CsGy3G029537 (gene) Cucumber (Gy14) v2.1

Overview


Name	CsGy3G029537
Type	gene
Organism	Cucumis sativus L. var. sativus cv. Gy14 (Cucumber (Gy14) v2.1)
Description	Inosine-5'-monophosphate dehydrogenase
Location	Gy14Chr3: 29989419 .. 29989970 (-)
RNA-Seq Expression	CsGy3G029537
Synteny	CsGy3G029537

Sequences

The following sequences are available for this feature:

Gene sequence (with intron)

Legend: polypeptideexonCDS

Hold the cursor over a type above to highlight its positions in the sequence below.

ATGGGGTCTTTAGAGGCAATGGCCAGAGGAAGTGACGACAGGTACTTGGGGGATATTGCAACCCTTAAGATAGTCGAGGGGGTTGCTGGAGCAATTGCTGATAAGGGTTCAGTCTTGAAATTCATACTCTATACCACGCAAGCAGTCAAGCAAGGGTTCCAAGAGATTGCTGCTTCTCCACTTTATGCTTTGTTGATTGTGAACATGAATTTGTTTAGAATCGTTGTCAATTTATTGGGTTTACCTATGTGCAAGTTCGTAAGGTGGCAGCACAGGTCGAAGGTGGAATTCATGGATTGGTCTCTTATGAAAAGAGATCGTTTTGAAAAACAAATACATTATGACTATAAGCTGCTCCTTAAAACTGGACTTGTATCAATAATTTATATACAGTGATGTGCATATTGTAGTCTCCAGGTTTCATCAATTCGAGCTAGCAGTGGATTTTTTTTTGCTCCTCTTCTACATATATTTGTTGATCTTTTATCAACACGGTCTATGCCTTCAAAACAGAGTGTTGGGAAGAAAGTTGTAACGAATGTGATTGGTTGA

mRNA sequence

ATGGGGTCTTTAGAGGCAATGGCCAGAGGAAGTGACGACAGGTACTTGGGGGATATTGCAACCCTTAAGATAGTCGAGGGGGTTGCTGGAGCAATTGCTGATAAGGGTTCAGTCTTGAAATTCATACTCTATACCACGCAAGCAGTCAAGCAAGGGTTCCAAGAGATTGCTGCTTCTCCACTTTATGCTTTGTTGATTGTGAACATGAATTTGTTTAGAATCGTTGTCAATTTATTGGGTTTACCTATGTGCAAGTTCGTAAGGTGGCAGCACAGGTCGAAGGTGGAATTCATGGATTGTCTCCAGGTTTCATCAATTCGAGCTAGCAGTGGATTTTTTTTTGCTCCTCTTCTACATATATTTGTTGATCTTTTATCAACACGGTCTATGCCTTCAAAACAGAGTGTTGGGAAGAAAGTTGTAACGAATGTGATTGGTTGA

Coding sequence (CDS)

ATGGGGTCTTTAGAGGCAATGGCCAGAGGAAGTGACGACAGGTACTTGGGGGATATTGCAACCCTTAAGATAGTCGAGGGGGTTGCTGGAGCAATTGCTGATAAGGGTTCAGTCTTGAAATTCATACTCTATACCACGCAAGCAGTCAAGCAAGGGTTCCAAGAGATTGCTGCTTCTCCACTTTATGCTTTGTTGATTGTGAACATGAATTTGTTTAGAATCGTTGTCAATTTATTGGGTTTACCTATGTGCAAGTTCGTAAGGTGGCAGCACAGGTCGAAGGTGGAATTCATGGATTGTCTCCAGGTTTCATCAATTCGAGCTAGCAGTGGATTTTTTTTTGCTCCTCTTCTACATATATTTGTTGATCTTTTATCAACACGGTCTATGCCTTCAAAACAGAGTGTTGGGAAGAAAGTTGTAACGAATGTGATTGGTTGA

Protein sequence

MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASPLYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKVEFMDCLQVSSIRASSGFFFAPLLHIFVDLLSTRSMPSKQSVGKKVVTNVIG*

Homology

[Close]

BLAST of CsGy3G029537 vs. ExPASy Swiss-Prot
Match: Q9SA34 (Inosine-5'-monophosphate dehydrogenase 2 OS=Arabidopsis thaliana OX=3702 GN=At1g16350 PE=1 SV=1)

HSP 1 Score: 91.7 bits (226), Expect = 7.6e-18
Identity = 45/61 (73.77%), Postives = 50/61 (81.97%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
           MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT  AVKQGFQ++ AS 
Sbjct: 404 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMHAVKQGFQDLGASS 463

Query: 61  L 62
           L
Sbjct: 464 L 464

[Close]

BLAST of CsGy3G029537 vs. ExPASy Swiss-Prot
Match: Q84XA3 (Inosine-5'-monophosphate dehydrogenase OS=Vigna unguiculata OX=3917 GN=impdh PE=1 SV=1)

HSP 1 Score: 88.6 bits (218), Expect = 6.5e-17
Identity = 44/61 (72.13%), Postives = 49/61 (80.33%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
           MGSLEAM +GSD RYLGD A LKI +GV GA+ DKGSVL FI YT QAV+QGFQ+I AS 
Sbjct: 404 MGSLEAMTKGSDARYLGDTAKLKIAQGVVGAVKDKGSVLNFIPYTLQAVRQGFQDIGASS 463

Query: 61  L 62
           L
Sbjct: 464 L 464

[Close]

BLAST of CsGy3G029537 vs. ExPASy Swiss-Prot
Match: P47996 (Inosine-5'-monophosphate dehydrogenase 1 OS=Arabidopsis thaliana OX=3702 GN=IMPDH PE=2 SV=1)

HSP 1 Score: 86.3 bits (212), Expect = 3.2e-16
Identity = 46/75 (61.33%), Postives = 55/75 (73.33%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
           MGSLEAM +GSD RYLGD   LKI +GV GA+ADKGSVLK I YT  AVKQGFQ++ AS 
Sbjct: 405 MGSLEAMTKGSDQRYLGDQTKLKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASS 464

Query: 61  LY-ALLIVNMNLFRI 75
           L  A  ++  N+ R+
Sbjct: 465 LQSAHGLLRSNILRL 479

[Close]

BLAST of CsGy3G029537 vs. ExPASy Swiss-Prot
Match: Q54QQ0 (Inosine-5'-monophosphate dehydrogenase OS=Dictyostelium discoideum OX=44689 GN=impdh PE=1 SV=1)

HSP 1 Score: 65.9 bits (159), Expect = 4.5e-10
Identity = 27/59 (45.76%), Postives = 40/59 (67.80%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAAS 60
           MGSLEAM +G D RY  +   +K+ +GV+G++ DKGSV KF+ Y  Q +K G Q++  +
Sbjct: 417 MGSLEAMVKGGDQRYFSETDKIKVAQGVSGSVVDKGSVKKFVPYLIQGIKHGLQDLGCN 475

[Close]

BLAST of CsGy3G029537 vs. ExPASy Swiss-Prot
Match: P50098 (Inosine-5'-monophosphate dehydrogenase OS=Trypanosoma brucei brucei OX=5702 PE=1 SV=1)

HSP 1 Score: 56.2 bits (134), Expect = 3.6e-07
Identity = 28/58 (48.28%), Postives = 41/58 (70.69%), Query Frame = 0


Query: 1   MGSLEAMARG--SDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEI 57
           MGS++AM +G  S  RYL +  TL++ +GVAGA+ DKGSVLK + Y  + ++Q  Q+I
Sbjct: 408 MGSIDAMLQGRESGKRYLSENETLQVAQGVAGAVLDKGSVLKLLAYIHKGLQQSAQDI 465

[Close]

BLAST of CsGy3G029537 vs. NCBI nr
Match: KGN58808.1 (hypothetical protein Csa_001721 [Cucumis sativus])

HSP 1 Score: 283 bits (723), Expect = 7.27e-96
Identity = 146/146 (100.00%), Postives = 146/146 (100.00%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
           MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP
Sbjct: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60

Query: 61  LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKVEFMDCLQVSSIRASSGFFFAPLLHI 120
           LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKVEFMDCLQVSSIRASSGFFFAPLLHI
Sbjct: 61  LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKVEFMDCLQVSSIRASSGFFFAPLLHI 120

Query: 121 FVDLLSTRSMPSKQSVGKKVVTNVIG 146
           FVDLLSTRSMPSKQSVGKKVVTNVIG
Sbjct: 121 FVDLLSTRSMPSKQSVGKKVVTNVIG 146

[Close]

BLAST of CsGy3G029537 vs. NCBI nr
Match: TQE02657.1 (hypothetical protein C1H46_011726 [Malus baccata])

HSP 1 Score: 93.6 bits (231), Expect = 1.20e-21
Identity = 46/61 (75.41%), Postives = 51/61 (83.61%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 1  MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTIQAVKQGFQDLGASS 60

[Close]

BLAST of CsGy3G029537 vs. NCBI nr
Match: RXH86657.1 (hypothetical protein DVH24_021930 [Malus domestica])

HSP 1 Score: 92.8 bits (229), Expect = 1.54e-21
Identity = 46/61 (75.41%), Postives = 50/61 (81.97%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM  GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 1  MGSLEAMTNGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 60

[Close]

BLAST of CsGy3G029537 vs. NCBI nr
Match: AAC19381.1 (inosine-5'-monophosphate dehydrogenase, partial [Prunus persica])

HSP 1 Score: 93.6 bits (231), Expect = 1.92e-21
Identity = 46/61 (75.41%), Postives = 51/61 (83.61%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 18 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTIQAVKQGFQDLGASS 77

[Close]

BLAST of CsGy3G029537 vs. NCBI nr
Match: XP_021804122.1 (inosine-5'-monophosphate dehydrogenase 2-like, partial [Prunus avium])

HSP 1 Score: 93.6 bits (231), Expect = 2.39e-21
Identity = 46/61 (75.41%), Postives = 51/61 (83.61%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 26 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 85

[Close]

BLAST of CsGy3G029537 vs. ExPASy TrEMBL
Match: A0A0A0LAC3 (IMPDH domain-containing protein OS=Cucumis sativus OX=3659 GN=Csa_3G732640 PE=4 SV=1)

HSP 1 Score: 283 bits (723), Expect = 3.52e-96
Identity = 146/146 (100.00%), Postives = 146/146 (100.00%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
           MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP
Sbjct: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60

Query: 61  LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKVEFMDCLQVSSIRASSGFFFAPLLHI 120
           LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKVEFMDCLQVSSIRASSGFFFAPLLHI
Sbjct: 61  LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKVEFMDCLQVSSIRASSGFFFAPLLHI 120

Query: 121 FVDLLSTRSMPSKQSVGKKVVTNVIG 146
           FVDLLSTRSMPSKQSVGKKVVTNVIG
Sbjct: 121 FVDLLSTRSMPSKQSVGKKVVTNVIG 146

[Close]

BLAST of CsGy3G029537 vs. ExPASy TrEMBL
Match: A0A540MV31 (IMPDH domain-containing protein OS=Malus baccata OX=106549 GN=C1H46_011726 PE=4 SV=1)

HSP 1 Score: 93.6 bits (231), Expect = 5.80e-22
Identity = 46/61 (75.41%), Postives = 51/61 (83.61%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 1  MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTIQAVKQGFQDLGASS 60

[Close]

BLAST of CsGy3G029537 vs. ExPASy TrEMBL
Match: A0A498IWK8 (IMPDH domain-containing protein OS=Malus domestica OX=3750 GN=DVH24_021930 PE=4 SV=1)

HSP 1 Score: 92.8 bits (229), Expect = 7.45e-22
Identity = 46/61 (75.41%), Postives = 50/61 (81.97%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM  GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 1  MGSLEAMTNGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 60

[Close]

BLAST of CsGy3G029537 vs. ExPASy TrEMBL
Match: O81282 (Inosine-5'-monophosphate dehydrogenase (Fragment) OS=Prunus persica OX=3760 PE=2 SV=1)

HSP 1 Score: 93.6 bits (231), Expect = 9.30e-22
Identity = 46/61 (75.41%), Postives = 51/61 (83.61%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 18 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTIQAVKQGFQDLGASS 77

[Close]

BLAST of CsGy3G029537 vs. ExPASy TrEMBL
Match: A0A6P5RND7 (inosine-5'-monophosphate dehydrogenase 2-like OS=Prunus avium OX=42229 GN=LOC110748449 PE=4 SV=1)

HSP 1 Score: 93.6 bits (231), Expect = 1.16e-21
Identity = 46/61 (75.41%), Postives = 51/61 (83.61%), Query Frame = 0


Query: 1  MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
          MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT QAVKQGFQ++ AS 
Sbjct: 26 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 85

[Close]

BLAST of CsGy3G029537 vs. TAIR 10
Match: AT1G16350.1 (Aldolase-type TIM barrel family protein )

HSP 1 Score: 91.7 bits (226), Expect = 5.4e-19
Identity = 45/61 (73.77%), Postives = 50/61 (81.97%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
           MGSLEAM +GSD RYLGD A LKI +GV GA+ADKGSVLKFI YT  AVKQGFQ++ AS 
Sbjct: 404 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMHAVKQGFQDLGASS 463

Query: 61  L 62
           L
Sbjct: 464 L 464

[Close]

BLAST of CsGy3G029537 vs. TAIR 10
Match: AT1G79470.1 (Aldolase-type TIM barrel family protein )

HSP 1 Score: 86.3 bits (212), Expect = 2.3e-17
Identity = 46/75 (61.33%), Postives = 55/75 (73.33%), Query Frame = 0


Query: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60
           MGSLEAM +GSD RYLGD   LKI +GV GA+ADKGSVLK I YT  AVKQGFQ++ AS 
Sbjct: 405 MGSLEAMTKGSDQRYLGDQTKLKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASS 464

Query: 61  LY-ALLIVNMNLFRI 75
           L  A  ++  N+ R+
Sbjct: 465 LQSAHGLLRSNILRL 479

The following BLAST results are available for this feature:

BLAST of CsGy3G029537 vs. ExPASy Swiss-Prot


Match Name	E-value	Identity	Description
Q9SA34	7.6e-18	73.77	Inosine-5'-monophosphate dehydrogenase 2 OS=Arabidopsis thaliana OX=3702 GN=At1g...	[more]
Q84XA3	6.5e-17	72.13	Inosine-5'-monophosphate dehydrogenase OS=Vigna unguiculata OX=3917 GN=impdh PE=...	[more]
P47996	3.2e-16	61.33	Inosine-5'-monophosphate dehydrogenase 1 OS=Arabidopsis thaliana OX=3702 GN=IMPD...	[more]
Q54QQ0	4.5e-10	45.76	Inosine-5'-monophosphate dehydrogenase OS=Dictyostelium discoideum OX=44689 GN=i...	[more]
P50098	3.6e-07	48.28	Inosine-5'-monophosphate dehydrogenase OS=Trypanosoma brucei brucei OX=5702 PE=1...	[more]

BLAST of CsGy3G029537 vs. NCBI nr


Match Name	E-value	Identity	Description
KGN58808.1	7.27e-96	100.00	hypothetical protein Csa_001721 [Cucumis sativus]	[more]
TQE02657.1	1.20e-21	75.41	hypothetical protein C1H46_011726 [Malus baccata]	[more]
RXH86657.1	1.54e-21	75.41	hypothetical protein DVH24_021930 [Malus domestica]	[more]
AAC19381.1	1.92e-21	75.41	inosine-5'-monophosphate dehydrogenase, partial [Prunus persica]	[more]
XP_021804122.1	2.39e-21	75.41	inosine-5'-monophosphate dehydrogenase 2-like, partial [Prunus avium]	[more]

BLAST of CsGy3G029537 vs. ExPASy TrEMBL


Match Name	E-value	Identity	Description
A0A0A0LAC3	3.52e-96	100.00	IMPDH domain-containing protein OS=Cucumis sativus OX=3659 GN=Csa_3G732640 PE=4 ...	[more]
A0A540MV31	5.80e-22	75.41	IMPDH domain-containing protein OS=Malus baccata OX=106549 GN=C1H46_011726 PE=4 ...	[more]
A0A498IWK8	7.45e-22	75.41	IMPDH domain-containing protein OS=Malus domestica OX=3750 GN=DVH24_021930 PE=4 ...	[more]
O81282	9.30e-22	75.41	Inosine-5'-monophosphate dehydrogenase (Fragment) OS=Prunus persica OX=3760 PE=2...	[more]
A0A6P5RND7	1.16e-21	75.41	inosine-5'-monophosphate dehydrogenase 2-like OS=Prunus avium OX=42229 GN=LOC110...	[more]

BLAST of CsGy3G029537 vs. TAIR 10


Match Name	E-value	Identity	Description
AT1G16350.1	5.4e-19	73.77	Aldolase-type TIM barrel family protein	[more]
AT1G79470.1	2.3e-17	61.33	Aldolase-type TIM barrel family protein	[more]

InterPro

Analysis Name: InterPro Annotations of Cucumber (Gy14) v2.1
Date Performed: 2021-10-25


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001093	IMP dehydrogenase/GMP reductase	PFAM	PF00478	IMPDH	coord: 1..64 e-value: 3.3E-8 score: 32.9
IPR013785	Aldolase-type TIM barrel	GENE3D	3.20.20.70	Aldolase class I	coord: 1..74 e-value: 1.1E-10 score: 42.5
None	No IPR available	PANTHER	PTHR11911:SF123	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE	coord: 1..62
None	No IPR available	SUPERFAMILY	51412	Inosine monophosphate dehydrogenase (IMPDH)	coord: 1..65
IPR005990	Inosine-5'-monophosphate dehydrogenase	PANTHER	PTHR11911	INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED	coord: 1..62

Relationships

The following mRNA feature(s) are a part of this gene:


Feature Name	Unique Name	Type
CsGy3G029537.1	CsGy3G029537.1	mRNA

GO Annotation

GO Assignments

This gene is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006177	GMP biosynthetic process
biological_process	GO:0006164	purine nucleotide biosynthetic process
cellular_component	GO:0005737	cytoplasm
molecular_function	GO:0003938	IMP dehydrogenase activity
molecular_function	GO:0046872	metal ion binding
molecular_function	GO:0000166	nucleotide binding
molecular_function	GO:0003824	catalytic activity