IVF0004320 (gene) Melon (IVF77) v1

Overview


Name	IVF0004320
Type	gene
Organism	Cucumis melo L. ssp. agrestis cv. IVF77 (Melon (IVF77) v1)
Description	Ribonuclease H
Location	chr02: 12957343 .. 12957994 (+)
RNA-Seq Expression	IVF0004320
Synteny	IVF0004320

Sequences

The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonCDSpolypeptide

Hold the cursor over a type above to highlight its positions in the sequence below.

ATGCCTATCATTGCAAAAGATATAGAATACAAAAAGCTTTTCACGGATGAGGAAGCAAATGAATTCTTGAAAATAGTAAAACAAAGTGAGTATAAGATCATAGAGCAAATGCATCATACTCCAGCTCGAATTTCTTTATTATCGTTGTTTTTGAATTCAGAGCCTCATCGCAAAGTGTTATTAGATATTTTGAACAAGGCACATGTCGGACATGACATTTCAGTGGAAAAGTTTAGTGGAATTATTGGAAACATTACATCTTCAAATTCCATAGTCTTCACAGATGACGAAATTCCTCCTGAAGGCTTAGGCCATACAAAAGCACTGCATATTCAAGTGAAGTGCAAAGACTACGTCATTGCAAGAGTTTTAGTGGATAACGGATCAACTCTCAATATAATGCCTAAATCTACACTATTGAAGCTTCCCGTGGATATGTCACACATAAAGTCAAGTACTATGGTTGTGAAAGCTTTCGATGGGTTGCGCAGAGAAGTAATGGGTGACATTGAACTACCAGTTAAAATTGGCCCATGTATTTTCAACATAGTCTTTCAAGTCATGGAGATAACACCCACATACAGTTTTTTATTAGGACGTCCTTGGATTCACTCCGCAGGAGTGGTGCCATCCACATTGCATCAAAAATTGA

mRNA sequence

ATGCCTATCATTGCAAAAGATATAGAATACAAAAAGCTTTTCACGGATGAGGAAGCAAATGAATTCTTGAAAATAGTAAAACAAAGTGAGTATAAGATCATAGAGCAAATGCATCATACTCCAGCTCGAATTTCTTTATTATCGTTGTTTTTGAATTCAGAGCCTCATCGCAAAGTGTTATTAGATATTTTGAACAAGGCACATGTCGGACATGACATTTCAGTGGAAAAGTTTAGTGGAATTATTGGAAACATTACATCTTCAAATTCCATAGTCTTCACAGATGACGAAATTCCTCCTGAAGGCTTAGGCCATACAAAAGCACTGCATATTCAAGTGAAGTGCAAAGACTACGTCATTGCAAGAGTTTTAGTGGATAACGGATCAACTCTCAATATAATGCCTAAATCTACACTATTGAAGCTTCCCGTGGATATGTCACACATAAAGTCAAGTACTATGGTTGTGAAAGCTTTCGATGGGTTGCGCAGAGAAGACGTCCTTGGATTCACTCCGCAGGAGTGGTGCCATCCACATTGCATCAAAAATTGA

Coding sequence (CDS)

ATGCCTATCATTGCAAAAGATATAGAATACAAAAAGCTTTTCACGGATGAGGAAGCAAATGAATTCTTGAAAATAGTAAAACAAAGTGAGTATAAGATCATAGAGCAAATGCATCATACTCCAGCTCGAATTTCTTTATTATCGTTGTTTTTGAATTCAGAGCCTCATCGCAAAGTGTTATTAGATATTTTGAACAAGGCACATGTCGGACATGACATTTCAGTGGAAAAGTTTAGTGGAATTATTGGAAACATTACATCTTCAAATTCCATAGTCTTCACAGATGACGAAATTCCTCCTGAAGGCTTAGGCCATACAAAAGCACTGCATATTCAAGTGAAGTGCAAAGACTACGTCATTGCAAGAGTTTTAGTGGATAACGGATCAACTCTCAATATAATGCCTAAATCTACACTATTGAAGCTTCCCGTGGATATGTCACACATAAAGTCAAGTACTATGGTTGTGAAAGCTTTCGATGGGTTGCGCAGAGAAGACGTCCTTGGATTCACTCCGCAGGAGTGGTGCCATCCACATTGCATCAAAAATTGA

Protein sequence

MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVLLDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVIARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRREDVLGFTPQEWCHPHCIKN

Homology

[Close]

BLAST of IVF0004320 vs. ExPASy TrEMBL
Match: A0A5D3DEB3 (Retrotrans_gag domain-containing protein OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold1721G00440 PE=4 SV=1)

HSP 1 Score: 319.3 bits (817), Expect = 1.0e-83
Identity = 162/165 (98.18%), Postives = 162/165 (98.18%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYKKL TDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL
Sbjct: 667 MPIIAKDIEYKKLVTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 726

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI
Sbjct: 727 LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 786

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 166
           ARVLVDNGS LNIMPKSTLLKLPVDMSHIKSSTMVVKAFDG RRE
Sbjct: 787 ARVLVDNGSALNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGSRRE 831

[Close]

BLAST of IVF0004320 vs. ExPASy TrEMBL
Match: A0A5A7TRL7 (Ribonuclease H OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold284G00010 PE=4 SV=1)

HSP 1 Score: 314.3 bits (804), Expect = 3.3e-82
Identity = 159/165 (96.36%), Postives = 161/165 (97.58%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYK L TDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL
Sbjct: 313 MPIIAKDIEYKNLVTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 372

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISV+KFSGIIGNITSSNSIVFTDD+IPPEGLGHTKALHIQVKCKDYVI
Sbjct: 373 LDILNKAHVGHDISVKKFSGIIGNITSSNSIVFTDDKIPPEGLGHTKALHIQVKCKDYVI 432

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 166
           ARVLVDNGS LNIMPKSTLLKLPVDMSHIKSSTMVVKAFDG RRE
Sbjct: 433 ARVLVDNGSALNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGSRRE 477

[Close]

BLAST of IVF0004320 vs. ExPASy TrEMBL
Match: A0A5A7T7R4 (Ribonuclease H OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold277G002820 PE=4 SV=1)

HSP 1 Score: 313.9 bits (803), Expect = 4.4e-82
Identity = 159/165 (96.36%), Postives = 159/165 (96.36%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYKKL TDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL
Sbjct: 459 MPIIAKDIEYKKLVTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 518

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNIT  NSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI
Sbjct: 519 LDILNKAHVGHDISVEKFSGIIGNITPPNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 578

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 166
           ARVLVDNGS LNIMPKSTLLKLPVDMSHIKSSTMVVK FDG RRE
Sbjct: 579 ARVLVDNGSALNIMPKSTLLKLPVDMSHIKSSTMVVKVFDGSRRE 623

[Close]

BLAST of IVF0004320 vs. ExPASy TrEMBL
Match: A0A5A7T0R1 (Uncharacterized protein OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold86G00300 PE=4 SV=1)

HSP 1 Score: 312.4 bits (799), Expect = 1.3e-81
Identity = 158/165 (95.76%), Postives = 161/165 (97.58%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYKKL TDEEANEFLKIVKQSEYKIIEQMH+TPARISLLSLFLNSEPHRK+L
Sbjct: 673 MPIIAKDIEYKKLVTDEEANEFLKIVKQSEYKIIEQMHYTPARISLLSLFLNSEPHRKLL 732

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQ+KCKDYVI
Sbjct: 733 LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQLKCKDYVI 792

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 166
           ARVLVDNGS LNIMPKSTLL LPVDMSHIKSSTMVVKAFDG RRE
Sbjct: 793 ARVLVDNGSALNIMPKSTLLMLPVDMSHIKSSTMVVKAFDGSRRE 837

[Close]

BLAST of IVF0004320 vs. ExPASy TrEMBL
Match: A0A5A7VIM6 (RNA-directed DNA polymerase (Reverse transcriptase), Ribonuclease H-like protein OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold138G001370 PE=4 SV=1)

HSP 1 Score: 310.1 bits (793), Expect = 6.3e-81
Identity = 157/165 (95.15%), Postives = 160/165 (96.97%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYKKL TDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL
Sbjct: 640 MPIIAKDIEYKKLVTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 699

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDIS+EKFSGIIGNITSSN IVFTDD+IPPEGLGHTKALHIQVKCKDYVI
Sbjct: 700 LDILNKAHVGHDISMEKFSGIIGNITSSNFIVFTDDKIPPEGLGHTKALHIQVKCKDYVI 759

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 166
           ARVLVDNGS LNIMPKSTLLKLPVDMSHIKSSTMVVK F+G RRE
Sbjct: 760 ARVLVDNGSALNIMPKSTLLKLPVDMSHIKSSTMVVKDFNGSRRE 804

[Close]

BLAST of IVF0004320 vs. NCBI nr
Match: KAA0065724.1 (uncharacterized protein E6C27_scaffold37G00080 [Cucumis melo var. makuwa] >TYK13749.1 uncharacterized protein E5676_scaffold488G00050 [Cucumis melo var. makuwa])

HSP 1 Score: 303 bits (776), Expect = 5.74e-101
Identity = 156/163 (95.71%), Postives = 157/163 (96.32%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYKKL TDEEANEFLKIVKQSE KIIEQMHHT ARISLLSLFLNSEPHR+VL
Sbjct: 101 MPIIAKDIEYKKLVTDEEANEFLKIVKQSENKIIEQMHHTQARISLLSLFLNSEPHREVL 160

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNITSSNSIV TDDEIPPEGLGHTKALHIQVKCKDYVI
Sbjct: 161 LDILNKAHVGHDISVEKFSGIIGNITSSNSIVLTDDEIPPEGLGHTKALHIQVKCKDYVI 220

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLR 163
           ARVLVDN STLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDG R
Sbjct: 221 ARVLVDNRSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGSR 263

[Close]

BLAST of IVF0004320 vs. NCBI nr
Match: TYK21788.1 (uncharacterized protein E5676_scaffold1721G00440 [Cucumis melo var. makuwa])

HSP 1 Score: 318 bits (816), Expect = 4.03e-98
Identity = 162/165 (98.18%), Postives = 162/165 (98.18%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYKKL TDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL
Sbjct: 667 MPIIAKDIEYKKLVTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 726

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI
Sbjct: 727 LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 786

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 165
           ARVLVDNGS LNIMPKSTLLKLPVDMSHIKSSTMVVKAFDG RRE
Sbjct: 787 ARVLVDNGSALNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGSRRE 831

[Close]

BLAST of IVF0004320 vs. NCBI nr
Match: TYK27304.1 (uncharacterized protein E5676_scaffold1784G00170 [Cucumis melo var. makuwa])

HSP 1 Score: 305 bits (782), Expect = 9.33e-98
Identity = 156/165 (94.55%), Postives = 159/165 (96.36%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           M IIAKDIEYKKL TDEEANEFLK+VKQSEYKII+QMHHTPA+ISLLSLFLNSEPH KVL
Sbjct: 443 MSIIAKDIEYKKLVTDEEANEFLKMVKQSEYKIIKQMHHTPAQISLLSLFLNSEPHCKVL 502

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDD IPPEGLGHTKALHIQVKCKDYVI
Sbjct: 503 LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDGIPPEGLGHTKALHIQVKCKDYVI 562

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 165
           ARVLVDNGS LNIMPKSTLLKLPVDMSHIKSSTMVVKAFDG RRE
Sbjct: 563 ARVLVDNGSALNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGSRRE 607

[Close]

BLAST of IVF0004320 vs. NCBI nr
Match: KAA0037781.1 (uncharacterized protein E6C27_scaffold471G00160 [Cucumis melo var. makuwa])

HSP 1 Score: 305 bits (782), Expect = 9.33e-98
Identity = 156/165 (94.55%), Postives = 159/165 (96.36%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           M IIAKDIEYKKL TDEEANEFLK+VKQSEYKII+QMHHTPA+ISLLSLFLNSEPH KVL
Sbjct: 443 MSIIAKDIEYKKLVTDEEANEFLKMVKQSEYKIIKQMHHTPAQISLLSLFLNSEPHCKVL 502

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDD IPPEGLGHTKALHIQVKCKDYVI
Sbjct: 503 LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDGIPPEGLGHTKALHIQVKCKDYVI 562

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 165
           ARVLVDNGS LNIMPKSTLLKLPVDMSHIKSSTMVVKAFDG RRE
Sbjct: 563 ARVLVDNGSALNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGSRRE 607

[Close]

BLAST of IVF0004320 vs. NCBI nr
Match: KAA0036950.1 (uncharacterized protein E6C27_scaffold86G00300 [Cucumis melo var. makuwa])

HSP 1 Score: 311 bits (798), Expect = 2.20e-96
Identity = 158/165 (95.76%), Postives = 161/165 (97.58%), Query Frame = 0


Query: 1   MPIIAKDIEYKKLFTDEEANEFLKIVKQSEYKIIEQMHHTPARISLLSLFLNSEPHRKVL 60
           MPIIAKDIEYKKL TDEEANEFLKIVKQSEYKIIEQMH+TPARISLLSLFLNSEPHRK+L
Sbjct: 673 MPIIAKDIEYKKLVTDEEANEFLKIVKQSEYKIIEQMHYTPARISLLSLFLNSEPHRKLL 732

Query: 61  LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQVKCKDYVI 120
           LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQ+KCKDYVI
Sbjct: 733 LDILNKAHVGHDISVEKFSGIIGNITSSNSIVFTDDEIPPEGLGHTKALHIQLKCKDYVI 792

Query: 121 ARVLVDNGSTLNIMPKSTLLKLPVDMSHIKSSTMVVKAFDGLRRE 165
           ARVLVDNGS LNIMPKSTLL LPVDMSHIKSSTMVVKAFDG RRE
Sbjct: 793 ARVLVDNGSALNIMPKSTLLMLPVDMSHIKSSTMVVKAFDGSRRE 837

The following BLAST results are available for this feature:

BLAST of IVF0004320 vs.


Match Name	E-value	Identity	Description

BLAST of IVF0004320 vs. ExPASy TrEMBL


Match Name	E-value	Identity	Description
A0A5D3DEB3	1.0e-83	98.18	Retrotrans_gag domain-containing protein OS=Cucumis melo var. makuwa OX=1194695 ...	[more]
A0A5A7TRL7	3.3e-82	96.36	Ribonuclease H OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold284G00010...	[more]
A0A5A7T7R4	4.4e-82	96.36	Ribonuclease H OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold277G00282...	[more]
A0A5A7T0R1	1.3e-81	95.76	Uncharacterized protein OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold...	[more]
A0A5A7VIM6	6.3e-81	95.15	RNA-directed DNA polymerase (Reverse transcriptase), Ribonuclease H-like protein...	[more]

BLAST of IVF0004320 vs. NCBI nr


Match Name	E-value	Identity	Description
KAA0065724.1	5.74e-101	95.71	uncharacterized protein E6C27_scaffold37G00080 [Cucumis melo var. makuwa] >TYK13...	[more]
TYK21788.1	4.03e-98	98.18	uncharacterized protein E5676_scaffold1721G00440 [Cucumis melo var. makuwa]	[more]
TYK27304.1	9.33e-98	94.55	uncharacterized protein E5676_scaffold1784G00170 [Cucumis melo var. makuwa]	[more]
KAA0037781.1	9.33e-98	94.55	uncharacterized protein E6C27_scaffold471G00160 [Cucumis melo var. makuwa]	[more]
KAA0036950.1	2.20e-96	95.76	uncharacterized protein E6C27_scaffold86G00300 [Cucumis melo var. makuwa]	[more]

BLAST of IVF0004320 vs. NCBI nr


Match Name	E-value	Identity	Description

InterPro

Analysis Name: InterPro Annotations of Melon (IVF77) v1
Date Performed: 2021-10-25


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PANTHER	PTHR33240:SF7	GAG-PRO-LIKE PROTEIN	coord: 11..165
None	No IPR available	PANTHER	PTHR33240	OS08G0508500 PROTEIN	coord: 11..165

Relationships

The following mRNA feature(s) are a part of this gene:


Feature Name	Unique Name	Type
IVF0004320.1	IVF0004320.1	mRNA

GO Annotation

GO Assignments

This gene is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0015074	DNA integration
biological_process	GO:0006310	DNA recombination
biological_process	GO:0006278	RNA-dependent DNA biosynthetic process
biological_process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
cellular_component	GO:0030430	host cell cytoplasm
cellular_component	GO:0005634	nucleus
molecular_function	GO:0003887	DNA-directed DNA polymerase activity
molecular_function	GO:0003723	RNA binding
molecular_function	GO:0003964	RNA-directed DNA polymerase activity
molecular_function	GO:0004523	RNA-DNA hybrid ribonuclease activity