Chy8G149900 (gene) Cucumber (hystrix) v1

Overview
NameChy8G149900
Typegene
OrganismCucumis hystrix (Cucumber (hystrix) v1)
DescriptionRNA polymerase II transcriptional coactivator KIWI-like
LocationchrH08: 9093031 .. 9093497 (+)
RNA-Seq ExpressionChy8G149900
SyntenyChy8G149900
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonCDSpolypeptide
Hold the cursor over a type above to highlight its positions in the sequence below.
ATGCGTTCTTGTATATTACGTTTTGAAGAGCAAAGAGTTTGTGAAGAAGTAGAAGAAGTCGAAGAAAAGAAAGCAAGCAAAAAAGGAGGAAGAAAAATGTCTGCAAGTGGAAAGCGAAAGGGCGATGAAGATCACGTATCCGAAGGAGATGCTCCTCCTTCCAAAACATTCAAGAAAGCTCCTGACGATACCGACGAAATCGTTGTTTGCGAGGTCATTCTTTCACTTCCTTTCTCCTTCCCCCTTTTTTTTACCGCCTTTACCCTCCTTTCAAACTCTTTAATGTCTCTTTTTTCTTCCTCTAGCTTTCAAAGAACCGTAGGGTTATGGTCAGGAACTGGCAAGGAAAGATTGTCGTCGATATTCGCGAGTTTTATGTCAAAGATGGCAAGCAGATGCCTGGAAAGAAAGGTTCATCTCCTCATCCCTATTCTTTTCTTTTTCGCTATCTCCCTGTGGATGGATGA

mRNA sequence

ATGCGTTCTTGTATATTACGTTTTGAAGAGCAAAGAGTTTGTGAAGAAGTAGAAGAAGTCGAAGAAAAGAAAGCAAGCAAAAAAGGAGGAAGAAAAATGTCTGCAAGTGGAAAGCGAAAGGGCGATGAAGATCACGTATCCGAAGGAGATGCTCCTCCTTCCAAAACATTCAAGAAAGCTCCTGACGATACCGACGAAATCGTTGTTTGCGAGCTTTCAAAGAACCGTAGGGTTATGGTCAGGAACTGGCAAGGAAAGATTGTCGTCGATATTCGCGAGTTTTATGTCAAAGATGGCAAGCAGATGCCTGGAAAGAAAGGTTCATCTCCTCATCCCTATTCTTTTCTTTTTCGCTATCTCCCTGTGGATGGATGA

Coding sequence (CDS)

ATGCGTTCTTGTATATTACGTTTTGAAGAGCAAAGAGTTTGTGAAGAAGTAGAAGAAGTCGAAGAAAAGAAAGCAAGCAAAAAAGGAGGAAGAAAAATGTCTGCAAGTGGAAAGCGAAAGGGCGATGAAGATCACGTATCCGAAGGAGATGCTCCTCCTTCCAAAACATTCAAGAAAGCTCCTGACGATACCGACGAAATCGTTGTTTGCGAGCTTTCAAAGAACCGTAGGGTTATGGTCAGGAACTGGCAAGGAAAGATTGTCGTCGATATTCGCGAGTTTTATGTCAAAGATGGCAAGCAGATGCCTGGAAAGAAAGGTTCATCTCCTCATCCCTATTCTTTTCTTTTTCGCTATCTCCCTGTGGATGGATGA

Protein sequence

MRSCILRFEEQRVCEEVEEVEEKKASKKGGRKMSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIREFYVKDGKQMPGKKGSSPHPYSFLFRYLPVDG*
Homology
BLAST of Chy8G149900 vs. ExPASy Swiss-Prot
Match: O65154 (RNA polymerase II transcriptional coactivator KIWI OS=Arabidopsis thaliana OX=3702 GN=KIWI PE=1 SV=1)

HSP 1 Score: 91.3 bits (225), Expect = 8.5e-18
Identity = 50/83 (60.24%), Postives = 58/83 (69.88%), Query Frame = 0

Query: 33  MSASGKRKGDE----DHVSEGDAPPSKTFKKA--PDDTDEIVVCELSKNRRVMVRNWQGK 92
           MS+ GKRK ++    D  SE  AP  K  K A   D +D+IVVC +SKNRRV VRNW GK
Sbjct: 1   MSSRGKRKDEDVRASDDESETHAPAKKVAKPADDSDQSDDIVVCNISKNRRVSVRNWNGK 60

Query: 93  IVVDIREFYVKDGKQMPGKKGSS 110
           I +DIREFYVKDGK +PGKKG S
Sbjct: 61  IWIDIREFYVKDGKTLPGKKGIS 83

BLAST of Chy8G149900 vs. ExPASy Swiss-Prot
Match: O65155 (RNA polymerase II transcriptional coactivator KELP OS=Arabidopsis thaliana OX=3702 GN=KELP PE=1 SV=1)

HSP 1 Score: 57.4 bits (137), Expect = 1.4e-07
Identity = 37/93 (39.78%), Postives = 53/93 (56.99%), Query Frame = 0

Query: 17  VEEVEEKKASKKGGRKMSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNR 76
           V  V EK   ++  R+   S   K +ED    GD    K  K+  DD D +++C LS  R
Sbjct: 51  VRSVVEKFLDEERAREYENSQVNKEEED----GDKDCGKGNKEFDDDGD-LIICRLSDKR 110

Query: 77  RVMVRNWQGKIVVDIREFYVKDGKQMPGKKGSS 110
           RV ++ ++GK +V IRE+Y KDGK++P  KG S
Sbjct: 111 RVTIQEFKGKSLVSIREYYKKDGKELPTSKGIS 138

BLAST of Chy8G149900 vs. ExPASy TrEMBL
Match: A0A0A0L2F1 (PC4 domain-containing protein OS=Cucumis sativus OX=3659 GN=Csa_4G496770 PE=3 SV=1)

HSP 1 Score: 146.7 bits (369), Expect = 6.3e-32
Identity = 73/77 (94.81%), Postives = 73/77 (94.81%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRKGDED VSEGDAPPSKTFKK  DDTDEIVVCELSKNRRVMVRNWQGKIVVDIR
Sbjct: 1   MSASGKRKGDEDDVSEGDAPPSKTFKKDSDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKGSS 110
           EFYVKDGKQMPGKKG S
Sbjct: 61  EFYVKDGKQMPGKKGIS 77

BLAST of Chy8G149900 vs. ExPASy TrEMBL
Match: A0A1S3B4K6 (RNA polymerase II transcriptional coactivator KIWI isoform X1 OS=Cucumis melo OX=3656 GN=LOC103486087 PE=3 SV=1)

HSP 1 Score: 142.1 bits (357), Expect = 1.5e-30
Identity = 70/77 (90.91%), Postives = 71/77 (92.21%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRK DED VSEGDAPPSKTF+K PDD DEIVVCELSKNRRVMVR WQGKIVVDIR
Sbjct: 1   MSASGKRKDDEDRVSEGDAPPSKTFRKDPDDADEIVVCELSKNRRVMVRKWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKGSS 110
           EFYVKDGKQMPGKKG S
Sbjct: 61  EFYVKDGKQMPGKKGIS 77

BLAST of Chy8G149900 vs. ExPASy TrEMBL
Match: A0A5D3DTF5 (RNA polymerase II transcriptional coactivator KIWI isoform X1 OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold124G001210 PE=3 SV=1)

HSP 1 Score: 141.0 bits (354), Expect = 3.4e-30
Identity = 69/75 (92.00%), Postives = 70/75 (93.33%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRK DED VSEGDAPPSKTF+K PDD DEIVVCELSKNRRVMVR WQGKIVVDIR
Sbjct: 1   MSASGKRKDDEDRVSEGDAPPSKTFRKDPDDADEIVVCELSKNRRVMVRKWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKG 108
           EFYVKDGKQMPGKKG
Sbjct: 61  EFYVKDGKQMPGKKG 75

BLAST of Chy8G149900 vs. ExPASy TrEMBL
Match: A0A5A7TD38 (RNA polymerase II transcriptional coactivator KIWI isoform X1 OS=Cucumis melo var. makuwa OX=1194695 GN=E6C27_scaffold128G003650 PE=3 SV=1)

HSP 1 Score: 141.0 bits (354), Expect = 3.4e-30
Identity = 69/75 (92.00%), Postives = 70/75 (93.33%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRK DED VSEGDAPPSKTF+K PDD DEIVVCELSKNRRVMVR WQGKIVVDIR
Sbjct: 1   MSASGKRKDDEDRVSEGDAPPSKTFRKDPDDADEIVVCELSKNRRVMVRKWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKG 108
           EFYVKDGKQMPGKKG
Sbjct: 61  EFYVKDGKQMPGKKG 75

BLAST of Chy8G149900 vs. ExPASy TrEMBL
Match: A0A1S3B509 (RNA polymerase II transcriptional coactivator KIWI isoform X2 OS=Cucumis melo OX=3656 GN=LOC103486087 PE=3 SV=1)

HSP 1 Score: 141.0 bits (354), Expect = 3.4e-30
Identity = 69/75 (92.00%), Postives = 70/75 (93.33%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRK DED VSEGDAPPSKTF+K PDD DEIVVCELSKNRRVMVR WQGKIVVDIR
Sbjct: 1   MSASGKRKDDEDRVSEGDAPPSKTFRKDPDDADEIVVCELSKNRRVMVRKWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKG 108
           EFYVKDGKQMPGKKG
Sbjct: 61  EFYVKDGKQMPGKKG 75

BLAST of Chy8G149900 vs. NCBI nr
Match: KAG7033606.1 (RNA polymerase II transcriptional coactivator KIWI [Cucurbita argyrosperma subsp. argyrosperma])

HSP 1 Score: 149 bits (375), Expect = 6.84e-44
Identity = 74/90 (82.22%), Postives = 77/90 (85.56%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSA GKRK DEDHVSEGDAPP KTF+K  D+TDEIVVCE+SKNRRVMVRNWQGKIVVDIR
Sbjct: 1   MSARGKRKDDEDHVSEGDAPPKKTFRKDSDETDEIVVCEISKNRRVMVRNWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKGSSPHPYSFLFRYLPV 122
           EFYVKDGKQMPGKKGSS H   F  R  PV
Sbjct: 61  EFYVKDGKQMPGKKGSSHHRLLFSLRTSPV 90

BLAST of Chy8G149900 vs. NCBI nr
Match: XP_004146395.1 (RNA polymerase II transcriptional coactivator KIWI isoform X1 [Cucumis sativus] >KGN54787.1 hypothetical protein Csa_012558 [Cucumis sativus])

HSP 1 Score: 145 bits (365), Expect = 2.82e-42
Identity = 73/77 (94.81%), Postives = 73/77 (94.81%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRKGDED VSEGDAPPSKTFKK  DDTDEIVVCELSKNRRVMVRNWQGKIVVDIR
Sbjct: 1   MSASGKRKGDEDDVSEGDAPPSKTFKKDSDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKGSS 109
           EFYVKDGKQMPGKKG S
Sbjct: 61  EFYVKDGKQMPGKKGIS 77

BLAST of Chy8G149900 vs. NCBI nr
Match: XP_011653896.1 (RNA polymerase II transcriptional coactivator KIWI isoform X2 [Cucumis sativus])

HSP 1 Score: 141 bits (356), Expect = 4.89e-41
Identity = 71/74 (95.95%), Postives = 71/74 (95.95%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRKGDED VSEGDAPPSKTFKK  DDTDEIVVCELSKNRRVMVRNWQGKIVVDIR
Sbjct: 1   MSASGKRKGDEDDVSEGDAPPSKTFKKDSDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKK 106
           EFYVKDGKQMPGKK
Sbjct: 61  EFYVKDGKQMPGKK 74

BLAST of Chy8G149900 vs. NCBI nr
Match: XP_008442141.1 (PREDICTED: RNA polymerase II transcriptional coactivator KIWI isoform X2 [Cucumis melo])

HSP 1 Score: 139 bits (351), Expect = 1.81e-40
Identity = 69/76 (90.79%), Postives = 70/76 (92.11%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRK DED VSEGDAPPSKTF+K PDD DEIVVCELSKNRRVMVR WQGKIVVDIR
Sbjct: 1   MSASGKRKDDEDRVSEGDAPPSKTFRKDPDDADEIVVCELSKNRRVMVRKWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKGS 108
           EFYVKDGKQMPGKKG 
Sbjct: 61  EFYVKDGKQMPGKKGK 76

BLAST of Chy8G149900 vs. NCBI nr
Match: XP_008442140.1 (PREDICTED: RNA polymerase II transcriptional coactivator KIWI isoform X1 [Cucumis melo])

HSP 1 Score: 140 bits (353), Expect = 1.89e-40
Identity = 70/77 (90.91%), Postives = 71/77 (92.21%), Query Frame = 0

Query: 33  MSASGKRKGDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGKIVVDIR 92
           MSASGKRK DED VSEGDAPPSKTF+K PDD DEIVVCELSKNRRVMVR WQGKIVVDIR
Sbjct: 1   MSASGKRKDDEDRVSEGDAPPSKTFRKDPDDADEIVVCELSKNRRVMVRKWQGKIVVDIR 60

Query: 93  EFYVKDGKQMPGKKGSS 109
           EFYVKDGKQMPGKKG S
Sbjct: 61  EFYVKDGKQMPGKKGIS 77

BLAST of Chy8G149900 vs. TAIR 10
Match: AT5G09250.1 (ssDNA-binding transcriptional regulator )

HSP 1 Score: 91.3 bits (225), Expect = 6.0e-19
Identity = 50/83 (60.24%), Postives = 58/83 (69.88%), Query Frame = 0

Query: 33  MSASGKRKGDE----DHVSEGDAPPSKTFKKA--PDDTDEIVVCELSKNRRVMVRNWQGK 92
           MS+ GKRK ++    D  SE  AP  K  K A   D +D+IVVC +SKNRRV VRNW GK
Sbjct: 1   MSSRGKRKDEDVRASDDESETHAPAKKVAKPADDSDQSDDIVVCNISKNRRVSVRNWNGK 60

Query: 93  IVVDIREFYVKDGKQMPGKKGSS 110
           I +DIREFYVKDGK +PGKKG S
Sbjct: 61  IWIDIREFYVKDGKTLPGKKGIS 83

BLAST of Chy8G149900 vs. TAIR 10
Match: AT5G09250.2 (ssDNA-binding transcriptional regulator )

HSP 1 Score: 90.9 bits (224), Expect = 7.9e-19
Identity = 49/82 (59.76%), Postives = 58/82 (70.73%), Query Frame = 0

Query: 33  MSASGKRKGDE----DHVSEGDAPPSKTFKKA--PDDTDEIVVCELSKNRRVMVRNWQGK 92
           MS+ GKRK ++    D  SE  AP  K  K A   D +D+IVVC +SKNRRV VRNW GK
Sbjct: 1   MSSRGKRKDEDVRASDDESETHAPAKKVAKPADDSDQSDDIVVCNISKNRRVSVRNWNGK 60

Query: 93  IVVDIREFYVKDGKQMPGKKGS 109
           I +DIREFYVKDGK +PGKKG+
Sbjct: 61  IWIDIREFYVKDGKTLPGKKGN 82

BLAST of Chy8G149900 vs. TAIR 10
Match: AT5G09240.3 (ssDNA-binding transcriptional regulator )

HSP 1 Score: 65.9 bits (159), Expect = 2.7e-11
Identity = 38/84 (45.24%), Postives = 49/84 (58.33%), Query Frame = 0

Query: 33  MSASGKRK------GDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGK 92
           MS +GKRK       D+   SE  APP K  K A D+ ++I +C L KNRRV VRN  G+
Sbjct: 1   MSENGKRKDEDVRASDDRDESETHAPPKKVAKPA-DEIEDIFICNLDKNRRVFVRNCNGR 60

Query: 93  IVVDIREFYVKDGKQMPGKKGSSP 111
           I + IR+F+VKDG  +P      P
Sbjct: 61  IWIAIRQFFVKDGITLPCNSKQGP 83

BLAST of Chy8G149900 vs. TAIR 10
Match: AT5G09240.2 (ssDNA-binding transcriptional regulator )

HSP 1 Score: 65.5 bits (158), Expect = 3.5e-11
Identity = 40/85 (47.06%), Postives = 52/85 (61.18%), Query Frame = 0

Query: 33  MSASGKRK------GDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGK 92
           MS +GKRK       D+   SE  APP K  K A D+ ++I +C L KNRRV VRN  G+
Sbjct: 1   MSENGKRKDEDVRASDDRDESETHAPPKKVAKPA-DEIEDIFICNLDKNRRVFVRNCNGR 60

Query: 93  IVVDIREFYVKDGKQMP--GKKGSS 110
           I + IR+F+VKDG  +P   K+G S
Sbjct: 61  IWIAIRQFFVKDGITLPCNSKQGIS 84

BLAST of Chy8G149900 vs. TAIR 10
Match: AT5G09240.1 (ssDNA-binding transcriptional regulator )

HSP 1 Score: 65.5 bits (158), Expect = 3.5e-11
Identity = 40/85 (47.06%), Postives = 52/85 (61.18%), Query Frame = 0

Query: 33  MSASGKRK------GDEDHVSEGDAPPSKTFKKAPDDTDEIVVCELSKNRRVMVRNWQGK 92
           MS +GKRK       D+   SE  APP K  K A D+ ++I +C L KNRRV VRN  G+
Sbjct: 1   MSENGKRKDEDVRASDDRDESETHAPPKKVAKPA-DEIEDIFICNLDKNRRVFVRNCNGR 60

Query: 93  IVVDIREFYVKDGKQMP--GKKGSS 110
           I + IR+F+VKDG  +P   K+G S
Sbjct: 61  IWIAIRQFFVKDGITLPCNSKQGIS 84

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
O651548.5e-1860.24RNA polymerase II transcriptional coactivator KIWI OS=Arabidopsis thaliana OX=37... [more]
O651551.4e-0739.78RNA polymerase II transcriptional coactivator KELP OS=Arabidopsis thaliana OX=37... [more]
Match NameE-valueIdentityDescription
A0A0A0L2F16.3e-3294.81PC4 domain-containing protein OS=Cucumis sativus OX=3659 GN=Csa_4G496770 PE=3 SV... [more]
A0A1S3B4K61.5e-3090.91RNA polymerase II transcriptional coactivator KIWI isoform X1 OS=Cucumis melo OX... [more]
A0A5D3DTF53.4e-3092.00RNA polymerase II transcriptional coactivator KIWI isoform X1 OS=Cucumis melo va... [more]
A0A5A7TD383.4e-3092.00RNA polymerase II transcriptional coactivator KIWI isoform X1 OS=Cucumis melo va... [more]
A0A1S3B5093.4e-3092.00RNA polymerase II transcriptional coactivator KIWI isoform X2 OS=Cucumis melo OX... [more]
Match NameE-valueIdentityDescription
KAG7033606.16.84e-4482.22RNA polymerase II transcriptional coactivator KIWI [Cucurbita argyrosperma subsp... [more]
XP_004146395.12.82e-4294.81RNA polymerase II transcriptional coactivator KIWI isoform X1 [Cucumis sativus] ... [more]
XP_011653896.14.89e-4195.95RNA polymerase II transcriptional coactivator KIWI isoform X2 [Cucumis sativus][more]
XP_008442141.11.81e-4090.79PREDICTED: RNA polymerase II transcriptional coactivator KIWI isoform X2 [Cucumi... [more]
XP_008442140.11.89e-4090.91PREDICTED: RNA polymerase II transcriptional coactivator KIWI isoform X1 [Cucumi... [more]
Match NameE-valueIdentityDescription
AT5G09250.16.0e-1960.24ssDNA-binding transcriptional regulator [more]
AT5G09250.27.9e-1959.76ssDNA-binding transcriptional regulator [more]
AT5G09240.32.7e-1145.24ssDNA-binding transcriptional regulator [more]
AT5G09240.23.5e-1147.06ssDNA-binding transcriptional regulator [more]
AT5G09240.13.5e-1147.06ssDNA-binding transcriptional regulator [more]
InterPro
Analysis Name: InterPro Annotations of Cucumber (hystrix) v1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003173Transcriptional coactivator p15 (PC4), C-terminalPFAMPF02229PC4coord: 70..107
e-value: 1.1E-15
score: 57.0
IPR009044ssDNA-binding transcriptional regulatorGENE3D2.30.31.10Transcriptional Coactivator Pc4; Chain Acoord: 60..121
e-value: 7.5E-17
score: 62.7
IPR009044ssDNA-binding transcriptional regulatorSUPERFAMILY54447ssDNA-binding transcriptional regulator domaincoord: 69..109
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 19..62
IPR045125RNA polymerase II transcriptional coactivator Sub1/Tcp4-likePANTHERPTHR13215RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATORcoord: 18..107

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Chy8G149900.1Chy8G149900.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
biological_process GO:0006355 regulation of transcription, DNA-templated
cellular_component GO:0005634 nucleus
cellular_component GO:0005667 transcription regulator complex
molecular_function GO:0003677 DNA binding
molecular_function GO:0003713 transcription coactivator activity