Cmc05g0129091 (gene) Melon (Charmono) v1.1

Overview
NameCmc05g0129091
Typegene
OrganismCucumis melo L. var. cantalupensis cv. Charmono (Melon (Charmono) v1.1)
DescriptionRNase H domain-containing protein
LocationCMiso1.1chr05: 6830508 .. 6834825 (+)
RNA-Seq ExpressionCmc05g0129091
SyntenyCmc05g0129091
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonfive_prime_UTRCDSpolypeptidethree_prime_UTR
Hold the cursor over a type above to highlight its positions in the sequence below.
TGTTGGCTTAAGTGGGGTGATAGGACCTCAAAGTGATCCCCCAACAAAGCATCCACGCAACGACAGAAAAACACAATCTAGGGTATAAAAATGAGAAGGGTGACTGGGTTGGAATGTTGACGGATTGCATTACATTAGTTAATTTTTCTTTGCTTGTTAACCGGGTGCCAACTAAAACCTTTTATCCAAAAAGGGGAATGAATTTTGGGGATCCTATATCCTTTATTCTATGTGCTGAAAGTTTCTTGGCTTTGCTTCTCAAAGGTAGCAGAACGTCAAAGCTTATAAGGTGTCAGATTGCCAGGAGTTCCCCAAGCATATCTCATCTTTTCTTTGCATATGATAGTCTTTTGTTTTACAAGGCAAGTCCTAAGGCTTGTTGCTTAATTAAAAAGATTCTTAAAATTTATGAAGCTGGCTTGGGCCAATGAGTAAAGTCTAACAAATTTTAAATGTTGTTTAGCCCAAATGTGAATAGAGATCGTGGGTTATATTAGGGAAACATTCTTGGAGTCAAGGTGTTTTCGGATCTTGGTCAATATTTGGGCCTTATTGCTCAGGTTTGCAGAAAGAGGAGTCGATATTTTCATTTCATCGAGGAGTAAATTCAAAAATGTGTTGCCGTTTGGAAAGGGAAACTTTTTTCAGTGGGAGGAAGGAGGTTTTGATAAAAGCATTGGCACAAGCCCTTCTCGCTTACACAATATCCTGCCTAAAATTGCCAAAGGGGGTTTACAATCAGCTTGTTCAATATGTGGCTCGGTCTTAGTAGGGATCATCTGGAAATCAATGTAAAATTCATTGGTTTAAATGGGATGCCCTTTTCAAACCCAAAATTAATGCAGGCCTCGAATTTTTGGATTTGGAGGGTTTTAATCAAGCCTTTTTAACAATGACAGCTTGAAGATTTTTGCAATAGCCCTGATCTATTGTTGCTCAAGTGTTTAGAGGAAAATGTTTCCATAATGAGGGATTTTTGGAGGCTAAGGAGGGTTATCTTCCATCTCATGTATTGAGGAGTATTTTGTGGAGCACTTCTTGTGAAAGGAACCAAAACGCAAATTGGCACTAGAAAGGAAACCTCACTATTTTGCAATCCTTGGATTCTCAGAGAGCATAGTTTTAAACCTTTAACTCATATGCCTTTTGGTCATGAACATTTAAAGGTTGCTCATGTCATTAATGATGAGGAGTGGAATCTGAATGAATTGAGGAAATGGCTCAATGAGGACAATATTATGACTGTGTTAGGCATTTTACAAAAAAAAAAATGGTATGTCCTCAACTTTTAGTGCATATAAATTATTTTCACAATCTAGGCTTGCCCCCTCTTCCTCTTACAGTGCCAGGGAAATATGATGGAAGAAGACGGGGGTCTCTCATCTTCTTACAAAGTCAAAATTTCTTACGGAAAGTGTTTCATTTGACATTGGCTACAAGAGTTAATTTACTTAAAAGACAGATTGTGGAGGAGGGTTGGTGTGTGTGCTGTGGGATGCAATATGAAATAAAGAAGCATATTTTTTTCAACAGTAGTAGAACAAAGAAAGTATGATGATGGTGTTTGACAAATATTTTGTGTGATAGTCAATATAAGGTGTCTATGAATGACTTTCTTGTGAATTTAGCTAAAGAAGCTTTCTACTACTGATTTTCTGTGTTTTGGCATAGTGTGCTGATTTATTTGGGAGGACCGAAACAAATAAAATTGAGGTTTTTTGGTAGCACCCGTTACGAAGAAGATTGAATGGAATGAAGATTAAATTCTAGAGGTGCAAGTTGCAGTTGGTAGATGAGGTGGGCATTCTGATTTCAAGTCTAATGTGCAAGTTTGAATAAGCCTACATTTGGGTAGGGTGGCTGATAACTTTGTTTCTGGTTGGCGTCGACCATAGTATGGATGTTGCATGTAGTCCGAACAACAAGGGTAATGGGTATGGTGTTGTGCTTCGCAATGATAAGGGTGAAATTGTTGTGGCTCAAGCTTTTTGTAGAGGTGAAAGCTTTCTGGTGGAAGCGAGCAAGATCATGGTAATAATGTTTGGTCTTCACTTGGTTGAAGGTCTTGGGTGTTTTGAGGTTTGGGTTCAATCAGATGCAGAGGTTGTGGTGAAAAAAACTAAAAGTCCATTGATTTCACATTTTCTCATTTTGGGGTTCTCTATGCCAAAGTTGTTGACTTAATGTCCAGATTGAAGGTGAGAAGGTTCAAGTATATTTCCAAGAAGGCTCCCTATTTCCATGAAGAGTAAGAGGGTTACTCATAATCTTACTTCTTTTGCTTTGTCTTATGATATGACTTGTTGGTTAGATCACCTTCCATTTTGGATAGATGTGGTGATTAGGGTTGAAATGTAATTGTTTCTTTGTTTGAAGTGATAATCTGTTAAAAAAAATTAAATTTAGAATATCATTGGATAAAATTCAAAATTATTTCTAACAAATCAATTAGTTTTAAAAATATTTTAAAAAAAAATTGTTAACGACGTGTATTAAGCATAGAATAGTTCAACTTGGGGGTTTTTTTTTCTATATTACTTTGAGAAACATTTTTCCATTCTATATGCAACTAGGGATTTAAGGACACAAAAACTCCTACGTATGCAACTGGTATACACGAATTTAATCCTAATTTCTGCTTATGTTTACCTAACAACAAACAAAAAGTGAATGAGTTTTCTAAACCACTTTTTCTTTTCGAACCTCTGAACTACCTATGTTCATAATTTCCCCCTTGTTTCGTTTCAGTGGCGAGGTGCAACAAACATTATTCTAAATCTAATATTCATATTCGTATTTCGTTTAGGCGTTGGTGGTGCGGTCATTGCGCATGTTATATCGCATAAAGCTTTATTTATATGTTGATTCAATTACACAACATATAGAGATTTTTCCTCCTATTATTCTTCCATTTACTTTTTATTTTGTAGATATCTAATTGCACTTATTCTTTTTTGAGATCAATGGGACAAATTGATCAGAACCTCCTAGTATCAAACATTTGCAATTTAGTCGGCTTCAGAAAAATGGTAAGTTTGAGATTCATGTCACATATTGGAAAATTGCAAGTTTCTTGTCTCATATGAATCAGATTGTAAATTATTTTTTCTTCAATCAATATCATCTTAGCCAAAAAAAGATTGTGTTATCAAATTACATGTCATATAGATTTATCGTCTATGCTTGCCACGGGAAAAAAAGGAATCTTGACTAGTCGAAAATGTAAAATTTAAGTTCTATTTTCTTACCTCTTTCTATTCATCTCTAACAATTATCTGAGAGTCTCAATGCCAAAAGCAAATAATGGTGAACTATGATAAATACCATTGGTTCTGCTTTATTAGTTGAAATTAACTTCTATAATTGTACCATGAAATTTTCAATCTAAAGTCTAGTATATTGTAGTAAACAATGTCCATTTTTCAACGAAAGTTTTGTATTTTGCTGTAACGACAACGAGGTTTAAAGATTTTCCAGTCTACATCTACTTCAATTTTTTATGTAGCATACATTAGGATTATTTAGTCTCACCCTAATGTGAATAGTGCACGTTGTTCCTTTTCATGATTTGATTCTTTTTGTCTTTTTTGTTTCTTTTGTAAGATTTAGAGAAGGTTATTGGTCATAAAATCTCAAGTTCACGCTACGAAAAATATCAAGTTGATCATTAAAAAAAGTAAGTGATGTACAATGTTAATTTAGTTTTTGTACATATTCTTAGGTTGGTTTAAGAGTTAAAGTGATACTTGGGAACTTTTTAGGTTGTTTTGAGAGTCAAGATGTGACTTTTTAGGAATTTATCTACGTGGTTTTTAGAGTTGGGATGTAGCACTTTTTAAGAGGTTGGGAGTGAAATGGTTACTTAAGAACCTTTTAGGTTGTTGAGATTTAAAAAGTGTCATTTAAGCAATTTTTGAGTGCTTTTGTTAGCCATAATGATATGTACTTCTTGTTCCAAAATGTGGTAAGGTAGCTTAACTCAAAATTTTTAAAGAATACATTGAGTTGGATCCAACTATATTTGTTTTACTCTACACATTTTGTTTTGCAGTATGCTCAAATAACGTACTAAGCTTCTCACCTCTCAGTCATCATCGAAGGTTCATCAGTGAGTAGTAACTCAACATGATCCCAAGGAAATAGGGTGATTGGTGGCTACAAAAGATTCGTGATGGGTCATCACAATGATCACAATACCAATATACCAATAGACAACCTGTTGGATTTGATATACACTATTAAGATGTTTTGCTTGTGGTCACATTTTGTTTATCTAATGAAATTGTATTAACTTCATTTTGTCCATATGTTCATTTGT

mRNA sequence

TGTTGGCTTAAGTGGGGTGATAGGACCTCAAAGTGATCCCCCAACAAAGCATCCACGCAACGACAGAAAAACACAATCTAGGGTATAAAAATGAGAAGGGTGACTGGGTTGGAATGTTGACGGATTGCATTACATTAGTTAATTTTTCTTTGCTTGTTAACCGGGTGCCAACTAAAACCTTTTATCCAAAAAGGGGAATGAATTTTGGGGATCCTATATCCTTTATTCTATGTGCTGAAAGTTTCTTGGCTTTGCTTCTCAAAGGTAGCAGAACGTCAAAGCTTATAAGGTGTCAGATTGCCAGGAGTTCCCCAAGCATATCTCATCTTTTCTTTGCATATGATAGTCTTTTGTTTTACAAGGCAAGTCCTAAGGCTTGTTGCTTAATTAAAAAGATTCTTAAAATTTATGAAGCTGGCTTGGGCCAATGAGTAAAGTCTAACAAATTTTAAATGTTGTTTAGCCCAAATGTGAATAGAGATCGTGGGTTATATTAGGGAAACATTCTTGGAGTCAAGGTGTTTTCGGATCTTGGTCAATATTTGGGCCTTATTGCTCAGGTTTGCAGAAAGAGGAGTCGATATTTTCATTTCATCGAGGAGTAAATTCAAAAATGTGTTGCCGTTTGGAAAGGGAAACTTTTTTCAGTGGGAGGAAGGAGGTTTTGATAAAAGCATTGGCACAAGCCCTTCTCGCTTACACAATATCCTGCCTAAAATTGCCAAAGGGGGTTTACAATCAGCTTGTTCAATATGTGGCTCGGTCTTAGTAGGGATCATCTGGAAATCAATGTAAAATTCATTGGTTTAAATGGGATGCCCTTTTCAAACCCAAAATTAATGCAGGCCTCGAATTTTTGGATTTGGAGGGTTTTAATCAAGCCTTTTTAACAATGACAGCTTGAAGATTTTTGCAATAGCCCTGATCTATTGTTGCTCAAGTGTTTAGAGGAAAATGTTTCCATAATGAGGGATTTTTGGAGGCTAAGGAGGGTTATCTTCCATCTCATGTATTGAGGAGTATTTTGTGGAGCACTTCTTGTGAAAGGAACCAAAACGCAAATTGGCACTAGAAAGGAAACCTCACTATTTTGCAATCCTTGGATTCTCAGAGAGCATAGTTTTAAACCTTTAACTCATATGCCTTTTGGTCATGAACATTTAAAGGTTGCTCATGTCATTAATGATGAGGAGTGGAATCTGAATGAATTGAGGAAATGGCTCAATGAGGACAATATTATGACTGTGTTAGGCATTTTACAAAAAAAAAAATGGTATGTCCTCAACTTTTAGTGCATATAAATTATTTTCACAATCTAGGCTTGCCCCCTCTTCCTCTTACAGTGCCAGGGAAATATGATGGAAGAAGACGGGGGTCTCTCATCTTCTTACAAAGTCAAAATTTCTTACGGAAAGTGTTTCATTTGACATTGGCTACAAGAGTTAATTTACTTAAAAGACAGATTGTGGAGGAGGGTTGGTGTGTGTGCTGTGGGATGCAATATGAAATAAAGAAGCATATTTTTTTCAACAGTAGTAGAACAAAGAAAGTATGATGATGGTGTTTGACAAATATTTTGTGTGATAGTCAATATAAGGTGTCTATGAATGACTTTCTTGTGAATTTAGCTAAAGAAGCTTTCTACTACTGATTTTCTGTGTTTTGGCATAGTGTGCTGATTTATTTGGGAGGACCGAAACAAATAAAATTGAGGTTTTTTGGTAGCACCCGTTACGAAGAAGATTGAATGGAATGAAGATTAAATTCTAGAGGTGCAAGTTGCAGTTGGTAGATGAGGTGGGCATTCTGATTTCAAGTCTAATGTGCAAGTTTGAATAAGCCTACATTTGGGTAGGGTGGCTGATAACTTTGTTTCTGGTTGGCGTCGACCATAGTATGGATGTTGCATGTAGTCCGAACAACAAGGGTAATGGGTATGGTGTTGTGCTTCGCAATGATAAGGGTGAAATTGTTGTGGCTCAAGCTTTTTGTAGAGGTGAAAGCTTTCTGGTGGAAGCGAGCAAGATCATGGTAATAATGTTTGGTCTTCACTTGGTTGAAGGTCTTGGGTGTTTTGAGGTTTGGGTTCAATCAGATGCAGAGGTTGTGGTGAAAAAAACTAAAAGTCCATTGATTTCACATTTTCTCATTTTGGGGTTCTCTATGCCAAAGTTGTTGACTTAATGTCCAGATTGAAGGTGAGAAGGTTCAAGTATATTTCCAAGAAGGCTCCCTATTTCCATGAAGAGTAAGAGGGTTACTCATAATCTTACTTCTTTTGCTTTGTCTTATGATATGACTTGTTGGTTAGATCACCTTCCATTTTGGATAGATGTGGTGATTAGGGTTGAAATGTAATTGTTTCTTTGTTTGAAGTGATAATCTGTTAAAAAAAATTAAATTTAGAATATCATTGGATAAAATTCAAAATTATTTCTAACAAATCAATTAGTTTTAAAAATATTTTAAAAAAAAATTGTTAACGACGTGTATTAAGCATAGAATAGTTCAACTTGGGGGTTTTTTTTTCTATATTACTTTGAGAAACATTTTTCCATTCTATATGCAACTAGGGATTTAAGGACACAAAAACTCCTACGTATGCAACTGGTATACACGAATTTAATCCTAATTTCTGCTTATGTTTACCTAACAACAAACAAAAAGTGAATGAGTTTTCTAAACCACTTTTTCTTTTCGAACCTCTGAACTACCTATGTTCATAATTTCCCCCTTGTTTCGTTTCAGTGGCGAGGTGCAACAAACATTATTCTAAATCTAATATTCATATTCGTATTTCGTTTAGGCGTTGGTGGTGCGGTCATTGCGCATGTTATATCGCATAAAGCTTTATTTATATGTTGATTCAATTACACAACATATAGAGATTTTTCCTCCTATTATTCTTCCATTTACTTTTTATTTTGTAGATATCTAATTGCACTTATTCTTTTTTGAGATCAATGGGACAAATTGATCAGAACCTCCTAGTATCAAACATTTGCAATTTAGTCGGCTTCAGAAAAATGTATGCTCAAATAACGTACTAAGCTTCTCACCTCTCAGTCATCATCGAAGGTTCATCAGTGAGTAGTAACTCAACATGATCCCAAGGAAATAGGGTGATTGGTGGCTACAAAAGATTCGTGATGGGTCATCACAATGATCACAATACCAATATACCAATAGACAACCTGTTGGATTTGATATACACTATTAAGATGTTTTGCTTGTGGTCACATTTTGTTTATCTAATGAAATTGTATTAACTTCATTTTGTCCATATGTTCATTTGT

Coding sequence (CDS)

ATGGATGTTGCATGTAGTCCGAACAACAAGGGTAATGGGTATGGTGTTGTGCTTCGCAATGATAAGGGTGAAATTGTTGTGGCTCAAGCTTTTTGTAGAGGTGAAAGCTTTCTGGTGGAAGCGAGCAAGATCATGGTAATAATGTTTGGTCTTCACTTGGTTGAAGGTCTTGGGTGTTTTGAGGTTTGGGTTCAATCAGATGCAGAGGTTGTGGTGAAAAAAACTAAAAGTCCATTGATTTCACATTTTCTCATTTTGGGGTTCTCTATGCCAAAGTTGTTGACTTAA

Protein sequence

MDVACSPNNKGNGYGVVLRNDKGEIVVAQAFCRGESFLVEASKIMVIMFGLHLVEGLGCFEVWVQSDAEVVVKKTKSPLISHFLILGFSMPKLLT
Homology
[Close]
BLAST of Cmc05g0129091 vs. NCBI nr
Match: KAA0031982.1 (hypothetical protein E6C27_scaffold134G00730 [Cucumis melo var. makuwa] >TYK16802.1 hypothetical protein E5676_scaffold96G00670 [Cucumis melo var. makuwa])

HSP 1 Score: 141.7 bits (356), Expect = 3.2e-30
Identity = 66/76 (86.84%), Postives = 71/76 (93.42%), Query Frame = 0 

Query: 1  MDVACSPNNKGNGYGVVLRNDKGEIVVAQAFCRGESFLVEASKIMVIMFGLHLVEGLGCF 60
          +DVACSPNNKGNGYGVVLRNDKGEIV+AQAFCRGESFLVEA KIM IMFGLHLVEGLGCF
Sbjct: 3  VDVACSPNNKGNGYGVVLRNDKGEIVLAQAFCRGESFLVEAGKIMAIMFGLHLVEGLGCF 62

Query: 61 EVWVQSDAEVVVKKTK 77
          EVWVQSDAE+  +K +
Sbjct: 63 EVWVQSDAEIEGEKVQ 78

[Close]
BLAST of Cmc05g0129091 vs. NCBI nr
Match: ONI12089.1 (hypothetical protein PRUPE_4G143500 [Prunus persica])

HSP 1 Score: 53.9 bits (128), Expect = 8.7e-04
Identity = 25/76 (32.89%), Postives = 40/76 (52.63%), Query Frame = 0 

Query: 1   MDVACSPNNKGNGYGVVLRNDKGEIVVAQAFCRGESFLVEASKIMVIMFGLHLVEGLGCF 60
           +D A  P     G G V+RNDKGE++ A A     +   + ++IM  +FG+      GC 
Sbjct: 53  VDAAFIPETGVGGIGAVVRNDKGEVMAAMALPLASATSSKHAEIMAFLFGMKFARDAGCS 112

Query: 61  EVWVQSDAEVVVKKTK 77
            + ++SD++ VV   K
Sbjct: 113 SILIESDSQGVVNDVK 128

[Close]
BLAST of Cmc05g0129091 vs. ExPASy TrEMBL
Match: A0A5A7SLR6 (RNase H domain-containing protein OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold96G00670 PE=4 SV=1)

HSP 1 Score: 141.7 bits (356), Expect = 1.5e-30
Identity = 66/76 (86.84%), Postives = 71/76 (93.42%), Query Frame = 0 

Query: 1  MDVACSPNNKGNGYGVVLRNDKGEIVVAQAFCRGESFLVEASKIMVIMFGLHLVEGLGCF 60
          +DVACSPNNKGNGYGVVLRNDKGEIV+AQAFCRGESFLVEA KIM IMFGLHLVEGLGCF
Sbjct: 3  VDVACSPNNKGNGYGVVLRNDKGEIVLAQAFCRGESFLVEAGKIMAIMFGLHLVEGLGCF 62

Query: 61 EVWVQSDAEVVVKKTK 77
          EVWVQSDAE+  +K +
Sbjct: 63 EVWVQSDAEIEGEKVQ 78

[Close]
BLAST of Cmc05g0129091 vs. ExPASy TrEMBL
Match: M5WZF6 (RNase H domain-containing protein (Fragment) OS=Prunus persica OX=3760 GN=PRUPE_ppa020664mg PE=4 SV=1)

HSP 1 Score: 53.9 bits (128), Expect = 4.2e-04
Identity = 25/76 (32.89%), Postives = 40/76 (52.63%), Query Frame = 0 

Query: 1   MDVACSPNNKGNGYGVVLRNDKGEIVVAQAFCRGESFLVEASKIMVIMFGLHLVEGLGCF 60
           +D A  P     G G V+RNDKGE++ A A     +   + ++IM  +FG+      GC 
Sbjct: 47  VDAAFIPETGVGGIGAVVRNDKGEVMAAMALPLASATSSKHAEIMAFLFGMKFARDAGCS 106

Query: 61  EVWVQSDAEVVVKKTK 77
            + ++SD++ VV   K
Sbjct: 107 SILIESDSQGVVNDVK 122

[Close]
BLAST of Cmc05g0129091 vs. ExPASy TrEMBL
Match: A0A251PKK0 (RNase H domain-containing protein OS=Prunus persica OX=3760 GN=PRUPE_4G143500 PE=4 SV=1)

HSP 1 Score: 53.9 bits (128), Expect = 4.2e-04
Identity = 25/76 (32.89%), Postives = 40/76 (52.63%), Query Frame = 0 

Query: 1   MDVACSPNNKGNGYGVVLRNDKGEIVVAQAFCRGESFLVEASKIMVIMFGLHLVEGLGCF 60
           +D A  P     G G V+RNDKGE++ A A     +   + ++IM  +FG+      GC 
Sbjct: 53  VDAAFIPETGVGGIGAVVRNDKGEVMAAMALPLASATSSKHAEIMAFLFGMKFARDAGCS 112

Query: 61  EVWVQSDAEVVVKKTK 77
            + ++SD++ VV   K
Sbjct: 113 SILIESDSQGVVNDVK 128

The following BLAST results are available for this feature:
BLAST of Cmc05g0129091 vs. NCBI nr
Match NameE-valueIdentityDescription
KAA0031982.13.2e-3086.84hypothetical protein E6C27_scaffold134G00730 [Cucumis melo var. makuwa] >TYK1680... [more]
ONI12089.18.7e-0432.89hypothetical protein PRUPE_4G143500 [Prunus persica][more]
BLAST of Cmc05g0129091 vs. NCBI nr
Match NameE-valueIdentityDescription
BLAST of Cmc05g0129091 vs. ExPASy TrEMBL
Match NameE-valueIdentityDescription
A0A5A7SLR61.5e-3086.84RNase H domain-containing protein OS=Cucumis melo var. makuwa OX=1194695 GN=E567... [more]
M5WZF64.2e-0432.89RNase H domain-containing protein (Fragment) OS=Prunus persica OX=3760 GN=PRUPE_... [more]
A0A251PKK04.2e-0432.89RNase H domain-containing protein OS=Prunus persica OX=3760 GN=PRUPE_4G143500 PE... [more]
BLAST of Cmc05g0129091 vs. ExPASy TrEMBL
Match NameE-valueIdentityDescription
InterPro
Analysis Name: InterPro Annotations of Melon (Charmono) v1.1
Date Performed: 2022-10-13
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002156Ribonuclease H domainPFAMPF13456RVT_3coord: 2..76
e-value: 1.5E-6
score: 28.0
IPR036397Ribonuclease H superfamilyGENE3D3.30.420.10coord: 1..83
e-value: 9.7E-6
score: 27.6
IPR012337Ribonuclease H-like superfamilySUPERFAMILY53098Ribonuclease H-likecoord: 2..76

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Cmc05g0129091.1Cmc05g0129091.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
molecular_function GO:0003676 nucleic acid binding
molecular_function GO:0004523 RNA-DNA hybrid ribonuclease activity