Chy4G089230 (gene) Cucumber (hystrix) v1

Overview
NameChy4G089230
Typegene
OrganismCucumis hystrix (Cucumber (hystrix) v1)
DescriptionInosine-5'-monophosphate dehydrogenase
LocationchrH04: 26977805 .. 26978346 (+)
RNA-Seq ExpressionChy4G089230
SyntenyChy4G089230
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonCDSpolypeptide
Hold the cursor over a type above to highlight its positions in the sequence below.
ATGGGGTCTTTAGAGGCAATGGCCAAAGGAAGTGATGGCAGGTACTTGGGGGATATTGCAACCCTTAAGATAGCCCGGGGGGTTGTTGGAGCAGTTGTCGAAAAGGGTGTAGTCTTCAAATTCATACTCTATACCATGCAAGCAGTCAAGCAAGGGTTCCAGGATATTGGTTCTTCTCCACTTTGTGCTTTGTTGGTTATGAACATGAATTTGTTTGGAATCGTTGTCATTTTATTGGGTTTACACATGTACAGGTTCGTACAGAGGCAGCACACAGGTCGAAGGTGGAATTCATGGATGGGTCTCTTATGAAAAGAGATCGTTTTGAAAAATAAATACATTATGACTATAAGCTGCTCCTTAAAACTGGACTTGTGTCAATAATTTATATACAGTGATGTGCATATTGTAGTCTTAAGATTTTATCAATTCGAGCTAGCAGTGGATTTTTTTTTCTCTCTCTCCTCTTCTACATATAATGTAACAACACGGTCTATGCCTTCAAAACAGAATATTGGGAAGAAAGTTGTAACAAATTGTGA

mRNA sequence

ATGGGGTCTTTAGAGGCAATGGCCAAAGGAAGTGATGGCAGGTACTTGGGGGATATTGCAACCCTTAAGATAGCCCGGGGGGTTGTTGGAGCAGTTGTCGAAAAGGGTGTAGTCTTCAAATTCATACTCTATACCATGCAAGCAGTCAAGCAAGGGTTCCAGGATATTGGTTCTTCTCCACTTTGTGCTTTGTTGGTTATGAACATGAATTTGTTTGGAATCGTTGTCATTTTATTGGGTTTACACATGTACAGGTTCGTACAGAGGCAGCACACAGGTCGAAGGTGGAATTCATGGATGGTCTTAAGATTTTATCAATTCGAGCTAGCAGTGGATTTTTTTTTCTCTCTCTCCTCTTCTACATATAATGTAACAACACGGTCTATGCCTTCAAAACAGAATATTGGGAAGAAAGTTGTAACAAATTGTGA

Coding sequence (CDS)

ATGGGGTCTTTAGAGGCAATGGCCAAAGGAAGTGATGGCAGGTACTTGGGGGATATTGCAACCCTTAAGATAGCCCGGGGGGTTGTTGGAGCAGTTGTCGAAAAGGGTGTAGTCTTCAAATTCATACTCTATACCATGCAAGCAGTCAAGCAAGGGTTCCAGGATATTGGTTCTTCTCCACTTTGTGCTTTGTTGGTTATGAACATGAATTTGTTTGGAATCGTTGTCATTTTATTGGGTTTACACATGTACAGGTTCGTACAGAGGCAGCACACAGGTCGAAGGTGGAATTCATGGATGGTCTTAAGATTTTATCAATTCGAGCTAGCAGTGGATTTTTTTTTCTCTCTCTCCTCTTCTACATATAATGTAACAACACGGTCTATGCCTTCAAAACAGAATATTGGGAAGAAAGTTGTAACAAATTGTGA

Protein sequence

MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSPLCALLVMNMNLFGIVVILLGLHMYRFVQRQHTGRRWNSWMVLRFYQFELAVDFFFSLSSSTYNVTTRSMPSKQNIGKKVVTNCX
Homology
[Close]
BLAST of Chy4G089230 vs. ExPASy Swiss-Prot
Match: Q9SA34 (Inosine-5'-monophosphate dehydrogenase 2 OS=Arabidopsis thaliana OX=3702 GN=At1g16350 PE=1 SV=1)

HSP 1 Score: 92.4 bits (228), Expect = 4.4e-18
Identity = 47/61 (77.05%), Postives = 51/61 (83.61%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD A LKIA+GVVGAV +KG V KFI YTM AVKQGFQD+G+S 
Sbjct: 404 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMHAVKQGFQDLGASS 463

Query: 61  L 62
           L
Sbjct: 464 L 464

[Close]
BLAST of Chy4G089230 vs. ExPASy Swiss-Prot
Match: Q84XA3 (Inosine-5'-monophosphate dehydrogenase OS=Vigna unguiculata OX=3917 GN=impdh PE=1 SV=1)

HSP 1 Score: 90.9 bits (224), Expect = 1.3e-17
Identity = 46/61 (75.41%), Postives = 51/61 (83.61%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD A LKIA+GVVGAV +KG V  FI YT+QAV+QGFQDIG+S 
Sbjct: 404 MGSLEAMTKGSDARYLGDTAKLKIAQGVVGAVKDKGSVLNFIPYTLQAVRQGFQDIGASS 463

Query: 61  L 62
           L
Sbjct: 464 L 464

[Close]
BLAST of Chy4G089230 vs. ExPASy Swiss-Prot
Match: P47996 (Inosine-5'-monophosphate dehydrogenase 1 OS=Arabidopsis thaliana OX=3702 GN=IMPDH PE=2 SV=1)

HSP 1 Score: 87.8 bits (216), Expect = 1.1e-16
Identity = 45/61 (73.77%), Postives = 49/61 (80.33%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD   LKIA+GVVGAV +KG V K I YTM AVKQGFQD+G+S 
Sbjct: 405 MGSLEAMTKGSDQRYLGDQTKLKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASS 464

Query: 61  L 62
           L
Sbjct: 465 L 465

[Close]
BLAST of Chy4G089230 vs. ExPASy Swiss-Prot
Match: Q54QQ0 (Inosine-5'-monophosphate dehydrogenase OS=Dictyostelium discoideum OX=44689 GN=impdh PE=1 SV=1)

HSP 1 Score: 67.4 bits (163), Expect = 1.5e-10
Identity = 32/64 (50.00%), Postives = 44/64 (68.75%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KG D RY  +   +K+A+GV G+VV+KG V KF+ Y +Q +K G QD+G + 
Sbjct: 417 MGSLEAMVKGGDQRYFSETDKIKVAQGVSGSVVDKGSVKKFVPYLIQGIKHGLQDLGCNS 476

Query: 61  LCAL 65
           +  L
Sbjct: 477 VTNL 480

[Close]
BLAST of Chy4G089230 vs. ExPASy Swiss-Prot
Match: B0UXP9 (Inosine-5'-monophosphate dehydrogenase 2 OS=Danio rerio OX=7955 GN=impdh2 PE=3 SV=1)

HSP 1 Score: 54.7 bits (130), Expect = 1.0e-06
Identity = 30/69 (43.48%), Postives = 42/69 (60.87%), Query Frame = 0 

Query: 1   MGSLEAMAK--GSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGS 60
           MGSL+AM K  GS  RY  +   +K+A+GV GAV +KG + KF+ Y +  ++   QDIG+
Sbjct: 414 MGSLDAMDKNLGSQTRYFSESDKIKVAQGVSGAVQDKGSIHKFVPYLLVGIQHSCQDIGA 473

Query: 61  SPLCALLVM 68
             L  L  M
Sbjct: 474 KSLTQLRAM 482

[Close]
BLAST of Chy4G089230 vs. ExPASy TrEMBL
Match: A0A0A0LAC3 (IMPDH domain-containing protein OS=Cucumis sativus OX=3659 GN=Csa_3G732640 PE=4 SV=1)

HSP 1 Score: 147.9 bits (372), Expect = 3.3e-32
Identity = 87/144 (60.42%), Postives = 104/144 (72.22%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAMA+GSD RYLGDIATLKI  GV GA+ +KG V KFILYT QAVKQGFQ+I +SP
Sbjct: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60

Query: 61  LCALLVMNMNLFGIVVILLGLHMYRFVQRQHTGRRWNSWMVLRFYQFELAVDFFFS--LS 120
           L ALL++NMNLF IVV LLGL M +FV+ QH   +      L+      +  FFF+  L 
Sbjct: 61  LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRS-KVEFMDCLQVSSIRASSGFFFAPLLH 120

Query: 121 SSTYNVTTRSMPSKQNIGKKVVTN 143
                ++TRSMPSKQ++GKKVVTN
Sbjct: 121 IFVDLLSTRSMPSKQSVGKKVVTN 143

[Close]
BLAST of Chy4G089230 vs. ExPASy TrEMBL
Match: A0A6J1HZF2 (Inosine-5'-monophosphate dehydrogenase OS=Cucurbita maxima OX=3661 GN=LOC111468080 PE=3 SV=1)

HSP 1 Score: 96.7 bits (239), Expect = 8.6e-17
Identity = 48/61 (78.69%), Postives = 53/61 (86.89%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD ATLKIA+GVVGAV +KG V KFI YTMQAVKQGFQD+G+S 
Sbjct: 396 MGSLEAMTKGSDARYLGDTATLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 455

Query: 61  L 62
           +
Sbjct: 456 I 456

[Close]
BLAST of Chy4G089230 vs. ExPASy TrEMBL
Match: A0A6J1D3Y1 (Inosine-5'-monophosphate dehydrogenase OS=Momordica charantia OX=3673 GN=LOC111016759 PE=3 SV=1)

HSP 1 Score: 96.7 bits (239), Expect = 8.6e-17
Identity = 48/61 (78.69%), Postives = 53/61 (86.89%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD ATLKIA+GVVGAV +KG V KFI YTMQAVKQGFQD+G+S 
Sbjct: 396 MGSLEAMTKGSDARYLGDTATLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 455

Query: 61  L 62
           +
Sbjct: 456 I 456

[Close]
BLAST of Chy4G089230 vs. ExPASy TrEMBL
Match: A0A6J1GLR9 (Inosine-5'-monophosphate dehydrogenase OS=Cucurbita moschata OX=3662 GN=LOC111455460 PE=3 SV=1)

HSP 1 Score: 96.7 bits (239), Expect = 8.6e-17
Identity = 48/61 (78.69%), Postives = 53/61 (86.89%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD ATLKIA+GVVGAV +KG V KFI YTMQAVKQGFQD+G+S 
Sbjct: 396 MGSLEAMTKGSDARYLGDTATLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 455

Query: 61  L 62
           +
Sbjct: 456 I 456

[Close]
BLAST of Chy4G089230 vs. ExPASy TrEMBL
Match: A0A5D3BCR0 (Inosine-5'-monophosphate dehydrogenase OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold986G00390 PE=3 SV=1)

HSP 1 Score: 96.3 bits (238), Expect = 1.1e-16
Identity = 48/61 (78.69%), Postives = 53/61 (86.89%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD ATLKIA+GVVGAV +KG V KFI YTMQAVKQGFQD+G+S 
Sbjct: 396 MGSLEAMIKGSDARYLGDTATLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 455

Query: 61  L 62
           +
Sbjct: 456 I 456

[Close]
BLAST of Chy4G089230 vs. NCBI nr
Match: KGN58808.1 (hypothetical protein Csa_001721 [Cucumis sativus])

HSP 1 Score: 146 bits (368), Expect = 7.40e-42
Identity = 87/144 (60.42%), Postives = 104/144 (72.22%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAMA+GSD RYLGDIATLKI  GV GA+ +KG V KFILYT QAVKQGFQ+I +SP
Sbjct: 1   MGSLEAMARGSDDRYLGDIATLKIVEGVAGAIADKGSVLKFILYTTQAVKQGFQEIAASP 60

Query: 61  LCALLVMNMNLFGIVVILLGLHMYRFVQRQHTGRRWNSWMVLRFYQFELAVDFFFS--LS 120
           L ALL++NMNLF IVV LLGL M +FV+ QH  +       L+      +  FFF+  L 
Sbjct: 61  LYALLIVNMNLFRIVVNLLGLPMCKFVRWQHRSKV-EFMDCLQVSSIRASSGFFFAPLLH 120

Query: 121 SSTYNVTTRSMPSKQNIGKKVVTN 142
                ++TRSMPSKQ++GKKVVTN
Sbjct: 121 IFVDLLSTRSMPSKQSVGKKVVTN 143

[Close]
BLAST of Chy4G089230 vs. NCBI nr
Match: XP_021804122.1 (inosine-5'-monophosphate dehydrogenase 2-like, partial [Prunus avium])

HSP 1 Score: 92.8 bits (229), Expect = 4.34e-21
Identity = 48/61 (78.69%), Postives = 52/61 (85.25%), Query Frame = 0 

Query: 1  MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
          MGSLEAM KGSD RYLGD A LKIA+GVVGAV +KG V KFI YTMQAVKQGFQD+G+S 
Sbjct: 26 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 85

[Close]
BLAST of Chy4G089230 vs. NCBI nr
Match: XP_019242259.1 (PREDICTED: inosine-5'-monophosphate dehydrogenase-like [Nicotiana attenuata] >OIT18750.1 inosine-5'-monophosphate dehydrogenase [Nicotiana attenuata])

HSP 1 Score: 92.0 bits (227), Expect = 4.36e-21
Identity = 46/61 (75.41%), Postives = 52/61 (85.25%), Query Frame = 0 

Query: 1  MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
          MGSLEAM KGSD RYLGD A LKIA+GVVG+V +KG + KFI YTMQAVKQGFQD+G+S 
Sbjct: 1  MGSLEAMTKGSDARYLGDTAKLKIAQGVVGSVADKGSILKFIPYTMQAVKQGFQDLGASS 60

[Close]
BLAST of Chy4G089230 vs. NCBI nr
Match: TQD90936.1 (hypothetical protein C1H46_023539 [Malus baccata])

HSP 1 Score: 91.7 bits (226), Expect = 6.17e-21
Identity = 47/61 (77.05%), Postives = 52/61 (85.25%), Query Frame = 0 

Query: 1  MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
          MGSLEAM KGSD RYLGD A LKIA+GVVGAV +KG V KF+ YTMQAVKQGFQD+G+S 
Sbjct: 1  MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFMPYTMQAVKQGFQDLGASS 60

[Close]
BLAST of Chy4G089230 vs. NCBI nr
Match: RXH86657.1 (hypothetical protein DVH24_021930 [Malus domestica])

HSP 1 Score: 90.9 bits (224), Expect = 7.95e-21
Identity = 47/61 (77.05%), Postives = 51/61 (83.61%), Query Frame = 0 

Query: 1  MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
          MGSLEAM  GSD RYLGD A LKIA+GVVGAV +KG V KFI YTMQAVKQGFQD+G+S 
Sbjct: 1  MGSLEAMTNGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMQAVKQGFQDLGASS 60

[Close]
BLAST of Chy4G089230 vs. TAIR 10
Match: AT1G16350.1 (Aldolase-type TIM barrel family protein )

HSP 1 Score: 92.4 bits (228), Expect = 3.1e-19
Identity = 47/61 (77.05%), Postives = 51/61 (83.61%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD A LKIA+GVVGAV +KG V KFI YTM AVKQGFQD+G+S 
Sbjct: 404 MGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTMHAVKQGFQDLGASS 463

Query: 61  L 62
           L
Sbjct: 464 L 464

[Close]
BLAST of Chy4G089230 vs. TAIR 10
Match: AT1G79470.1 (Aldolase-type TIM barrel family protein )

HSP 1 Score: 87.8 bits (216), Expect = 7.7e-18
Identity = 45/61 (73.77%), Postives = 49/61 (80.33%), Query Frame = 0 

Query: 1   MGSLEAMAKGSDGRYLGDIATLKIARGVVGAVVEKGVVFKFILYTMQAVKQGFQDIGSSP 60
           MGSLEAM KGSD RYLGD   LKIA+GVVGAV +KG V K I YTM AVKQGFQD+G+S 
Sbjct: 405 MGSLEAMTKGSDQRYLGDQTKLKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASS 464

Query: 61  L 62
           L
Sbjct: 465 L 465

The following BLAST results are available for this feature:
BLAST of Chy4G089230 vs. ExPASy Swiss-Prot
Match NameE-valueIdentityDescription
Q9SA344.4e-1877.05Inosine-5'-monophosphate dehydrogenase 2 OS=Arabidopsis thaliana OX=3702 GN=At1g... [more]
Q84XA31.3e-1775.41Inosine-5'-monophosphate dehydrogenase OS=Vigna unguiculata OX=3917 GN=impdh PE=... [more]
P479961.1e-1673.77Inosine-5'-monophosphate dehydrogenase 1 OS=Arabidopsis thaliana OX=3702 GN=IMPD... [more]
Q54QQ01.5e-1050.00Inosine-5'-monophosphate dehydrogenase OS=Dictyostelium discoideum OX=44689 GN=i... [more]
B0UXP91.0e-0643.48Inosine-5'-monophosphate dehydrogenase 2 OS=Danio rerio OX=7955 GN=impdh2 PE=3 S... [more]
BLAST of Chy4G089230 vs. ExPASy TrEMBL
Match NameE-valueIdentityDescription
A0A0A0LAC33.3e-3260.42IMPDH domain-containing protein OS=Cucumis sativus OX=3659 GN=Csa_3G732640 PE=4 ... [more]
A0A6J1HZF28.6e-1778.69Inosine-5'-monophosphate dehydrogenase OS=Cucurbita maxima OX=3661 GN=LOC1114680... [more]
A0A6J1D3Y18.6e-1778.69Inosine-5'-monophosphate dehydrogenase OS=Momordica charantia OX=3673 GN=LOC1110... [more]
A0A6J1GLR98.6e-1778.69Inosine-5'-monophosphate dehydrogenase OS=Cucurbita moschata OX=3662 GN=LOC11145... [more]
A0A5D3BCR01.1e-1678.69Inosine-5'-monophosphate dehydrogenase OS=Cucumis melo var. makuwa OX=1194695 GN... [more]
BLAST of Chy4G089230 vs. NCBI nr
Match NameE-valueIdentityDescription
KGN58808.17.40e-4260.42hypothetical protein Csa_001721 [Cucumis sativus][more]
XP_021804122.14.34e-2178.69inosine-5'-monophosphate dehydrogenase 2-like, partial [Prunus avium][more]
XP_019242259.14.36e-2175.41PREDICTED: inosine-5'-monophosphate dehydrogenase-like [Nicotiana attenuata] >OI... [more]
TQD90936.16.17e-2177.05hypothetical protein C1H46_023539 [Malus baccata][more]
RXH86657.17.95e-2177.05hypothetical protein DVH24_021930 [Malus domestica][more]
BLAST of Chy4G089230 vs. TAIR 10
Match NameE-valueIdentityDescription
AT1G16350.13.1e-1977.05Aldolase-type TIM barrel family protein [more]
AT1G79470.17.7e-1873.77Aldolase-type TIM barrel family protein [more]
InterPro
Analysis Name: InterPro Annotations of Cucumber (hystrix) v1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR013785Aldolase-type TIM barrelGENE3D3.20.20.70Aldolase class Icoord: 1..72
e-value: 5.8E-10
score: 40.2
IPR001093IMP dehydrogenase/GMP reductasePFAMPF00478IMPDHcoord: 1..63
e-value: 2.4E-7
score: 30.1
IPR005990Inosine-5'-monophosphate dehydrogenasePANTHERPTHR11911INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATEDcoord: 1..61
NoneNo IPR availablePANTHERPTHR11911:SF123INOSINE-5'-MONOPHOSPHATE DEHYDROGENASEcoord: 1..61
NoneNo IPR availableSUPERFAMILY51412Inosine monophosphate dehydrogenase (IMPDH)coord: 1..65

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Chy4G089230.1Chy4G089230.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006177 GMP biosynthetic process
biological_process GO:0006164 purine nucleotide biosynthetic process
cellular_component GO:0005737 cytoplasm
molecular_function GO:0003938 IMP dehydrogenase activity
molecular_function GO:0046872 metal ion binding
molecular_function GO:0000166 nucleotide binding
molecular_function GO:0003824 catalytic activity