%), Query Frame = 0

Query: 23 KFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYVVLDERGVVIDV 82
          K  WPE++G  G +A   +ERE      + L  G     DF C+RV+V++++ GVV  V
Sbjct: 7  KNAWPELVGKSGNMAAATVERENRNVHAIVLKEGSAMTKDFRCDRVWVIVNDHGVVTSV 65

BLAST of MC02g1240 vs. ExPASy Swiss-Prot
Match: P80211 (Trypsin/subtilisin inhibitor OS=Amaranthus caudatus OX=3567 PE=1 SV=1)

HSP 1 Score: 45.4 bits (106), Expect = 3.6e-04
Identity = 27/59 (45.76%), Postives = 36/59 (61.02%), Query Frame = 0

Query: 23 KFRWPEVIGMKGGVARVIIEREAP--YAIVVYLVPGMVRLSDFCCNRVYVVLDERGVVI 80
          K  WPE++G  G  A  IIERE P   +IV +   G  +  DF C+RV+VV+D  GVV+
Sbjct: 7  KQEWPELVGEYGYKAAAIIERENPNVRSIVKHERSGFTK--DFRCDRVWVVVDSTGVVV 63

BLAST of MC02g1240 vs. NCBI nr
Match: XP_022147245.1 (uncharacterized protein LOC111016241 [Momordica charantia])

HSP 1 Score: 134 bits (336), Expect = 1.51e-34
Identity = 66/75 (88.00%), Postives = 69/75 (92.00%), Query Frame = 0

Query: 15  CCTL----GQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYV 74
           CC +     QGRKFRWPEVIGMKGGVARVII+REAPYAIVVYLVPGMVRLSDFCCNRVYV
Sbjct: 472 CCRILAMEKQGRKFRWPEVIGMKGGVARVIIKREAPYAIVVYLVPGMVRLSDFCCNRVYV 531

Query: 75  VLDERGVVIDVSVIG 85
           VLDERGVVIDV+VIG
Sbjct: 532 VLDERGVVIDVAVIG 546

BLAST of MC02g1240 vs. NCBI nr
Match: TYK07514.1 (proteinase inhibitor-like [Cucumis melo var. makuwa] >TYK21960.1 proteinase inhibitor-like [Cucumis melo var. makuwa] >TYK21972.1 proteinase inhibitor-like [Cucumis melo var. makuwa])

HSP 1 Score: 108 bits (269), Expect = 1.76e-28
Identity = 50/85 (58.82%), Postives = 61/85 (71.76%), Query Frame = 0

Query: 2  YPPCASGTCTDVVCCTLGQG-RKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 61
          YPPC SGTCTD  CCTLG+G RKFRWPE+ G  GG A+  I ++AP+  VV++ PG V L
Sbjct: 9  YPPCVSGTCTDSACCTLGRGQRKFRWPELRGKNGGDAKNQINKDAPFVTVVFIRPGQVAL 68

Query: 62 SDFCCNRVYVVLDERGVVIDVSVIG 85
           +FCCNRV VVLD  G V ++  IG
Sbjct: 69 PNFCCNRVNVVLDPSGKVSNIPFIG 93

BLAST of MC02g1240 vs. NCBI nr
Match: KAA0035178.1 (proteinase inhibitor-like [Cucumis melo var. makuwa])

HSP 1 Score: 105 bits (263), Expect = 1.44e-27
Identity = 49/85 (57.65%), Postives = 60/85 (70.59%), Query Frame = 0

Query: 2  YPPCASGTCTDVVCCTLGQG-RKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 61
          YPPC SGTCTD  CCTLG+G RKFRWPE+ G  G  A+  I ++AP+  VV++ PG V L
Sbjct: 9  YPPCVSGTCTDSACCTLGRGQRKFRWPELRGKNGADAKNQINKDAPFVTVVFIRPGQVAL 68

Query: 62 SDFCCNRVYVVLDERGVVIDVSVIG 85
           +FCCNRV VVLD  G V ++  IG
Sbjct: 69 PNFCCNRVNVVLDPSGKVSNIPFIG 93

BLAST of MC02g1240 vs. NCBI nr
Match: XP_022764760.1 (proteinase inhibitor-like [Durio zibethinus])

HSP 1 Score: 103 bits (256), Expect = 1.54e-26
Identity = 45/85 (52.94%), Postives = 58/85 (68.24%), Query Frame = 0

Query: 1  RYPPCASGTCTDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 60
          RYPPCASG+CTD +CC+   GRKF WPE++G  G VA+  IE++ P   V  + PG V  
Sbjct: 8  RYPPCASGSCTDPICCS--HGRKFTWPELLGKNGQVAKATIEKDNPEVTVEIITPGRVGF 67

Query: 61 SDFCCNRVYVVLDERGVVIDVSVIG 85
           DFCCNRVY+VLD  G V ++  +G
Sbjct: 68 PDFCCNRVYLVLDNNGNVTNMPTVG 90

BLAST of MC02g1240 vs. NCBI nr
Match: MBA0577456.1 (hypothetical protein [Gossypium lobatum] >MBA0692327.1 hypothetical protein [Gossypium aridum] >MBA0692329.1 hypothetical protein [Gossypium aridum])

HSP 1 Score: 101 bits (251), Expect = 8.40e-26
Identity = 45/85 (52.94%), Postives = 55/85 (64.71%), Query Frame = 0

Query: 1  RYPPCASGTCTDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 60
          RYPPCA+GTCTDVVCC    G K RWPE++G  G  A+  IE+E P      L PG V  
Sbjct: 6  RYPPCATGTCTDVVCCA--HGHKLRWPELLGKNGAAAKATIEKENPEVTAEILTPGRVGP 65

Query: 61 SDFCCNRVYVVLDERGVVIDVSVIG 85
           DFCCNRV+V++D  G V ++  IG
Sbjct: 66 HDFCCNRVFVIVDTHGNVTNIPTIG 88

BLAST of MC02g1240 vs. ExPASy TrEMBL
Match: A0A6J1CZL8 (uncharacterized protein LOC111016241 OS=Momordica charantia OX=3673 GN=LOC111016241 PE=3 SV=1)

HSP 1 Score: 134 bits (336), Expect = 7.32e-35
Identity = 66/75 (88.00%), Postives = 69/75 (92.00%), Query Frame = 0

Query: 15  CCTL----GQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYV 74
           CC +     QGRKFRWPEVIGMKGGVARVII+REAPYAIVVYLVPGMVRLSDFCCNRVYV
Sbjct: 472 CCRILAMEKQGRKFRWPEVIGMKGGVARVIIKREAPYAIVVYLVPGMVRLSDFCCNRVYV 531

Query: 75  VLDERGVVIDVSVIG 85
           VLDERGVVIDV+VIG
Sbjct: 532 VLDERGVVIDVAVIG 546

BLAST of MC02g1240 vs. ExPASy TrEMBL
Match: A0A5D3DF00 (Proteinase inhibitor-like OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold543G00060 PE=3 SV=1)

HSP 1 Score: 108 bits (269), Expect = 8.50e-29
Identity = 50/85 (58.82%), Postives = 61/85 (71.76%), Query Frame = 0

Query: 2  YPPCASGTCTDVVCCTLGQG-RKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 61
          YPPC SGTCTD  CCTLG+G RKFRWPE+ G  GG A+  I ++AP+  VV++ PG V L
Sbjct: 9  YPPCVSGTCTDSACCTLGRGQRKFRWPELRGKNGGDAKNQINKDAPFVTVVFIRPGQVAL 68

Query: 62 SDFCCNRVYVVLDERGVVIDVSVIG 85
           +FCCNRV VVLD  G V ++  IG
Sbjct: 69 PNFCCNRVNVVLDPSGKVSNIPFIG 93

BLAST of MC02g1240 vs. ExPASy TrEMBL
Match: A0A5A7SX46 (Proteinase inhibitor-like OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold57G002800 PE=3 SV=1)

HSP 1 Score: 105 bits (263), Expect = 6.97e-28
Identity = 49/85 (57.65%), Postives = 60/85 (70.59%), Query Frame = 0

Query: 2  YPPCASGTCTDVVCCTLGQG-RKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 61
          YPPC SGTCTD  CCTLG+G RKFRWPE+ G  G  A+  I ++AP+  VV++ PG V L
Sbjct: 9  YPPCVSGTCTDSACCTLGRGQRKFRWPELRGKNGADAKNQINKDAPFVTVVFIRPGQVAL 68

Query: 62 SDFCCNRVYVVLDERGVVIDVSVIG 85
           +FCCNRV VVLD  G V ++  IG
Sbjct: 69 PNFCCNRVNVVLDPSGKVSNIPFIG 93

BLAST of MC02g1240 vs. ExPASy TrEMBL
Match: A0A6P6AIT5 (proteinase inhibitor-like OS=Durio zibethinus OX=66656 GN=LOC111309978 PE=3 SV=1)

HSP 1 Score: 103 bits (256), Expect = 7.45e-27
Identity = 45/85 (52.94%), Postives = 58/85 (68.24%), Query Frame = 0

Query: 1  RYPPCASGTCTDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 60
          RYPPCASG+CTD +CC+   GRKF WPE++G  G VA+  IE++ P   V  + PG V  
Sbjct: 8  RYPPCASGSCTDPICCS--HGRKFTWPELLGKNGQVAKATIEKDNPEVTVEIITPGRVGF 67

Query: 61 SDFCCNRVYVVLDERGVVIDVSVIG 85
           DFCCNRVY+VLD  G V ++  +G
Sbjct: 68 PDFCCNRVYLVLDNNGNVTNMPTVG 90

BLAST of MC02g1240 vs. ExPASy TrEMBL
Match: A0A7J8XZZ6 (Uncharacterized protein OS=Gossypium aridum OX=34290 GN=Goari_009898 PE=3 SV=1)

HSP 1 Score: 101 bits (251), Expect = 4.07e-26
Identity = 45/85 (52.94%), Postives = 55/85 (64.71%), Query Frame = 0

Query: 1  RYPPCASGTCTDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 60
          RYPPCA+GTCTDVVCC    G K RWPE++G  G  A+  IE+E P      L PG V  
Sbjct: 6  RYPPCATGTCTDVVCCA--HGHKLRWPELLGKNGAAAKATIEKENPEVTAEILTPGRVGP 65

Query: 61 SDFCCNRVYVVLDERGVVIDVSVIG 85
           DFCCNRV+V++D  G V ++  IG
Sbjct: 66 HDFCCNRVFVIVDTHGNVTNIPTIG 88

BLAST of MC02g1240 vs. TAIR 10
Match: AT3G46860.1 (Serine protease inhibitor, potato inhibitor I-type family protein )

HSP 1 Score: 92.8 bits (229), Expect = 1.4e-19
Identity = 41/85 (48.24%), Postives = 56/85 (65.88%), Query Frame = 0

Query: 1  RYPPCASGTCTDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRL 60
          RYPPC SG+C D  CC +  G+K+RWPE++G  G +A++ IERE P  + + L  G  R+
Sbjct: 3  RYPPCWSGSCEDPECCAI--GKKYRWPELVGKNGQLAKMTIERENPNVLAIVLRYGEKRI 62

Query: 61 SDFCCNRVYVVLDERGVVIDVSVIG 86
           +FCCNRV+V L   G V D  +IG
Sbjct: 63 ENFCCNRVFVYLGSNGQVADAPMIG 85

BLAST of MC02g1240 vs. TAIR 10
Match: AT3G50020.1 (Serine protease inhibitor, potato inhibitor I-type family protein )

HSP 1 Score: 57.0 bits (136), Expect = 8.6e-09
Identity = 28/68 (41.18%), Postives = 38/68 (55.88%), Query Frame = 0

Query: 3  PPCASGTCTDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSD 62
          PPC   +C  + C  L  G K  WPE+ G+KG  A+ IIE + P  +VV +   +  L+ 
Sbjct: 10 PPCQRCSCAGITCQPLFPGIKVDWPELNGVKGLEAKRIIEHDNPKVVVVIIPDDVAVLAV 69

Query: 63 FCCNRVYV 71
           CCNRV V
Sbjct: 70 NCCNRVIV 77

BLAST of MC02g1240 vs. TAIR 10
Match: AT5G43580.1 (Serine protease inhibitor, potato inhibitor I-type family protein )

HSP 1 Score: 55.5 bits (132), Expect = 2.5e-08
Identity = 26/63 (41.27%), Postives = 40/63 (63.49%), Query Frame = 0

Query: 23 KFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYVVLDERGVVIDVS 82
          K  WPE++G KG  A+ +IERE P    V ++ G V    F C+RVYV +++ G+V+ + 
Sbjct: 37 KSSWPELLGAKGEDAKEVIERENPKMKAVIILDGTVVPEIFICSRVYVWVNDCGIVVQIP 96

Query: 83 VIG 86
          +IG
Sbjct: 97 IIG 99

BLAST of MC02g1240 vs. TAIR 10
Match: AT5G43570.1 (Serine protease inhibitor, potato inhibitor I-type family protein )

HSP 1 Score: 48.9 bits (115), Expect = 2.3e-06
Identity = 24/68 (35.29%), Postives = 39/68 (57.35%), Query Frame = 0

Query: 11 TDVVCCTLGQGRKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYV 70
          +DV   T G+G K  WPE++G +G   + II+RE        +    V L+   C+RVYV
Sbjct: 2  SDVCQNTAGEGMKSSWPELVGRRGEEVKEIIDRENTKVTAKIISENAVVLAVVICDRVYV 61

Query: 71 VLDERGVV 79
           ++++G+V
Sbjct: 62 RVNDQGIV 69

BLAST of MC02g1240 vs. TAIR 10
Match: AT2G38870.1 (Serine protease inhibitor, potato inhibitor I-type family protein )

HSP 1 Score: 47.0 bits (110), Expect = 8.9e-06
Identity = 23/58 (39.66%), Postives = 32/58 (55.17%), Query Frame = 0

Query: 22 RKFRWPEVIGMKGGVARVIIEREAPYAIVVYLVPGMVRLSDFCCNRVYVVLDERGVVI 80
          RK  WPE+ G  G  A V+IERE P      ++ G    +DF C+RV V +D   +V+
Sbjct: 7  RKNSWPELTGTNGDYAAVVIERENPTVNAAVILDGSPVTADFRCDRVRVFVDGNRIVV 64

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
P198733.0e-0641.27Inhibitor of trypsin and hageman factor OS=Cucurbita maxima OX=3661 PE=1 SV=1[more]
P240761.9e-0539.39Glu S.griseus protease inhibitor OS=Momordica charantia OX=3673 PE=1 SV=1[more]
P823813.3e-0537.29Proteinase inhibitor OS=Linum usitatissimum OX=4006 PE=1 SV=1[more]
P802113.6e-0445.76Trypsin/subtilisin inhibitor OS=Amaranthus caudatus OX=3567 PE=1 SV=1[more]
Match NameE-valueIdentityDescription
XP_022147245.11.51e-3488.00uncharacterized protein LOC111016241 [Momordica charantia][more]
TYK07514.11.76e-2858.82proteinase inhibitor-like [Cucumis melo var. makuwa] >TYK21960.1 proteinase inhi... [more]
KAA0035178.11.44e-2757.65proteinase inhibitor-like [Cucumis melo var. makuwa][more]
XP_022764760.11.54e-2652.94proteinase inhibitor-like [Durio zibethinus][more]
MBA0577456.18.40e-2652.94hypothetical protein [Gossypium lobatum] >MBA0692327.1 hypothetical protein [Gos... [more]
Match NameE-valueIdentityDescription
A0A6J1CZL87.32e-3588.00uncharacterized protein LOC111016241 OS=Momordica charantia OX=3673 GN=LOC111016... [more]
A0A5D3DF008.50e-2958.82Proteinase inhibitor-like OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffo... [more]
A0A5A7SX466.97e-2857.65Proteinase inhibitor-like OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffo... [more]
A0A6P6AIT57.45e-2752.94proteinase inhibitor-like OS=Durio zibethinus OX=66656 GN=LOC111309978 PE=3 SV=1[more]
A0A7J8XZZ64.07e-2652.94Uncharacterized protein OS=Gossypium aridum OX=34290 GN=Goari_009898 PE=3 SV=1[more]
Match NameE-valueIdentityDescription
AT3G46860.11.4e-1948.24Serine protease inhibitor, potato inhibitor I-type family protein [more]
AT3G50020.18.6e-0941.18Serine protease inhibitor, potato inhibitor I-type family protein [more]
AT5G43580.12.5e-0841.27Serine protease inhibitor, potato inhibitor I-type family protein [more]
AT5G43570.12.3e-0635.29Serine protease inhibitor, potato inhibitor I-type family protein [more]
AT2G38870.18.9e-0639.66Serine protease inhibitor, potato inhibitor I-type family protein [more]
InterPro
Analysis Name: InterPro Annotations of Bitter gourd (Dali-11) v1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000864Proteinase inhibitor I13, potato inhibitor IPFAMPF00280potato_inhibitcoord: 23..85
e-value: 1.4E-16
score: 60.9
IPR000864Proteinase inhibitor I13, potato inhibitor IPANTHERPTHR33091PROTEIN, PUTATIVE, EXPRESSED-RELATEDcoord: 1..85
IPR000864Proteinase inhibitor I13, potato inhibitor IPROSITEPS00285POTATO_INHIBITORcoord: 26..37
NoneNo IPR availableGENE3D3.30.10.10Trypsin Inhibitor V, subunit Acoord: 17..85
e-value: 1.0E-17
score: 66.1
NoneNo IPR availablePANTHERPTHR33091:SF44SERINE PROTEASE INHIBITOR POTATO INHIBITOR I-TYPE FAMILY PROTEINcoord: 1..85
IPR036354Proteinase inhibitor I13, potato inhibitor I superfamilySUPERFAMILY54654CI-2 family of serine protease inhibitorscoord: 20..85

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
MC02g1240.1MC02g1240.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0010951 negative regulation of endopeptidase activity
biological_process GO:0009611 response to wounding
cellular_component GO:0016021 integral component of membrane
molecular_function GO:0004867 serine-type endopeptidase inhibitor activity