Bhi09G001555 (gene) Wax gourd (B227) v1

Overview
NameBhi09G001555
Typegene
OrganismBenincasa hispida (Wax gourd (B227) v1)
Descriptioncysteine proteinase inhibitor 1-like
Locationchr9: 51064674 .. 51065361 (+)
RNA-Seq ExpressionBhi09G001555
SyntenyBhi09G001555
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: five_prime_UTRexonCDSpolypeptidethree_prime_UTR
Hold the cursor over a type above to highlight its positions in the sequence below.
CACCAATACTCATTACAAAGTCTTTTTCAAACTATTCATCAGACGTTACGATGAGTTCATATGTGGAGGTTGCCCCGGGACAAAACGAAGCCTTGATCCAAGGTCCAAAGGATGTCGAACTCGGCCGGTGGGAACCGATCGAGAACATCGAAGATCCATACGTGCAAGAGATGGGAAGGTTTTCAGTGATGGAGCACAACAAGCAAACAGGGGCAAACCTAAAGTTCATTCGTGTGGTAAATGGTGAGAAACAAGTTGTGGCTGGAATAAATTATAGGCTTAGGATTGAAGCAAGGAATGAAATGAATTTGGTTTGGACTTATGAGGCTATGGTGAATGATAGGCCATGGGAGAAGAAGTGGAAGCTCATATATTTTGTACCTCTCCTCAAGAACTGATCTACTTATTGCTTCTCTTCTTGCATTATCTATGAAATAATAAAGGGAGACCAATAAAATAAAAGCTATCTTTATGTCTAATATTTTGGTTGTGTTTCCTTTTATGATCTATTAATGAGAGAATAAAATAAAAGTTTTATCCATGCATGCTATGAGTAATATTGTCTCTTATTTGGGGTTTTCTTTTCTCTTTCTTTTTGATTATAGGTTTAGAGCTAGTTCAATCAAATATGATTCACTCAATTGTGTGAGAATTTCATATTAAAATATAGATCTCATCAACTTTGGAA

mRNA sequence

CACCAATACTCATTACAAAGTCTTTTTCAAACTATTCATCAGACGTTACGATGAGTTCATATGTGGAGGTTGCCCCGGGACAAAACGAAGCCTTGATCCAAGGTCCAAAGGATGTCGAACTCGGCCGGTGGGAACCGATCGAGAACATCGAAGATCCATACGTGCAAGAGATGGGAAGGTTTTCAGTGATGGAGCACAACAAGCAAACAGGGGCAAACCTAAAGTTCATTCGTGTGGTAAATGGTGAGAAACAAGTTGTGGCTGGAATAAATTATAGGCTTAGGATTGAAGCAAGGAATGAAATGAATTTGGTTTGGACTTATGAGGCTATGGTGAATGATAGGCCATGGGAGAAGAAGTGGAAGCTCATATATTTTGTACCTCTCCTCAAGAACTGATCTACTTATTGCTTCTCTTCTTGCATTATCTATGAAATAATAAAGGGAGACCAATAAAATAAAAGCTATCTTTATGTCTAATATTTTGGTTGTGTTTCCTTTTATGATCTATTAATGAGAGAATAAAATAAAAGTTTTATCCATGCATGCTATGAGTAATATTGTCTCTTATTTGGGGTTTTCTTTTCTCTTTCTTTTTGATTATAGGTTTAGAGCTAGTTCAATCAAATATGATTCACTCAATTGTGTGAGAATTTCATATTAAAATATAGATCTCATCAACTTTGGAA

Coding sequence (CDS)

ATGAGTTCATATGTGGAGGTTGCCCCGGGACAAAACGAAGCCTTGATCCAAGGTCCAAAGGATGTCGAACTCGGCCGGTGGGAACCGATCGAGAACATCGAAGATCCATACGTGCAAGAGATGGGAAGGTTTTCAGTGATGGAGCACAACAAGCAAACAGGGGCAAACCTAAAGTTCATTCGTGTGGTAAATGGTGAGAAACAAGTTGTGGCTGGAATAAATTATAGGCTTAGGATTGAAGCAAGGAATGAAATGAATTTGGTTTGGACTTATGAGGCTATGGTGAATGATAGGCCATGGGAGAAGAAGTGGAAGCTCATATATTTTGTACCTCTCCTCAAGAACTGA

Protein sequence

MSSYVEVAPGQNEALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFIRVVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVNDRPWEKKWKLIYFVPLLKN
Homology
BLAST of Bhi09G001555 vs. TAIR 10
Match: AT5G47550.1 (Cystatin/monellin superfamily protein )

HSP 1 Score: 83.6 bits (205), Expect = 1.2e-16
Identity = 41/88 (46.59%), Postives = 57/88 (64.77%), Query Frame = 0

Query: 24  LGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFIRVVNGEKQVVAGINYRLRIEARN 83
           +G W PI N+ DP V E+G F+V E+NK++ + LKF  VV+GE QVV+G NYRL++ A +
Sbjct: 28  VGGWSPISNVTDPQVVEIGEFAVSEYNKRSESGLKFETVVSGETQVVSGTNYRLKVAAND 87

Query: 84  EMNLVWTYEAMVNDRPWEKKWKLIYFVP 112
              +   Y A+V D+PW K   L  F P
Sbjct: 88  GDGVSKNYLAIVWDKPWMKFRNLTSFEP 115

BLAST of Bhi09G001555 vs. TAIR 10
Match: AT4G16500.1 (Cystatin/monellin superfamily protein )

HSP 1 Score: 65.9 bits (159), Expect = 2.5e-11
Identity = 30/77 (38.96%), Postives = 50/77 (64.94%), Query Frame = 0

Query: 24  LGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFIRVVNGEKQVVAGINYRLRIEARN 83
           LG  +PI+N+ DP V  + ++++ EHNK++   L F++VV G  QVV+G  Y L+I A++
Sbjct: 29  LGSRKPIKNVSDPDVVAVAKYAIEEHNKESKEKLVFVKVVEGTTQVVSGTKYDLKIAAKD 88

Query: 84  EMNLVWTYEAMVNDRPW 101
               +  YEA+V ++ W
Sbjct: 89  GGGKIKNYEAVVVEKLW 105

BLAST of Bhi09G001555 vs. TAIR 10
Match: AT5G12140.1 (cystatin-1 )

HSP 1 Score: 52.0 bits (123), Expect = 3.7e-07
Identity = 35/104 (33.65%), Postives = 54/104 (51.92%), Query Frame = 0

Query: 7   VAPGQNEALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFIRVVNGE 66
           +A  Q   ++ G +D++        N  D  V+ + RF+V EHNK     L++ R++  +
Sbjct: 1   MADQQAGTIVGGVRDID-------ANANDLQVESLARFAVDEHNKNENLTLEYKRLLGAK 60

Query: 67  KQVVAGINYRLRIE-ARNEMNLVWTYEAMVNDRPWEKKWKLIYF 110
            QVVAG  + L +E A  E N V  YEA V ++ WE   +L  F
Sbjct: 61  TQVVAGTMHHLTVEVADGETNKV--YEAKVLEKAWENLKQLESF 95

BLAST of Bhi09G001555 vs. TAIR 10
Match: AT2G40880.1 (cystatin A )

HSP 1 Score: 51.2 bits (121), Expect = 6.4e-07
Identity = 25/63 (39.68%), Postives = 39/63 (61.90%), Query Frame = 0

Query: 38  VQEMGRFSVMEHNKQTGANLKFIRVVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVND 97
           ++ + RF++ EHNKQ    L+F ++V   +QVVAG  Y L +EA+ E +    +EA V  
Sbjct: 50  IESLARFAIQEHNKQQNKILEFKKIVKAREQVVAGTMYHLTLEAK-EGDQTKNFEAKVWV 109

Query: 98  RPW 101
           +PW
Sbjct: 110 KPW 111

BLAST of Bhi09G001555 vs. TAIR 10
Match: AT2G31980.1 (PHYTOCYSTATIN 2 )

HSP 1 Score: 50.1 bits (118), Expect = 1.4e-06
Identity = 34/112 (30.36%), Postives = 55/112 (49.11%), Query Frame = 0

Query: 20  KDVELGRWEPIENIE-DPYVQEMGRFSVMEHNKQT-----------------GANLKFIR 79
           K V LG    + NI  +  +Q++GR+ V + N+Q                     L+F R
Sbjct: 32  KSVVLGGKSGVPNIRTNREIQQLGRYCVEQFNQQAQNEQGNIGSIAKTDTAISNPLQFSR 91

Query: 80  VVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVNDRPWEKKWKLIYFVPLL 114
           VV+ +KQVVAG+ Y LRIE          ++++V  +PW    +L+ F P++
Sbjct: 92  VVSAQKQVVAGLKYYLRIEVTQPNGSTRMFDSVVVIQPWLHSKQLLGFTPVV 143

BLAST of Bhi09G001555 vs. ExPASy Swiss-Prot
Match: Q41916 (Cysteine proteinase inhibitor 5 OS=Arabidopsis thaliana OX=3702 GN=CYS5 PE=2 SV=2)

HSP 1 Score: 83.6 bits (205), Expect = 1.6e-15
Identity = 41/88 (46.59%), Postives = 57/88 (64.77%), Query Frame = 0

Query: 24  LGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFIRVVNGEKQVVAGINYRLRIEARN 83
           +G W PI N+ DP V E+G F+V E+NK++ + LKF  VV+GE QVV+G NYRL++ A +
Sbjct: 28  VGGWSPISNVTDPQVVEIGEFAVSEYNKRSESGLKFETVVSGETQVVSGTNYRLKVAAND 87

Query: 84  EMNLVWTYEAMVNDRPWEKKWKLIYFVP 112
              +   Y A+V D+PW K   L  F P
Sbjct: 88  GDGVSKNYLAIVWDKPWMKFRNLTSFEP 115

BLAST of Bhi09G001555 vs. ExPASy Swiss-Prot
Match: P86472 (Cysteine proteinase inhibitor 1 OS=Actinidia chinensis var. chinensis OX=1590841 GN=CYT1 PE=1 SV=2)

HSP 1 Score: 80.9 bits (198), Expect = 1.1e-14
Identity = 42/87 (48.28%), Postives = 56/87 (64.37%), Query Frame = 0

Query: 14  ALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFIRVVNGEKQVVAGI 73
           A++ G K V  G W PIEN+    VQ++ +F+V EHNKQ    L++  VV G  QVVAG 
Sbjct: 19  AVVGGRKRVAAGGWRPIENLNSAEVQDVAQFAVSEHNKQANDELQYQSVVRGYTQVVAGT 78

Query: 74  NYRLRIEARNEMNLVWTYEAMVNDRPW 101
           NYRL I A++   +V  YEA+V D+PW
Sbjct: 79  NYRLVIAAKDGA-VVGNYEAVVWDKPW 104

BLAST of Bhi09G001555 vs. ExPASy Swiss-Prot
Match: Q6TPK4 (Cysteine proteinase inhibitor 1 OS=Actinidia deliciosa OX=3627 PE=1 SV=1)

HSP 1 Score: 78.2 bits (191), Expect = 6.8e-14
Identity = 41/87 (47.13%), Postives = 56/87 (64.37%), Query Frame = 0

Query: 14  ALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFIRVVNGEKQVVAGI 73
           A++ G K V  G W PIE++    VQ++ +F+V EHNKQ    L++  VV G  QVVAG 
Sbjct: 19  AVVGGRKLVAAGGWRPIESLNSAEVQDVAQFAVSEHNKQANDELQYQSVVRGYTQVVAGT 78

Query: 74  NYRLRIEARNEMNLVWTYEAMVNDRPW 101
           NYRL I A++   +V  YEA+V D+PW
Sbjct: 79  NYRLVIAAKDGA-VVGNYEAVVWDKPW 104

BLAST of Bhi09G001555 vs. ExPASy Swiss-Prot
Match: Q10Q47 (Putative cysteine proteinase inhibitor 7 OS=Oryza sativa subsp. japonica OX=39947 GN=Os03g0210100 PE=3 SV=1)

HSP 1 Score: 77.8 bits (190), Expect = 8.9e-14
Identity = 44/101 (43.56%), Postives = 64/101 (63.37%), Query Frame = 0

Query: 14  ALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGA-NLKFIRVVNGEKQVVAG 73
           A++ G     +G WEP++ I DP+VQE+GR++V E ++   A  L F RV +GEKQVVAG
Sbjct: 17  AIVAGATAATVGSWEPVD-INDPHVQELGRWAVAEEDRGVAAGGLTFERVTDGEKQVVAG 76

Query: 74  INYRLRIEARNEMNLVWTYEAMVNDR-PWEKKWKLIYFVPL 113
           +NYRL +EA +       YEA+V ++ P     KL+ F P+
Sbjct: 77  VNYRLTLEASSSGAKDGRYEAVVYEQDPRSNARKLVSFEPI 116

BLAST of Bhi09G001555 vs. ExPASy Swiss-Prot
Match: Q10Q46 (Cysteine proteinase inhibitor 6 OS=Oryza sativa subsp. japonica OX=39947 GN=Os03g0210200 PE=3 SV=1)

HSP 1 Score: 75.5 bits (184), Expect = 4.4e-13
Identity = 38/85 (44.71%), Postives = 61/85 (71.76%), Query Frame = 0

Query: 27  WEPIENIEDPYVQEMGRFSVMEHNKQTGAN-LKFIRVVNGEKQVVAGINYRLRIEARN-E 86
           W PI+NI+DP++QE+GR+++ E+N+ + ++ L F RV  GE+QVV+G+NYRL IEA +  
Sbjct: 23  WSPIKNIDDPHIQELGRWAITENNRVSPSDELTFHRVTGGEQQVVSGMNYRLEIEAASGG 82

Query: 87  MNLVWTYEAMVNDRPWEKKWKLIYF 110
            ++  +Y A+V ++ W    KLI F
Sbjct: 83  GDVTGSYGAVVFEQEWSNTRKLISF 107

BLAST of Bhi09G001555 vs. ExPASy TrEMBL
Match: A0A6J1FCN1 (cysteine proteinase inhibitor 1-like OS=Cucurbita moschata OX=3662 GN=LOC111442885 PE=4 SV=1)

HSP 1 Score: 170.2 bits (430), Expect = 4.9e-39
Identity = 81/115 (70.43%), Postives = 95/115 (82.61%), Query Frame = 0

Query: 1   MSSYVEVAPGQNEALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFI 60
           MSSYVE  PGQNEALIQ PK++E GRWEPIE I  PYV+E+GRF+VMEHN+Q+G +LKFI
Sbjct: 1   MSSYVEADPGQNEALIQDPKNLEFGRWEPIEKI-TPYVEEIGRFAVMEHNQQSGEHLKFI 60

Query: 61  RVVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVNDRPWEKKWKLIYFVPLLKN 116
            V+ G  Q+VAG NYRL IEARN++ L W YEAMV D+PWEK WKLI F+PLLKN
Sbjct: 61  CVLRGWSQLVAGTNYRLIIEARNDVGLAWNYEAMVYDKPWEKTWKLIEFIPLLKN 114

BLAST of Bhi09G001555 vs. ExPASy TrEMBL
Match: A0A6J1IHH5 (cysteine proteinase inhibitor 1-like OS=Cucurbita maxima OX=3661 GN=LOC111475753 PE=4 SV=1)

HSP 1 Score: 168.3 bits (425), Expect = 1.9e-38
Identity = 80/115 (69.57%), Postives = 95/115 (82.61%), Query Frame = 0

Query: 1   MSSYVEVAPGQNEALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFI 60
           MSSYVE APGQNEALIQG K++E+G+W+PIE I  PYV+E+GRF+VMEHN+Q+G +LKFI
Sbjct: 1   MSSYVEAAPGQNEALIQGSKNLEVGQWKPIEKI-TPYVEEIGRFAVMEHNQQSGEHLKFI 60

Query: 61  RVVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVNDRPWEKKWKLIYFVPLLKN 116
            V+ G  Q+VAG NYRL IEARN + L W YEAMV D+PWEK WKLI FVPLL N
Sbjct: 61  CVIRGWSQIVAGTNYRLIIEARNHVGLAWNYEAMVYDKPWEKTWKLIEFVPLLMN 114

BLAST of Bhi09G001555 vs. ExPASy TrEMBL
Match: A0A6J1IDU0 (cysteine proteinase inhibitor 8-like OS=Cucurbita maxima OX=3661 GN=LOC111475783 PE=4 SV=1)

HSP 1 Score: 154.5 bits (389), Expect = 2.8e-34
Identity = 75/116 (64.66%), Postives = 93/116 (80.17%), Query Frame = 0

Query: 1   MSSYVEVAPGQNEALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEH-NKQTGANLKF 60
           MSS+VE APGQNEA+ Q  K +E+G+W+PIE+I+DPYVQEMGRF+VMEH + +TG NLKF
Sbjct: 1   MSSHVEAAPGQNEAMFQDKKGIEVGQWKPIEDIKDPYVQEMGRFAVMEHDDMRTGENLKF 60

Query: 61  IRVVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVNDRPWEKKWKLIYFVPLLKN 116
           I V +GEKQVV G+NYRL I+A N + +   Y A+V D+PWEK WKLI FVPLL N
Sbjct: 61  ICVQSGEKQVVEGMNYRLLIKASNHLGISSLYMAVVYDKPWEKTWKLIEFVPLLMN 116

BLAST of Bhi09G001555 vs. ExPASy TrEMBL
Match: A0A6J1FCN5 (cysteine proteinase inhibitor 8-like OS=Cucurbita moschata OX=3662 GN=LOC111442890 PE=4 SV=1)

HSP 1 Score: 154.1 bits (388), Expect = 3.6e-34
Identity = 75/116 (64.66%), Postives = 92/116 (79.31%), Query Frame = 0

Query: 1   MSSYVEVAPGQNEALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEH-NKQTGANLKF 60
           MSS+VE APGQNEA+ Q  K +E+G+W+PIE+I+DPYVQEMGRF+VMEH N + G NLKF
Sbjct: 1   MSSHVEAAPGQNEAMFQDKKGIEVGQWKPIEDIKDPYVQEMGRFAVMEHDNMRIGENLKF 60

Query: 61  IRVVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVNDRPWEKKWKLIYFVPLLKN 116
           I V +GEKQVV G+NYRL I+A N + +   Y A+V D+PWEK WKLI FVPLL N
Sbjct: 61  ICVQSGEKQVVEGMNYRLLIKASNHLGISSLYMAIVYDKPWEKTWKLIEFVPLLMN 116

BLAST of Bhi09G001555 vs. ExPASy TrEMBL
Match: A0A6J1IK23 (cysteine proteinase inhibitor A-like OS=Cucurbita maxima OX=3661 GN=LOC111475738 PE=4 SV=1)

HSP 1 Score: 152.1 bits (383), Expect = 1.4e-33
Identity = 75/115 (65.22%), Postives = 88/115 (76.52%), Query Frame = 0

Query: 1   MSSYVEVAPGQNEALIQGPKDVELGRWEPIENIEDPYVQEMGRFSVMEHNKQTGANLKFI 60
           MSSYVE APGQNEA+ Q  K +E G+WEPI NI DPYVQE+GRF+VME+NK T  +LKFI
Sbjct: 1   MSSYVEAAPGQNEAVFQDQKGIECGQWEPIVNIMDPYVQELGRFAVMENNKNTRGHLKFI 60

Query: 61  RVVNGEKQVVAGINYRLRIEARNEMNLVWTYEAMVNDRPWEKKWKLIYFVPLLKN 116
            V+ G  QVVAG NYRL IEA NE+    TYEA+V  +PWEK W+LI F PLL+N
Sbjct: 61  CVIKGWTQVVAGKNYRLIIEACNELGFPGTYEAIVYVKPWEKTWELIEFKPLLRN 115

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
AT5G47550.11.2e-1646.59Cystatin/monellin superfamily protein [more]
AT4G16500.12.5e-1138.96Cystatin/monellin superfamily protein [more]
AT5G12140.13.7e-0733.65cystatin-1 [more]
AT2G40880.16.4e-0739.68cystatin A [more]
AT2G31980.11.4e-0630.36PHYTOCYSTATIN 2 [more]
Match NameE-valueIdentityDescription
Q419161.6e-1546.59Cysteine proteinase inhibitor 5 OS=Arabidopsis thaliana OX=3702 GN=CYS5 PE=2 SV=... [more]
P864721.1e-1448.28Cysteine proteinase inhibitor 1 OS=Actinidia chinensis var. chinensis OX=1590841... [more]
Q6TPK46.8e-1447.13Cysteine proteinase inhibitor 1 OS=Actinidia deliciosa OX=3627 PE=1 SV=1[more]
Q10Q478.9e-1443.56Putative cysteine proteinase inhibitor 7 OS=Oryza sativa subsp. japonica OX=3994... [more]
Q10Q464.4e-1344.71Cysteine proteinase inhibitor 6 OS=Oryza sativa subsp. japonica OX=39947 GN=Os03... [more]
Match NameE-valueIdentityDescription
A0A6J1FCN14.9e-3970.43cysteine proteinase inhibitor 1-like OS=Cucurbita moschata OX=3662 GN=LOC1114428... [more]
A0A6J1IHH51.9e-3869.57cysteine proteinase inhibitor 1-like OS=Cucurbita maxima OX=3661 GN=LOC111475753... [more]
A0A6J1IDU02.8e-3464.66cysteine proteinase inhibitor 8-like OS=Cucurbita maxima OX=3661 GN=LOC111475783... [more]
A0A6J1FCN53.6e-3464.66cysteine proteinase inhibitor 8-like OS=Cucurbita moschata OX=3662 GN=LOC1114428... [more]
A0A6J1IK231.4e-3365.22cysteine proteinase inhibitor A-like OS=Cucurbita maxima OX=3661 GN=LOC111475738... [more]
InterPro
Analysis Name: InterPro Annotations of Wax gourd (B227) v1
Date Performed: 2021-10-22
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000010Cystatin domainSMARTSM00043CY_4coord: 22..112
e-value: 7.9E-11
score: 52.0
IPR000010Cystatin domainPFAMPF16845SQAPIcoord: 30..109
e-value: 7.0E-25
score: 87.2
IPR000010Cystatin domainCDDcd00042CYcoord: 25..81
e-value: 6.78193E-12
score: 55.558
NoneNo IPR availableGENE3D3.10.450.10coord: 22..113
e-value: 2.2E-28
score: 100.3
NoneNo IPR availablePANTHERPTHR47364CYSTEINE PROTEINASE INHIBITOR 5coord: 21..110
NoneNo IPR availablePANTHERPTHR47364:SF2CYSTEINE PROTEINASE INHIBITOR 5coord: 21..110
NoneNo IPR availableSUPERFAMILY54403Cystatin/monellincoord: 25..112
IPR018073Proteinase inhibitor I25, cystatin, conserved sitePROSITEPS00287CYSTATINcoord: 67..80

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
Bhi09M001555Bhi09M001555mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0010951 negative regulation of endopeptidase activity
molecular_function GO:0004869 cysteine-type endopeptidase inhibitor activity