CmoCh19G003850 (gene) Cucurbita moschata (Rifu) v1

Overview
NameCmoCh19G003850
Typegene
OrganismCucurbita moschata (Cucurbita moschata (Rifu) v1)
Descriptioncleavage and polyadenylation specificity factor subunit 1 isoform X1
LocationCmo_Chr19: 3864374 .. 3868046 (+)
RNA-Seq ExpressionCmoCh19G003850
SyntenyCmoCh19G003850
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonfive_prime_UTRCDSpolypeptide
Hold the cursor over a type above to highlight its positions in the sequence below.
CTGCATATCGAATCCTTCCTCCCGCCAAACCTCCCCAAAGCCCTAAGTCTGCTGGTCTCTTTTGAGTTCTTCTTCCAACTCTCTGCTTCACCTCATTGTCTGCAACTCCCTCTTCCCTTCCCACCACCATCTCCCTCCAATTCATACTTTTCTCCCACATTCTTACGCTTCTCCTTTATCCACTTCTCACTCTCTCAGGATGAGTTTTGCCGCTTATAGAATGATGCACTGCCCTACGGGCATCGAGAATTGTGATTCAGGCTTTATCACGCATTCTCGCTCCGATTTCGTACCCCGCGTCACTTCTCACGCCGACGACCTTGAGTCCGATTGGCCGCCGCGCCGAGAAATTGGTCCGGTTCCGAATCTCGTTGTCACCGCCGGTAATGTCCTTGAGGTATATGTTGTCAGGGTTCAAGAAGATGGTGGCAAAGAATCAAGAAGCTCTGGAGAAGTCAGACGGGGTGGCATTATGGATGGAGTCTCTGGGGCCTCGCTCGAGCTTGTTTGCCACTATAGGTATACTCCAAGTTTTGTGAATGTACGTTAGGAGTTTCGTGTTAGTATGTTCTTTGTTATAACTAGCTTGTCGAAACGTACACCATAGAGCAGCCTTTTGCGAGTTCCTCGATTCTGGGTCTTTTTATTGCGTCTCATTTTATACTTCTCATCAAACGAGTGACAAGTTTGCTGCTCGTTGGAAAGAAAAATTAATGTGACTAGCAATCTTGAGTAAAGGATATCCCTTGATTTATTTCTGGTAAGCACTTGCTATTTTTGTTTAGTGATAATTTACTTTTCTCGGGGCCTGAATTGCAGGTTGCACGGTAATGTTGAGTCCATGGTAATTTTGTCTAGTAGAGGAGGTGATGGTTCCAAGAAGAGAGATTCGATCATATTAGTCTTTAAAGAAGCAAAAATTTCAGTGCTAGAGTTTGATGATTCTATCCATAGTCTCCGTACAAGGTACGCTTTTTTCTTTCTCTTTCACTCTCTTGTGGAGCTTAGTCTCTTTTTATTTCATCAATGAAAAGTTTCGTCTGTTGTAAAAAAAAAGAAAAAAACATTATTGGCGAATTAGACTATCTTCTCTTTAAGTTATATATATAATTTGTGGAATGTAAAATCGAAAGACTGAAAGTGTAATTCATTCCAAATGTGCATGTTCCTAGTCTTTCTACATGCCCTCGATCGTTGTGCCCTGTCTAGTATCTTGACCAACAATTTTCTTGGGCTTTAATTTATTATGTGACTGATATCTTGGCAACATAATTGTGTGTTATCCATGACCACCACGTAATTATCCTGCCCCTCCAAATTATTTCCGAATTGGTTCCTTCCTCCACCGGACAGATGTACAAATGTACTATGCTTGGAAAGAACTTGTGCAAGATGATACTCTGGTTATTCATTATTTAGCTGTCTTTTCATCGAAAAACTTATTTTAGTTGTCTAATTTTCTTTGGCATTTCACAATTACTATTGAGTGGAAATTTTCATTTGTAGCTCAATGCATTGCTTTGAGGGTCCACAATGGCTTCATTTGAAAAGAGGTCGTGAATCATTTGCAAGAGGTCCAGTGGTAAAGGTTGATCCTCAAGGCAGGTGTGGAGGAGTTCTTGTTTATGGTTTGCAAATGATAATACTTAAGGCTTCTCAGGTGTTTTTTGCCTTTCACACTTTTTTATTTGGATGTGCATGACAACTTTATGCCATGCTTTGTTGACGTGTAGTTCTTAATATCTTTTATAATATATTGGATAGAAAGAGAAACTATGTTGTCTTAATAAGTAATTCTATCCACCGCCTTGTGTTTACCACTATCCTTCAATTAAGTTTCTTGGTTAGCATTGAAATCTACTAAAGTTGACTTTCCTTACCCATGTTTGCACGTTGAGTTAGATCAGATGTGACTAGTAGTTTTTAGTGATGATGGTAGTCAAACTCAAATTAATGAAGGTGATATATGGAGCAAATGTGTAGAAGATTTGTTTGATTATACTTTTGAGCTATTTTGGTAAACCTTAATGGACATGGATGATTGCCTCTATCTTTTTCATAGCGAAGAAGAAATGGAGATTTCCAATGGCTGCTATTTATGGACCCAAGATGGATTGGAATAACATCTGATAGACAATAAACAATGTTATGATGTCTCTCGAAAGTGATTATGGAGAAGCTTAAGAGACTTTGTATGTGGATGGACTTCCCTAGACATTGGCCAAAATTTAGCGAAGTAGAGCGTCACCTCACTGCCTGGTTTAGGTGTGGGCAAGCTTAACACTAGAAACAGTAGCCTTTTTCAACTAAAGGGGGCTGGAGATTCTTAATTGATCCCAATGCTCTTGGAAGAAGGGTTATTGTTAATAAGTATAAATTGTCTTGGATCAGCTGGATATATATATTTTTTTGATAAGAATGAGTAAAAAAATAAAAGAATACGAGGGCATACAAAATTCCATGGAAGGGATCCCAACTAAAGAAAGGGGCTCAAATCATGCAAAATAATGCCTATAAAATTACTACAAAAGGTATTTGAAATCTAAGTCCAAGGAGAAACATGAAATCTAAAAAGAGACCAAACATCACTTGGATCTCTCTCCAAACCTTTAAAAGCTCTATTATTCCTCTCACTCTAAAGATCCGGATAGTATACACCCCAACAAGCCATGAAAATCGGTTTTTCTCATGAAAAGACGGATGGAGGAGGAACTCCCCATTCATATCATGTCCCTATAATGGGCAAGCAAGAAGTTGAATGTTTGAAAGAAAAAAAATTCCAAATGGCCCCGCAAACTAACATCTCCAAAGAATATGGTCCAGGTCTTTGCCTTTCGACTGAGAATACAACAAAACAAGCCAAACTTGCCAGGTACAGACATTCACTTTCTTTGCGATCTTAATCCTCCAAAGAGGGAAAAAAAAAAAAAACAAAAAACTCACTAGTGGGAGAAGTGTCTATCAAGCAACAGAAGAAAGATTTACAAGAGATCCCTCTTAAGGGTGGGGCTCTAGACACAAACATTCCTTCTCCCACGCCTAAAATCAAACTCCCCTATCAAGGACGAGAGACAACATACTTTGCTTTCCTGTTGGACAAGTGACTGAACCCAAAAGATTCATTGGAATGTTGTGCCCACCCCACCCTTCCAAACGTTTTAGAGGTTCTTGGTCTACTATTGCTAAGTGTTGCCTTTTAGTGGACAAGTGGTATACTCGTAATGTTGGCAAAGGAAAGAAACTTCGGATTTTAGATTTTTTTTGGATTAGAGATGCTCCCCTTAAAGTTTCCTATCCAAGGTTGTAGGTAGTGGTTAAGTCGATTTGGTCGTCTATTCTGAAGGTTTGGGTTGGAGCAGTTAGTAGTTAGGTCTTGAAATTTAGAAGGAATCTCACAAACACCTCCTACTTATTTGAAGTCGATTTAATTTGTCATTACAAGAAGAGGATTATTTCTAAGAGGAACCGTTTGGTGGCTGGTATTGGGAGTGATTCCTCTATTTTTCTGGGTTCTTTTGCTCACTATTTGATAGGTAAACTGACAGATATTGTGGCTCATTTAGCCTTGGTTGAGGAGTTTTTGAATAGACTTGAATGGAGATTATCATATTTGGATAGTATCCCTTATGGTATTTTGAATCTTGAATCGTGTTTGGAGTACTTCAATGGGTAA

mRNA sequence

CTGCATATCGAATCCTTCCTCCCGCCAAACCTCCCCAAAGCCCTAAGTCTGCTGGTCTCTTTTGAGTTCTTCTTCCAACTCTCTGCTTCACCTCATTGTCTGCAACTCCCTCTTCCCTTCCCACCACCATCTCCCTCCAATTCATACTTTTCTCCCACATTCTTACGCTTCTCCTTTATCCACTTCTCACTCTCTCAGGATGAGTTTTGCCGCTTATAGAATGATGCACTGCCCTACGGGCATCGAGAATTGTGATTCAGGCTTTATCACGCATTCTCGCTCCGATTTCGTACCCCGCGTCACTTCTCACGCCGACGACCTTGAGTCCGATTGGCCGCCGCGCCGAGAAATTGGTCCGGTTCCGAATCTCGTTGTCACCGCCGGTAATGTCCTTGAGGTATATGTTGTCAGGGTTCAAGAAGATGGTGGCAAAGAATCAAGAAGCTCTGGAGAAGTCAGACGGGGTGGCATTATGGATGGAGTCTCTGGGGCCTCGCTCGAGCTTGTTTGCCACTATAGGTTGCACGGTAATGTTGAGTCCATGGTAATTTTGTCTAGTAGAGGAGGTAAACTGACAGATATTGTGGCTCATTTAGCCTTGGTTGAGGAGTTTTTGAATAGACTTGAATGGAGATTATCATATTTGGATAGTATCCCTTATGGTATTTTGAATCTTGAATCGTGTTTGGAGTACTTCAATGGGTAA

Coding sequence (CDS)

ATGAGTTTTGCCGCTTATAGAATGATGCACTGCCCTACGGGCATCGAGAATTGTGATTCAGGCTTTATCACGCATTCTCGCTCCGATTTCGTACCCCGCGTCACTTCTCACGCCGACGACCTTGAGTCCGATTGGCCGCCGCGCCGAGAAATTGGTCCGGTTCCGAATCTCGTTGTCACCGCCGGTAATGTCCTTGAGGTATATGTTGTCAGGGTTCAAGAAGATGGTGGCAAAGAATCAAGAAGCTCTGGAGAAGTCAGACGGGGTGGCATTATGGATGGAGTCTCTGGGGCCTCGCTCGAGCTTGTTTGCCACTATAGGTTGCACGGTAATGTTGAGTCCATGGTAATTTTGTCTAGTAGAGGAGGTAAACTGACAGATATTGTGGCTCATTTAGCCTTGGTTGAGGAGTTTTTGAATAGACTTGAATGGAGATTATCATATTTGGATAGTATCCCTTATGGTATTTTGAATCTTGAATCGTGTTTGGAGTACTTCAATGGGTAA

Protein sequence

MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVTAGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSSRGGKLTDIVAHLALVEEFLNRLEWRLSYLDSIPYGILNLESCLEYFNG
Homology
BLAST of CmoCh19G003850 vs. ExPASy Swiss-Prot
Match: Q9FGR0 (Cleavage and polyadenylation specificity factor subunit 1 OS=Arabidopsis thaliana OX=3702 GN=CPSF160 PE=1 SV=2)

HSP 1 Score: 163.3 bits (412), Expect = 2.4e-39
Identity = 80/128 (62.50%), Postives = 101/128 (78.91%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDF---VPRVTSHADDLESDWP-PRREIGPVPN 60
           MSFAAY+MMH PTG+ENC SG+ITHS SD    +P V+ H DD+E++WP P+R IGP+PN
Sbjct: 1   MSFAAYKMMHWPTGVENCASGYITHSLSDSTLQIPIVSVH-DDIEAEWPNPKRGIGPLPN 60

Query: 61  LVVTAGNVLEVYVVRVQEDGG-KESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESM 120
           +V+TA N+LEVY+VR QE+G  +E R+    +RGG+MDGV G SLELVCHYRLHGNVES+
Sbjct: 61  VVITAANILEVYIVRAQEEGNTQELRNPKLAKRGGVMDGVYGVSLELVCHYRLHGNVESI 120

Query: 121 VILSSRGG 124
            +L   GG
Sbjct: 121 AVLPMGGG 127

BLAST of CmoCh19G003850 vs. ExPASy Swiss-Prot
Match: Q7XWP1 (Probable cleavage and polyadenylation specificity factor subunit 1 OS=Oryza sativa subsp. japonica OX=39947 GN=Os04g0252200 PE=3 SV=2)

HSP 1 Score: 124.0 bits (310), Expect = 1.6e-27
Identity = 67/131 (51.15%), Postives = 85/131 (64.89%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDFV---------PRVTSHADDLESDWPPRREI 60
           MS+AAY+MMH PTG+++C +GF+THS SD           P      D   +   PRR +
Sbjct: 1   MSYAAYKMMHWPTGVDHCAAGFVTHSPSDAAAFFTAATVGPGPEGDIDSAAAASRPRR-L 60

Query: 61  GPVPNLVVTAGNVLEVYVVRVQ---EDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRL 120
           GP PNLVV A NVLEVY VR +   EDGG  ++ S     G ++DG+SGA LELVC+YRL
Sbjct: 61  GPSPNLVVAAANVLEVYAVRAETAAEDGGGGTQPSSS--SGAVLDGISGARLELVCYYRL 120

BLAST of CmoCh19G003850 vs. ExPASy TrEMBL
Match: A0A6J1EY93 (cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucurbita moschata OX=3662 GN=LOC111439584 PE=4 SV=1)

HSP 1 Score: 255.8 bits (652), Expect = 1.3e-64
Identity = 123/123 (100.00%), Postives = 123/123 (100.00%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVT 60
           MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVT
Sbjct: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVT 60

Query: 61  AGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSS 120
           AGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSS
Sbjct: 61  AGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSS 120

Query: 121 RGG 124
           RGG
Sbjct: 121 RGG 123

BLAST of CmoCh19G003850 vs. ExPASy TrEMBL
Match: A0A6J1I7X9 (cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucurbita maxima OX=3661 GN=LOC111472174 PE=4 SV=1)

HSP 1 Score: 251.9 bits (642), Expect = 1.9e-63
Identity = 120/123 (97.56%), Postives = 123/123 (100.00%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVT 60
           MSFAAYRMMHCPTGIENCDSGFITHSR+DFVPRVTSHADDLESDWPPRREIGPVPNLVVT
Sbjct: 1   MSFAAYRMMHCPTGIENCDSGFITHSRADFVPRVTSHADDLESDWPPRREIGPVPNLVVT 60

Query: 61  AGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSS 120
           AGNVLEVYVVRVQE+GGKESRSSGEVRRGGIMDG+SGASLELVCHYRLHGNVESMVILSS
Sbjct: 61  AGNVLEVYVVRVQEEGGKESRSSGEVRRGGIMDGLSGASLELVCHYRLHGNVESMVILSS 120

Query: 121 RGG 124
           RGG
Sbjct: 121 RGG 123

BLAST of CmoCh19G003850 vs. ExPASy TrEMBL
Match: A0A5A7U6U4 (Cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold13G00480 PE=4 SV=1)

HSP 1 Score: 231.9 bits (590), Expect = 2.0e-57
Identity = 111/123 (90.24%), Postives = 117/123 (95.12%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVT 60
           MSFAAYRMMH PTGIENCDS FITHSR+DFVP VTSH+DDL+SDW PRR+IGPVPNLVVT
Sbjct: 1   MSFAAYRMMHWPTGIENCDSAFITHSRADFVPAVTSHSDDLDSDWHPRRDIGPVPNLVVT 60

Query: 61  AGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSS 120
           AGNVLEVYVVRV E+GG+ESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESM ILSS
Sbjct: 61  AGNVLEVYVVRVLEEGGRESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMAILSS 120

Query: 121 RGG 124
           RGG
Sbjct: 121 RGG 123

BLAST of CmoCh19G003850 vs. ExPASy TrEMBL
Match: A0A5D3C8Q8 (Cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold105G00350 PE=4 SV=1)

HSP 1 Score: 231.9 bits (590), Expect = 2.0e-57
Identity = 111/123 (90.24%), Postives = 117/123 (95.12%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVT 60
           MSFAAYRMMH PTGIENCDS FITHSR+DFVP VTSH+DDL+SDW PRR+IGPVPNLVVT
Sbjct: 1   MSFAAYRMMHWPTGIENCDSAFITHSRADFVPAVTSHSDDLDSDWHPRRDIGPVPNLVVT 60

Query: 61  AGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSS 120
           AGNVLEVYVVRV E+GG+ESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESM ILSS
Sbjct: 61  AGNVLEVYVVRVLEEGGRESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMAILSS 120

Query: 121 RGG 124
           RGG
Sbjct: 121 RGG 123

BLAST of CmoCh19G003850 vs. ExPASy TrEMBL
Match: A0A1S3B4E8 (cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucumis melo OX=3656 GN=LOC103485885 PE=4 SV=1)

HSP 1 Score: 231.9 bits (590), Expect = 2.0e-57
Identity = 111/123 (90.24%), Postives = 117/123 (95.12%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDFVPRVTSHADDLESDWPPRREIGPVPNLVVT 60
           MSFAAYRMMH PTGIENCDS FITHSR+DFVP VTSH+DDL+SDW PRR+IGPVPNLVVT
Sbjct: 1   MSFAAYRMMHWPTGIENCDSAFITHSRADFVPAVTSHSDDLDSDWHPRRDIGPVPNLVVT 60

Query: 61  AGNVLEVYVVRVQEDGGKESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMVILSS 120
           AGNVLEVYVVRV E+GG+ESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESM ILSS
Sbjct: 61  AGNVLEVYVVRVLEEGGRESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESMAILSS 120

Query: 121 RGG 124
           RGG
Sbjct: 121 RGG 123

BLAST of CmoCh19G003850 vs. TAIR 10
Match: AT5G51660.1 (cleavage and polyadenylation specificity factor 160 )

HSP 1 Score: 163.3 bits (412), Expect = 1.7e-40
Identity = 80/128 (62.50%), Postives = 101/128 (78.91%), Query Frame = 0

Query: 1   MSFAAYRMMHCPTGIENCDSGFITHSRSDF---VPRVTSHADDLESDWP-PRREIGPVPN 60
           MSFAAY+MMH PTG+ENC SG+ITHS SD    +P V+ H DD+E++WP P+R IGP+PN
Sbjct: 1   MSFAAYKMMHWPTGVENCASGYITHSLSDSTLQIPIVSVH-DDIEAEWPNPKRGIGPLPN 60

Query: 61  LVVTAGNVLEVYVVRVQEDGG-KESRSSGEVRRGGIMDGVSGASLELVCHYRLHGNVESM 120
           +V+TA N+LEVY+VR QE+G  +E R+    +RGG+MDGV G SLELVCHYRLHGNVES+
Sbjct: 61  VVITAANILEVYIVRAQEEGNTQELRNPKLAKRGGVMDGVYGVSLELVCHYRLHGNVESI 120

Query: 121 VILSSRGG 124
            +L   GG
Sbjct: 121 AVLPMGGG 127

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
Q9FGR02.4e-3962.50Cleavage and polyadenylation specificity factor subunit 1 OS=Arabidopsis thalian... [more]
Q7XWP11.6e-2751.15Probable cleavage and polyadenylation specificity factor subunit 1 OS=Oryza sati... [more]
Match NameE-valueIdentityDescription
A0A6J1EY931.3e-64100.00cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucurbit... [more]
A0A6J1I7X91.9e-6397.56cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucurbit... [more]
A0A5A7U6U42.0e-5790.24Cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucumis ... [more]
A0A5D3C8Q82.0e-5790.24Cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucumis ... [more]
A0A1S3B4E82.0e-5790.24cleavage and polyadenylation specificity factor subunit 1 isoform X1 OS=Cucumis ... [more]
Match NameE-valueIdentityDescription
AT5G51660.11.7e-4062.50cleavage and polyadenylation specificity factor 160 [more]
InterPro
Analysis Name: InterPro Annotations of Cucurbita moschata (Rifu) v1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availablePANTHERPTHR10644DNA REPAIR/RNA PROCESSING CPSF FAMILYcoord: 2..123
NoneNo IPR availablePANTHERPTHR10644:SF2CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1coord: 2..123

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
CmoCh19G003850.1CmoCh19G003850.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006378 mRNA polyadenylation
cellular_component GO:0005634 nucleus
molecular_function GO:0003684 damaged DNA binding